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Platycladus orientalis shells promote melanogenesis via p38,AKT and Wnt/β-catenin signaling pathways

Traditional Medicine Research 2022年第6期7卷 56-64页

作者： fu-rui liu Hao Xiang Qian-Bei Guo Shu-Li Man Long Ma State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China

Background:Platycladus orientalis,which has been employed in traditional Chinese medicine for cool blood,antibacterial,promotion of hair growth and therapy of poliosis for ***,there have been few reports focusing on Platycladus orientalis shells treating pigmentary ***:In present study,gas chromatography–mass spectrometry was applied to analyzing the volatile composition of Platycladus orientalis shells and cellular *** in vivo were carried out to evaluate the effect of Platycladus orientalis shells treating pigmentation disorders in C57BL/6J ***:Our results indicated that cedrol occupied the largest percentage in Platycladus orientalis shells(17.1%).Meanwhile,Platycladus orientalis shells up-regulated the content of palmitic acid and increased melanin content and tyrosinase *** mechanism possibly involved in the inhibiting phosphorylation of AKT and β-catenin,increasing phosphorylation of p38 to promote microphthalmia-associated transcription factor *** animal experiment also proved that Platycladus orientalis shells promoted melanogensis and hair blacken in C57BL/6J ***:All in all,Platycladus orientalis shells potentially promoted melanogenesis in vitro and in *** was regarded as the main active substance in Platycladus orientalis ***,it could be used for treatment of pigmentary disorders under safe concentration in the prospective application.

关键词： GC-MS Platycladus orientalis shells melanogenesis tyrosinase pigmentary disorders

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo liu rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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在Si-Ge晶体外延生长中的RHEED花样研究

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物理学报 2009年第11期58卷 7765-7772页

作者：张冲叶辉张磊皇甫幼睿刘旭浙江大学现代光学仪器国家重点实验室杭州310027

在晶体衍射理论基础上,利用运动学理论解释了反射式高能电子衍射(reflection high energy electron diffraction,RHEED)在Si-Ge晶体外延生长过程中不同阶段出现的花样.尤其研究了晶体岛状生长之后出现的RHHED透射式衍射花样,并给出了相... 详细信息

在晶体衍射理论基础上,利用运动学理论解释了反射式高能电子衍射(reflection high energy electron diffraction,RHEED)在Si-Ge晶体外延生长过程中不同阶段出现的花样.尤其研究了晶体岛状生长之后出现的RHHED透射式衍射花样,并给出了相应的解释.解释了硅锗外延生长过程中的多晶环图案和孪晶衍射图案的含义,并给出各个生长阶段演化的工艺条件.

关键词：硅锗外延生长反射式高能电子衍射表面重构透射式衍射花样

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Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan HUANG Yin YANG Hua WANG Xintian SHI Jianping liu Lixia fu Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

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Design and characterization study of dual D-shaped no-core fiber based SPR sensor for refractive index and temperature measurement

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Optoelectronics Letters 2025年

作者： liu Yinggang Li rui Li Fei Xu Xinyi Zhou rui Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection & Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells， Xi'an Shiyou University

To address the issue of temperature cross-sensitivity in refractive index （RI） measurement， a fiber-optic Surface Plasmon Resonance （SPR） sensor based on dual D-shaped no-core fiber （NCF） is proposed and designed. The sensor mainly consists of D-shaped NCF， Ag/Fe2O3composite film， and polydimethylsiloxane （PDMS）， where the silver and Fe2O3are successively coated on both D-shaped surfaces of NCF to generate SPR and enhance the oxidation resistance. The layer of PDMS coated on one D-shaped surface acts as a tunable ambient medium sensing the temperature variation and affecting the transmission spectrum of the sensor. Since the surface plasmon waves are excited in the two D-shaped surfaces with different films， the two RI and temperature-dependent spectral resonance peaks with different wavelengths will be produced. Research results demonstrate that the two peaks’ wavelengths have different responses to the variations of ambient RI and temperature. In the refractive index range of 1.36-1.376 and temperature range of 10-100 °C， the RI and temperature sensitivities reach to 5000 nm/RIU and -0.546 nm/°C， respectively. With the sensitivity coefficient matrix， simultaneous measurement of refractive index and temperature can be realized， and the corresponding accuracy is superior to 0.4×10-5RIU and 0.037°C.

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Multi-receptive field interaction network for shape from polarization

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Science China(Information Sciences) 2025年第1期 394-395页

作者： Yini PENG rui liu Zhiyuan ZHANG Zhongyuan WANG Jiayi MA Xin TIAN Electronic Information School Wuhan University Computer Science School Wuhan University Wuhan Institute of Quantum Technology

Shape from polarization (SfP) method can use the polarization information in reflected light to estimate the surface normal of the target,which can further reconstruct the shape of the *** a simple image capture process,it can use low-cost equipment to meet a high precision imaging requirement,which can be used in remote scenes and other applications.

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Spin-modulated near-infrared-Ⅰ emission in a xanthene-decorated Fe(Ⅱ) spin-crossover complex

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Science China Chemistry 2025年

作者： Cheng Yi Duyong Chen Shihui Zhang rui Cai Chunying Duan Yinshan Meng Tao liu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials and Chemical Engineering School of Chemical Engineering Dalian University of Technology Instrumental Analysis Center Dalian University of Technology School of Chemistry Dalian University of Technology Liaoning Binhai Laboratory

Molecular materials showing synergetic coupling of near-infrared （NIR） fluorescence and spin-crossover （SCO） are promisingly applicable in in-vivo bioimaging,temperature sensing,and spintronic *** the related study faces formidable *** this work we graft the NIR fluorophore xanthene onto the dipyridyl substituted triazole ligand and construct a new Febased SCO material,{FeⅡ（ddxc-abpt）2[N（CN）2]2}(1,ddxc-abpt:（E）-4-(((3,5-di（pyridin-2-yl）-4H-1,2,4-triazol-4-yl)imino)methyl)-N,N-diethyl-2,3-dihydro-1H-xanthen-6-amine).Magnetic studies indicate that compound 1 exhibits thermally induced SCO property in both the solid and solution ***-temperature fluorescence emission spectra reveal a remarkable 7-fold increase in photoluminescence intensity upon the transition from the low-spin state at 110 K to the high-spin state at 280 K,which is the record of all reported coupled fluorescence-SCO ***-temperature ultraviolet-visible （UV-Vis）absorption spectra show a significant change in absorption intensity within the fluorescence emission window,consistent with the F?rster resonance energy transfer （FRET） ***-dependent density functional theory （TD-DFT） calculations demonstrate that the strong coupling is attributed to disrupted energy transfer between the xanthene fluorophore and high-spin *** work provides a feasible approach for expanding the synergetic SCO-fluorescence materials to the NIR-Iwavelength region,and hopefully contributes to the applications of tunable NIR-SCO molecule-based sensors and devices.

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Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong Cui Yan liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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西南地区河成湖与火山湖土地利用对水质的多时空尺度影响差异

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湖泊科学 2025年第1期37卷 132-148,I0011-I0014页

作者：刘捷刘睿左书林张静重庆师范大学地理与旅游学院重庆401331 重庆师范大学 GIS应用研究重庆市重点实验室重庆401331

为探究不同时空尺度下不同湖泊类型土地利用对水质的影响差异,以四川省自贡市富顺西湖(河成湖)和云南省腾冲市青海湖(火山湖)为研究对象,提取6个空间尺度(50、60、70、80、90、100 m湖岸带缓冲区)的景观格局指数,结合雨季(2022年7月)和... 详细信息

为探究不同时空尺度下不同湖泊类型土地利用对水质的影响差异,以四川省自贡市富顺西湖(河成湖)和云南省腾冲市青海湖(火山湖)为研究对象,提取6个空间尺度(50、60、70、80、90、100 m湖岸带缓冲区)的景观格局指数,结合雨季(2022年7月)和旱季(2023年4月)湖泊水质参数,采用冗余分析法定量探究不同时空尺度下土地利用对两类湖泊水质影响的差异性。结果表明:(1)富顺西湖与腾冲青海湖水质参数季节性差异显著,雨季水质优于旱季,两个湖泊水环境质量存在显著差异,腾冲青海湖水环境质量优于富顺西湖,腾冲青海湖符合地表水环境Ⅱ类、Ⅲ类水质标准,富顺西湖达到Ⅳ类、Ⅴ类水质标准。(2)富顺西湖在旱季和50~60 m湖岸带缓冲区尺度下土地利用参数对水质变量的解释率最大,腾冲青海湖在雨季和60 m湖岸带缓冲区尺度下土地利用参数对水质变量的解释率最大。(3)土地利用指数对两类湖泊水质的影响各不相同。富顺西湖流域内斑块密度、景观形状指数和聚合度指数与多数水质指标呈正相关,“源”景观聚集程度和破碎化程度高会加剧对水质的威胁。腾冲青海湖流域内林地面积占比和聚合度指数对水质具有正效应,能够改善水环境质量;斑块指数和景观形状指数值的增加会加剧斑块破碎化,导致水质恶化。本研究基于不同时空尺度对土地利用与两类湖泊水质关系的差异性进行深入探讨,指导不同类型湖泊的区域规划与管理,为湖泊环境质量评价及保护和制定针对性的湖泊缓冲带设置、生态修复等策略提供科学依据,进而促进湖泊水质安全和水资源可持续利用。

关键词：土地利用水质多尺度效应冗余分析西南地区湖泊

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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