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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang fu-Min Zhang Ai-Jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

R-DA-EPOCH方案治疗复发难治性弥漫性大B细胞淋巴瘤的疗效观察

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中国实用医药 2019年第24期14卷 75-77页

作者：付曾强西部战区总医院

目的评价利妥昔单抗联合调整剂量的EPOCH(R-DA-EPOCH)方案治疗复发难治性弥漫性大B细胞淋巴瘤(DLBCL)的疗效及安全性。方法36例复发难治性弥漫性大B细胞淋巴瘤患者,采用R-DA-EPOCH方案治疗,观察其临床疗效和不良反应发生情况。结果治疗... 详细信息

目的评价利妥昔单抗联合调整剂量的EPOCH(R-DA-EPOCH)方案治疗复发难治性弥漫性大B细胞淋巴瘤(DLBCL)的疗效及安全性。方法36例复发难治性弥漫性大B细胞淋巴瘤患者,采用R-DA-EPOCH方案治疗,观察其临床疗效和不良反应发生情况。结果治疗后,36例患者完全缓解(CR)8例(22.2%),部分缓解(PR)12例(33.3%),稳定(SD)6例(16.7%),疾病进展(PD)10例(27.8%),总缓解率(RR)为55.6%。36例患者的不良反应主要包括白细胞减少、血小板减少、贫血、心脏毒性、脱发,发生率分别为100.0%(36/36)、80.6%(29/36)、86.1%(31/36)、19.4%(7/36)、100.0%(36/36)。36例患者的中位生存期为12.4个月。结论采用R-DA-EPOCH方案治疗复发难治性弥漫性大B细胞淋巴瘤具有较好疗效,不良反应可控,有助于提高总生存期。

关键词：利妥昔单抗联合调整剂量的EPOCH方案难治性弥漫性大B细胞淋巴瘤疗效

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MDS矩阵和对合MDS矩阵的新构造方法

计算机应用研究 2014年第1期31卷 222-225页

作者：郭磊郑浩然傅增强王月解放军信息工程大学三院郑州450004 空军西安飞行学院西安710300

首先对Lacan等人给出的由Vandermonde矩阵构造MDS码的方法进行了研究,指出了其中存在的问题,给出了由两个Vandermonde矩阵构造MDS矩阵的充要条件;然后利用矩阵乘的方法,给出了由标量乘Vandermonde矩阵构造MDS矩阵的充要条件;最后在Sajad... 详细信息

首先对Lacan等人给出的由Vandermonde矩阵构造MDS码的方法进行了研究,指出了其中存在的问题,给出了由两个Vandermonde矩阵构造MDS矩阵的充要条件;然后利用矩阵乘的方法,给出了由标量乘Vandermonde矩阵构造MDS矩阵的充要条件;最后在Sajadieh等人给出的由两个Vandermonde矩阵构造对合MDS矩阵方法的基础之上,给出了标量乘Vandermonde矩阵构造对合MDS矩阵的方法。对标量乘矩阵来讲,可以通过调控标量中分量的大小来调整标量乘矩阵元素大小和元素重量大小来满足其软、硬件实现性能,因此该构造MDS矩阵及对合MDS矩阵的方法具有实用价值。

关键词：分组密码扩散结构分支数 MDS矩阵 Vandermonde矩阵

^(125)Ⅰ粒子植入治疗结肠直肠癌肝转移

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介入放射学杂志 2012年第9期21卷 773-776页

作者：彭晶晶谭勇谭艳魏东付增强张涛成都成都军区总医院肿瘤诊治中心 600038

目的探讨放射性^(125)Ⅰ粒子植入治疗结肠直肠癌肝转移(CRLM)的疗效及安全性。方法为24例化疗失败或不能耐受化疗的CRLM患者共计65个肝转病灶行CT引导下植入^(125)Ⅰ粒子,粒子的放射性活度介于0.5～0.7 mCi,每例患者接种的粒子数为18～... 详细信息

目的探讨放射性^(125)Ⅰ粒子植入治疗结肠直肠癌肝转移(CRLM)的疗效及安全性。方法为24例化疗失败或不能耐受化疗的CRLM患者共计65个肝转病灶行CT引导下植入^(125)Ⅰ粒子,粒子的放射性活度介于0.5～0.7 mCi,每例患者接种的粒子数为18～109枚,最小边缘剂量为110～160 Gv植入后进行质量验证。结果在6个月的随访中,肿瘤的最长径基线和从术前(7.21±3.28)cm降到术后3个月时的(4.47±3.34)和6个月时的(3.94±2.05)cm,差异有统计学意义(P<0.05)。CEA南术前的(293±89)ng/ml降至术后3、6个月的(198±103)ng/ml、(155±6 1)ng/ml,差异有统计学意义(P<0.05)。未出现与治疗相关的死亡。1、2年生存率分圳为87.5%和75.0%。结论 CT引导下^(125)Ⅰ粒子植入治疗CRLM微创、安全,近期疗效确切,远期疗效有待观察。

关键词：结直肠癌肝转移 ^125Ⅰ粒子组织间内放疗

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气固流化床床高的测控研究

湘潭矿业学院学报 2002年第1期17卷 9-12页

作者：陶秀祥严德崑骆振福陈增强杨毅中国矿业大学化工学院江苏徐州221008

在对目前常用气固流化床床高测量方法分析研究的基础上 ,开发应用性能优越、抗干扰能力强的雷达测距仪来进行选煤流化床床高的测量 ,提出采用逆系统控制方法解决气固流化床床高的控制问题 .床高采用闭环控制系统 ,雷达仪所测量的信号通... 详细信息

在对目前常用气固流化床床高测量方法分析研究的基础上 ,开发应用性能优越、抗干扰能力强的雷达测距仪来进行选煤流化床床高的测量 ,提出采用逆系统控制方法解决气固流化床床高的控制问题 .床高采用闭环控制系统 ,雷达仪所测量的信号通过其内部的 Echofox软件分析处理后 ,经与设定值比较 ,根据偏差大小 ,控制循环介质给料机的转速 ,从而达到控制床高的目的 .图 5 ,表 1,参

关键词：气固流化床床高雷达测距仪逆系统闭环控制系统

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

High Refractive Index without Absorption in a Ladder-Type System

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Chinese Physics Letters 2014年第3期31卷 58-61页

作者： zeng Zhi-qiang HOU Bang-Pin LIU fu-Ti SHAO Ju-Xiang School of Physics and Electronic Engineering Yibin University Yibin 644000 Computational Physics Key Laboratory of Sichuan Province Yibin University Yibin 644000 School of Physics and Electronic Engineering Sichuan Normal University Chengdu 610066

A three-level ladder-type system with vacuum-induced coherence and incoherent pumping is studied to obtain a high refractive index without absorption. It is shown that the enhancement of the refractive index without absorption can be accomplished by choosing the proper values of the incoherent pumping, the angle between the two dipole moments, the probe detuning and the relative phase of the two coherent fields.

关键词： Refractive index

Current status and future prospects of stem cell therapy in Alzheimer’s disease

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Neural Regeneration Research 2020年第2期15卷 242-250页

作者： fu-qiang Zhang Jin-Lan Jiang Jing-Tian Zhang Han Niu Xue-Qi fu Lin-Lin zeng Scientific Research Centre of China-Japan Union Hospital Jilin UniversityChangchunJilin ProvinceChina School of Life Sciences Jilin UniversityChangchunJilin ProvinceChina

Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only alleviate the symptoms without curing the disease, which is a serious issue and influences the quality of life of the patients and their caregivers. In recent years, stem cell technology has provided new insights into the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Currently, the main sources of stem cells include neural stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells. In this review, we discuss the pathophysiology and general treatment of Alzheimer’s disease, and the current state of stem cell transplantation in the treatment of Alzheimer’s disease. We also assess future challenges in the clinical application and drug development of stem cell transplantation as a treatment for Alzheimer’s disease.

关键词： Alzheimer's disease β-amyloid drug development embryonic stem cells induced pluripotent stem cells mesenchymal stem cells nerve regeneration neural regeneration neural stem cells neurodegenerative disorders stem cell therapy

Experimental study on the oxidation kinetics of coal in typical coal mining areas of the Southern Junggar coalfield,Xinjiang,China

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International Journal of Coal Science & Technology 2022年第6期9卷 138-150页

作者： qiang zeng Li Shen School of Ecology and Environment Sciences Xinjiang UniversityUrumqi 830017China Institute for Arid Ecology and Environment Xinjiang UniversityUrumqi 830017China Key Laboratory of Oasis Ecology of Ministry of Education Urumqi 830017China

Coal spontaneous combustion(CSC)is a disaster associated with coal mining that leads to loss of coal resources and envi-ronmental and human health *** investigate kinetic characteristics for oxidation of coal,three coal samples were collected from different coal mining areas in the Southern Junggar ***,the collected coal samples were ground into different particle sizes and tested using microscopic and macroscopic methods,including thermal gravimetric analysis,Fourier transform infrared spectroscopy,X-ray diffraction,and temperature-programmed *** results obtained are as follows:the sharpest absorption peak(002)indicates that graphitization is ***,the results show that the SKS coal sample is prone to spontaneous combustion;the greater the aromatic hydrocarbon content is,the more difficult it is for CSC to occur,while the opposite is true for oxygen-containing functional *** SKS data confirmed this conclusion;the rate for generation of CO and CO_(2)controlled the possibility of SKS oxidation at 110℃and provided an indication of the *** the dehydration stage,the WD sample had the lowest activation energy,indicating that it was most susceptible to spontaneous *** the combustion stage,the lowest activation energy was found for the SKS sample with particle sizes<0.075 mm,indicating that particle size was one of the factors affecting spontane-ous *** activation energy for dehydration was significantly lower than that for combustion,which showed that the coal oxygen reaction was more likely to occur in the dehydration *** on DSC curves,the SKS sample had the largest exothermicity,indicating that it would ignite more readily.

关键词： Southern Junggar coalfield Oxidation Kinetics Coal spontaneous combustion