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Total salvianolic acid improves ischemia-reperfusion-induced microcirculatory disturbance in rat mesentery

World Journal of Gastroenterology 2010年第42期16卷 5306-5316页

作者： Ming-Xia Wang Yu-Ying Liu Bai-He Hu Xiao-Hong Wei Xin Chang Kai Sun Jing-Yu Fan fu-long liao ChuanShe Wang Jun Zheng Jing-Yan Han Ming-Xia Wang Tasly Microcirculation Research Center Peking University Health Science Center Beijing 100191 China Department of Pharmacology Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tasly Microcirculation Research Center Peking University Health Science Center Beijing 100191 China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPekingUniversityBeijing 100191China

AIM:To investigate the effect of total salvianolic acid(TSA) on ischemia-reperfusion(I/R)-induced rat mesenteric microcirculatory ***:Male Wistar rats were randomly distributed into 5 groups(n = 6 each):Sham group and I/R group(infused with saline),TSA group,TSA + I/R group and I/R + TSA group(infused with TSA,5 mg/kg per hour).Mesenteric I/R were conducted by a ligation of the mesenteric artery and vein(10 min) and subsequent release of the *** was continuously infused either starting from 10 min before the ischemia or 10 min after *** in mesenteric microcirculatory variables,including diameter of venule,velocity of red blood cells in venule,leukocyte adhesion,free radicals released from venule,albumin leakage and mast cell degranulation,were observed through an inverted intravital ***,the expression of adhesion molecules CD11b/CD18 on neutrophils was evaluated by flow *** evidence of mesenteric venules damage was assessed after microcirculation ***:I/R led to multiple responses in mesenteric post-capillary venules,including a significant increase in the adhesion of leukocytes,production of oxygen radicals in the venular wall,albumin efflux and enhanced mast cell degranulation in *** the I/R-induced manifestations were significantly reduced by pre-or post-treatment with TSA,with the exception that the I/R-induced increase in mast cell degranulation was inhibited only by pre-treatment with ***,preor post-treatment with TSA significantly attenuated the expression of CD11b/CD18 on neutrophils,reducing the increase in the number of caveolae in the endothelial cells of mesentery post-capillary venules induced by I/***:The results demonstrated that TSA protects from and ameliorates the microcirculation disturbance induced by I/R,which was associated with TSA inhibiting the production of oxygen-free radicals in the venular wall and the expression of CD1

关键词： Salvia miltiorrhiza Leukocyte adherence Oxygen-free radicals Albumin leakage Ischemiareperfusion

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Effects of Water-Soluble Tomato Concentrate on Platelet Aggregation

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World Journal of Traditional Chinese Medicine 2019年第4期5卷 260-268页

作者： Qian Zhang Xu-Guang Zhang Lei Liu Qiong-Ling Zhang Shi-Lan Ding Ying Chen Jin-Yu Wang Lan Wang Ri-Xin Liang fu-long liao Ya-Hong Wang Yun You Centerfor Biomechanopharmacology Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing Science and Technology Center ByHeaIth Co.Ltd.Guangzhou Department of Cardiovascular Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina

Objective:To investigate the antiplatelet aggregation effect of water-soluble tomato concentrate(WSTC)and explore the underlying molecular *** and Methods:Platelet aggregometry was used to quantify rat platelet aggregation with the maximum aggregation rate in vitro and ex ***,the fibrinogen(FIB)binding assay was employed to detect the effect of WSTC on the activation of platelet integrinαIIβ3(GP IIb/IIIa).furthermore,Western blot was performed to assess the platelet protein levels of phosphoinositide 3-kinase 110β(PI3 K110β),protein disulfide isomerase(PDI),platelet endothelial cell adhesion molecule 1(PECAM-1),andβ***:WSTC inhibited adenosine diphosphate(ADP)and collagen-induced platelet aggregation in a concentration-dependent manner in vitro,at IC50 values of 3.05 g/L and 8.03 g/L,*** reduced ex vivo ADP induced platelet aggregation was observed after oral consumption of WSTC for 4 weeks in rats;average inhibition rates were 24.42%,21.48%,and 20.87%for 25 mg/Kg,75 mg/Kg,and 150 mg/Kg WSTC,*** appeared that WSTC had no influence on coagulation function in *** with WSTC decreased FIB binding to GP IIb/IIIa by 17.47%and 32.29%at the concentrations of 0.6 and 6 g/L,*** at 0.6 and 6 g/L markedly downregulated PI3 K110β,PDI,and PECAM-1 in platelets,and upregulatedβ1-Tubulin,in a concentration-dependent ***:WSTC inhibits platelet activation through modulation of platelet skeletal stability and suppresses GP IIb/IIIa receptor-mediated platelet aggregation,likely via the PI3 K signaling pathway and PDI inhibition.

关键词： GP IIb/IIIa platelet aggregation PDI PI3K PECAM-1 watersoluble tomato concentrate

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Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion

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World Journal of Gastroenterology 2008年第1期14卷 29-37页

作者： Wei-Xing Chen Fang Wang, Yu-Ying Liu, Qing-Jiang Zeng, Kai Sun, Xin Xue, Xiang Li, Ji-Ying Yang, Li-Hua An,Bai-He Hu, Jin-Hui Yang, Chuan-She Wang, Zhi-Xin Li, Lian-Yi Liu, Yan Li, Jun Zheng, fu-long liao, Dong Han,Jing-Yu Fan, Jing-Yan Han Fang Wang Yu-Ying Liu Qing-Jiang Zeng Kai Sun Xin Xue Xiang Li Ji-Ying Yang Li-Hua An Bai-He Hu Jin-Hui Yang Chuan-She Wang Zhi-Xin Li Lian-Yi Liu Yan Li Jun Zheng fu-long liao Dong Han Jing-Yu Fan Jing-Yan Han Tasly Microcirculation Research Center Peking University Health Science Center Beijing 100083 China Department of Pharmacology Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Integrated Chinese and Western Medicine School of Basic Medical Sciences Peking University Beijing 100083 China

AIM： To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion （I/R） in mice. METHODS： The superior mesenteric artery （SMA） of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-rain reperfusion. In another set of experiments, R1 was continuously infused （10 mg/kg per hour） from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. Hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell （RBC） velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase （LDH）, alanine aminotransferase （ALl＇） and aspartate transaminase （AST） in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor- alpha （TNF-α）, interleukin-6 （IL-6） and monocyte chemotactic protein-1 （MCP-1） in plasma were evaluated by flow Oltometry. E-selectin and intercellular adhesion molecule-1 （ICAM-1） in hepatic tissue were examined by ***： After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1. CONCLUSION： R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury, The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils.

关键词： Ischemia/reperfusion Notoginsenoside R1 Leukoytes adhesion E-selectin Hepatic injury

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Graphene oxide wrapped-silica microspheres humidity sensor with fast response/recovery, high sensitivity, and selectivity for pig respiratory rate monitoring

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Science China Technological Sciences 2025年

作者： Jing LI Bo LI Ziqi liao Yunhui DUAN Xinglan fu Yuehua HUANG Guanglin LI College of Engineering and Technology Southwest University Modern Agricultural Equipment Research Institute Xihua University

Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases. Humidity sensing is an important noncontact method to monitor pig respiration, which does not cause direct harm to pigs and meets the requirements of animal welfare. This paper proposes a humidity sensor based on graphene oxide wrapped-silica microspheres （GO@SiO2）. First, the sensor shows fast response/recovery performances of0.24/0.73 s. Experiments demonstrate that the wrapped microsphere structure can inhibit water aggregation. It is speculated that the wrapped microsphere structure can inhibit the stacking of GO, and its curved surface can promote the evaporation of water molecules. Second, the sensor shows a high sensitivity of 1.2%/%RH–4.2%/%RH in 11%–95%RH range. This can be attributed to different sensing mechanisms, from hopping transport to increasing ion transport, leading to a significant change in the sensor’s resistance. Third, the sensor shows selectivity to water molecules due to the hydrophilic characteristic of GO and the significant increase in conductivity by ion transport. Finally, the sensor is applied to realize the respiratory rate monitoring of adult pigs and piglets.

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Biomechanopharmacological effects of exercise and tetramethyparizine on inflammatory cytokines secreted by endothelial cells in rat

Biomechanopharmacological effects of exercise and tetramethy...

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2008年全国生物流变学与生物力学学术会议

作者： Peng Yang,Chang-an Yu,Geng Li,Jian-yan Wen and fu-long liao(National Cardiovascular Center of Integrated Traditional Chinese and Western Medicine,China-Japan Friendship Hospital)

Background and Objective:The new borderline discipline,biomechanopharmacology,is forming at the boundary between biomechanics and pharmacology,Regular aerobic exercise may lower the risk for coronary artery disease by mitigating inflammation,which plays a key role in the pathophysiology of *** study was to investigate the effects of exercise and tetramethylparazine(TMP) originated from herbal medicine against the inflammatory cytokines secreted by endothelial cells in rat.

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Fatigue Strength Analysis of Dissimilar Aluminum Alloy TIG Welds

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 265-274页

作者： liao Xiangyun WANG Ruijie LIU Guoshou ZHAO Pinglin Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China Faculty of Civil Engineering and Mechanics Kunming University of Science and TechnologyKunming 650500China

The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was *** experimental results show that most specimens mainly failed at the 7075 side weld toes even though the base material tensile strength of 7075 is higher than that of *** maximum stress-strain concentration in the two finite element models is located at the 7075 side weld toe,which is basically consistent with the actual fracture *** weld zone on the 7075 side experiences severe material softening,with a large ***,the Vickers hardness value on the 6061 side negligibly changes and fluctuates around 70 *** obvious defects are found on the fatigue fracture,but a large number of secondary cracks *** germinate from the weld toe and propagate in the direction of the plate *** reinforcement has a serious impact on fatigue *** life will decrease exponentially as the weld reinforcement increases under low *** is found that the notch stress method can give a better fatigue life prediction for TIG weldments,and the errors of the predicted results are within the range of two factors,while the prediction accuracy decreases under low *** equivalent structural stress method can also be used for fatigue life prediction of TIG weldments,but the errors of prediction results are within the range of three factors,and the accuracy decreases under high stress.

关键词： TIG welding notch stress method equivalent structural stress method fatigue life finite element analysis

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Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

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Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao Lai Saad Arif Cong Feng Guangjun liao Chuntao Wang School of Automation Guangdong University and TechnologyGuangzhou510006China School of Immigration Administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China School of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

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High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Polymer membrane electrodes

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A six-variable quasi-3D isogeometric approach for free vibration of functionally graded graphene origami-enabled auxetic metamaterial plates submerged in a fluid medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 157-176页

作者： Wei CHEN Zhihong TANG Yufen liao Linxin PENG College of Civil Engineering University of South China College of Civil Engineering and Architecture Guangxi University Key Laboratory of Disaster Prevention and Structural Safety of Ministry of Education Guangxi University

This paper presents, for the first time, an effective numerical approach based on the isogeometric analysis(IGA) and the six-variable quasi-three dimensional(3D)higher-order shear deformation theory(HSDT) to study the free vibration characteristics of functionally-graded(FG) graphene origami(GOri)-enabled auxetic metamaterial(GOEAM) plates submerged in a fluid medium. The plate theory incorporates the thickness stretching and the effects of transverse shear deformation without using any shear correction factors. The velocity potential function and Bernoulli's equation are used to derive the hydrodynamic pressure acting on the plate surface. Both horizontally and vertically immersed plate configurations are considered here in the form of inertia *** plates are composed of multilayer GOEAMs, with the GOri content varying through the plate's thickness in a layer-wise manner. This design results in graded auxetic *** material properties are evaluated by mixing rules and a genetic programming(GP)-assisted micromechanical model. The governing equations of motion for the FG-GOEAM plates immersed in a fluid medium are derived by Hamilton's principle. After validating the convergence and accuracy of the present model, a comprehensive parametric study is carried out to examine the effects of the GOri content, GOri distribution pattern, GOri folding degree, fluid level, immersed depth, and geometric parameter on the natural frequencies of the FG-GOEAM plates. The results show that the natural frequencies for the four GOri distribution patterns increase with the increase in the layer number when the lay number is fewer than 10, and then stabilize after the layer number reaches ***, in general, the natural frequency of the FG-GOEAM plate in a vacuum or fluid increases when the GOri content increases, while decreases when the GOri folding degree increases. Some additional findings related to the numerical results are presented in the conclusions. It is belie

关键词： Equations of motion

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Effects of water level variations on the water quality of Huayang Lakes, China

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Journal of Geographical Sciences 2025年第1期35卷 173-188页

作者： AN Lesheng LIU Chun FAN Zhongya liao Kaihua WANG Wencai WANG Nan School of Resources and Environment Anqing Normal University South China Institute of Environmental Sciences Ministry of Ecology and Environment The Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyCAS

To explore water level variations and their dynamic influence on the water quality of Huayang Lakes, the water level from 1967 to 2023 and water quality from 2015 to 2023 were analyzed using the Mann–Kendall trend test, box plots, and violin plots. The results show a notable hydrological rhythm of water level alternation between dry and flood seasons in Huayang Lakes, with an average water level of 12.82 m and a monthly range of 11.21–17.24m. Since 2017, the water level of Huayang Rivers has shown a decreasing trend of –0.02 m/*** phosphorus(TP) has become the primary pollutant. The TP concentrations in longgan Lake(the largest lake) during the dry, rising, flood, and retreating seasons from 2015 to 2023were 0.083, 0.061, 0.050, and 0.059 mg/L, respectively. The effect of water level on TP was mainly observed during the low-water period. When the water level in the dry season rose to 12.25 and 13.00 m, the percentage of TP exceeding 0.1 mg/L in longgan Lake decreased to 55.8% and 33.3%, respectively. During the dry season, wind and wave disturbances caused the release of endogenous phosphorus in Huayang Lakes. This led to drastic fluctuations in TP concentration, reducing the correlation between water level and TP. When external control is limited, the water level during the dry season should be maintained between 12.25 and 13.0 m. Additionally, it is necessary to accelerate the restoration of submerged macrophyte species(such as Hydrilla verticillata and Vallisneria natans) in the Huayang Rivers.

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