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Sulfonylation from sodium dithionite or thiourea dioxide

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Chinese Chemical Letters 2021年第1期32卷 461-464页

作者： fu-sheng he Min Yang shengqing Ye Jie Wu School of Pharmaceutical and Materials Engineering E/Institute for Advanced Studies Taizhou UniversityTaizhou 318000China School of Basic Medicine Gannan Medical UniversityGanzhou 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The cheap and easily available sodium dithionite and thiourea dioxide have been used as the source of sulfonyl group in the synthesis of sulfones and sulfonamides *** with other methods for the sulfonylation reactions,the strategies using sodium dithionite or thiourea dioxide provide an alternative and complementary route to diverse sulfonyl *** the reaction process,sulfur dioxide anion radical is the key intermediate,which is usually generated from a single electron transfer under suitable *** advantages using sodium dithionite or thiourea dioxide in the sulfonylation reactions include mild conditions and broad substrate scope with excellent functional group *** applications by using sodium dithionite and thiourea dioxide in organic transformations will be anticipated.

关键词： Sodium dithionite Thioureadioxide Sulfones Sulfonamides Sulfur dioxide anion radical

Photoredox-Catalyzed functionalization of Alkenes w ith Thiourea Dioxide:Construction of Alkyl Sulfones or Sulfonamides

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Chinese Journal of Chemistry 2020年第4期38卷 361-366页

作者： Yuewen Li Jin-Biao Liu fu-sheng he Jie Wu School of Pharmaceutical and Materials Engineering&Institute for Advanced Studies Taizhou University1139 Shifu AvenueTaizhouZhejiang 318000Chino School of Metallurgical and Chemical Engineering Jiangxi University of Science and TechnologyGonzhouJiangxi 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Ling ling RoadShanghai 200032China

Summary of main observation and conclusion Sulfonylation of alkenes through photoredox-catalyzed functionalization of alkenes with thiourea dioxide under visible-ight rradiation is achleved,The reaction of alkenes,thiourea dioxide and electropiles provides a green and fficient access to alkyl sul-fones and sulfonamides.A broad reaction scope is presented with good functional group compat bility and excellent regiaselectivity.A plausible mecha-nism involving a radical addition process with sulfur dioxide rpdical anion(SO2-)derived from the oxidation of sulfur dioxide anion(S02^-2) is proposed,which is supported by fluorescence quenching experiments.

关键词： dioxide redox anion

Nitrosoarenes as Nitrogen Source for Generation of Sulfonamides with the Insertion of Sulfur Dioxide under Metal-Free Conditions

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Chinese Journal of Chemistry 2020年第10期38卷 1098-1102页

作者： Xuefeng Wang Yanmei Lin Jin-Biao Liu fu-sheng he Yunyan Kuang Jie Wu Department of Chemistry Fudan University2005 Songhu RoadShanghai 200438China Schoo/of Pharmaceutical and Materials Engineering&Institute for Advanced Studies Taizhou University1139 Shifu AvenueTaizhouZhejiang 318000China School of Metollurgical and Chemical Engineering Jiangxi University of Science and TechnologyGanzhouJiangxi 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Summary of main observation and conclusion A metal-free reaction of nitrosoarenes,aryldiazonium tetrafluoroborates,and sulfur dioxide under mild conditions is developed,giving rise to sulfonamides in moderate to good *** transformation proceeds eficiently at room temperature in the presence of cyclohexa-1,4-diene with a broad reaction *** functional group compatibility is observed,including cyano,halo,and ester.A plausi-ble mechanism involving a radical process with the insertion of sulfur dioxide is proposed,and cyclohexa-1,4-diene serves as the reductant during the transformation.

关键词： dioxide sulfur Sulfur

Initial experience with circumferential pulmonary vein ablation guided by fusion of magnetic resonance imaging with three-dimensional electroanatomic mapping

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Chinese Medical Journal 2006年第12期119卷 1047-1052页

作者： TANG Kai MA Jian MA fu-sheng JIA Yu-he ZHANG Shu Center of Arrhythmia Diagnosis and Treatment Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037China

Catheter ablation for the treatment of atrial fibrillation （AF） has been a focal target ofelectrophysiological study in recent years. Up to date, circumferential pulmonary vein ablation （CPVA） guided by three-dimensional （3-D） electreanatomic mapping （Carto, USA） has been one of the most favourable procedures for the treatment of AF. However, it is still difficult to acquire the detailed information on number, location, and branching pattern of all pulmonary veins （PVs） when the 3-D electroanatomic mapping system is used alone.

关键词： circumferential pulmonary vein ablation magnet resonance imaging three-dimensional electroanatomic mapping atrial fibrillation

Enantioselective [3+2] Cycloaddition of Azomethine Ylides with β-Amino Nitroalkene Catalyzed by a Novel N,O-Ligand/Cu（I） Complex

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Enantioselective [3+2] Cycloaddition of Azomethine Ylides wi...

Asymmetric Synthesis of Highly functionalized Pyrrolidine Derivatives via Catalytic 1,3-Dipolar Cycloaddition

中国化学会第29届学术年会

作者： fu-sheng he Xingxin Yu Wei-Ping Deng Shanghai Key Laboratory of New Drug Design ＆ School of Pharmcy East China University of Science and Technology

The catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to substituted olefins provides a powerful and atom economical approach for the preparation of highly-functionalized pyrrolidines,1 which can serve as valuable building blocks for natural products, bio-active molecules and organocatalysts.2 Among them, enantiopure 3,4-diaminopyrolidines were found to be important scaffolds in HIV protease inhibitors, DPP-4 inhibitors as well as salen-type chiral ligands.3 However, despite the impressive effort made in asymmetric 1,3-dipolar cycloaddition during the past few decades, the process with β-amino α,β-unsaturated alkenes as dipolarphiles has rarely been explored. Based on previous work,4 the cycloaddition of azomethine ylides to β-amino nitroalkene catalyzed by a novel N,O-ligand/Cu（I） complex is developed, affording 4-nitro-3-aminopyrrolidines in high yields with excellent diastereoselectivities and enantioselectivities.

关键词： 4-nitro-3-aminopyrrolidines asymmetric catalysis azomethine ylides cycloaddition

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Asymmetric Synthesis of Highly Functionalized Pyrrolidine De...

Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection

手性中国2014学术研讨会

作者： Wu-Lin Yang fu-sheng he Xingxin Yu Wei-Ping Deng Shanghai Key Laboratory of New Drug Design ＆ School of Pharmacy East China University of Science and Technology

＜正＞Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient alkenes has arguably been one of the most ideal synthetic strategies for the stereoselective construction of highly fiinctionalized chiral pyrrolidines,especially those with spiro quaternary *** dipolarophiles employed in these reactions are 2-oxoindolin-3-ylidene 1,whileα-alkylidene succinimides and P-amino

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World Journal of Gastroenterology 2001年第4期7卷 537-541页

作者： fu-sheng Wang Li-he Xing Ming-Xu Liu Chuan-Lin Zhu Hui-Gang Liu Hui-Fen Wang Zhou-Yun Lei Division of Biological Engineering,~2 Fourth Department of Liver Diseases,Beijing Institute of Infectious Diseases,Beijing Hospital of Infectious Diseases,Beijing 100039,China Division of Biological Engineering Beijing Institute of Infectious Diseases 26 Fengtai Road Beijing 100039 China. fswang@***

AIM: To identify the property of dendritic cells (DCs) of peripheral blood monocytes (PBMC) in patients with chronic HBV infection. METHODS: Twenty patients with persistent HBV infection were included in this study, 10 healthy subjects being used as a control group. The peripheral blood mononuclear cells (PBMC) of T cell-depleted populations were incubated and induced into mature dendritic cells in the RPMI-1640 medium in the presence of cytokines GM-CSF, IL-4, FLt-3,TNF-alpha and 100mL.L(-1 )of fetal calf serum for a total of 10-12 days. The expressions of surface markers on DCs were evaluated using flow cytometric analysis. ELISA method was used to determine the cytokine levels of interleukin-12 (IL-12) and IL-10 in the supernatant produced by DCs. For detection of the stimulatory capacity of DCs to T cell proliferation, mytomycin C-treated DC were incubated with allogenic T cells. RESULTS: A typical morphology of mature DCs from healthy subjects and HBV-infected patients was induced in in vitro incubation, but the proliferation ability and cellular number of DCs from HBV-infected patients significantly decreased compared with healthy individuals. In particular, the expression levels of HLA-DR, CD80 (B7-1) and CD86 (B7-2) on DC surface from patients were also lower than that from healthy individuals (0.46 vs 0.92 for HLA-DR, 0.44 vs 0.88 for CD80 and 0.44 vs 0.84 for CD86,Phe stimulatory capacity and production of IL-12 of DCs from patients in allogenic mixed lymphocyte reaction (AMLR) significantly decreased, but the production level of nitric oxide (NO) by DCs simultaneously increased compared with healthy subjects (86 +/- 15 vs 170 +/- 22 micromol.L(-1), P he patients with chronic HBV infection have the defective function and immature phenotype of dendritic cells, which may be associated with the inability of efficient presentation of HBV antigens to host immune system for the clearance of HBV.

关键词： Adolescent Adult Antigens, Surface Cell Division Child Dendritic Cells Female Flow Cytometry hepatitis B, Chronic Humans Interleukin-10 Interleukin-12 Male Middle Aged Nitric Oxide Research Support, Non-U.S. Gov't

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发挥高校图书馆优势加强大学生信息素养教育

科技情报开发与经济 2011年第29期21卷 54-56页

作者：傅生合青海师范大学图书馆青海西宁810008

探讨了我国加强大学生信息素养教育的必要性,分析了高校图书馆在开展大学生信息素养教育方面的作用及优势,提出了高校图书馆开展大学生信息素养教育的若干举措。

关键词：高校图书馆大学生信息素养教育

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung sheng-fu Wang Nai-Jen Liu Department of Gastroenterology and hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation