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Asian Journal of Andrology 2008年第2期10卷 214-218页

作者： Lu fu Qian-ping gao Jing-Xia Shen Cardiovascular Department the First Affiliated Hospital of Harbin Medical University Harbin 150001 China

Aim： To investigate the relationship between androgen level and the indexes indicating endothelial function in male patients with coronary heart disease （CHD）. Methods： We registered the following data for 106 50-70-year-old men： age, weight, blood lipid, including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride, whether a smoker, sugar levels, blood pressure, free testosterone （FT）, vascular cell adhesion molecule- 1 （VCAM- 1） and the intima-media thickness （IMT） of common carotid artery, common carotid diameter, maximum velocity in systolic phase, minimum velocity in diastolic phase and resistent index. Among the 106 men, 51 were patients with CHD. The relationships between FT level, VCAM-1 concentration and IMT were examined, respectively, using a stepwise linear regression technique among all the 106 men. Results： There was no statistical difference in terms of age, blood pressure, whether a smoker, sugar levels, HDL-C, minimum velocity in diastolic phase, resistent index between male CHD patients and controls; whereas results for weight, total cholesterol, low density lipoprotein cholesterol, triglyceride, VCAM- 1 and IMT of male CHD patients were higher than those of controls; FT level and maximum velocity in systolic phase were lower. It was found that among all the objects, FT level was inversely correlated with IMT and VCAM-1 concentration. Condusion： FT level was inversely correlated with VCAM-I concentration and IMT which are indicators of endothelial function. （Asian JAndro12008 Mar; 10： 214-218）

关键词： testosterone coronary heart disease endothelial function

Intelligent modelling of clay compressibility using hybrid meta-heuristic and machine learning algorithms

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Geoscience Frontiers 2021年第1期12卷 441-452页

作者： Pin Zhang Zhen-Yu Yin Yin-fu Jin Tommy HTChan fu-ping gao Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Civil Engineering&Built Environment Science and Engineering FacultyQueensland University of Technology(QUT)BrisbaneQld4001Australia Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China

Compression index Ccis an essential parameter in geotechnical design for which the effectiveness of correlation is still a *** paper suggests a novel modelling approach using machine learning(ML)*** performance of five commonly used machine learning(ML)algorithms,***-propagation neural network(BPNN),extreme learning machine(ELM),support vector machine(SVM),random forest(RF)and evolutionary polynomial regression(EPR)in predicting Cc is comprehensively investigated.A database with a total number of 311 datasets including three input variables,*** void ratio e0,liquid limit water content wL,plasticity index Ip,and one output variable Cc is first *** algorithm(GA)is used to optimize the hyper-parameters in five ML algorithms,and the average prediction error for the 10-fold cross-validation(CV)sets is set as thefitness function in the GA for enhancing the robustness of ML *** results indicate that ML models outperform empirical prediction formulations with lower prediction *** yields the lowest error followed by BPNN,ELM,EPR and *** the ranges of input variables in the database are large enough,BPNN and RF models are recommended to predict ***,if the distribution of input variables is continuous,RF model is the best ***,EPR model is recommended if the ranges of input variables are *** predicted correlations between input and output variables using five ML models show great agreement with the physical explanation.

关键词： Compressibility Clays Machine learning Optimization Random forest Genetic algorithm

Elasto-plasticity and pore-pressure coupled analysis on the pullout behaviors of a plate anchor

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Theoretical & Applied Mechanics Letters 2015年第2期5卷 89-92页

作者： Cun Hu fu-ping gao Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of Sciences

A numerical method is proposed for the elasto-plasticity and pore-pressure coupled analysis on the pull- out behaviors of a plate anchor. The bounding-surface plasticity （BSP） model combined with Blot＇s consol- idation theory is employed to simulate the cyclic loading induced elasto-plastic deformation of the soil skeleton and the accompanying generation/dissipation of the excess pore water pressure. The suction force generated around the anchor due to the cyclic variation of the pore water pressure has much effect on the pullout capacity of the plate anchor. The calculated pullout capacity with the proposed method （i.e., the coupled analysis） gets lower than that with the conventional total stress analysis for the case of long-term sustained loading, but slightly higher for the case of short-term monotonic loading. The cyclic loading induced accumulation of pore water pressure may result in an obvious decrease of the stiffness of the soil-Plate anchor svstem.

关键词： Plate anchor Bounding-surface plasticity model Pore pressure Coupled analysis

A modified criterion for wave-induced momentary liquefaction of sandy seabed

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Theoretical & Applied Mechanics Letters 2015年第1期5卷 20-23页

作者： Wen-Gang Qi fu-ping gao Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of Sciences

The assessment of the wave-induced soil liquefaction plays a key role in the geotechnical design for offshore foundations. The underlying shortcomings of the existing momentary liquefaction criteria are identified and clarified by mechanism analyses and the recent field observations. A modified criterion for the wave-induced momentary liquefaction of a sandy seabed is given to describe the vertical pore- pressure distributions. An improved approximation of the momentary liquefaction depth is further presented. Parametric study of the effects of the saturation degree of soils indicates that this modification is significant for the evaluation of wave-induced momentary liauefaction.

关键词： Pore-pressure responseLiquefaction criterionMomentary LiquefactionAnalytical approximation

Editorial:Special issue on offshore structure-soil interaction

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Theoretical & Applied Mechanics Letters 2015年第2期5卷 63-63页

作者： fu-ping gao Mark J.Cassidy Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of Sciences Centre for Offshore Foundation Systems and ARC CoE for Geotechnical Science and Engineering University of Western Australia

As the offshore industries move from shallow to deep waters in excess of 1000 m, there has been rapid development of ocean engineering practices. Innovations in theoretical and applied me- chanics have been essential in this shift and in underpinning the exploitation of offshore oil and gas and renewable energy re- sources worldwide. Understanding and predicting physical mech- anisms of structure-soil interactions are vital for the stability and safety of offshore engineering structures. Accordingly, in this spe- cial issue of Theoretical ＆ Applied Mechanics Letters （TAME）, eight letter-papers are published to present recent advances in analyti- cal and numerical analysis and in physical modeling of offshore structure-soil interactions in marine environments. They all provide examples of how enhanced understanding of mechanics can imoact on aoDlied oroiects.

关键词： soil Editorial

几种生长调节物质对培矮64S异交性状的调控

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江西农业大学学报 2005年第3期27卷 385-388,393页

作者：陈小荣钟蕾付高平江西农业大学江西省作物生理生态与遗传育种重点实验室江西南昌330045 江西省农业厅种子站江西南昌330046

以清水对照,对培矮64S喷施赤霉素、稻多收、植物龙、天丰素,比较了4种生长调节物质对培矮64S花时、花期、颖花开放角度、颖尖距离、柱头外露率、人工辅助授粉下杂交种子结实率、杂交种子的粒重、株高、剑叶长、外露颈穗长等性状的影响,... 详细信息

以清水对照,对培矮64S喷施赤霉素、稻多收、植物龙、天丰素,比较了4种生长调节物质对培矮64S花时、花期、颖花开放角度、颖尖距离、柱头外露率、人工辅助授粉下杂交种子结实率、杂交种子的粒重、株高、剑叶长、外露颈穗长等性状的影响,认为总体上赤霉素和稻多收有利于改善培矮64S异交性状,在以培矮64S为母本的杂交稻制种中有较大的应用前景,并就赤霉素和稻多收在培矮64S制种上联合使用问题进行了讨论。

关键词：赤霉素稻多收植物龙天丰素培矮64S 异交性状

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin fu Peiyan Long Xiao gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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化学反应中酶的动态平衡系统模型

天津工业大学学报 2001年第4期20卷 44-46页

作者：边馥萍高韡天津大学理学院天津300072

建立了化学反应中酶的动态平衡系统模型和基质与酶在拟稳定状态下的无量纲模型 ,应用扰动理论分析了边界解。

关键词：化学反应酶基质无量纲模型动态平衡系统模型

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen Ma Jin-Hua gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei fu Yue-Jing Li Ran Yu Rui-Qing Guo Li-Xia gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect