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TNF /TNFR1 signaling pathway and endocytoplasmic reticulum stress (ERs) mediated apoptosis are involved in ofloxacin and marbofloxacin-induced apoptosis of juvenile dog joint chondrocytes in early stage in vitro.

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畜牧与兽医 2012年第S2期44卷 46-47页

作者： fu-tao zhang Dan Xing Ming-Xing Ding College of Veterinary Medicine Huazhong Agricultural University

Quinolones (QNs) are widely used for their broad antibacterial spectrum and good antibacterial activities,desirable pharmacokinetic characteristics and few cross reactions with other therapeutic agents. However,QNs have adverse effects including chondrotoxicity in juvenile animals,so the use of QNs is contraindicated in children and adolescents. In regarding to the chondrotoxicity of QNs,numerous studies have been done. The current hypothesis suggests that QNs compete with the β1 integrin receptors residing on chondrocyte surface for extracellular Mg ions,which leads to alternation in β1 integrin expression,or function and eventually results in chondrocyte death. Stupack et al (2001)demonstrated that caspase-8 could be recruited to unligated integrins in adherent cells and further initiate apoptosis in a death receptor-independent manner. Sheng et al (2008) found that ofloxacin induced rabbit's chondrocyte apoptosis by causing disturbance of β1 integrin functions and subsequently through caspase-8-dependent mitochondrial *** could be initiated through the stimulation of death receptors and through an intrinsic pathway from mitochondria. Santangelo and Bertone (2011) and Wu et al (2011) found that TNFα could be expressed in human primary condrocytes inducing by interleukin-1beta (IL-1) or lipopolysaccharide (LPS). However,to date there have not been sufficient results to support that signaling from the death receptors was involved in QNs-induced chondrocyte *** addition,dilated cisternae of rough endoplasmic reticulum (ER) have been noticed in QNs-induced *** can participate in the initiation of apoptosis. Varieties of harmful cellular stimuli could lead to ERs (ER stress). Elevated ERs results in cellular apoptosis. But whether ERs mediates apoptosis in QNs-treated chondrocytes is not clear *** this study,we chose two QNs agents and chondrocytes were treated with ofloxacin and marbofloxacin at final concentrations of 20 μg / mL,5

关键词： ofloxacin marbofloxacin TNF/TNFR1 ERs apoptosis

THE PHOTOACTIVITY OF SUBSTITUTED PHTHALOCYANINES TO PRODUCE ~1O_2

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Chinese Chemical Letters 1994年第2期5卷 115-116页

作者： Xian fu zhang and tao SHEN(Institute of Photographic Chemistry, Academia Sinica, Beijing, 100101)

The guantum yields of 1O2 generated by photosensitization of some substituted metal phthalocyanlnes(Φ▲)were measured by using DPBF(diphenylisobenzofuran)as chemical trap of 1O2 in oxygen saturated DMSO solution. Both strong electron-withdrawing(-NO2)or strong electron-donating(-NH2)group decrease the ability to produce 1O2,whereas halogenation(Cl, Br, I)changes this ability only slightly.

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Role of Glutamine in the Mediation of E-cadherin, p120-catenin and Inflammation in Ventilator-induced Lung Injury

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Chinese Medical Journal 2018年第7期131卷 804-812页

作者： Jian-Lei Qiu Bai-Ling Song Yu-Juan Wang fu-tao zhang Yue-Lan Wang Department of Anesthesiology Shandong Provincial Qianfoshan Hospital Shandong University Jinan Shandong 250014 China Department of Anesthesiology Dezhou People's Hospital Dezhou Shandong 253014 China Department of Surgery Rizhao People's Hospital Rizhao Shandong 276826 China Department of Anesthesiology Rizhao People's Hospital Rizhao Shandong 276826 China Department of Emergency Dezhou People's Hospital Dezhou Shandong 253014 China

Background： Ventilator-induced lung injury （VILI） is commonly associated with barrier dysfunction and inflammation reaction. Glutamine could ameliorate VILI, but its role has not been fully elucidated, This study examined the relationship between inflammatory cytokines （interleukin JILl-6, tumor necrosis factor [TNF]-α, and IL-10） and adherens junctions （E-cadherin, p 120-catenin）, which were ameliorated by glutamine in VILI, both in vitro and in vivo. Methods： For the in vivo study, 30 healthy C57BL/6 mice weighing 25-30 g were randomly divided into five groups with random number table （n = 6 in each group）： control （Group C）; low tidal volume （Group L）; low tidal volume ＋ glutamine （Group L ＋ G）; high tidal volume （Group H）; and high tidal volume ＋ glutamine （Group H ＋ G）. Mice in all groups, except Group C, underwent mechanical ventilation for 4 h. For the in vitro study, mouse lung epithelial 12 （MLE- 12） cells pretreated with glutamine underwent cyclic stretching at 20% for 4 h. Cell lysate and lung tissue were obtained to detect the junction proteins, inflammatory cytokines, and lung pathological changes by the Western blotting, cytokine assay, hematoxylin and eosin staining, and immunofluorescence. Results： In vivo, compared with Group C, total cell counts （t= -28.182, P 〈 0.01）, the percentage of neutrophils （t = -28.095, P 〈 0.01）, IL-6 （t = -28.296, P 〈 0.01 ）, and TNF-α（t = - 19.812, P 〈 0.01 ） in bronchoalveolar lavage （BAL） fluid, lung injury scores （t = -6.708, P 〈 0.01）, and the wet-to-dry ratio （t = - 15.595, P 〈 0.01 ） were increased in Group H; IL- 10 in BAL fluid （t = 9.093, P 〈 0.01 ） and the expression of E-cadherin （t= 10.044, P 〈 0.01） and p120-catenin （t = 13.218, P 〈 0.01） were decreased in Group H. Compared with Group H, total cell counts （t - 14.844, P 〈 0.01 ）, the percentage of neutrophils （t = 18.077, P 〈 0.0 l ）, IL-6 （t - 18.007, P 〈 0.01 ）, and TNF-α （t =1 0.171, P 〈 0.01 ） in BAL fluid were decreased in Group H ＋ G; IL-10 in BAL flu

关键词： Adherens Junctions Glutamine Inflammatory Cytokines Ventilation-induced Lung Injury

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考虑返修的建设项目时间-成本-质量问题

运筹与管理 2018年第7期27卷 193-199页

作者：付芳张涛中国石油大学(华东)经济管理学院山东青岛266580

当施工过程中质量不达标需要返修以改进项目质量,但相应地会影响项目工期和成本。本文基于经典多模式资源受限项目调度问题构建一种新的非线性规划模型,目标为项目成本最小和工期最短,其中项目成本考虑返修成本以提高项目质量。首先,使... 详细信息

当施工过程中质量不达标需要返修以改进项目质量,但相应地会影响项目工期和成本。本文基于经典多模式资源受限项目调度问题构建一种新的非线性规划模型,目标为项目成本最小和工期最短,其中项目成本考虑返修成本以提高项目质量。首先,使用二元非独立正态分布函数描述活动质量,根据活动间的串联或并联关系定义隐蔽工程质量为活动质量的函数。其次,本文提出一种基于NSGA的混合蛙跳算法,采用串行进度产生方案和调整的活动列表编码,其中蛙跳过程结合了遗传算法中的交叉操作和基于置换的局域搜索。最后,整个模型算法应用于框架铁路立交桥施工项目,验证本文算法性能在支配解数量和质量上都优于标准NSGA。

关键词：项目调度混合蛙跳算法隐蔽工程双目标规划

Phase separation of ploy(ethylene glycol) + n-butanol mixture induced by supercritical CO_2

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Chinese Chemical Letters 2007年第6期18卷 738-740页

作者： Min Qiang Hou, Shu Guang Liang, Ji Yuan Song, Xiao Yong Li, Zhao fu zhang, tao Jiang, Bu Xing Han Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China [a]Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The phase behavior of supercritical (SC) CO2 + PEG 1000 (PEG with average molecular weight of 1000 g/mol) + n-butanol system was studied. It was demonstrated that SC CO2 could induce phase separation of PEG 1000 + n-butanol system under suitable conditions. This hints that SC CO2 has potential applications in the separation of mixtures of PEG + organic compound.

关键词： PEG1000 CO2 n-Butanol Phase behavior Separation

针对双馈感应风力发电机的PSASP与PSS/E仿真一致性分析

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电力系统自动化 2017年第6期41卷 66-71页

作者：傅涛王茂励张恒旭电网智能化调度与控制教育部重点实验室(山东大学) 山东省济南市250061

风电大规模并网对电力系统数值仿真提出了更高的要求。含风力发电机组的系统动态行为仿真一致性对电网运行控制和安全决策产生重要影响。构建了仿真一致性评估指标体系,提出了一种基于蒙特卡洛模拟的仿真一致性评估方法;从模型构造上对P... 详细信息

风电大规模并网对电力系统数值仿真提出了更高的要求。含风力发电机组的系统动态行为仿真一致性对电网运行控制和安全决策产生重要影响。构建了仿真一致性评估指标体系,提出了一种基于蒙特卡洛模拟的仿真一致性评估方法;从模型构造上对PSASP和PSS/E中的双馈感应风力发电机模型进行对比分析;通过典型算例,详尽评估了两种软件在不同风力发电机渗透率情况下的机电暂态仿真一致性。研究表明,随着风力发电机渗透率的提高,两种软件的仿真一致性逐步变差。

关键词： PSASP PSS/E 双馈感应发电机仿真一致性

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian zhang Chenhao zhang tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan zhang Shichao Cheng Chuankai fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry