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Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong li li-yan WU Yu-huang TAN Yin-feng CHEN Long liu Pei liANG Chang-fu HE Xiao-ning li Yong-hui Hainan Provincial Key Lab of Research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China Department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(Ali) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the Ali mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(Pli in mice through repairing endothelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

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Effects of warming and drought stress on the growth characteristics,photosynthetic-transpiration rates,and yield of winter wheat

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 121-129页

作者： Qian li Yang Gao Abdoul Kader Mounkaila Hamani Guangshuai Wang Junming liu Yuanyuan fu Xingpeng Wang College of Water Resource and Architecture Engineering Tarim UniversityAlar 843300XinjiangChina Institute of Farmland Irrigation Chinese Academy of Agricultural SciencesXinxiang 453002HenanChina

Climate change has limited crop productivity *** crop response to global climate changes is vital to maintaining agricultural sustainable development.A two-year experiment was conducted to investigate the effects of warming and drought on crop growth and winter wheat yield *** results showed that both warming and drought shortened the crop growth period,reduced the leaf area index,and increased winter wheat biomass *** sufficient water supply conditions,warming would increase photosynthetic and transpiration rates and water use efficiency,while under water deficit conditions,the opposite was *** warming conditions,the grain yield of the water deficit treatment was 8.9%lower than that of the sufficient water supply *** non-warming conditions,the grain yield of water deficit treatment was 12.4%lower than that of the sufficient water *** the conditions of water-sufficient supply,the grain yield of the warming treatment was 4.4%lower than that of the non-warming treatment,and under the conditions of water deficit,the grain yield of the warming treatment was 1.3%lower than that of the non-warming *** tends to decrease wheat growth and grain yield,but sufficient water supply could improve winter wheat’s water use efficiency and reduce the warming limitation on wheat production.

关键词： winter wheat warming leaf area index photosynthetic rate yield biomass

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A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue li Yang DI Lei CHENG Ranran liu lijuan li Hongmei li Yi TANG Zhangrui YAN Yongming LU Tao fu Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

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Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

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Defence Technology（防务技术） 2024年第2期32卷 496-509页

作者： Shan liu Chunyuan liu Yifei Hao Yi Zhang li Chen Zhan li Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Prefabricated Buildings and Intelligent Construction Hebei University of TechnologyTianjin 300400China Institute of Defense Engineering AMSPLABeijing 100850China Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing 211189JiangsuChina State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of the PLANanjing 210007JiangsuChina

The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil *** geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and ***,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are *** this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and *** experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of *** that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical *** tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact *** was found that EGC could effectively enhance the blast resistance of structural elements in different *** AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly *** plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.

关键词： Engineered geopolymer composites Fiber optimization Strengthening material Blast resistance Masonry wall Reinforced AAC panel Plain concrete slab

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Modulation mechanism of electron energy dissipation on superlubricity based on fluorinated 2D ZIFs

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Nano Research 2024年第4期17卷 3198-3209页

作者： Yuxin li Lei liu Kunpeng Wang Yuhong liu State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China School of Mechatronic Engineering Shanghai UniversityShanghai 200444China

Electron energy dissipation is an important energy dissipation pathway that cannot be ignored in friction ***-dimensional zeolite imidazole frameworks(2D ZIFs)and fluorine doping strategies give 2D Zn-ZIF and 2D Co-ZIF unique electrical properties,making them ideal materials for studying electron energy dissipation *** this paper,based on the superlubricity modulation of 2D fluoridated ZIFs,the optimal tribological properties are obtained on the 2D F-Co-ZIF surface,with the friction coefficient as low as *** experiments,density functional theory(DFT)simulation,and fluorescence detection are used to explain the mechanism of fluorine doping regulation of tribological properties from the two stages,namely energy transfer and energy ***,the energy will transfer into the friction system through the generation of electron–hole pairs under an external excitation,and release by radiation and non-radiation energy dissipation *** reduces energy transfer by altering the electronic properties and band structures of ZIFs,and slows down the charge transfer by enhancing the shielding efficiency,thus slowing the non-radiative energy dissipation rate during the energy release *** insights not only help us better understand the role of fluorine doping in improving tribological properties,but also provide a new way to further explore the electron energy dissipation pathway during friction.

关键词： superlubricity electron energy dissipation modulation two-dimensional zeolite imidazole frameworks(2D ZIFs) fluorination

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Cationic engineered nanodiamonds for efficient antibacterial surface with strong wear resistance

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Nano Research 2024年第3期17卷 939-948页

作者： fu-Kui li Wen-Bo Zhao Yong Wang Wen-Tao Huang Ya-Lun Ku Hang liu Rui Guo Hui-Hui Yu Kai-Kai liu Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics&MicroelectronicsZhengzhou UniversityZhengzhou 450052China

The spread of diseases caused by bacterial adhesion and immobilization in public places constitutes a serious threat to public *** of bacteria spread by the construction of an antibacterial surface takes precedence over post-infection ***,we demonstrate an effective antibacterial surface with strong wear resistance by constructing cationic engineered nanodiamonds(C-NDs).The C-NDs with positive surface potentials interact effectively with bacteria through electrostatic interactions,where the C-NDs act on the phospholipid bilayer and lead to bacterial membrane collapse and rupture through hydrogen bonding and residual surface oxygen-containing reactive *** this case,bactericidal rate of 99.99%and bacterial biofilm inhibition rate of more than 80%can be achieved with the C-NDs concentration of 1 mg/*** addition,the C-NDs show outstanding antibacterial stability,retaining over 87%of the antibacterial effect after stimulation by adverse environments of heat,acid,and external ***,an antibacterial surface with high wear resistance obtained by integrating C-NDs with commercial plastics has been *** antibacterial surface with a mass fraction of 1 wt.%C-NDs improved abrasion resistance by 3981 times,with 99%killing of adherent *** work provides an effective strategy for highly efficient antibacterial wear-resistant surface,showing great practical applications in public health environments.

关键词： antibacterial surface cationic engineered nanodiamonds wear-resistant

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Removal of Cr(Ⅵ)by glutaraldehyde-crosslinked chitosan encapsulating microscale zero-valent iron:Synthesis,mechanism,and longevity

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Journal of Environmental Sciences 2024年第8期142卷 115-128页

作者： Yijun Duan Fang liu Xiang liu Miao li School of Environment Tsinghua UniversityBeijing 100084China Transportation Institute of Inner Mongolia University Hohhot 010070China

Microscale zero-valent iron(mZVI)has shown great potential for groundwater Cr(Ⅵ)***,low Cr(Ⅵ)removal capacity caused by passivation restricted the wide use of *** prepared mZVI/GCS by encapsulating mZVI in a porous glutaraldehydecrosslinked chitosan matrix,and the formation of the passivation layer was alleviated by reducing the contact between zero-valent iron *** average pore diameter of mZVI/GCS was 8.775 nm,which confirmed the mesoporous characteristic of this *** of batch experiments demonstrated that mZVI/GCS exhibited high Cr(Ⅵ)removal efficiency in a wide range of pH(2-10)and temperature(5-35℃).Common groundwater coexisting ions slightly affected m ZVI/*** material showed great reusability,and the average Cr(Ⅵ)removal efficiency was 90.41%during eight *** this study,we also conducted kinetics and isotherms ***-second-order model was the most matched kinetics *** Cr(Ⅵ)adsorption process was fitted by both Langmuir and Freundlich isotherms models,and the maximum Langmuir adsorption capacity of m ZVI/GCS reached243.63 mg/g,which is higher than the adsorption capacities of materials reported in most of the previous ***,the column capacity for Cr(Ⅵ)removal of a mZVI/GCS-packed column was 6.4 times higher than that of a mZVI-packed column in a 50-day ***,mZVI/GCS with a porous structure effectively relieved passivation problems of mZVI and showed practical application prospects as groundwater Cr(Ⅵ)remediation material with practical application prospects.

关键词： Chitosan Glutaraldehyde mZVI Cr(Ⅵ) Groundwater

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Localization−delocalization transitions in non-Hermitian Aharonov−Bohm cages

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Frontiers of physics 2024年第3期19卷 39-50页

作者： Xiang li Jin liu Tao liu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

A unique feature of non-Hermitian systems is the extreme sensitivity of the eigenspectrum to boundary conditions with the emergence of the non-Hermitian skin effect (NHSE). A NHSE originates from the point-gap topology of complex eigenspectrum, where an extensive number of eigenstates are anomalously localized at the boundary driven by nonreciprocal dissipation. Two different approaches to create localization are disorder and flat-band spectrum, and their interplay can lead to the anomalous inverse Anderson localization, where the Bernoulli anti-symmetric disorder induces mobility in a full-flat band system in the presence of Aharonov−Bohm (AB) Cage. In this work, we study the localization−delocalization transitions due to the interplay of the point-gap topology, flat band and correlated disorder in the one-dimensional rhombic lattice, where both its Hermitian and non-Hermitian structures show AB cage in the presence of magnetic flux. Although it remains the coexistence of localization and delocalization for the Hermitian rhombic lattice in the presence of the random anti-symmetric disorder, it surprisingly becomes complete delocalization, accompanied by the emergence of NHSE. To further study the effects from the Bernoulli anti-symmetric disorder, we found the similar NHSE due to the interplay of the point-gap topology, correlated disorder and flat bands. Our anomalous localization−delocalization property can be experimentally tested in the classical physical platform, such as electrical circuit.

关键词： non-Hermitian skin effects disorder flat band localization−delocalization transition

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Topology modulation of tetraphenylethylene graphdiyne at a liquid-liquid interface

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Nano Research 2024年第6期17卷 4661-4667页

作者： Tingting Xu Pei Wen Ng Shaofei Wu Danjun fu Yunhan Ma Yao liu lidao li Xiaofei Zhang Jun Zhu Department of Chemistry National University of SingaporeSingapore 117543Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Monomers with low symmetries can form different topological structures in the preparation of organic two-dimensional(2D)***,it remains challenging to modulate the topologies in practical *** theoretical insights into the formation energy of potential structural configurations,we report the topology modulation of a graphdiyne(GDY)derivative constructed from two-fold symmetric tetrakis(4-ethynylphenyl)ethene precursor by changing solvent combinations in a liquid-liquid interfacial *** aqueous-organic(water-dichloromethane)interface afforded GDY with a kagome topology while a rhombic topology was formed at an organic-organic(hexane-acetonitrile)interface.A comprehensive evaluation of their structures and optoelectronic properties was conducted through various characterization techniques and theoretical *** study provided new insights to modulate the topology of not only GDY but also other framework structures and obtain topologically pure materials in situations where different topologies are possible during practical synthesis.

关键词： graphdiyne derivative tetraphenylethylene topology modulation aggregation-induced emission(AIE)two-dimensional(2D)polymers interfacial synthesis

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Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 445-454页

作者： li Yuchun Shen Chao liu Wei li Dong Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this *** auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on *** parametric vibration equation is established for the test model using the finite-element *** auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent *** effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test *** with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental *** a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric *** with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.

关键词： auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge

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