检索结果-南通市图书馆

Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

World Journal of Gastroenterology 2017年第8期23卷 1367-1374页

作者： Yu-Mei Zhang Hong-Yu Ren Xian-Lin Zhao Juan Li Jun-Yi Li fu-sheng wu Hang Su Wen-fu Tang Sichuan Provincial Pancreatitis Center Department of Integrative Medicine West China Hospital Sichuan University Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital School of Acupuncture Chengdu University of Traditional Chinese Medicine

AIM To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloeemodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase (ALT) and aspartate transaminase (AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated. RESULTS The major components of DCQD were detected in the liver, and their concentrations increased dose-dependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-a and interleukin (IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG (P < 0.05). DCQD could reduce the pathological scores in the pancreas and liver of the rats with SAP, especially in the HDG. Compared to the SOG, the ALT and AST levels in serum were higher in the MG (P < 0.05), while there was no statistical difference in the MG and HDG. CONCLUSION DCQD could alleviate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components.

关键词： Pharmacokinetics Pharmacodynamics Da-Cheng-Qi decoction Acute pancreatitis Acute liver injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma:A case report

引用

World Journal of Clinical Cases 2022年第25期10卷 9104-9111页

作者： Shao-Cheng Wang Yan-Yan Chen Fei Cheng Hai-Yong Wang fu-sheng wu Li-Song Teng Department of Surgical Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Biliary adenofibromas(BAFs)are rare primary hepatic neoplasms,some of which can potentially undergo malignant ***,we describe a rare case of malignant transformation of *** SUMMARY A 51-year-old female was referred to our hospital with epigastric *** tomography showed a solitary liver mass combined with the enlargement of multiple mediastinal and cervical lymph nodes,clinically mimicking a liver carcinoma with extensive lymph node ***,core needle biopsy suggested BAF with malignant ***,the patient underwent curative resection of the neoplasm and was recurrence-free for 12 *** Our case serves as an example of a rare manifestation of *** report and the previously published experience,reinforce that curative resection should be considered the primary treatment for BAFs with malignant transformation,leading to a favorable prognosis.

关键词： Biliary adenofibroma Malignant transformation Lymphadenopathy Surgery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apoptosis induced by preoperative oral 5′-DfuR administration in gastric adenocarcinoma and its mechanism of action

引用

World Journal of Gastroenterology 2006年第9期12卷 1356-1361页

作者： Wen-He Zhao Shi-fu Wang Wei Ding Jian-Ming sheng Zhi-Min Ma Li-Song Teng Min Wang fu-sheng wu Bing Luo Department of Oncological Surgery The First Affiliated Hospital of Medical College Zhejiang University Hangzhou 310003 Zhejiang Province China Bing Luo The Third People's Hospital of Wenling Taizhou 317523 Zhejiang Province China

AIM： To study the apoptosis induced by preoperative oral 5＇-DfuR administration in gastric adenocarcinorna and its mechanism of action. METHODS： Sixty gastric cancer patients were divided randomly into three groups （20 each group） before operation： group one： 5＇-DfuR oral administration at the dose of 800-1200mg/d for 3 - 5 d, group two： 500mg 5-fu ± 200 mg/d CF by venous drip for 3 - 5 d, group three （control group）. One or two days after chemotherapy, the patients were operated. Fas/FasL, PD-ECGF and PCNA were examined by immunohistochemistry and apoptotic tumor cells were detected by in situ TUNEL method. Fifty-four patients received gastrectomy, including 12 palliative resections and 42 radical resections. Six patients were excluded. Finally 18 cases in 5＇-DfuR group, 16 cases in CF ± 5-fu group, and 20 cases in control group were analyzed. RESULTS： There was no significant difference in patient mean age, gender, white blood cell count, haernatoglobin （HB）, thromboplastin, perioperative complication incidence, radical or palliation resection, invasion depth （T）, Iymphonode involvement （N）, metastasis （M） and TNM staging among the three groups. However, the PCNA index （PI） in 5＇-DfuR group （40.51 ± 12.62） and 5-fu ±CF group （41.12± 15.26） was significantly lower than that in control group （58.33± 15.69）（F=9.083, P= 0.000）. The apoptotic index （AI） in 5＇-DfuR group （14.39 ±9.49） and 5-fu±CF group （14.11±9.68） was significantly higher than that in control group （6.88 ± 7.37）（F= 4.409, P= 0.017）. The expression rates of Fas and FasL in group one and group three were 66.7% （12/18） and 50% （9/18）, 43.8% （7/16） and 81.3% （13/16）, 45.0% （9/20） and 85% （17/20）, respectively. The expression rate of FasL in 5＇-DfuR group was significantly lower than that in the other two groups （X^2=6.708, P= 0.035）. Meanwhile, the expression rate of PD-ECGF was significantly lower in 5＇-DfuR group （4/18, 28.6%） than in CF±5-fu group （9/16, 56.3%） and control group （13/20, 65.0%）（7,

关键词： Apoptosis Preoperative chemotherapy 5'-DfuR Gastric carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malignant gastric carcinoids with liver metastasis

引用

Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 406-410页

作者： fu-sheng wu, Xiong-Fei Yu, Li-Song Teng and Zhi-Min Ma Department of Surgical Oncology, First AffiliatedHospital, Zhejiang University School of Medicine, Hangzhou 310003 , Chi-na Department of Surgical Oncology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. qiouhang@***

BACKGROUND: Malignant gastric carcinoids are often ac-companied with liver metastasis synchronously or meta-chronously. Because of the slow growth rate of carcinoids,patients with metastatic tumors can undergo resection forpotential cure or for symptom palliation. This study wasdesigned to evaluate the clinicopathologic characteristicsand the diagnosis and management of malignant ***: Seven patients with malignant gastric carci-noids admitted to our hospital between 1990 and 2002 werefollowed up and reviewed ***: Liver metastases were found in all the patients,of whom 3 had lesions simultaneously and the other 4 hadlesions postoperatively. More than 2 lesions were found inall these patients, except a solitary liver lesion in one. Fol-low-up showed two patients died within 2 months, threepatients in 20, 25 and 32 months after operation respective-ly, and the other two have been surviving for more than 5and 3 years ***: Malignant gastric carcinoids have a highmetastatic tendency to the liver. Surgical treatment in com-bination with other therapeutic approaches can significantlyprolong the survival rate of the patients.

关键词： stomach carcinoid liver metastasis surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of a Mobile Station Electronic Health Record on Documentation Compliance and Nurses’ Attitudes

引用

Open Journal of Nursing 2015年第7期5卷 678-688页

作者： Mei-Wen wu Ting-Ting Lee Tzu-Chuan Tsai Chin-Yi Huang Francis fu-sheng wu Mary Etta Mills Changhua Christian Hospital Changhua City Taiwan National Taipei University of Nursing and Health Sciences Taipei Taiwan University of Otago Wellington New Zealand University of Maryland Baltimore USA

Electronic Health Record (EHR) Systems have been adopted by healthcare organizations for documentation of patient care. Often these information systems are embedded in mobile nurse stations. As part of assessing the impact of this technology it is important to determine the effect it has on charting compliance and user acceptance. Data were collected at a medical center in Taiwan in two stages. The first stage involved use of a 28-item medical review tool to measure charting compliance in 99 charts before and after implementation of the EHR system. In stage two, a survey was conducted with 709 nurse users to determine their level of mobile EHR acceptance 3 months after this documentation technology was initiated. Results demonstrated that EHR significantly improved documentation compliance in standardized data entry format (name, date, time), abbreviation, content correction/revision, patient care needs, and care goals. Analysis of data from the five categories of a user acceptance survey revealed the following results (based on a 4-point Likert scale): patient care (2.92), nursing efficiency (2.78), education and training (2.98), usability (2.61), and usage benefits (2.87). The study concluded that use of mobile nurse stations with EHR can improve documentation compliance and that although frequent system downtime needs improvement, nurses generally have positive attitudes toward this technology application.

关键词： Documentation Compliance Information System Mobile Nursing Station Nurse Attitudes Technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Chinese classification system compared with TNM staging in prognosis of patients with primary hepatic carcinoma after resection

引用

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 561-564页

作者： Jian-Ming sheng, Wen-He Zhao, fu-sheng wu, Zhi-Min Ma, Yi-Zheng Feng, Xing-Ren Zhou and Li-Song Teng Department of Oncological Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China Department of Oncological Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. sjm418@***

BACKGROUND: The life expectancy of a patient with primary hepatic carcinoma (PHC) is hard to predict, and it is related to many prognostic factors. The Chinese classification system including five parameters: tumor, vascular thrombosis, lymph node metastasis, distant metastasis and Child-Pugh stage developed in 1999 was adopted by the 8th National Conference on liver Cancer of the Chinese Anti-Cancer Association in 2001. In this study, the discriminatory ability of the Chinese classification system -was compared with that of the TNM staging in patients for resection of PHC, in addition to the evaluation of prognostic value. METHODS: The data of 246 patients who had undergone resection of PHC from January 1986 to December 2000 (average age, 51 years; male/female ratio, 213/33) were retrospectively studied. Among the 246 patients, 227 were followed up for at least 3 years. RESULTS: The 1-, 3-, 5-, 7-, and 10-year tumor-free survival rates were 55% , 30% , 25% , 20% and 18% , respectively. The Chinese classification system was better than the TNM staging system in predicting survival rate of patients with PHC, as confirmed by survival curves shown by the Kaplain-Meier method. The mean survival time was 155, 70, 39, 16, and 4 months in patients with die Chinese classification stages Ⅰa, Ⅰb, Ⅱa,Ⅱb, and Ⅲ, respectively. The 1-, 3-, 5-, 7-, and 10-year tumor-free survival rates of the Chinese classification system and TNM staging were statistically significant and had a slightly positive relationship. The predictive capacity of the Chinese classification system was confirmed in any two subgroups of patients undergoing operation. COX proportional hazards regression analysis showed that the Chinese classification system was the only independent prognostic factor for survival. CONCLUSIONS: Taking both tumor extension and liver function into account, we consider that the Chinese classification system making up for the deficiency of UICC TNM staging is more precise in predictin

关键词： primary liver cancer staging system liver functional status prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

食品中氯丙醇测定方法研究进展

引用

食品科学 2007年第3期28卷 353-357页

作者：傅武胜吴永宁福建省疾病预防控制中心福建福州350001 中国疾病预防控制中心营养食品安全所北京100050

本文综述了食品中氯丙醇检测的方法,主要介绍了基质固相分散萃取法(MSPD)、固相微萃取法(SPME)、液-液萃取法在食品样品氯丙醇提取、净化上的应用;对目前用于氯丙醇衍生化的试剂七氟丁酰类(HFBI、HFBA)、硼酸类(丁基硼酸、苯基硼酸)、... 详细信息

本文综述了食品中氯丙醇检测的方法,主要介绍了基质固相分散萃取法(MSPD)、固相微萃取法(SPME)、液-液萃取法在食品样品氯丙醇提取、净化上的应用;对目前用于氯丙醇衍生化的试剂七氟丁酰类(HFBI、HFBA)、硼酸类(丁基硼酸、苯基硼酸)、丙酮或庚酮、三氟乙酸酐(TFAA)、N,O-双三甲基-三氟乙酰胺(BSTFA)的适用性作了评述,重点地介绍了HFBI的应用;从氯丙醇及其衍生物分析的内标选择、色谱柱、分离条件、检测等方面对作了简要评价;最后介绍了3-MCPD的快速筛选方法。

关键词：氯丙醇食品分析综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

食用植物油中脂肪酸氯丙醇酯形成机制的研究进展

引用

食品科学 2014年第1期35卷 266-270页

作者：吴少明傅武胜杨贵芝福建省疾病预防控制中心人兽共患病研究重点实验室福建福州350001 福州大学化学化工学院食品安全分析与检测技术教育部重点实验室福建福州350108 福建医科大学省疾控中心教学基地福建福州350001 福建中医药大学药学院福建福州350004

脂肪酸氯丙醇酯的污染是近年来国际上新出现的热点食品安全问题之一,尤其是脂肪酸3-氯-1,2-丙二醇酯(3-chlorine-1,2-propylene glycol ester,3-MCPD酯)污染问题更为突出。研究表明,食用植物油中3-MCPD酯主要形成于精炼过程,而未精炼的... 详细信息

脂肪酸氯丙醇酯的污染是近年来国际上新出现的热点食品安全问题之一,尤其是脂肪酸3-氯-1,2-丙二醇酯(3-chlorine-1,2-propylene glycol ester,3-MCPD酯)污染问题更为突出。研究表明,食用植物油中3-MCPD酯主要形成于精炼过程,而未精炼的食用植物油几乎不含3-MCPD酯。欧盟国家已对食用植物油中3-MCPD酯的形成机制开展了相关研究。本文主要对食用植物油种类、可能的前体物质、精炼工艺与3-MCPD酯形成的关系加以综述。

关键词：脂肪酸氯丙醇酯食用植物油精炼工艺形成机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

引用

Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

多同位素内标气相色谱-质谱法测定食品中4种氯丙醇含量

引用

食品科学 2013年第18期34卷 131-136页

作者：吴少明傅武胜傅海庆方勤美华娟福建省人兽共患病研究重点实验室福建省疾病预防控制中心福建福州350001 福建省产品质量检验研究院福建福州350002 福建农林大学金山学院福建福州350002 福建省农业科学院生物技术研究所福建福州350003 福建农林大学食品科学学院福建福州350002

采用多同位素内标法，结合七氟丁酰基咪唑（HFBI）衍生化的气相色谱-质谱（GC—MS）联用技术，建立了食品中4种氯丙醇含量的检测方法。对比了不同来源HFBI衍生试剂的作用性能，对定量内标物和校正标准的选择进行了比较。结果表明：仅用... 详细信息

采用多同位素内标法，结合七氟丁酰基咪唑（HFBI）衍生化的气相色谱-质谱（GC—MS）联用技术，建立了食品中4种氯丙醇含量的检测方法。对比了不同来源HFBI衍生试剂的作用性能，对定量内标物和校正标准的选择进行了比较。结果表明：仅用2种同位素内标（3．氯-1，2．丙二醇-d5（或2．氯．1，3．丙二醇．d，）和1，3．二氯．2．丙醇-d5）校正，同样可达到准确测定食品中4种氯丙醇含量的要求；若采用3-氯-1，2-丙二醇（3-MCPD）为标准物定量测定2-氯-1，3-丙二醇（2-MCPD）时，所得2-MCPD结果偏低，仅为以***为标准物定量结果（真实值）的52．1％-77．8％。在最佳条件下进行了方法学指标的系统验证。4种氯丙醇的最低检出限为2．5～10gg／kg：在100-2000ng范围内，氯丙醇与内标物峰面积的比值和质量呈线性关系俾z〉0．9990）。以酱油和方便面调料粉为基质，进行100、200、4001xg／kg-1．个水平的加标回收实验，4种氯丙醇的回收率均值为90．1％～107％，相对标准偏差（RSD）为3．37％～10．4％（n=6），均满足痕量分析的要求。

关键词：食品氯丙醇基质分散固相萃取法同位素稀释技术气相色谱-质谱法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：