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World Journal of Clinical Cases 2019年第2期7卷 130-136页

作者： fu-Liang He Chuan Li fu-quan liu Xing-Shun Qi Department of Interventional Therapy Beijing Shijitan HospitalCapital Medical University Liver Cirrhosis Study Group Department of GastroenterologyGeneral Hospital of Shenyang Military Area Section of Medical Services General Hospital of Shenyang Military Area

BACKGROUND Collagen proportionate area(CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari *** To explore the role of CPA in predicting the outcomes of patients with BuddChiari *** Nine patients with Budd-Chiari syndrome undergoing transjugular intrahepatic portosystemic shunt(TIPS) were included. The median CPA level and correlation of CPA and prognosis of TIPS were *** Median CPA was 23.07%(range: 0%-40.20%). Pearson's χ2 test demonstrated a significant correlation of CPA with history of gastrointestinal bleeding(Pearson's coefficient: 0.832, P = 0.005), alanine aminotransferase(Pearson's coefficient:-0.694, P = 0.038), and prothrombin time(Pearson's coefficient: 0.68, P = 0.044).Although CPA was not significantly correlated with shunt dysfunction or hepatic encephalopathy after TIPS, the absolute CPA was relatively larger in patients who developed shunt dysfunction or hepatic encephalopathy after *** This preliminary clinicopathological study found a marginal effect of CPA on the outcomes of Budd-Chiari syndrome patients treated with TIPS.

关键词： Budd-Chiari syndrome Hepatic vein Occlusion Thrombosis Fibrosis

Immunological factors in cirrhosis diseases from a bibliometric point of view

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World Journal of Gastroenterology 2023年第24期29卷 3899-3921页

作者： Dan Zhang Bo-Wen liu Xiao-Qing Liang fu-quan liu Department of Interventional Therapy Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Oncology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Cirrhosis results from persistent liver injury that leads to liver *** factors play important regulatory roles in the development and progression of *** is one of the most commonly used methods for systematic evaluation of a field of *** date,there are no bibliometric studies on the role of immunological factors in *** To provide a comprehensive overview of the knowledge structure and research hotspots of immunological factors in *** We retrieved publications related to immunological factors in cirrhosis between 2003 to 2022 from the Web of Science Core Collection database on December 7,*** search strategy was TS=((Liver Cirrhosis OR hepatic cirrhosis OR liver fibrosis)AND(Immunologic*Factor*OR Immune Factor*OR Immunomodulator*OR Biological Response Modifier*OR Biomodulator*)).Only original articles and reviews were included.A total of 2873 publications were analyzed using indicators of publication and citation metrics,countries,institutes,authors,journals,references,and keywords by CiteSpace and *** A total of 5104 authors from 1173 institutions across 51 countries published 2873 papers on cirrhosis and immunological factors in 281 *** the past 20 years,the increasing number of related annual publications and citations indicates that research on immunological factors in cirrhosis has become the focus of attention and has entered a period of accelerated *** United States(781/27.18%),China(538/18.73%),and Germany(300/10.44%)were the leading countries in this *** of the top 10 authors were from the United States(4)and Germany(3),with Gershwin ME contributing the most related articles(42).World Journal of Gastroenterology was the most productive journal,whereas Hepatology was the most co-cited *** research hotspots regarding immunological factors in cirrhosis include fibrosis,cirrhosis,inflammation,liver fibrosis,expression,hepatocell

关键词： Immunological factors Cirrhosis CiteSpace VOSviewer Bibliometrics Visualization

Hepatic amyloidosis leading to hepatic venular occlusive disease and Budd-Chiari syndrome: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3282-3288页

作者： Ting-Ting Li Yi-Fan Wu fu-quan liu fu-Liang He Department of Interventional Therapy Beijing Shijitan Hospital Capital Medical University The 9th Affiliated Hospital of Peking University

BACKGROUND Systemic amyloidosis in which multiple systems can be involved has become a common clinical *** the liver is affected,symptoms such as abdominal distension,fatigue,edema,liver,and jaundice could *** date,hepatic amyloidosis combined with hepatic venular occlusive disease and Budd-Chiari syndrome has not been *** SUMMARY A 54-year-old female patient was admitted to the Beijing Shijitan Hospital with hepatic amyloidosis leading to hepatic venular occlusion and Budd-Chiari syndrome in *** patient underwent surgery 1 mo previously for liver rupture and hemorrhage after Budd-Chiari syndrome was *** was diagnosed with hepatic venular occlusion,liver amyloidosis,and Budd-Chiari syndrome(*** hepatic vein occlusion).Transjugular intrahepatic portosystem shunt was *** the treatment,the clinical symptoms improved markedly with increase in urine *** Hepatic amyloidosis with hepatic venous occlusion and Budd-Chiari syndrome is relatively rare clinically,and transjugular intrahepatic portosystem shunt is an effective treatment for this disease.

关键词： Hepatic venular occlusion Liver amyloidosis Budd-Chiari syndrome Portal hypertension Case report

Establishment of a hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol

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World Journal of Gastroenterology 2015年第32期21卷 9544-9553页

作者： Lei Wang fu-Liang He fu-quan liu Zhen-Dong Yue Hong-Wei Zhao Department of Interventional Therapy Beijing Shijitan Hospital Capital Medical University

AIM: To determine the feasibility and safety of establishing a porcine hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% ***: Twenty-one healthy Guizhou miniature pigs were randomly divided into three experimental groups and three control groups. The pigs in the three experimental groups were subjected to hepatic arterial perfusion with 7, 12 and 17 m L of 80% alcohol, respectively, while those in the three control groups underwent hepatic arterial perfusion with 7, 12 and 17 m L of saline, respectively. Hepatic arteriography and direct portal phlebography were performed on all animals before and after perfusion, and the portal venous pressure and diameter were measured before perfusion, immediately after perfusion, and at 2, 4 and 6 wk after perfusion. The following procedures were performed at different time points: routine blood sampling, blood biochemistry, blood coagulation and blood ammonia tests before surgery, and at 2, 4 and 6 wk after surgery; hepatic biopsy before surgery, within 6 h after surgery, and at 1, 2, 3, 4 and 5 wk after surgery; abdominal enhanced computed tomography examination before surgery and at 6 wk after surgery; autopsy and multi-point sampling of various liver lobes for histological examination at 6 wk after surgery. RESULTS: In experimental group 1, different degrees of hepatic fibrosis were observed, and one pig developed hepatic cirrhosis. In experimental group 2, there were cases of hepatic cirrhosis, different degrees of increased portal venous pressure, and intrahepatic portal venous bypass, but neither extrahepatic portalsystemic bypass circulation nor death occurred. In experimental group 3, two animals died and threeanimals developed hepatic cirrhosis, and different degrees of increased portal venous pressure and intrahepatic portal venous bypass were also observed, but there was no extrahepatic portal-systemic bypass circulation. CONCLUSION: It is feasible to establish an anima

关键词： Alcohol Hepatic arterial perfusion Hepatic cirrhos

Parallel transjugular intrahepatic portosystemic shunt for controlling portal hypertension complications in cirrhotic patients

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World Journal of Gastroenterology 2014年第33期20卷 11835-11839页

作者： fu-Liang He Lei Wang Zhen-Dong Yue Hong-Wei Zhao fu-quan liu Department of Interventional Therapy Beijing Shijitan Hospital Capital Medical University

AIM: To evaluate the feasibility of a second parallel transjugular intrahepatic portosystemic shunt (TIPS) to reduce portal venous pressure and control complications of portal hypertension.

关键词： Transjugular intrahepatic portosystemic shunt Portal hypertension Portosystemic pressure gradient

Safety and efficacy of transfemoral intrahepatic portosystemic shunt for portal hypertension: A single-center retrospective study

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World Journal of Clinical Cases 2019年第12期7卷 1410-1420页

作者： Yu Zhang fu-quan liu Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan fu-Liang He Department of Interventional Therapy Peking University Ninth School of Clinical MedicineBeijing Shijitan Hospital and Capital Medical University

BACKGROUND Transfemoral intrahepatic portosystemic shunt (TFIPS) can be performed to treat portal hypertension. However, few studies have evaluated the safety and efficacy of this technique. AIM To retrospectively evaluate the safety and clinical outcomes of TFIPS and compare them with those of typical transjugular intrahepatic portosystemic shunt (TIPS). METHODS This retrospective study was approved by our hospital ethics committee. From November 2012 to November 2015, 19 patients who underwent successful TFIPS placement were included. In addition, 21 patients treated with TIPS during the same period were selected as controls. Data collected included the success rate and complications of TIPS and TFIPS. Continuous data were expressed as the mean ± SD and were compared using the Student’s t test. All categorical data were expressed as count (percentage) and were compared using the χ2 test or Fisher’s exact test. The Kaplan–Meier method was used to calculate cumulative survival rate and survival curves. RESULTS Baseline characteristics were comparable between the two groups. The success rate of TFIPS and TIPS was 95%(19/20) and 100%(21/21), respectively. Effective portal decompression and free antegrade shunt flow was completed in all patients. The portal pressure gradient prior to TIPS and TFIPS placement was 23.91 ± 4.64 mmHg and 22.61 ± 5.39 mmHg, respectively, and it was significantly decreased to 10.85 ± 3.33 mmHg and 10.84 ± 3.33 mmHg after stent placement, respectively. Time–to-event calculated rates of shunt patency at one and two years in the TFIPS and TIPS groups were not statistically different (94.7% vs 95.2% and 94.7% vs 90.5%, respectively). De nova hepatic encephalopathy was 27.5%(11/40) with five patients in the TFIPS group (26.3%) and six patients (28.6%) in the TIPS group experiencing it (P = 0.873). The cumulative survival rates were similar between the two groups: 94.7% and 94.7% at 1 and 2 years, respectively, in the TFIPS group vs 100% and 95.2%

关键词： Transjugular intraheptic portosystemic shunt Transfemoral intraheptic portosystemic shunt Portal hypertension Variceal bleeding

Transjugular intrahepatic portosystemic shunt for severe jaundice in patients with acute Budd-Chiari syndrome

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World Journal of Gastroenterology 2015年第8期21卷 2413-2418页

作者： fu-Liang He Lei Wang Hong-Wei Zhao Zhen-Hua Fan Meng-Fei Zhao Shan Dai Zhen-Dong Yue fu-quan liu Department of Interventional Therapy Beijing Shijitan Hospital Capital Medical University

AIM:To evaluate the feasibility of transjugular intrahepatic portosystemic shunt(TIPS)for severe jaundice secondary to acute Budd-Chiari syndrome(BCS).METHODS:From February 2009 to March 2013,37patients with severe jaundice secondary to acute BCS were *** patients without hepatic venule,hepatic veins(HV)obstruction underwent percutaneous angioplasty of the inferior vena cava(IVC)and/or ***-one patients with HV occlusion underwent *** bilirubin,liver function,demographic data and operative data of the two groups of patients were ***:Twenty-one patients underwent TIPS and the technical success rate was 100%,with no technical *** patients underwent recanalization of the IVC and/or HVs and the technical success rate was 100%.The mean procedure time for TIPS was 84.0±12.11 min and angioplasty was44.11±5.12 min(Pfunction improved faster than *** 2 wk,in the TIPS group,alanine aminotransferase(ALT)decreased significantly from 50.33±40.61 U/L to 28.67±7.02U/L(P<0.01)and aspartate aminotransferase(AST)from 49.46±34.33 U/L to 26.89±8.68 U/L(P<0.01).In the angioplasty group,ALT decreased significantly from 51.56±27.90 to 14.22±2.59μmol/L(P<0.01)and AST from 60.66±39.89μmol/L to 8.18±1.89μmol/L(P<0.01).After mean follow-up of 12.6 m

关键词： Budd-Chiari syndrome Jaundice Transjugular intrahe

Stents combined with iodine-125 implantation to treat main portal vein tumor thrombus

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 496-504页

作者： Yi-Fan Wu Tao Wang Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan fu-Liang He fu-quan liu Department of Interventional Therapy Beijing Shijitan HospitalCapital Medical University Department of Interventional Therapy The Affiliated Yantai Yuhuangding Hospital of Qingdao University

AIM To evaluate the efficacy of main portal vein stents combined with iodine-125(^(125)Ⅰ) to treat main portal vein tumor *** From January 1, 2010 to January 1, 2015, 111 patients were diagnosed with liver cancer combined with main portal vein tumor thrombus. They were non-randomly assigned to undergo treatment with transarterial chemoembolization(TACE)/transarterial embolization(TAE) + portal vein stents combined with ^(125)Ⅰ implantation(Group A) and TACE/TAE + portal vein stents only(Group B). After the operation, scheduled follow-up was performed at 6, 12 and 24 mo. The recorded information included clinical manifestations, survival rate, and stent restenosis rate. Kaplan–Meier curves, log-rank test and Cox regression were used for data analyses. RESULTS From January 1, 2010 to January 1, 2015, 54 and 57 patients were allocated to Groups A and B, respectively. The survival rates at 6, 12 and 24 mo were 85.2%, 42.6% and 22.2% in Group A and 50.9%, 10.5% and 0% in Group B. The differences were significant [log rank P < 0.05, hazard ratio(HR): 0.37, 95%CI: 0.24-0.56]. The rates of stent restenosis were 18.5%, 55.6% and 83.3% in Group A and 43.9%, 82.5% and 96.5% in Group B. The differences were significant(log rank P < 0.05, HR: 0.42, 95%CI: 0.27-0.63). Cox regression identified that treatment was the only factor affecting survival rate in this *** Main portal vein stents combined with ^(125)Ⅰ can significantly improve survival rate and reduce the rate of stent restenosis.

关键词： Iodine-125 Liver cancer Stent Main portal vein tumor thrombus Transarterial chemoembolization/ transarterial embolization

Accurate ultrasonography-based portal pressure assessment in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 931-941页

作者： Yu Zhang Zhong Wang Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Yi-Fan Wu fu-LiangHe fu-quan liu Department of Interventional Therapy Peking University Ninth School of Clinical MedicineBeijing Shijitan Hospital and Capital Medical UniversityBeijing 100038China

BACKGROUND Portal pressure is of great significance in the treatment of hepatocellular carcinoma(HCC),but direct measurement is complicated and costly;thus,noninvasive measurement methods are urgently *** To investigate whether ultrasonography(US)-based portal pressure assessment could replace invasive transjugular *** A cohort of 102 patients with HCC was selected(mean age:54±13 years,male/female:65/37).Pre-operative US parameters were assessed by two independent investigators,and multivariate logistic analysis and linear regression analysis were conducted to develop a predictive formula for the portal pressure gradient(PPG).The estimated PPG predictors were compared with the transjugular PPG *** was conducted on another cohort of 20 non-surgical *** The mean PPG was 17.32±1.97 *** analysis identified the association of the following four parameters with PPG:Spleen volume,portal vein diameter,portal vein velocity(PVV),and portal blood flow(PBF).Multiple linear regression analysis was performed,and the predictive formula using the PVV and PBF was as follows:PPG score=19.336-0.312×PVV(cm/s)+0.001×PBF(mL/min).The PPG score was confirmed to have good accuracy with an area under the curve(AUC)of 0.75(0.68-0.81)in training *** formula was also accurate in the validation patients with an AUC of 0.820(0.53-0.83).CONCLUSION The formula based on ultrasonographic Doppler flow parameters shows a significant correlation with invasive PPG and,if further confirmed by prospective validation,may replace the invasive transjugular assessment.

关键词： Portal pressure gradient Hepatic vein pressure gradient Hepatocellular carcinoma Transjugular Portal pressure Portal vein pressure

Iodine-125 implantation with transjugular intrahepatic portosystemic shunt for main portal vein tumor thrombus

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 310-321页

作者： Yue Zhang Yi-Fan Wu Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan fu-Liang He Tao Wang fu-quan liu Department of Interventional Therapy Peking University Ninth School of Clinical Medicine Beijing Shijitan Hospital and Capital Medical University Department of Interventional Therapy Beijing Shijitan Hospital and Capital Medical University Department of Interventional Therapy The affiliated Yantai Yuhuangding Hospitalof Qingdao University

BACKGROUND Main portal vein tumor thrombus(MPVTT), which has a high incidence, is the major complication of terminal liver cancer. The occurrence of MPVTT is always a negative prognostic factor for patients with hepatocellular carcinoma(HCC).Therefore, attention should be paid to the treatment of MPVTT and its *** To evaluate the efficacy of transarterial chemoembolization/transarterial embolization(TACE/TAE)+^(125)I seeds implantation with transjugular intrahepatic portosystemic shunt(TIPS) in treating MPVTT and its *** From January 2007 to March 2015, 85 consecutive patients with MPVTT were nonrandomly assigned to undergo treatment with TACE/TAE + TIPS and ^(125)I implantation(TIPS-^(125)I group) or TACE/TAE + TIPS only(TIPS only group) in Beijing Shijitan Hospital, and all clinical data were collected. During 24 mo follow-up, the incidence of overall survival, stent stenosis and symptom recurrence was analyzed to evaluate the efficacy of TIPS-^(125)*** During 24 mo follow-up of all patients, we collected data at 6, 12 and 24 mo. The rates of survival were 80%, 45%, and 20%, respectively, in the TIPS-^(125)I group,whereas those in the TIPS only group were 64.4%, 24.4%, and 4.4%, respectively(P < 0.05). The rates of symptom recurrence were 7.5%, 22.5%, and 35%,respectively, in the TIPS-^(125)I group, whereas those in the TIPS only group were31.1%, 62.2%, and 82.2%(P < 0.05). The rates of stent restenosis were 12.5%,27.5%, and 42.5%, respectively, in the TIPS-^(125)I group, and 42.2%, 68.9%, and84.4%, respectively, in the TIPS only group(P < 0.05). TIPS-^(125)I was found to be significantly favorable in treating MPVTT and its complications in patients with *** TACE/TAE+^(125)I combined with TIPS is effective in treating MPVTT and its complications, improving quality of life of patients and reducing mortality.

关键词： Iodine-125 Transjugular intrahepatic portosystemic shunt Main portal vein tumor thrombus Metastasis Portal hypertension