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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 58-62页

作者： Chu, Kai-Jian Yao, xiao-Ping fu, xiao-hui Second Military Med Univ Eastern Hepatobiliary Surg Hosp Dept Oncol Comprehens Treatment Shanghai 200438 Peoples R China

BACKGROUND: Pleural effusion frequently complicates hepatectomy and multiple factors contribute to its development following hepatectomy for primary liver cancer. The purpose of this study was to evaluate these factors. METHODS: From March 2003 to May 2005, 228 consecutive patients with primary liver cancer underwent hepatectomy in our department were evaluated retrospectively to identify factors related to postoperative pleural effusion. RESULTS: Among the 228 patients, postoperative pleural effusions arose in 58 (25.4%). Univariate analysis showed significant differences in postoperative ascites, subphrenic collection, Pringle manoeuvre length, drainage amount on postoperative day 1, albumin level on postoperative day 7, alanine aminotransferase (ALT) level on postoperative days I and 3, prealbumin level on postoperative days 3 and 7, and tumor size (Pfusion (Pfusion after hepatectomy for primary liver cancer.

关键词： postoperative pleural effusion primary liver cancer hepatectomy etiology

Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging

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National Science Review 2023年第6期10卷 60-63页

作者： fu-hui xiao Hao-Tian Wang xiao-Qiong Chen Ming-Xia Ge Dongjing Yan Xing-Li Yang Li-Qin Yang Rong Lin Rong-hui Guo Wen Zhang Nelson Leung-Sang Tang Yonghan He Jumin Zhou Wang-Wei Cai Qing-Peng Kong State Key Laboratory of Genetic Resources and Evolution Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Key Laboratory of Healthy Aging Study Kunming Institute of ZoologyChinese Academy of Sciences KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming College of Life Science University of Chinese Academy of Sciences Department of Biochemistry and Molecular Biology Hainan Medical College Department of Biology Hainan Medical College Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Centenarians,as excellent examples of extreme yet successful aging,not only display a much longer lifespan but can also delay or even escape major agerelated diseases,such as cardiovascular disorders,neurodegenerative diseases,and cancer [1].Studies have suggested that genetic factors account for 20%-30%of human longevity [2];however,only a handful of longevity-associated genes/mutations have been observed in long-lived individuals,even with the use of genome-wide scanning/sequencing assays [3,4].In contrast,evidence has shown the crucial roles of epigenetic alternations in aging and age-related diseases [5],suggesting that epigenetic modifications play central roles in human healthy ***,a comprehensive analysis of the epigenomic landscape of centenarians is urgently needed.

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Cidan Capsule in Combination with Adjuvant Transarterial Chemoembolization Reduces Recurrence Rate after Curative Resection of Hepatocellular Carcinoma:A Multicenter,Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第1期29卷 3-9页

作者： ZHENG Dong-hai YANG Jia-mei WU Jian-xiong CHENG Shu-qun ZHANG Shao-geng WU Dong LI Aijun fu xiao-hui LI Xun QI fu-chen DUAN Wei-hong CHEN Jun-hui YANG Zhi-ying LIANG Lu ZENG Jin-xiong ZHENG Wei-da WU Meng-chao Department of Oncology Beijing Weida Traditional Chinese Medicine Cancer HospitalBeijing100023China Department of Hepatic Surgery the Third Affiliated Hospital of Naval Medical UniversityShanghai200433China Department of Abdominal Surgery Cancer Hospital of Chinese Academy of Medical SciencesBeijing100021China Department of Hepatic Surgery the Fifth Medical Center of PLA General HospitalBeijing100161China Department of Hepatic Surgery the First Hospital of Lanzhou UniversityLanzhou730013China Department of Hepatic Surgery Huai’an First People’s HospitalNanjing Medical UniversityHuai’anJiangsu Province223399China Department of Hepatic Surgery PLA Rocket Army General HospitalBeijing100088China Department of Interventional Therapy Shenzhen Hospital of Peking UniversityShenzhenGuangdong Province518036China Department of Hepatic Surgery China-Japan Friendship HospitalBeijing100029China Department of Hepatic Surgery Baotou Central HospitalBaotouInner Mongolia Autonomous Region014042China Department of Traditional Chinese Medicine No.900 Hospital of the Joint Logistics Support Force of PLAFuzhou350025China

Objective:To evaluate the efficacy and safety of Cidan Capsule combined with adjuvant transarterial chemoembolization(TACE) in patients with a high risk of early recurrence after curative resection of hepatocellular carcinoma(HCC).Methods:A multicenter,randomized controlled trial was conducted in patients with high-risk recurrence factors after curative resection of HCC from 9 medical centers between July 2014 and July ***249 patients were randomly assigned to TACE with or without Cidan Capsule administration groups by stratified block in a 1:1 *** adjuvant TACE was given 4-5 weeks after hepatic resection in both ***,125 patients in the TACE plus Cidan group were administrated Cidan Capsule(0.27 g/capsule,5 capsules every time,4 times a day) for 6 months with a 24-month *** endpoints included diseasefree survival(DFS) and tumor recurrence rate(TRR).Secondary endpoint was overall survival(OS).Any drugrelated adverse events(AEs) were observed and ***:As the data cutoff on July 9th,2018,the median DFS was not reached in the TACE plus Cidan group and 234.0 days in the TACE group(hazard ratio,0.420,95%confidence interval,0.290-0.608;P<0.01).The 1-and 2-year TRR in the TACE plus Cidan and TACE groups were 31.5%,37.1%,and 60.8%,63.4%,respectively(P<0.01).Median OS was not reached in both ***1-and 2-year OS rates in TACE plus Cidan and TACE groups were 98.4%,98.4%,and 89.5%,87.9%,respectively(P<0.05).The most common grade 3-4 AEs included fatigue,abdominal pain,lumbar pain,and *** serious AE was reported in 1 patient in the TACE plus Cidan group,the death was due to retroperitoneal mass hemorrhage and hemorrhagic shock,and was not related to study ***:Cidan Capsule in combination with TACE can reduce the incidence of early recurrence in HCC patients at high-risk of recurrence after radical hepatectomy and may be an appropriate option in postoperative anti-recurrence treatment.(Reg

关键词： hepatocellular carcinoma hepatectomy recurrence survival transarterial chemoembolization Cidan Capsule

Micro-Mechanical Behavior of HOPG in Nano-Indentation

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厦门大学学报（自然科学版） 2002年第S1期41卷 82-83页

作者： fu hui-nan, WANG xiao-hong, WANG Cheng-yong (Institute of Manufacturing Technology, Guangdong University of Techn ology, Guangzhou 510090, China)

The mechanical behavior of highly oriented pyrolyti c graphite (HOPG) has been investigated in this paper, by simulating a machining p rocess in a nano-indent test with the method of molecular dynamics (MD) and by doing an experiment directly using the probe tip of atomic force microscope (AFM ) as tool. The characteristics and properties of graphite crystal lattice are di scussed firstly, then, three potentials are selected for different interaction b etween graphite atoms according to the graphite properties, and molecular dynami c calculations of nano-indent test are carried out. After that, an experiments for nano-indentation of graphite crystal and its observation, directly by using an AFM tip as indent tool and consequential measurement, are introduced and don e. The topography of the hole indented by the tip, the profile, surface of the g raphite, as well the indented force and the strength of HOPG are measured and ca lculated. Results show the indentation experiment and the MD calculation consist ent with each other, that MD may be a good tool for comprehending the micro-mac hining behavior and the mechanism of materials.

关键词： graphite SPM nano-machining molecular dynamic s

硅酸钠与乙烯基三乙氧基硅烷的二维相关近红外光谱分析

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光谱学与光谱分析 2020年第3期40卷 782-786页

作者：符小慧张文博北京林业大学材料科学与技术学院

关于超疏水涂层的制备有许多研究,其中硅衍生物涂层是一个重点,然而硅衍生物形成机理的研究还鲜有报道。以硅酸钠和乙烯基三乙氧基硅烷(VTES)作为硅衍生物的反应物,利用近红外光谱(near infrared, NIR)和二维相关分析(2D-correlation an... 详细信息

关于超疏水涂层的制备有许多研究,其中硅衍生物涂层是一个重点,然而硅衍生物形成机理的研究还鲜有报道。以硅酸钠和乙烯基三乙氧基硅烷(VTES)作为硅衍生物的反应物,利用近红外光谱(near infrared, NIR)和二维相关分析(2D-correlation analysis, 2DCorr)方法探讨硅衍生物的反应机理。首先,采用德国Bruker公司的MPA型傅里叶近红外光谱仪采集样品的光谱信息,分析了17 Wt%硅酸钠、 97 Wt%VTES以及两者1:5摩尔比混合体系的分子结构变化特征,结果发现:混合体系在5 176~4 250 cm^-1范围内出现了Si-O-H和Si-O-Si基团的吸收峰,说明溶液中两者混合后发生了水解缩合反应;并发现10 262 cm^-1处的游离羟基减少并向低频方向偏移, 8 905 cm^-1处以氢键缔合的羟基增加;含氢键的醇从7 203 cm^-1偏移到6 846 cm^-1。将硅酸钠和VTES按照7种不同摩尔比混合并搅拌成溶胶凝胶状,采集这些样品的光谱信息,并且对吸收峰进行归属,结果发现:随着VTES的比例增加,游离羟基以及含氢键的醇减少,结合羟基增加,含硅基团也在增加。最后,对不同摩尔比的混合体系的光谱数据进行基线校正,运用软件Matlab 6.5计算基于摩尔比例扰动的二维相关光谱,提高近红外光谱的分辨率和分析不同官能团之间的变化顺序。结果发现:10 262 cm^-1处吸收峰的变化先于8 905 cm^-1处吸收峰的变化, 7 026(6 846) cm^-1处吸收峰的变化晚于5 859 cm^-1处吸收峰的变化, 5 264(5 176) cm^-1处吸收峰的变化晚于4 397 cm^-1处吸收峰的变化, 4 667 cm^-1处吸收峰的变化晚于4 397 cm^-1处吸收峰的变化。不同波数的吸收峰变化顺序对应其归属的官能团的变化顺序,进而揭示了近红外光谱中基团变化的原因。硅酸钠和VTES两种溶液混合后形成的溶胶凝胶是具有三维网状结构的硅-聚合物,这种聚合物具有疏水性质能被广泛应用。研究结果将有利于更深刻地理解硅酸钠和VTES混合体系水解缩合反应过程以及分子结构变化,为其进一步的研究和使用提供参考。

关键词：近红外光谱二维相关光谱硅酸钠乙烯基三乙氧基硅烷

Correlation between the survival rate of the patients with synchronous hepatic metastases from gastric carcinoma after surgical resection and patient＇s index

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Chinese Medical Journal 2012年第5期125卷 747-751页

作者： YANG Xin-wei LI Zhe LIU Kai fu xiao-hui YANG Jia-he WU Meng-chao Department of Laparoscopy Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

Background Many studies have reported the benefit of hepatic resection for solitary and metachronous metastases from gastric cancer. However, indications and surgical results for synchronous hepatic metastases from gastric carcinoma have not been clearly defined. This study was performed to assess the benefits and limits of simultaneous combined resection of both primary gastric cancer and synchronous hepatic metastases, as well as to identify prognostic factors affecting the survival.

关键词： synchronous hepatic metastases gastric carcinoma surgery

牵引成骨技术在严重小颌畸形伴中重度阻塞性睡眠呼吸暂停低通气综合征治疗中的应用

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中华整形外科杂志 2011年第5期27卷 332-336页

作者：傅潇慧陈军徐旭辉杭州市滨江医院口腔科杭州310009 浙江大学医学院附属第二医院口腔颌面外科

目的探讨应用牵引成骨技术治疗严重小颌畸形伴中、重度阻塞性睡眠呼吸暂停低通气综合征（obstructivesleepapneaandhypopneasyndrome，OSAHS）的疗效。方法采用下颌骨牵引成骨技术治疗严重小颌畸形伴中、重度OSAHS患者19例，分别于术前... 详细信息

目的探讨应用牵引成骨技术治疗严重小颌畸形伴中、重度阻塞性睡眠呼吸暂停低通气综合征（obstructivesleepapneaandhypopneasyndrome，OSAHS）的疗效。方法采用下颌骨牵引成骨技术治疗严重小颌畸形伴中、重度OSAHS患者19例，分别于术前、后行多导睡眠监测仪监测及螺旋CT扫描，评价疗效并比较患者上气道三维结构的改变。结果根据OSAHS疗效判定标准，19例中17例治愈，2例显效；手术后上气道各段的矢状径、矢状面积、横径和横截面积均较术前明显增加，气道容积从治疗前的（15572．03±3370．11）mm^3变为治疗后的（21182．69±4533．15）mm^3，变化主要发生在腭咽及舌咽，喉咽变化不明显。腭咽及舌咽区段气道各项检测指标与术前相比，差异均有统计学意义（P〈0．01或P〈0．05））。结论下颌骨牵引成骨技术可明显扩张上气道腭咽段和舌咽段气道容积，从而有效治疗严重小颌畸形伴中、重度OSAHS。CT作为一种影像学手段，在该研究中有独到和重要的作用。

关键词：骨生成,牵张小颌畸形睡眠呼吸暂停综合征体层摄影术,螺旋计算机

外源Ca^(2+)和H_2O_2对NaCl胁迫下枸杞离体叶片叶绿体中活性氧代谢的影响研究

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干旱地区农业研究 2009年第5期27卷 191-195页

作者：毛桂莲付晓辉宁夏大学生命科学学院宁夏银川750021

以枸杞离体叶片为材料,研究NaCl胁迫下外源Ca2+和H2O2对枸杞离体叶片叶绿体中O2.产生速率、丙二醛(MDA)含量及抗坏血酸过氧化物酶(APX)、过氧化物酶(POD)和过氧化氢酶(CAT)活性的影响。结果表明:在NaCl胁迫下O2.产生速率呈上升趋势,丙... 详细信息

以枸杞离体叶片为材料,研究NaCl胁迫下外源Ca2+和H2O2对枸杞离体叶片叶绿体中O2.产生速率、丙二醛(MDA)含量及抗坏血酸过氧化物酶(APX)、过氧化物酶(POD)和过氧化氢酶(CAT)活性的影响。结果表明:在NaCl胁迫下O2.产生速率呈上升趋势,丙二醛含量增大,保护酶APX、CAT、POD活性较对照升高。在NaCl胁迫下,加入外源Ca2+和H2O2时丙二醛(MDA)含量和O2.产生速率较单纯NaCl胁迫下降低;保护酶APX、CAT、POD活性较单纯NaCl胁迫下升高。表明外源Ca2+和H2O2在一定程度上可以缓解NaCl胁迫对植物体造成的伤害。

关键词：枸杞外源Ca2+和H2O2 NaCl胁迫活性氧代谢

社区团购商业模式下团长生成内容对成员持续参与意愿的影响研究——社区团购认同的中介与社区成员生成内容的调节作用

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软科学 2023年第1期37卷 102-108页

作者：王炳成傅晓晖山东科技大学经济管理学院山东青岛266590

运用社会认同理论和交际顺应理论,采用实验研究(研究一)和问卷调查(研究二),探讨了社区团购商业模式下,社区团长生成内容影响社区成员持续参与意愿的路径、边界条件与作用机理。结果表明:(1)社区团长生成内容对社区成员持续参与意愿产... 详细信息

运用社会认同理论和交际顺应理论,采用实验研究(研究一)和问卷调查(研究二),探讨了社区团购商业模式下,社区团长生成内容影响社区成员持续参与意愿的路径、边界条件与作用机理。结果表明:(1)社区团长生成内容对社区成员持续参与意愿产生正向作用;(2)社区团购认同在社区团长生成内容与社区成员持续参与意愿之间发挥部分中介作用;(3)社区成员生成内容不仅能够强化社区团长生成内容与社区团购认同之间的关系,同时也能够强化社区团购认同在社区团长生成内容与社区成员持续参与意愿之间的中介作用。

关键词：社区团购商业模式社区团长生成内容社区成员生成内容社区成员持续参与意愿