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食管裂孔疝与膈疝的诊疗异同及对策

中国实用外科杂志 2024年第4期44卷 428-430页

作者：杨福全中国医科大学附属盛京医院结直肠、疝、微创外科辽宁沈阳110004

食管裂孔疝和膈疝均有与疝病相关的临床表现,食管裂孔疝多伴有胃食管反流相关的症状。胸部CT有助于确诊膈疝,食管裂孔疝病人还需要进行胃镜和食管测酸测压检查以明确胃食管反流情况。应根据病人临床症状和辅助检查结果制定相应的治疗方... 详细信息

食管裂孔疝和膈疝均有与疝病相关的临床表现,食管裂孔疝多伴有胃食管反流相关的症状。胸部CT有助于确诊膈疝,食管裂孔疝病人还需要进行胃镜和食管测酸测压检查以明确胃食管反流情况。应根据病人临床症状和辅助检查结果制定相应的治疗方案,手术修补是治疗食管裂孔疝和膈疝的有效方法,对于有胃食管反流症状病人需要同时进行胃底折叠抗反流手术,部分研究证据表明采用补片加强修补有助于降低疝的复发率。

关键词：食管裂孔疝膈疝胃食管反流病外科治疗

Argа-Bilig theory in traditional Mongolian medicine:a theoretical and practical perspective

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History & Philosophy of Medicine 2024年第3期6卷 23-28页

作者： Tegele Si Xue-Mei Bao Ming-Hai fu Xiu-Mei Wang Laxinamujila bai NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine(Mongolian Medicine) School of Mongolian MedicineInner Mongolia Minzu UniversityTongliao 028000China.

The concept of Arga and Bilig serves as a foundational principle in both ancient Mongolian philosophy and traditional Mongolian medicine (TMM). Arga, symbolized by brightness and associated with qualities of fire and activity, complements Bilig, symbolized by darkness and representing attributes of water and stillness. Together, these opposing forces permeate all aspects of existence, from the genesis of parenthood to the interplay of day and night. Understanding Arga-Bilig is crucial for diagnosing and treating diseases, as it illuminates the source of imbalance within the body. This review provides an overview of the significance of Arga-Bilig in Mongolian philosophy and its application in TMM, emphasizing the dynamic interplay of these opposing forces and their role in maintaining balance and harmony within the body.

关键词： traditional Mongolian medicine Arga and Bilig theory holistic dynamic interplay

Development of a new Cox model for predicting long-term survival in hepatitis cirrhosis patients underwent transjugular intrahepatic portosystemic shunts

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 491-502页

作者： Yi-Fan Lv Bing Zhu Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Shao-Li You Sa Lv Yong-Ping Yang fu-quan Liu Liver Disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver Vascular Disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ***,there have been no specific studies on predicting long-term survival after TIPS *** To establish a model to predict long-term survival in patients with hepatitis cirrhosis after *** A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS *** univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after ***,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)***,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing *** The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS *** NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation ***,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients

关键词： Transjugular intrahepatic portosystemic shunt Long-term survival Predictive model

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang fu Yanyan Lin Mingzhen bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

On-chip terahertz orbital angular momentum demultiplexer

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Photonics Research 2024年第5期12卷 1044-1054页

作者： XIAOHAN JIANG WANYING LIU quan XU YUANHAO LANG YIKAI fu FAN HUANG HAITAO DAI YANFENG LI XUEQIAN ZHANG JIANQIANG GU JIAGUANG HAN WEILI ZHANG Center for Terahertz Waves College of Precision Instrument and Optoelectronics Engineeringand Key Laboratory of Optoelectronics Information and Technology(Ministry of Education)Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of ScienceTianjin UniversityTianjin 300072China Guangxi Key Laboratory of Optoelectronic Information Processing School of Optoelectronic EngineeringGuilin University of Electronic TechnologyGuilin 541004China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078USA

The terahertz regime is widely recognized as a fundamental domain with significant potential to address the demands of next-generation wireless *** parallel,mode division multiplexing based on orbital angular momentum(OAM)shows promise in enhancing bandwidth utilization,thereby expanding the overall communication channel *** this study,we present both theoretical and experimental demonstrations of an on-chip terahertz OAM *** device effectively couples and steers seven incident terahertz vortex beams into distinct high-quality focusing surface plasmonic beams,and the focusing directions can be arbitrarily *** proposed design strategy integrates space-to-chip mode conversion,OAM recognition,and on-chip routing in a compact space with subwavelength thickness,exhibiting versatility and superior performance.

关键词： demultiplexer momentum angular

Design and implementation of low-cost geomagnetic field monitoring equipment for high-density deployment

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Applied Geophysics 2024年第3期21卷 505-512,618页

作者： Sun Lu-Qiang bai Xian-fu Kang Jian Zeng Ning Zhu Hong Zhang Ming-Dong Tianjin Earthquake Agency Tianjin 300201China Yunnan Earthquake Agency Kunming 650224China

The observation of geomagnetic field variations is an important approach to studying earthquake *** 1987,the China Earthquake Administration has explored this seismomagnetic *** particular,they studied local magnetic field anomalies over the Chinese mainland for earthquake *** to the years of research on the seismomagnetic relationship,earthquake prediction experts have concluded that the compressive magnetic effect,tectonic magnetic effect,electric magnetic fluid effect,and other factors contribute to preearthquake magnetic ***,this involves a small magnitude of magnetic field *** is difficult to relate them to the abnormal changes of the extremely large magnetic field in regions with extreme earthquakes owing to the high cost of professional geomagnetic equipment,thereby limiting large-scale ***,it is difficult to obtain strong magnetic field changes before an *** Tianjin Earthquake Agency has developed low-cost geomagnetic field observation equipment through the Beijing–Tianjin–Hebei geomagnetic equipment test *** new system was used to test the availability of equipment and determine the findings based on big data..

关键词： geomagnetic field earthquake prediction low cost high density big data

体育锻炼对儿童注意力和认知灵活性的影响研究

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天津体育学院学报 2024年第2期39卷 233-240页

作者：武艳钦付全首都体育学院北京100191

目的:学龄前儿童的认知功能正处于快速发展过程中,体育锻炼对儿童的认知能力具有促进作用,但这种促进作用是体育锻炼的单独作用还是锻炼中认知任务的作用,抑或二者存在某种交互作用,学界还缺乏足够的实验证据。对一般性体育锻炼和不同... 详细信息

目的:学龄前儿童的认知功能正处于快速发展过程中,体育锻炼对儿童的认知能力具有促进作用,但这种促进作用是体育锻炼的单独作用还是锻炼中认知任务的作用,抑或二者存在某种交互作用,学界还缺乏足够的实验证据。对一般性体育锻炼和不同认知参与的体育锻炼进行控制,考察不同锻炼方式对学龄前儿童的注意力和认知灵活性的影响。方法:采用实验组控制组前测-后测设计,自变量为儿童锻炼活动中认知参与程度(高认知参与锻炼组,一般性锻炼组,控制条件下的自然成长组),选取4~5岁儿童120名,随机分配到3组,每组各40人进行为期12周的干预。结果:3组儿童在认知能力和身体能力方面均有提高;在注意转移能力和注意交换稳定能力方面,组别主效应显著,高认知参与锻炼组与一般性锻炼组和控制组差异显著,一般性锻炼组与控制组差异边缘显著;在持续性注意力反应时和正确率变化方面,组别和时间交互作用达到显著和边缘显著水平;在持续性注意力变化方面,组别和时间交互作用达到边缘显著和显著水平;在集中性注意力变化方面,组别和时间交互作用显著;认知灵活性方面,组别和时间交互作用显著。结论:参加额外体育锻炼对儿童的注意力和认知灵活性有显著促进作用;与参加一般性体育锻炼和不参与额外体育锻炼相比,较高认知参与的体育锻炼更有利于儿童注意力和认知灵活性的改善。

关键词：认知参与体育锻炼注意力认知灵活性

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几种特殊火山碎屑岩的形成机制及研究意义

地震地质 2024年第2期46卷 297-311页

作者：魏海泉陈正全刘永顺白志达中国地震局地质研究所吉林长白山火山国家野外科学观测研究站北京100029 首都师范大学北京100048 中国地质大学(北京) 北京100083

火山碎屑岩是火山物理学研究的最直接对象,也是鉴别碎屑化过程最重要的研究对象。一些特殊类型的火山碎屑岩及相关岩石往往可以反映出某些特征的火山岩浆作用过程,这正是甄别不同类型火山灾害发生概率的基本依据。火山灾害是与火山和火... 详细信息

火山碎屑岩是火山物理学研究的最直接对象,也是鉴别碎屑化过程最重要的研究对象。一些特殊类型的火山碎屑岩及相关岩石往往可以反映出某些特征的火山岩浆作用过程,这正是甄别不同类型火山灾害发生概率的基本依据。火山灾害是与火山和火山喷发有关的灾害,它是人类在自然界面临的最重要的灾害类型之一。火山灾害与火山喷发类型直接相关,其中的爆破性火山喷发则可以形成最为致命的强烈火山灾害。爆破性火山喷发的直接产物是形成各式各样的火山碎屑岩,它们代表了喷发过程所带来的不同类型与强度的火山灾害。原生火山碎屑与次生碎屑反映了火山喷发期与喷发间歇期火山表面过程的差异,而岩浆喷发、射汽岩浆喷发和射汽喷发堆积物的鉴定则标志了现代火山学研究的系统性深化,它们是从事火山灾害研究的先导性工作。细粒空降火山灰在水盆地里保存的火山灰纹层因其良好的等时面与环境指示意义而受到人们的重视,与其伴生的岩石则可能需要区分层凝灰岩、沉凝灰岩、凝灰质泥岩等各种不同火山沉积作用类型。熔岩流动碎屑化产生的自碎角砾岩和熔岩流水下淬火形成的碎玻熔岩代表了与熔岩流直接相关的碎屑化,而不是与爆破性火山作用相关的碎屑化。通常把它们划归为原生火山作用碎屑,但其灾害意义却完全不同。不同类型的火山碎屑岩形成于不同的碎屑化机理与成岩方式,其中一些特定的火山碎屑岩更是代表了极为特殊的火山灾害类型与规模。对于隐爆角砾岩,尽管它是一种火山碎屑岩的岩石名称,但其实我们更关心它的资源经济学意义。

关键词：特殊类型火山碎屑岩碎屑化过程成因分类命名灾害性分析

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Structural,mechanical and electronic properties of precipitates in Mg−Zn alloys

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2507-2520页

作者： Tian-zhi ZHANG Yang-zhen LIU Qing-yun fu bai-song GUO Wei-hong JIN Zhen-tao YU Institute of Advance Wear&Corrosion Resistant and functional Materials Jinan UniversityGuangzhou 510632China Shaoguan Research Institute of Jinan University Shaoguan 512027China Stomatological Hospital Southern Medical UniversityGuangzhou 510280China

To accelerate the development and design of magnesium(Mg)alloys,the structural and mechanical properties of important precipitates in Mg−Zn alloys were studied by experiments and density functional *** nano-indentation tests revealed that the hardness of the precipitates initially increased and then decreased with increasing Zn content,and was significantly higher than that of pure Mg and *** calculation results revealed that the precipitates stability initially increased and then decreased with increasing Zn *** bulk moduli of the precipitates increased,whereas their shear and Young’s moduli initially increased and then decreased with increasing Zn *** decreasing order of ductility for these compounds is MgZn_(2)>Mg_(21)Zn_(25)>Mg_(2)Zn_(11)>Mg_(4)Zn_(7).The surface profiles of the compounds revealed that they are obvious *** the degree of covalency and bond length of covalent bonds initially increased and then decreased with increasing Zn content.

关键词： Mg−Zn alloy nano-indentation modulus hardness chemical bonding