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Investigation on quality of life of hospitalized patients in China with digestive system malignancy

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Journal of Nutritional Oncology 2024年第2期9卷 53-62,I0001页

作者： Kai-Lun Zhang Hong-Xia Xu Wei Li Jiu-Wei Cui Min Weng Qing-Hua Yao Zeng-Qing Guo Yi Ba fu-xiang zhou Zhi-Kang Chen Su-Yi Li Qing-Chuan Zhao Chun-Ling zhou Ming Liu Lan zhou Han-Ping Shi Chun-Hua Song Department of Epidemiology and Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400038China Cancer Center of the First Hospital of Jilin University Changchun 130021JilinChina Department of Clinical Nutrition The First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina Department of Integrated Traditional Chinese andWestern Medicine Zhejiang Cancer Hospital and Key Laboratory of Traditional Chinese Medicine OncologyZhejiang Cancer HospitalHangzhou 310022ZhejiangChina Department of Medical Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Colorectal and Anus Surgery Xiangya Hospital of Central South UniversityChangsha 410008HunanChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina Department of Digestive Diseases Xijing HospitalFourth Military Medical UniversityXi'an 710032ShaanxiChina Department of Clinical Nutrition The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001HeilongjiangChina Department of General Surgery The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001HeilongjiangChina Department of Nutrition Third Affiliated Hospital of Kunming Medical CollegeTumor Hospital of Yunnan ProvinceKunming 650118YunnanChina Center of Cancer Nutrition and Metabolism Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Henan Key Laboratory of Tumor Epidemiology Zhengzhou UniversityZhengzhou 450

Background: The purpose of this study is to evaluate the quality of life(QoL) of hospitalized patients in China suffering from digestive system malignancies and to identify potential risk factors for a decrease in ***: The European Organization for Research and Treatment Core Quality of Life questionnaire(EORTC QLQ-C30) was applied to evaluate the QoL of 23,519 patients with six digestive malignancies(esophageal cancer, gastric cancer, colorectal cancer, liver cancer, biliary tract cancer, and pancreatic cancer). A t test or analysis of variance was employed to analyze the total EORTC QLQ-C30 scale scores and domain scores of the EORTC QLQ-C30 scale among patients in different ***: The average QoL score was 50.4 ± 10.8. The tumor type, age, sex, and TNM stage al had an impact on QoL ratings. Colorectal cancer patients had a better total QoL score(49.3 ± 10.3) and scores in the domains of functioning, with milder symptoms, except for diarrhea. Patients with biliary tract cancer(54.2 ± 12.3) and pancreatic cancer(54.2 ± 12.3) reported a poorer QoL, significant functional impairment, and more pronounced symptoms. Patients with esophageal cancer experienced the most severe financial difficulties(35.2 ± 27.5). Patients aged ≥65 years, women, and those with TNM stage Ⅲ/Ⅳ reported lower QoL. In addition, the disparities in total QoL scores and scores in specific domains were significant among patients with some types of tumors, and based on ethnicity, educational level, occupation, treatment(s) received, and place of ***: There is a need to focus on elderly individuals, those with low educational levels, and patients with progressive malignant tumors and to improve routine disease monitoring and symptom management to enhance the quality of life for patients with malignancies of the digestive system.

关键词： Quality of life Digestive system malignancy Cross-sectional study EORTC QLQ-C30

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Reconfigurable spin-decoupled conformal metasurface: 3D-printing with independent beam shaping and multi-focusing dual-channel reconfigurability techniques

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Photonics Research 2025年第1期13卷 150-162页

作者： YANG fu XIAOFENG zhou HOUYUAN CHENG YUEJIE YANG xiangLI zhou FAN DING JING JIN HELIN YANG College of Physical Science and Technology Central China Normal University Hanjiang National Laboratory

This paper describes a 3D-printed conformal reconfigurable spin-decoupled metasurface and supports both independent beam shaping and dual-channel reconfigurability. The increasing complexity of metasurface structures and reconfigurable spin-decoupling among conformal structures are rarely reported due to their challenging properties. In this paper, a reconfigurable metasurface based on 3D-printing technology is proposed for reconfigurable spin-decoupled curved structures at 13.5–14.5 GHz. Curved surface spin-decoupling is realized for the first time and verified by simulation and experiment. Beam deflection(20° and 35°) and near-field focusing(100 mm and 150 mm) were achieved at different circularly polarized wave incidences. Switching the beam between the two states was achieved by incorporating the water-based metasurface. As a proof of concept, metasurfaces that have anomalous reflections in both channels were fabricated and measured. furthermore,reconfigurable spin-decoupling was achieved using a water-based metasurface. This work extends the phase engineering approach in metasurfaces and may have a wide range of applications in communications, sensing,imaging, and camouflage.

关键词： Beam shaping Berry phase Metasurfaces Optical wireless communication Phase compensation Phase shift

Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： xiang-Tian Bai Li-Hui Cao Xu-Yong Chen Jia-Yu Wang Zi-Ye zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Passive-state preparation for quantum secure direct communication

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Science China(Physics,Mechanics & Astronomy) 2025年第04期Mechanics & Astronomy) .卷 39-48页

作者： Jia-Wei Ying Jin-Yu Wang Yu-xiang Xiao Shi-Pu Gu Xing-fu Wang Wei Zhong Ming-Ming Du Xi-Yun Li Shu-Ting Shen An-Lei Zhang Lan zhou Yu-Bo Sheng College of Electronic and Optical Engineering and College of Flexible Electronics (future Technology) Nanjing University of Posts and Telecommunications Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications College of Science Nanjing University of Posts and Telecommunications

Quantum secure direct communication（QSDC） can transmit the secret message directly. Single-photon-based QSDC protocol requires the active modulation of the quantum state of the source, potentially introducing various side-channel vulnerabilities. In this paper, we propose a passive-state preparation QSDC protocol. By utilizing a passive-state preparation method, we remove the need for active modulation, thus eliminating the side-channel risks associated with the source encoder. To evaluate the performance of the protocol, we develop a system model and improve the decoy state method. Through parameter optimization,we identify the optimal secrecy message capacity for various communication distances and compare it with active modulation QSDC. At a communication distance of 10（15） km, the secrecy message capacity of passive-state preparation QSDC reaches3.894 × 10-4（3.715 × 10-5） bit/pulse, achieving 95.3%（91.5%） of the active case's performance. Meanwhile, we consider the resource consumption and optimize the secrecy message transmission rate of passive-state preparation QSDC. Using a coherent light source with a frequency of 10～6Hz, at communication distances of 5, 10, and 15 km, the secrecy message transmission rates for passive-state preparation QSDC reach 2.370 × 10～2, 4.218 × 10, and 2.504 bit/s, respectively.

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin fu Xiaoting Yang Ya Yu Kang zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen fuqiang Fan Yuhang Li Yu fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

Efficient inhibition of human telomerase activity by antisense oligonucle-otides sensitizes cancer cells to radiotherapy

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Acta Pharmacologica Sinica 2006年第9期27卷 1185-1191页

作者： Xue-mei JI~2 Cong-hua XIE~2 Ming-hao FANG~3 fu-xiang zhou~2 Wen-jie ZHANG~4 Ming-sheng ZHANG~2 Yun-feng zhou~(2,5)2 Department of Chemotherapy and Radiation Oncology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China 3 Department of Emergency,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 4 Cancer Research Institute,Wuhan University,Wuhan 430071,China Department of Chemotherapy and Radiation Oncology Zhongnan Hospital Wuhan University Wuhan China Department of Emergency Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Cancer Research Institute Wuhan University Wuhan China

Aim:To investigate the effect of the antisense otigonucleotides（ASODN）spe-cific for human telomerase RNA（hTR）on radio sensitization and proliferationinhibition in human neurogliocytoma cells（U251）.Methods:U251 cells weretransfected with hTR ASODN or nonspecific oligonucleotides（NSODN）.Beforeand after irradiation of60Co-γray,telomerase activity was assayed by telomericrepeat amplification protocol（TRAP-PCR-ELISA）,and DNA damage and repairwere examined by the comet *** classical colony assay was used to plotthe cell-survival curve,to detect the ***:hTR antisense oligo-nucleotides could downregulate the telomerase activity,increase radiation in-duced DNA damage and reduce the subsequent ***,it could in-hibit the proliferation and decrease the D0value which demonstrates ***,telomere length was unchanged over a short period ***:These findings suggest that an ASODN-based strategy may beused to develop telomerase inhibitors,which can efficiently sensitize radiotherapy.

关键词： oligonucleotides,antisense telomerase radiotherapy glioma,astrocytic gene therapy

Receiver-device-independent quantum secure direct communication

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Cheng Liu Cheng Zhang Shi-Pu Gu Xing-fu Wang Lan zhou Yu-Bo Sheng College of Science Nanjing University of Posts and Telecommunications College of Electronic and Optical Engineering College of Flexible Electronics (Future Technology)Nanjing University of Posts and Telecommunications

Quantum secure direct communication (QSDC) enables the sender to directly transmit secure messages to the receiver via a quantum channel without the need for ***-independent (DI) and measurement-device-independent (MDI) QSDC protocols theoretically enhance the practical security of ***,DI QSDC requires extremely high global detection efficiency and has a limited secure communication *** DI and MDI QSDC protocols depend on high-quality *** entanglement sources,which generate entangled photon pairs with low efficiency,significantly reduce their practical communication *** this paper,we propose a single-photon-based receiver-device-independent (RDI) QSDC *** protocol relies solely on the practical single-photon source,which is nearly on-demand with current technology,and treats all receiving devices on both ends of the communication as“black boxes”.The security of the message is ensured only through the observed *** also develop a numerical method to simulate the protocol’s performance under practical noisy communication *** RDI QSDC protocol provides the same security level as MDI *** to DI and MDI QSDC,RDI QSDC has several ***,it uses single-photon sources and single-photon measurements,which allow it to achieve practical communication efficiency approximately 3415 times greater than that of DI QSDC,while being easier to *** entire protocol is feasible with current ***,it offers higher robustness to photon loss and better noise tolerance than DI QSDC,enabling a secure communication distance approximately 26 times greater than that of DI *** on these advantages,the RDI QSDC protocol presents a promising approach for achieving highly secure and efficient QSDC in the near future.

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Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie Weijie Yang Xin Wang xiang Li Lele Wei Xiaolin Bai Lin Liu Feng fu Jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Accelerating homogenization kinetics and enhancing hot-workability of as-cast nickel-based superalloy via prior hot-deformation

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Journal of Iron and Steel Research International 2025年第1期32卷 215-226页

作者： Jia-jun Chen Yang zhou Hao-ran Han Xian-guang Zhang Goro Miyamoto Ping-mei Tang Dong-ping Xiao Jian-hui fu Peng Shi Yi-wu Pei Jian Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Chengdu Advanced Metal Materials Industrial Technology Institute Co. Ltd.Chengdu 610300SichuanChina Institute for Materials Research Tohoku UniversitySendai 980-8577Aoba-KuJapan

Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability via a simple way of prior hot-deformation was proposed,which was not widely accepted for wrought *** homogenization efficiency is increased by 40%-70%via performing 10%-20%prior *** theoretical and experimental analyses revealed that the increment in homogenization efficiency is mainly attributed to the decrease in interdendritic-segregation spacing,and thus the necessary diffusion distance,rather than that of *** addition,dynamic and static recrystallizations occurred during the prior hot-deformation and diffusion-annealing processes,and the grains were significantly refined even after the ***,the size of the precipitates was refined as *** enhanced the hot-workability of the homogenized ingot for the subsequent cogging process.

关键词： Nickel-based superalloy Homogenization kinetics Prior hot-deformation Grain size Hot workability