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Synthesis and Characterization of Polyurethane

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Journal of Wuhan university of Technology(Materials Science) 2010年第6期25卷 984-986页

作者：贺纯静倪家骧 Department of Pain Xuanwu HospitalCapital Medical University

Polyurethane was synthesized by the copolymerization with isocyanate and *** structure and properties of the copolymers were characterized by infrared spectrometer（IR）,differential scanning calorimetry（DSC） and thermogravimetry（TG）.The rabbit blood samples was dripped on the polyurethane,which was prepared by drying and die,and the contact angle was measured by contact angle measurement,then infiltration phenomenon was observed by electron *** results showed that the contact angle of blood samples and polyurethane was decreased with increasing time,and the platelets on the polyurethane would gradually increase and more *** the polyurethane coating had good hydrophilic property and anticoagulant activity.

关键词： polyurethane hydrophilicity anticoagulant

The role of the DLPFC in inductive reasoning of MCI patients and normal agings:An fMRI study

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Science china(Life Sciences) 2009年第8期52卷 789-795页

作者： YANG YanHui1,3,LIANG PeiPeng2,3,LU Shengfu2,3,LI KunCheng1,3 & ZHONG Ning2,3,4 1 Xuanwu hospital,capital medical university,beijing 100053,china 2 The International WIC Institute,beijing university of Technology,beijing 100124,china 3 beijing Municipal Lab of Brain Informatics,beijing 100124,china 4 Department of Life Science and Informatics,Maebashi Institute of Technology,Maebashi 371-0816,Japan Xuanwu hospital Capital Medical University Beijing China beijing Municipal Lab of Brain Informatics Beijing China The International WIC Institute Beijing University of Technology Beijing China Department of Life Science and Informatics Maebashi Institute of Technology Maebashi Japan

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex(DLPFC) plays an important role in inductive *** fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings,and whether the activation pattern of this region was different between MCI patients and normal *** fMRI results indicated that MCI patients had no difference from normal agings in behavior performance(reaction time and accuracy) and the activation pattern of ***,the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings,and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal *** together,these results indicated that DLPFC plays an important role in inductive reasoning of agings,and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

关键词： mild cognitive impairment functional MRI inductive reasoning

Low Correspondence of EGFR Mutations in Tumor Tissue And Paired Serum of Non-Small-Cell Lung Cancer Patients

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Chinese Journal of Cancer research 2010年第1期22卷 27-31页

作者： Guo-hong Song,Jun Ren,Li-jian zhang,Li-jun Di, Yan-hua Yuan,Jing Yu,Jun Jia Key Laboratory of Carcinogenesis and Translational research (Ministry of Education) Department of medical Oncology,Peking university School of Oncology,beijing Cancer hospital & Institute,beijing 100142,china Key laboratory of Carcinogenesis and Translational research (Ministry of Education) Department of medical Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing China

Objective： Epidermal growth factor receptor （EGFR） mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer （NSCLC） patients. The aim of this study was to evaluate the correspondence between EGFR mutations in non-small-cell lung cancer tissues and in circulating DNA. Methods： The research was conducted in 50 non-small-cell lung cancer patients who had undergone curative surgery, and in whom both serum and neoplastic tissues were available. Meanwhile sera of 33 cases of advanced NSCLC patients were also analyzed. DNA were extracted from each sample. Mutations of EGFR in exonl8-21 were examined by PCR amplification method and direct sequencing. Results： EGFR mutations were detected in 15 （30%） of 50 neoplastic tissue samples, 6 cases were in-frame deletion del E746-A750 in exonl9, 9 cases were substitution in exon 21 （all were L858R except one was L861Q）, but no mutated DNA resulted in paired serum circulating DNA samples of 50 resectable patients. As the 33 advanced NSCLC patients, EGFR mutations were detected in only 2 serum circulating DNA samples, all were L858R mutation in exon 21. Conclusion： These data indicated that it was difficult to identify EGFR mutations in circulating DNA of NSCLC patients. The use of EGFR mutation in serum as a clinical method for decision making of TKI therapy is unsatisfactory.

关键词： Circulating DNA Epidermal growth factor receptor (EGFR) Mutation Non-small-cell lung cancer (NSCLC)

The Expression of Fibrosis Related Factors in Scleroderma Mouse Model

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The Expression of Fibrosis Related Factors in Scleroderma Mo...

3D-QSAR study on phenoxy-alkylamine compounds of α_1-adrenoceptor antagonist

中华医学会第十八次全国皮肤性病学术年会

作者： Gaoyun Yang~1,wenyin cui~1 1 beijing friendship hospital Of capital medical university 2 beijing friendship hospital Of capital medical university

Objective To investigate the expression of fibrosis related factors and genes in scleroderma mouse model induced by Bleomycin(BLM). Methods Scleroderma mouse model was established by repeated sub-cutanious injection with 500μl of Bleomycin(200ug/ml) on every other-day,the mice skin samples were harvested on day 10th and day 20th. The ELISA assay was applied to measure the protein levels of Collagen,JE,MMP3,MMP9,and Real-Time

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Chinese Science Bulletin 2001年第4期46卷 303-306页

作者： FANG Hao, LU Jingfen, XIA Lin & zhang LineDepartment of Medicinal Chemistry, china Pharmaceutical university, Nanjing 210009, china State Key Laboratory of Natural and Biomimetic Drugs, beijing medical university, beijing 100083, china Department of Medicinal Chemistry China Pharmaceutical University Nanjing China State Key Laboratory of Natural and Biomimetic Drugs Beijing Medical University Beijing China

The study of three-dimensional quantitative structure-activity relationship (3D-QSAR) of DDPH and its derivatives that have been known with their activity parameters has been developed using the comparative molecular field analysis (CoMFA) method. Here, (+)-DDPH crystal structure was selected as the active conformation model and comparisons between the influences of different charge calculation methods and grid setup were conducted. The coefficients of cross-validation (q2) and regression (r2) are 0.481 and 0.997, respectively. The standard error (SE) is 0.102. The research result suggests that the steric field makes more contributions to the activity than the electrostatic field. This model can help us not only in improving our understanding of the receptor-ligand interactions, but also in predicting the activity of derivatives and designing new compounds with better potency.

关键词： CoMFA. α1 -adrenoceptor antagonist.

Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer(2024 edition)

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Radiation Medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of Radiation Oncology china Anti-Cancer Association Branch of Radiation Oncology Chinese medical Association Branch of Radiation Oncology TreatmentPhysician Chinese medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui Wencheng zhang 不详 Tianjin medical university Cancer Institute&hospital Tianjin 300060China the Fourth hospital of Hebei medical university Shijiazhuang 050011China National Cancer center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin medical university Cancer hospital China

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of Radiation Oncology,china Anti-Cancer Association,the Branch of Radiation Oncology,Chinese medical Association,and the Branch of Radiation Oncology Treatment Physician,Chinese medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

Volumetric Measurement Pulmonary Ground-Glass Opacity Nodules with Multi-detector CT:Effect of Various Tube Current on Measurement Accuracy——A Chest CT Phantom Study

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Volumetric Measurement Pulmonary Ground-Glass Opacity Nodule...

Evaluation of frequency-lowering algorithms for intelligibility of Chinese speech in hearing-aid users

中华医学会第16次全国放射学学术大会

作者： E Linning Ma Dqing The Department of Radiology beijing friendship hospital-Affiliated capital medical university beijing china

PURPOSE The purpose of our study was to evaluate the effect of various tube current on accuracy of volumetric measurement of ground-glass nodules by using a chest phantom.

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Progress in Natural Science:Materials International 2009年第6期19卷 741-749页

作者： Xianbo Xiao a, Hui zhang a, Guangshu Hua, Chunhong Liu b, Jia Liu c a Biomedical Engineering, Tsinghua university, Room 209, medical Tech. Bld., beijing 100084, china b Department of Otolaryngology, Xuanwu hospital, beijing 100053, china c Bo Na Feng medical Instrument Co., Ltd., beijing 100028, china Biomedical Engineering Tsinghua University Room 209 Medical Tech. Bld. Beijing 100084 China Department of Otolaryngology Xuanwu Hospital Beijing 100053 China Bo Na Feng medical Instrument Co. Ltd. Beijing 100028 China

Despite the attention being given to and the knowledge of the benefits of evaluating frequency-lowering algorithms for hearing-impaired people, the causality between these algorithms and their benefits is still not clear. This is aggravated by the fact that comparative research on the methodologies and skills required for fitting an appropriate algorithm to individual patients is lacking. Against this back-drop, the current study has attempted to make progress in this area. In this experiment, six experienced traditional hearing-aid users with severe impairments in the high frequencies were fitted with two different frequency-lowering methods, and weekly hearing tests were conducted to track the benefits of such methods. After the experiment, five of the listeners accepted the frequency-lowering algorithms. Both methods showed superior results when compared with the listeners’ own hearing aids in most of the tests, and the segmented compression algorithm was indicated to have better "anti-noise" quality and speech intelligibility improvement capabilities. A preference for the application of proportional compression to unvoiced speech was also found in this algorithm. Unlike in previous studies, all speech materials here are recorded in Chinese. Therefore, the results could also be used to evaluate the benefits of frequency-lowering to the intelligibility of Chinese speech for patients. As a result, an improvement was found, especially in the recognition of consonants. Moreover, no adverse effect was found in intonation recognition.

关键词： Hearing aid Frequency-lowering Speech intelligibility

Right prefrontal laterality of Chinese boys during a Chinese high conflict Stroop task measured by multi-channel near-infrared spectroscopy imaging

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Progress in Natural Science:Materials International 2007年第9期17卷 1023-1028页

作者： Liu Jiacheng1,Bai Jing1,Peng Miao2,Fan Xiaofei1 and Guo Qiyong3(1.Department of Biomedical Engineering,Tsinghua university,beijing 100084,china 2.Department of Electroneurophysiology,the Sixth hospital of Peking university,beijing 100085,china 3.Department of Radiology,The Second hospital of china medical university,Shenyang 110003,china) Department of Biomedical Engineering Tsinghua University Beijing 100084 China Department of Electroneurophysiology Sixth Hospital of Peking University Beijing 100085 China Department of Radiology Second Hospital of China Medical University Shenyang 110003 China

Some studies have shown that native Chinese speakers have different laterality in matched Stroop tasks from native English ***,many imaging data,which show left laterality of English-matched Stroop interference,have been *** a few functional imaging studies have been conducted to investigate the phenomenon of the Chinese version of Stroop *** this study,functional activity in the lateral prefrontal cortex of a group of normal Chinese boys with functional near-infrared imaging during a Stroop color-word task was measured to show different Stroop interferences in the prefrontal *** results show obvious fluctuation of the cerebral blood volume in the right prefrontal cortex in all boys,which agrees with the finding of previous studies,that is,Chinese native boys have right laterality in their brain when the Chinese version of Stroop color-word task is applied.

关键词： laterality Stroop effect prefrontal cortex near-infrared