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Sensing with extended gate negative capacitance ferroelectric field-effect transistors

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Chip 2024年第1期3卷 18-23页

作者： Honglei Xue Yue Peng Qiushi Jing Jiuren zhou Genquan Han Wangyang fu Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China School of Microelectronics Xidian UniveristyXi’an 710071China

With major signal analytical elements situated away from the measurement environment,extended gate(EG)ion-sensitive fieldeffect transistors(ISFETs)offer prospects for whole chip circuit design and system integration of chemical *** this work,a highly sensitive and power-efficient ISFET was proposed based on a metal-ferroelectric-insulator gate stack with negative capacitance–induced super-steep subthreshold swing and ferroelectric memory *** with a remotely connected EG electrode,the architecture facilitates diverse sensing functions for future establishment of smart biochemical sensor platforms.

关键词： Extended gate Ion-sensitive field-effect transistors Negative capacitance Sub-60 mV/dec subthreshold swing Ferroelectric memory effect

Defect-mode and Fabry-Perot resonance induced multi-band nonreciprocal thermal radiation

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Science China(Technological Sciences) 2024年第8期67卷 2405-2412页

作者： CHEN ZiHe YU ShiLv YUAN Cheng CUI XinYou HU run School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China Wuhan Fiberhome fuhua Electric Co. Ltd.Wuhan 430074China

According to Kirchhoff's radiation law,the spectral-directional absorptivity(α)and spectral-directional emissivity(e)of an object are widely believed to be identical,which places a fundamental limit on photonic energy conversion and *** introduction of Weyl semimetals and magneto-optical(MO)materials into photonic crystals makes it possible to violate Kirchhoff's law,but most existing work only report the unequal absorptivity and emissivity spectra in a single band,which cannot meet the requirements of most practical ***,we introduce a defect layer into the structure composed of one-dimensional(1D)magnetophotonic crystal and a metal layer,which realizes dual-band nonreciprocal thermal radiation under a 3-T magnetic field with an incident angle of 60°.The realization of dual-band nonreciprocal radiation is mainly due to the Fabry-Perot(FP)resonance occurring in the defect layer and the excitation of Tamm plasmon,which is proved by calculating the magnetic field *** addition,the effects of incident angle and structural parameters on nonreciprocity are also *** is more,the number of nonreciprocal bands could be further increased by tuning the defect layer *** the defect layer thickness increases to 18.2μm,tri-band nonreciprocal thermal radiation is realized due to the enhanced number of defect modes in the photonic band gap and the FP resonance occurring in the defect ***,the effect of defect location on nonreciprocity is also *** present work provides a new way for the design of multi-band or even broad-band nonreciprocal thermal emitters.

关键词： Kirchhoff's law multi-band nonreciprocal thermal radiation magnetophotonic crystal Tamm plasmon defect layer Fabry-Perot resonance

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

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Oncology Research 2024年第5期32卷 943-953页

作者： JIANBO zhou FENG WAN BIN XIAO XIN LI CHENG PENG fu PENG Department of Pharmacology West China School of PharmacySichuan UniversityChengduChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduChina Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologySichuan UniversityChengduChina Chengdu No.1 Pharmaceutical Co. Ltd.PengzhouChina Chengdu Push Bio-Technology Co. Ltd.ChengduChina

Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,*** the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well *** this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent *** induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in ***,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 *** triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 *** mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.

关键词： Metochalcone Breast cancer Lung cancer SASP JAK2/STAT3

Evaluation of microRNA expression profiles in human sperm frozen using permeable cryoprotectant-free droplet vitrification and conventional methods

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Asian Journal of Andrology 2024年第4期26卷 366-376页

作者： Li-Xin Zhang Jing Mao Yan-Dong zhou Guang-Yao Mao run-Fa Guo Hong-Shan Ge Xia Chen Department of Histology and Embryology Medical SchoolNantong UniversityNantong 226001China Department of Reproductive Medicine The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityTaizhou 225300China.

For sperm cryopreservation,the conventional method,which requires glycerol,has been used for a long *** addition,the permeable cryoprotectant-free vitrification method has been continuously *** the differences of cryopreservation effects between the two methods have being studied,differences in microRNA(miRNA)profiles between them remain *** this study,we investigated the differences in miRNA expression profiles among conventional freezing sperm,droplet vitrification freezing sperm and fresh human *** also analyzed the differences between these methods in terms of differentially expressed miRNAs(DEmiRs)related to early embryonic development and paternal *** results showed no significant differences between the cryopreservation methods in terms of sperm motility ratio,plasma membrane integrity,DNA integrity,mitochondrial membrane potential,acrosome integrity,and ultrastructural ***,sperm miRNA-sequencing showed differences between the two methods in terms of the numbers of DEmiRs(28 and 19 with vitrification using a nonpermeable cryoprotectant and the conventional method,respectively)in postthaw and fresh sperm *** related to early embryonic development and paternal epigenetics mainly included common DEmiRs between the *** results showed that the differences between conventional freezing and droplet vitrification were minimal in terms of miRNA expression related to embryonic development and *** in sperm miRNA expression due to freezing are not always detrimental to embryonic *** study compared differences in miRNA expression profiles before and after cryopreservation between cryopreservation by conventional and vitrification *** offers a new perspective to evaluate various methods of sperm cryopreservation.

关键词： cryopreservation cryoprotectant-free vitrification early embryonic development paternal epigenetic inheritance sperm miRNAs sucrose

Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX)genetransfected hepatic stellate cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 499-512页

作者： Hongyi LIU Yuanyuan zhou Peng GUO Xiongwei ZHENG Weibin CHEN Shichao ZHANG Yu fu Xu zhou Zheng WAN Bin ZHAO Yilin ZHAO Department of Oncology and Vascular Interventional Radiology Zhongshan Hospital Affiliated to Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361004China School of Medicine Xiamen UniversityXiamen 361102China Xiamen Health and Medical Big Data Center Xiamen 361008China fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma(Zhongshan Hospital Affiliated to Xiamen University) Xiamen 361004China Xiamen Key Laboratory of Cellular Intervention and Interventional Medical Materials Xiamen 361004China

Artificial vascular graft(AVG)fistula is widely used for hemodialysis treatment in patients with renal ***,it has poor elasticity and compliance,leading to stenosis and *** ideal artificial blood vessel for dialysis should replicate the structure and components of a real artery,which is primarily maintained by collagen in the extracellular matrix(ECM)of arterial *** have revealed that in hepatitis B virus(HBV)-induced liver fibrosis,hepatic stellate cells(HSCs)become hyperactive and produce excessive ECM ***,mechanical stimulation can encourage ECM secretion and remodeling of a fiber *** on the above factors,we transfected HSCs with the hepatitis B viral X(HBX)gene for simulating the process of HBV ***,these HBX-HSCs were implanted into a polycaprolactonepolyurethane(PCL-PU)bilayer scaffold in which the inner layer is dense and the outer layer consists of pores,which was mechanically stimulated to promote the secretion of collagen nanofiber from the HBX-HSCs and to facilitate crosslinking with the *** obtained an ECM-PCL-PU composite bionic blood vessel that could act as access for dialysis after ***,the vessel scaffold was implanted into a rabbit’s neck arteriovenous fistula *** exhibited strong tensile strength and smooth blood flow and formed autologous blood vessels in the rabbit’s *** study demonstrates the use of human cells to create biomimetic dialysis blood vessels,providing a novel approach for creating clinical vascular access for dialysis.

关键词： Composite bilayer bionic blood vessel Extracellular matrix(ECM) Hepatic stellate cells(HSCs) Hepatitis B viral X(HBX)gene Mechanical force

A Tutorial on Quantized Feedback Control

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 5-17页

作者： Minyue fu IEEE the School of System Design and Intelligent Manufacturing Shenzhen Key Laboratory of Control Theory and Intelligent Systems and Centre for Control Science and TechnologySouthern University of Science and TechnologyShenzhen 518055China

In this tutorial paper, we explore the field of quantized feedback control, which has gained significant attention due to the growing prevalence of networked control systems. These systems require the transmission of feedback information, such as measurements and control signals, over digital networks, presenting novel challenges in estimation and control design. Our examination encompasses various topics, including the minimal information needed for effective feedback control, the design of quantizers, strategies for quantized control design and estimation,achieving consensus control with quantized data, and the pursuit of high-precision tracking using quantized measurements.

关键词： Consensus control high-precision control networked control quantized estimation quantized feedback control robust control

A Graph with Adaptive AdjacencyMatrix for Relation Extraction

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Computers, Materials & Continua 2024年第9期80卷 4129-4147页

作者： run Yang YanpingChen Jiaxin Yan Yongbin Qin Engineering Research Center of Text Computing&Cognitive Intelligence Ministry of EducationGuizhou UniversityGuiyang550025China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China College of Computer Science and Technology Guizhou UniversityGuiyang550025China

The relation is a semantic expression relevant to two named entities in a *** a sentence usually contains several named entities,it is essential to learn a structured sentence representation that encodes dependency information specific to the two named *** related work,graph convolutional neural networks are widely adopted to learn semantic dependencies,where a dependency tree initializes the adjacency ***,this approach has two main ***,parsing a sentence heavily relies on external toolkits,which can be ***,the dependency tree only encodes the syntactical structure of a sentence,which may not align with the relational semantic *** this paper,we propose an automatic graph learningmethod to autonomously learn a sentence’s structural *** of using a fixed adjacency matrix initialized by a dependency tree,we introduce an Adaptive Adjacency Matrix to encode the semantic dependency between *** elements of thismatrix are dynamically learned during the training process and optimized by task-relevant learning objectives,enabling the construction of task-relevant semantic dependencies within a *** model demonstrates superior performance on the TACRED and SemEval 2010 datasets,surpassing previous works by 1.3%and 0.8%,*** experimental results show that our model excels in the relation extraction task,outperforming prior models.

关键词： Relation extraction graph convolutional neural network adaptive adjacency matrix

Surface reconstruction of heterostructures in alkaline medium towards enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第6期43卷 2636-2647页

作者： Ming-Yang Yang Ji Yuan Xue-Lian fu Jing-Jing Chen Jing Hu zhou-Guang Lu Chen Liu Guangdong Research Center for Interfacial Engineering of functional Materials Shenzhen Key Laboratory of Polymer Science and TechnologyShenzhen Key Laboratory of Energy Electrocatalytic MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Constructing heterostructures has proved to be a successful strategy to fabricate electrocatalysts with high efficiency for water ***,the structure evolution in alkaline hydrogen evolution reaction lacks investigation and the specific active center remains ***,we take the well-designed Ni_(3)S_(2)@VO_(2) heterostructures as a model to investigate the electrocatalytic activity and the surface reconstruction process of heterostructure catalysts in alkaline *** Ni_(3)S_(2)@VO_(2) heterostructures,with Ni_(3)S_(2) nanorods as the core and VO_(2) nanoflakes as the shell,coupled with the high conductive Ni_(3)S_(2),the hydrophilic VO_(2) and modulated electronic structures at the interfaces,exhibited prominent activity and superior stability at various current ***,the ex-situ characterizations confirmed that the surface reconstruction from Ni_(3)S_(2)@VO_(2) into Ni_(3)S_(2)@amorphous-Ni(OH)_(2) in alkaline media could optimize the water dissociation barrier and exposed large active area,thereby contributing to improved electrocatalytic *** study not only introduces novel high-performance electrocatalysts for hydrogen evolution reaction(HER),but also provides a new avenue for re-examining hetero-structural catalysts in alkaline solutions.

关键词： Heterostructures Ni_(3)S_(2)@VO_(2) Surface reconstruction Water dissociation Alkaline hydrogen evolution

Performance of elastic ball screen-cleaning device based on DEM-MBD coupling simulation

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Particuology 2024年第10期93卷 247-263页

作者： Yubin Bi Qingbin Song Jingyu Zhu Jintao Feng Jianxin Dong Pengfei Zhao Yuxiang Huang Zuoli fu Jixing zhou College of Mechanical and Electric Engineering Northwest A&F UniversityYangling712100China Shaanxi Engineering Research Center for Agricultural Equipment Yangling712100China Zhengzhou Dufeng Technology Co. Ltd.Zhengzhou450000China

In seed breeding, the vibrating screen used for pre-sowing grading parental seeds often has the problem of poor self-purification rate. Using elastic balls to clean the plugging seeds and ensure the self-purification of the screen is a viable technical solution. To clarify and improve the operating performance of the elastic ball particles, a DEM-MBD coupling simulation model of the elastic ball screen-cleaning device was established in this study, and a numerical simulation analysis of the complex motion process was carried out. The mechanism of action of the elastic ball was explained more completely from the aspects of excitation force and energy transfer. Through the Plackett-Burman test, it was determined that the vibration frequency has the most significant effect on the excitation force. Multiple linear regression analysis was performed on each factor and the mathematical relationship equation. It was found that when the maximum excitation force was greater than 7 N and the average excitation force was greater than 2 N, the self-purification rate was greater than 95%. The self-purification rate was then increased to 99.81% by variable frequency tests. The variable frequency achieved better self-purification effect.

关键词： Seed breeding Grading Vibrating screen Self-purification Coupling simulation Variable frequency