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Relationship between Radiosensitivity and Telomere Length in Human Carcinoma Cell Lines

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生物医学工程学杂志 2005年第S1期22卷 135-136页

作者： fu-xiang zhou Zhi-Guo LUO Zhen CAO Yun-Feng zhou~△(Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan 430071,China) Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 IntroducionRadiotherapy has long been used as a curative treatment for many cancers. The sensitivity to the irradiation differs in various cancers, and relates to the individual radiotherapy protocol for each patient who suffered from malignancys. So what we will do is to find some definite indicators for radiosensitivity in order to make the individual treatment available. The length of telomere which is known as the 'miototic clock' to determine the cell division ability[1]. Radiosensitivity is correlated with the cell division ability, therefore it maybe hypothesized that there is some intrinsic relationship between telomere length and radiosensitivity. In order to explore if the telomere length could be a valid indicator for radiosensitivity, we investigated the correlation between the radiosensitivity and telomere length with or without the pretreatment of azidothymidine (AZT), a telomerase inhibitor which can shorten the telomere, in several carcinoma cell lines.

关键词： Cell length Relationship between Radiosensitivity and Telomere Length in Human Carcinoma Cell Lines Hep AZT

Phenotypic Heterogeneity in Cell Proliferation and Radiosensitivity in Human Laryngocarcinoma Hep-2 Cells

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生物医学工程学杂志 2005年第S1期22卷 77-78页

作者： Guang HAN Chuang-Ying XIAO fu-xiang zhou Yun-Feng zhou~Δ Wen-Jie ZHANG(Department of Radio-Chemotherapy, Zhongnan Hospital, Cancer Research Center,Wuhan University, Wuhan 430071, China)

The Effects of Reverse Transcriptase Inhibitor on Radiosensitization of Human Malignant Glioma Cells

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生物医学工程学杂志 2005年第S1期22卷 121-122页

作者： Jing DAI fu-xiang zhou Cong-Hua XIE Zhi-Guo LUO Yun-Feng zhou~Δ(Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan 430071, China) Department of Radio-Chematheraty of Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 IntroductionTelomerase is a reverse transcriptase that maintains the telomeric structures at the chromosome termini, which play an important role in chromosome stability. Recent reports have shown telomerase reactivation in a large number of cancers and proposed that telomerase as a cancer marker and a promising target for anticancer therapy[1].

关键词： The Effects of Reverse Transcriptase Inhibitor on Radiosensitization of Human Malignant Glioma Cells DSB AZT

Chinese Medicine Angelica Sinensis Suppresses Radiation-induced TNF-αand TGF-β_1 Expression in Mice

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生物医学工程学杂志 2005年第S1期22卷 69-70页

作者： Cong-Hua XIE fu-xiang zhou Ming-Sheng ZHANG Guang HAN Zhi-Guo LUO Yun-Feng zhou~Δ(Department of Radio-Chemotherapy, Zhongnan Hospital, Cancer Research Center,Wuhan University, Wuhan 430071, China)

Establishment and Characterization of a Radioresistant Human Squamous Carcinoma Cell Line Induced by Radiation

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生物医学工程学杂志 2005年第S1期22卷 131-132页

作者： Zhi-Guo LUO fu-xiang zhou Zhen CAO Jin DAI Ming-Sheng ZHANGJian-Ping WU Cong-Hua XIE Yun-Feng zhou~△(Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan 430071, China) Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 IntroductionRadiotherapy is one of the major clinical treatments for malignant tumors. Radio-sensitivity is the key element in controlling radioresistant tumor cells, so is an important content of radiotherapy basic research to make clear the mechanism of radioresistance[1]. There are many factors affecting the radiosensitivity such as hereditary background, growth environment, and others. It' s difficult to weigh such mixed factors. In this study, a radioresistant cell line Hep-2R has been obtained and characterized from its parental line Hep-2 known as human larynx squamous carcinoma cell line after long-term radiation induction. The Hep-2R and its parental line Hep-2 have offered a good model for the research of radiosensitivity.

关键词： Hep Radio line

Reduced expression of α-tocopherol-associated protein is associated with tumor cell proliferation and the-increased risk of prostate cancer recurrence

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Asian Journal of Andrology 2007年第2期9卷 206-212页

作者： Xing-Qiao Wen Xiao-Juan Li Zu-Lan Su Yong Liu xiang-fu zhou Yu-Bin Cai Wen-Tao Huang Xin Gao Department of Urology Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Health Care Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Pathology Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

Aim： To examine the impact and prognostic significance of α-tocopherol associated protein （TAP） expression in a series of prostate cancer patients. Methods： Tissues from 87 patients underwent radical prostatectomy were examined for TAP expression by immunohistochemistry. The relationships of the staining results, the clinic pathological characteristics and the recurrence times were analyzed. Results： Compared with the adjacent areas of normal and benign glands, immunoreactivity of TAP was reduced in areas of prostate cancer. A lower TAP-positive cell number per mm^2 of the largest cancer area （defined as TAP-PN） was associated with higher clinical stage （r = -0.248, P = 0.0322）. Inverse associations were found among the TAP-PN and positive lymph nodes （r = -0.231, P = 0.0325）, preoperative prostatespecific antigen （PSA） levels （r = -0.423, P = 0.0043）, tumor size （r = -0.315, P = 0.0210） and elevated tumor cell proliferation, which was indicated by the staining of Ki-67 （r = -0.308, P = 0.0026）. TAP-PN was a significant predictor of recurrence univariately （P = 0.0006）, as well as multivariately, adjusted for known markers including preoperative PSA, clinical stage, Gleason score, surgical margin, extra-prostatic extension, seminal vesicle invasion and lymph node metastasis （P = 0.0012）. Conclusion： Reduced expression of TAP was associated with the cell proliferation status of prostate cancer, adverse pathological parameters and the increased risk of recurrence.

关键词： α-tocopherol associated protein prostate neoplasms recurrence vitamin E

The Potential Mechanisms Underlying Aspirin-induced Inhibition of Ovarian Tumor Cell Growth

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生物医学工程学杂志 2005年第S1期22卷 145-147页

作者： Yu LIU~1 Jin KE~2 Shi-Quan LIU~1 fu-xiang zhou~1 Cong-Hua XIE~1 Yun-Feng zhou~(1△)1(Department of Radio-Chematherapy of Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan 430071, China)2(Key Lab. for Oral Biomedical Engineering of Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China) Department of Radio- Chematherapy of Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China Key Lab. for Oral Biomedical Engineering of Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan 430079 China

1 IntroductionOvarian cancer remains the most lethal disease of the gynecological cancers. Owing to the lack of an effective screening approach combined with inadequate therapeutic approach for advanced disease, fewer than 25% of ovarian cancers are identified at an early curable stage. Thus these make ovarian cancer a strong candidate for chemoprevention. In 2001, Akhmedkhanov et al. demonstrated a 2-3 folds decrease in epithelial ovarian cancer associated with Aspirin use. These epidemiological observations suggest that an improved understanding of the mechanisms by which NSAID may decrease the development of ovarian cancer could lead to improved approaches for chemoprevention of this deadly disease. In this research, we explored the potential mechanism underlying epidemiological observations that ovarian cancer occurs at a lower frequency in women exposed to Aspirin(ASP).

关键词： In Cell The Potential Mechanisms Underlying Aspirin-induced Inhibition of Ovarian Tumor Cell Growth COX

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玉米收储制度改革进展、成效与推进建议

经济纵横 2018年第4期 99-105页

作者：刘慧秦富赵一夫周向阳中国农业科学院农业经济与发展研究所北京100081

2016年启动的玉米收储制度改革是我国深化粮食等重要农产品价格形成机制和收储制度改革的重要举措。目前,在建立市场价格形成机制、改善深加工企业经营状况、减少玉米及替代品进口和库存、加快种植结构调整方面取得显著成效,改革中面临... 详细信息

2016年启动的玉米收储制度改革是我国深化粮食等重要农产品价格形成机制和收储制度改革的重要举措。目前,在建立市场价格形成机制、改善深加工企业经营状况、减少玉米及替代品进口和库存、加快种植结构调整方面取得显著成效,改革中面临的最突出问题是非优势产区农户种粮收支基本持平甚至亏损。建议加强补贴的导向性,即玉米生产者补贴进一步向优势产区倾斜和支持农业结构调整补贴进一步向非优势产区集中,并着重从培育杂粮品牌和扶持龙头企业两方面引导和带动非优势产区农户种植结构调整。

关键词：玉米收储制度改革成效种粮收入

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs