检索结果-南通市图书馆

Neuroscience Bulletin 2015年第5期31卷 541-549页

作者： Haiyan Liu Meng Han Qingyi Li Xiao Zhang Wen-An Wang fu-de huang department of Neurology Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Center for Stem Cell and Nano Medicine Laboratory for System Biology Shanghai Advanced Research Institute Chinese Academy of Sciences Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences department of Neurology Xin Hua Hospital Chongming Branch Affiliated to Shanghai Jiaotong University School of Medicine

The negative-geotaxis climbing assay is used to efficiently study aging and neurodegeneration in *** make it suitable for large-scale study,a method called the rapid iterative negative geotaxis（RING） assay has been established by simultaneously photographing the climbing of multiple groups of flies when they are manually tapped down in test ***,we automated the assay by using a well-controlled electric motor to drive the tapping,and a homemade program to analyze the climbing height of *** the automated RING（aRING） assay,we found that the climbing ability of a strain of wild-type flies,males in particular,declined rapidly before day 21 after eclosion,but slowly from day 21 to *** also found that the expression of arctic mutant Aβ_（42） accelerated the age-dependent decline in the climbing ability of ***,using aRING,we examined the effect of third chromosome deficiencies on the accelerated locomotor decline in Aβ_（42）-expressing flies,and isolated 7 suppressors and15 enhancers.

关键词： RING negative geotaxis giant fiber age-dependent locomotor decline Drosophila beta amyloid

An Efficient and Reliable Assay for Investigating the Effects of Hypoxia/Anoxia on Drosophila

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2018年第2期34卷 397-402页

作者： Yiling Xia Wangchao Xu Shiquan Meng Nastasia K.H.Lim Wenan Wang fu-de huang department of Neurology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine department of Neurology Xinhua Hospital Chongming Branch Affiliated to Shanghai Jiaotong University School of Medicine Institute of Neuroscience University of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai Advanced Research Institute University of the Chinese Academy of Sciences Chinese Academy of Sciences

Stroke is a leading cause of death worldwide. Up to one thousand potential drugs or interventions have been developed to treat stroke, out of which;60 have gone on to clinical trials. However, none of them has been successful. New insights into the molecular and cellular mechanisms of ischemia-induced injury are needed for discovering new therapeutic targets. Recently, Drosophila has been used to uncover new hypoxia-related genes. In this study, we describe an efficient and reliable assay with a sophisticated apparatus for studying the effects of oxygen deprivation on flies. Using this assay, wild-type flies were exposed to an anoxic environment for varying lengths of time, then the cumulative death rate and mobility recovery were systematically analyzed. We found that anoxia for over one hour caused lethality. The cumulative death rate on day 5 after anoxia was linearly and positively correlatedwith the duration of anoxia, and reached 50% when the duration was 2.5 h–3 h. We also found that the mobility recovery in normoxia was slow, as the climbing ability remained largely unchanged 4 h–6 h after 2.5-h of *** suggest that 2.5 h–3 h of anoxia and 4 h–6 h of recovery before mobility analysis are appropriate for future use of the anoxia assay.

关键词： Hypoxia Anoxia Drosophila Mortality Locomotor activity

Intraneuronal accumulation of Aβ42 induces age-dependent slowing of neuronal transmission in Drosophila

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2014年第2期30卷 185-190页

作者： Jing-Ya Lin Wen-An Wang Xiao Zhang Hai-Yan Liu Xiao-Liang Zhao fu-de huang department of Neurology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Center for Stem Cell and Nanomedicine Laboratory for System Biology Shanghai Advanced Research Institute Chinese Academy of Sciences department of Neurology Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Chongming Branch Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Beta amyloid （Aβ42）-induced dysfunction and loss of synapses are believed to be major underlying mechanisms for the progressive loss of learning and memory abilities in Alzheimer＇s disease （AD）. The vast majority of investigations on AD-related synaptic impairment focus on synaptic plasticity, especially the decline of long-term potentiation of synaptic transmission caused by extracellular Aβ42. Changes in other aspects of synaptic and neuronal functions are less studied or undiscovered. Here, we report that intraneuronal accumulation of Aβ42 induced an age- dependent slowing of neuronal transmission along pathways involving multiple synapses.

关键词： neuronal transmission synaptic dysfunction latency Alzheimer's disease intraneuronal betaamyloid

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan huang Yin YANG Hua WANG Xintian SHI Jianping LIU Lixia fu Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

Graphene oxide wrapped-silica microspheres humidity sensor with fast response/recovery, high sensitivity, and selectivity for pig respiratory rate monitoring

在线全文

学校读者我要写书评

暂无评论

Science China Technological Sciences 2025年

作者： Jing LI Bo LI Ziqi LIAO Yunhui DUAN Xinglan fu Yuehua huang Guanglin LI College of Engineering and Technology Southwest University Modern Agricultural Equipment Research Institute Xihua University

Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases. Humidity sensing is an important noncontact method to monitor pig respiration, which does not cause direct harm to pigs and meets the requirements of animal welfare. This paper proposes a humidity sensor based on graphene oxide wrapped-silica microspheres （GO@SiO2）. First, the sensor shows fast response/recovery performances of0.24/0.73 s. Experiments demonstrate that the wrapped microsphere structure can inhibit water aggregation. It is speculated that the wrapped microsphere structure can inhibit the stacking of GO, and its curved surface can promote the evaporation of water molecules. Second, the sensor shows a high sensitivity of 1.2%/%RH–4.2%/%RH in 11%–95%RH range. This can be attributed to different sensing mechanisms, from hopping transport to increasing ion transport, leading to a significant change in the sensor’s resistance. Third, the sensor shows selectivity to water molecules due to the hydrophilic characteristic of GO and the significant increase in conductivity by ion transport. Finally, the sensor is applied to realize the respiratory rate monitoring of adult pigs and piglets.

关键词：

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

阿托伐他汀对高血压合并血脂异常患者的疗效及对机体炎症反应的影响

在线全文

学校读者我要写书评

暂无评论

上海交通大学学报（医学版） 2014年第11期34卷 1642-1646页

作者：黄海源潘兴寿黄显南周柳芳刘燕罗薇符黄德右江民族医学院附属医院心血管内科百色533000 右江民族医学院附属医院神经外科百色533000

目的探讨阿托伐他汀对高血压合并血脂异常患者的临床疗效及其对机体炎症反应的影响。方法选取120例高血压合并血脂异常的患者为研究对象,随机分为联合用药组(联合组)和单独用药组(单独组),每组各60例,同时匹配选择60名同期接受体检的健... 详细信息

目的探讨阿托伐他汀对高血压合并血脂异常患者的临床疗效及其对机体炎症反应的影响。方法选取120例高血压合并血脂异常的患者为研究对象,随机分为联合用药组(联合组)和单独用药组(单独组),每组各60例,同时匹配选择60名同期接受体检的健康志愿者为对照组。单独组患者仅使用苯磺酸左旋氨氯地平片(2.5 mg/d),联合组患者则在此基础之上加用阿托伐他汀(20 mg/d),疗程8周。比较两种治疗方案的降压效果及其对血脂水平、颈-股动脉脉搏波传导速度(cf PWV)及血清hs-CRP、MMP-9及炎症细胞因子水平的影响。结果治疗后2组患者的高血压病情均得到不同程度的控制和改善,其中联合组的显效和有效例数为58例,总体有效率为96.67%;单独组显效和有效例数为44例,总体有效率为73.33%,明显低于联合组(P<0.05)。与治疗前比较,联合组和单独组治疗后的血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、白介素-4(IL-4)、IL-6、MMP-9和hs-CRP水平及cf PWV均明显降低,血清高密度脂蛋白胆固醇(HDL-C)和IL-10水平则显著升高(P<0.05),且联合组上述指标的改变明显优于单独组(P<0.05)。血压值与IL-4、IL-6、MMP-9、hs-CRP及cf PWV呈显著正相关,与IL-10呈显著负相关。结论阿托伐他汀对高血压合并血脂异常患者的临床疗效显著,且可有效抑制机体的炎症反应。

关键词：阿托伐他汀高血压高敏C-反应蛋白基质金属蛋白酶-9 炎症细胞因子

Economic effect of China's carbon neutrality target under shared socioeconomic pathways

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 142-157页

作者： Zemiao LIU Xianjin huang Xinxian QI School of Geography and Ocean Science Nanjing University Key Laboratory of Carbon Neutrality and Territory Optimization Ministry of Natural Resources Frontiers Science Center for Critical Earth Material Cycling Nanjing University

Economic feasibility is crucial for achieving the carbon neutrality target. However, current integrated assessments often underestimate the economic impacts of mitigation policies due to the lack of consideration of their economic benefits. This study integrates a warming-labour productivity model with a typical integrated assessment model using shared socioeconomic pathways. It simulates China's economic development and carbon emission levels under both baseline and carbon-neutral policy scenarios, evaluating the economic costs and benefits of emission reduction policies aimed at achieving carbon neutrality. These findings reveal the following:(1) The economic costs of emission reduction policies are projected to peak between 2050 and 2060, ranging from 0.41% to 9.37% of total GDP in the baseline scenario, primarily due to increased energy prices and R&D investments. These costs are expected to decline rapidly after 2070.(2) China's carbon-neutral policies will mitigate global warming, with the economic benefits of mitigation projected to reach 5.65% to 17.24% of China's total GDP by 2100.(3) Lowcarbon scenarios SSP1 and SSP4 could significantly reduce initial economic costs and advance the onset of net economic gains to 2060. This integrated assessment confirms that China's carbon neutrality target offers substantial net economic benefits in the long term. To minimize initial economic costs, efforts should focus on enhancing consumption-side transitions, upgrading lowcarbon technologies, and adopting new energy sources.

关键词： Climate change China Carbon neutrality Economic effects Policy

同方期刊数据库

Tectonic modes of mantle convection and their implications for Earth's tectonic evolution based on three-dimensional numerical simulations

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年第1期68卷 270-296页

作者： Song XIANG Jinshui huang Bingcheng WU School of Earth and Space Sciences University of Science and Technology of China CAS Center of Excellence in Comparative Planetary Studies

Five tectonic modes of mantle convection are obtained and analyzed with three-dimensional numerical models in a spherical shell domain. The five tectonic convective modes are non-plate mobile-lid, plate-like mobile-lid, episodic plate-like mobile-lid, episodic stagnant-lid, and stagnant-lid convective modes, respectively. The typical characteristics of these five tectonic modes and their numerical classification criteria based on plateness, mobility, and their standard deviations are presented and discussed. The results show that the yield stress of the lithosphere has profound effects on the tectonic convective *** the gradual increase of yield stress, the tectonic mode of mantle convection changes from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number increases, the range of yield stress for the platelike mobile-lid convective mode decreases, and the dimensionless transition stress between different tectonic modes ***, the dimensional transition stress between the non-plate mobile-lid convective mode and plate-like mobile-lid convective mode increases with the increase of Rayleigh number, but decreases between other tectonic modes. furthermore, we find that the transition stress between different tectonic modes is inversely proportional to the internal heating rate, with the transition stress decreasing as the internal heating rate increases. The fitting analysis of the transition stress between tectonic modes shows that Earth's current plate tectonics correspond to a lithospheric yield stress of 150–250 MPa, which aligns with the strength of serpentinized mantle rock determined by experimental petrography. If the Archean mantle was 300°C warmer than it is today, then the Earth was in an episodic stagnant-lid convective mode. The tectonic evolution of the Earth's surface is closely related to the lithospheric strength and the process of thermal evolution. If the lithospheric strength w

关键词： Tectonic mode of mantle convection Plate-like mobile-lid convection Episodic plate-like mobile-lid convection Episodic stagnant-lid convection Plate tectonics and tectonic evolution of the Earth

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

脑胶质瘤术后复发的治疗进展

医学综述 2014年第17期20卷 3143-3145页

作者：符黄德黄海源右江民族医学院附属医院神经外科广西百色533000 右江民族医学院附属医院心血管内科广西百色533000

脑胶质瘤是源自神经上皮的肿瘤,又称胶质细胞瘤,是中枢神经系统最常见、预后较差的原发性恶性肿瘤。目前,对于胶质瘤的治疗手段以手术为主,术后辅以放疗、化疗等。由于胶质瘤呈浸润性生长,使得手术难以全切,因而胶质瘤术后复发不可避免... 详细信息

脑胶质瘤是源自神经上皮的肿瘤,又称胶质细胞瘤,是中枢神经系统最常见、预后较差的原发性恶性肿瘤。目前,对于胶质瘤的治疗手段以手术为主,术后辅以放疗、化疗等。由于胶质瘤呈浸润性生长,使得手术难以全切,因而胶质瘤术后复发不可避免;复发后脑胶质瘤的治疗预后效果欠佳,尤其是高级别胶质瘤术后复发的预后很不理想。该文就脑胶质瘤术后复发的治疗予以综述。

关键词：胶质瘤复发治疗