检索结果-南通市图书馆

Small-molecule agents for cancer immunotherapy

Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye zhang Zhi Shi Zeping Hu Min Huang Liwu fu State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gyroid Triply Periodic Minimal Surface Lattice Structure Enables Improved Superelasticity of CuAlMn Shape Memory Alloy

引用

Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1047-1065页

作者： Mengwei Wu Chunmei Ma Ruiping Liu Huadong fu Department of Materials Science and Engineering China University of Mining and Technology(Beijing)Beijing100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China

Improving the shape memory effect and superelasticity of Cu-based shape memory alloys(SMAs)has always been a research hotspot in many *** work systematically investigates the effects of Gyroid triply periodic minimal surface(TPMS)lattice structures with different unit sizes and volume fractions on the manufacturing viability,compressive mechanical response,superelasticity and heating recovery properties of CuAlMn *** results show that the increased specific surface area of the lattice structure leads to increased powder adhesion,making the manufacturability proportional to the unit size and volume *** compressive response of the CuAlMn SMAs Gyroid TPMS lattice structure is negatively correlated with the unit size and positively correlated with the volume *** superelastic recovery of all CuAlMn SMAs with Gyroid TPMS lattice structures is within 5%when the cyclic cumulative strain is set to be 10%.The lattice structure shows the maximum superelasticity when the unit size is 3.00 mm and the volume fraction is 12%,and after heating recovery,the total recovery strain increases as the volume fraction *** study introduces a new strategy to enhance the superelastic properties and expand the applications of CuAlMn SMAs in soft robotics,medical equipment,aerospace and other fields.

关键词： Shape memory alloys Superelasticity Gyroid triply periodic minimal surface(TPMS)lattice structure Selective laser melting(SLM)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ghrelin protects myocardium from isoproterenol-induced injury in rats

引用

Acta Pharmacologica Sinica 2004年第9期 29-35页

作者： Lin CHANG, Jing ZHAO, Gui-zhong LI, Bin GENG2, Chun-shui PAN, Yong-fen QI, Chao-shu TANGInstitute of Cardiovascular Disease research, the First hospital beijing 100034, china Key Lab for Cardiovascular Biology of Education Ministry, china, beijing 100083, china Department of Physiology, Peking university, beijing 100083, chinaDepartment of Ningxia medical College, Yinchuan 750004, china

AIM: To investigate the cardiac protective effects of ghrelin in rat with myocardial injury induced by isoproterenol (ISO). METHODS: Rats were subcutaneously injected ISO 40 mg·kg-1·d-1 with or without ghrelin 1 or 10 nmol·kg-1·d-1 for 2 d. Hemodynamic parameters including mean arterial blood pressure and left ventricular pressure were measured at 12 h after the last injection

关键词： ghrelin hemodynamics endothelin-1 lactate dehydrogenase malondialdehyde isoproterenol heart rats

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Expert Consensus for the Diagnosis and Treatmentof Cholestatic liver Disease

引用

国际感染病学（电子版） 2012年第2期1卷 118-128页

作者： Chinese Expert Committee on the Diagnosis and Treatment of Cholestatic liver Disease Institute of Infectious Diseases, beijing Ditan hospital, capital medical university Institute of Infectious Diseases Beijing Ditan Hospital Capital Medical University.No.8 Jingshun East Street Chaoyang District Beijing 100015 China

Cholestatic liver disease (CLD) is a common problem in clinical practice with the main manifestation being ***,there has been a steady increase in knowledge associated with the diagnosis and treatment of ***,the experts in china were organized by the editorial board of Chinese Journal of Experimental and Clinical Infectious Diseases (Electronic Edition),Chinese Journal of liver Diseases (Electronic Edition) and Infection International (Electronic Edition) to collect and analyze relevant research,ultimately resulting in the development of this work (Chinese Expert consensus for the diagnosis and treatment of CLDs,also abbreviated as consensus).

关键词： UDCA CLD Chinese Expert Consensus for the Diagnosis and Treatmentof Cholestatic liver Disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1

引用

Chinese Science Bulletin 2009年第16期54卷 2786-2793页

作者： JIA XiaoLing1,2,3, CHEN Juan1,2 & LONG Mian1,2 1 National Microgravity Laboratory, Institute of Mechanics, Chinese Academy of Sciences, beijing 100190, china 2 center of Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, beijing 100190, china 3 School of Biological Science and medical Engineering, Beihang university, beijing 100083, china National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beijing China center of Biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing China School of Biological Science and medical Engineering Beihang University Beijing China

L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation, the remaining membrane-anchored L-selectin may still play an important role in regulating leukocyte rolling and adhesion with different binding kinetics. Here we developed an in vitro model to activate Jurkat cells via interlukin-8 (IL-8) and quantified the two-dimensional (2D) binding kinetics, using a micropipette aspiration assay, of membrane-anchored L-selectin to P-selectin glycoprotein ligand 1 (PSGL-1) ligand coupled onto human red blood cells (RBCs). The data indicated that L-selectin shedding reduced the amount of membrane-anchored L-selectin and lowered both its reverse and forward rates. These results suggested that the rolling dynamics of activated leukocytes was determined by two opposite impacts: reducing the surface presentation would enhance the rolling but lowering the kinetic rates would decrease the rolling. This finding provides a new insight into under-standing how L-selectin shedding regulates leukocyte rolling and adhesion.

关键词：结合动力学选择素配体白细胞介素8 Jurkat细胞诱导细胞表面微管吸吮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electroacupuncture improves cognitive function in a rat model of mild traumatic brain injury by regulating the SIRT-1/PGC-1α/mitochondrial pathway

引用

Chinese medical Journal 2024年第6期137卷 711-719页

作者： Bo Jin Yemei Gao Yixian fu Suxin zhang Ke zhang Yibing Su Department of Neurosurgery Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China Department of Traditional Chinese Medicine Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Breast Surgical Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:Mild traumatic brain injury(mTBI)is a common neurological trauma that can lead to cognitive *** sirtuin-1(SIRT-1)/peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α)pathway has been reported to have neuroprotective effects in rats with craniocerebral *** evaluated potential mechanisms underlying electroacupuncture-mediated recovery of cognitive function after mTBI,focusing on the SIRT-1/PGC-1α/mitochondrial ***:We included forty 6-week-old male Sprague-Dawley rats in this *** were randomly divided into four groups:controlled cortical impactor(CCI,n=10),sham operation(sham,n=10),electroacupuncture-treated CCI(CCI+EA,n=10),and electroacupuncture-treated sham(sham+EA,n=10)*** was performed by assigning a random number to each rat and using a random number *** mTBI rat model was established using a controllable cortical *** therapy was performed on the back of rats,by inserting acupuncture needles to the specific acupoints and setting appropriate parameters for *** evaluated spatial learning and memory functions with the Morris water maze *** performed quantitative real-time polymerase chain reaction(qRT-PCR),western blotting,adenosine triphosphate(ATP)determination,and mitochondrial respiratory chain complex I(MRCC I)determination on rat hippocampal *** analyzed SIRT-1/PGC-1α expression levels and the results of mitochondrial function assays,and compared differences between groups using bilateral Student’s ***:Compared with the sham group,SIRT-1/PGC-1α expression was downregulated in the hippocampus of CCI group(P<0.01).Although this expression was upregulated following electroacupuncture,it did not reach the levels observed in the sham group(P<0.05).Compared with the sham group,MRCC I and ATP levels in the CCI group were significantly reduced,and increased after electroacupuncture(P<0.01).In the Morris water maze,electroacupun

关键词： Electroacupuncture Cognitive impairment Sirtuin-1 Mild traumatic brain injury SIRT-1/PGC-1α/mitochondrial pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

醋酸钙与碳酸钙改善血透患者钙磷代谢的对比研究

引用

肾脏病与透析肾移植杂志 1999年第1期8卷 31-33页

作者：郭王王质刚首都医科大学附属北京友谊医院肾内科北京100050

目的：为了寻找一种安全有效的降磷药物。　方法：在３７名维持性血液透析患者中试用醋酸钙代替碳酸钙治疗，并自身对照。　结果：醋酸钙可以更有效地降低血磷，虽然出现了血钙的升高，但是钙磷乘积却显著性地降低。　结论：醋酸钙是... 详细信息

目的：为了寻找一种安全有效的降磷药物。　方法：在３７名维持性血液透析患者中试用醋酸钙代替碳酸钙治疗，并自身对照。　结果：醋酸钙可以更有效地降低血磷，虽然出现了血钙的升高，但是钙磷乘积却显著性地降低。　结论：醋酸钙是一种新型的、有效的降磷升钙药物，对改善维持性透析患者的钙磷代谢、防止肾性骨病的发生有着积极的作用。

关键词：血液透析碳酸钙醋酸钙钙磷代谢

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration

引用

Military medical research 2024年第1期11卷 152-155页

作者： Enhe Jirigala Bin Yao Zhao Li Yi-Jie zhang Chao zhang Li-Ting Liang Fan-Liang zhang Xing-Yu Yuan Xian-Lan Duan Wei Song Meng-De zhang Yi Kong Xiao-Bing fu Sha Huang research center for Tissue Repair and Regeneration Medical Innovation Research DepartmentChinese PLA General Hospital and PLA Medical CollegeBeijing 100048China Institute of Basic medical research Inner Mongolia Medical UniversityHohhot 010110China Academy of medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Medicine Nankai UniversityTianjin 300071China

Dear Editor,Three dimensional(3D)bioprinted extracellular matrix(ECM)can be used to provide both biochemical and biophysical cues to direct mesenchymal stem cells(MSCs)differentiation,and then differentiated cells were isolated for implantation in vivo using surgical ***,the reduced cell activity after cell isolation from 3D constructs and low cell retention in injured sites limit its application[1].Methacrylated gelatin(GelMA)hydrogel has the advantage of fast crosslinking,which could resemble complex architectures of tissue construct in vivo[2].Here,we adopted a noninvasive bioprinting procedure to imitate the regenerative microenvironment that could simultaneously direct the sweat gland(SG)and vascular differentiation from MSCs and ultimately promote the replacement of glandular tissue in situ(Fig.1a).

关键词： Sweat gland GelMA In situ niche Cell differentiation Tissue incorporation Vascularization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cells therapy for Parkinson's disease-so close and so far away

引用

Science china(Life Sciences) 2009年第7期52卷 610-614页

作者： REN ZhenHua & zhang Yu Cell Therapy center,Xuanwu hospital,capital medical university and Key Laboratory of Neurodegeneration,Ministry of Education,beijing 100053,china Cell Therapy center Xuanwu Hospital Capital Medical University and Key Laboratory of Neurodegeneration Ministry of Education Beijing 100053 China

One of the strategies of treating Parkinson's disease(PD) is the replacement of lost neurons in the substantia nigra with healthy dapamingergic *** sources for cells range from autologous grafts of dopamine secreting cells,fetal ventral mesencephalon tissue,to various stem cell *** the past quarter century,many experimental replacement therapies have been tried on PD animal models as well as human patients,yet none resulted in satisfactory outcomes that warrant wide *** progress in stem cell biology has shown that nuclear transfer embryonic stem cells(ntES) or induced pluripotent stem cells(iPS) derived cells can be used to successfully treat rodent PD models,thus solving the problem of immunorejection and paving the way for future autologous transplantations for treating ***,however,post mortem analysis of patients who received fetal brain cell transplantation revealed that implanted cells are prone to degeneration just like endogenous neurons in the same pathological area,indicating long-term efficacy of cell therapy of PD needs to overcome the degenerating environment in the brain.A better understanding of neurodegeneration in the midbrain appeared to be a necessary step in developing new cell therapies in Parkinson's *** is likely that future cell replacement will focus on not only ameliorating symptoms of the disease but also trying to slow the progression of the disease by either neuroprotection or restoring the micro-environment in the midbrain.

关键词： Parkinson’s disease dopamine neurons cell replacement transplantation stem cell fetal ventral mesencephalon carotid body embryonic stem cells nuclear transfer embryonic stem cells induced pluripotent stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibition of the activating signals in NK92 cells by recombinant GST-sHLAG1α chain

引用

Cell research 2004年第2期14卷 155-160页

作者： Ai Yu YAO~(1,2), Hai Yang TANG~1, Yun WANG~1, Mei fu FENG~(1,*), Rou Li ZHOU~(2,*) ~1State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Science, beijing 100080, china ~2Department of Cell Biology and medical Genetics, School of Basic medical Sciences, Health Science center, Peking university, beijing 100083, china. 2Department of Cell Biology and medical Genetics School of Basic Medical Sciences Health Science Center Peking University Beijing 100083 China. 1State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Science Beijing 100080 China 1State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Science Beijing 100080 China 1State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Science Beijing 100080 China 2Department of Cell Biology and medical Genetics School of Basic Medical Sciences Health Science Center Peking University Beijing 100083 China.

The soluble HLA-G1 (sHLA-G1) isoform was found to be secreted by trophoblast cells at the matemo-fetal interface, which suggests that it may act as an immunomodulator during pregnancy. In this paper, we reported that GST-sHLA-G1α chain could bind to its receptor ILT-2 on NK92 cells and then the latter recruited Src homology 2 domaincontaining tyrosine phosphatase-1 (SHP-1), which consequently dephosphorylated some important protein tyrosine kinases and blocked the activation of downstream molecules such as MEK and ERK so that the cytotoxicity of natural killer (NK) cells was inhibited. These results indicated that GST-sHLA-G1α chain might be exploited in new immunotherapy strategies aiming at inducing immunotolerance during allograft, xenograft and autoimmune situations. In addition, we found that modification of O-linked β-N-acetylglucosamine (O-GlcNAc) was involved in NK cells’ activating and inhibitory signals. This may provide a novel molecular target for inducing immunotolerance but needs furthe

关键词： NK92 GST-sHLA-G1α chain signal transduction SHP-1 O-G1cNAc.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：