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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong LI Shuo-fu MEI Wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Pfurthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study

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World Journal of Gastroenterology 2022年第37期28卷 5469-5482页

作者： Dong Jiang Zi-Xiang Chen fu-Xiao Ma Yu-Yong Gong Tian Pu Jiang-Ming Chen Xue-Qian liu Yi-Jun Zhao Kun Xie Hui Hou Cheng Wang Xiao-Ping Geng fu-bao liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina

BACKGROUND Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms(PCNs)are *** To establish a nomogram-based online calculator for predicting the risk of malignancy in patients with *** In this study,the clinicopathological data of target patients in three medical centers were *** independent sample t-test,Mann–Whitney U test or chi-squared test were used as appropriate for statistical *** univariable and multivariable logistic regression analysis,five independent factors were screened and incorporated to develop a calculator for predicting the risk of ***,the concordance index(C-index),calibration,area under the curve,decision curve analysis and clinical impact curves were used to evaluate the performance of the *** Enhanced mural nodules[odds ratio(OR):4.314;95%confidence interval(CI):1.618–11.503,P=0.003],tumor diameter≥40 mm(OR:3.514;95%CI:1.138–10.849,P=0.029),main pancreatic duct dilatation(OR:3.267;95%CI:1.230–8.678,P=0.018),preoperative neutrophil-to-lymphocyte ratio≥2.288(OR:2.702;95%CI:1.008–7.244,P=0.048],and preoperative serum CA19-9 concentration≥34 U/mL(OR:3.267;95%CI:1.274–13.007,P=0.018)were independent risk factors for a high risk of malignancy in patients with *** the training cohort,the nomogram achieved a C-index of 0.824 for predicting the risk of *** predictive ability of the model was then validated in an external cohort(C-index:0.893).Compared with the risk factors identified in the relevant guidelines,the current model showed better predictive performance and clinical *** The calculator demonstrates optimal predictive performance for identifying the risk of malignancy,potentially yielding a personalized method for patient selection and decision-making in clinical practice.

关键词： Pancreatic cystic neoplasms Risk of malignancy Nomogram Model Prediction Calculator

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A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods:antioxidant and bile acid-binding capacity

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Food Science and Human Wellness 2024年第1期13卷 494-505页

作者： Qiaoyun Li Zuman Dou Qingfei Duan Chun Chen Ruihai liu Yueming Jiang bao Yang Xiong fu SCUT-Zhuhai Institute of Modern Industrial Innovation School of Food Science and EngineeringSouth China University of Technology381 Wushan RoadGuangzhou 510640China Guangzhou Institute of Modern Industrial Technology Nansha 511458China Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou 510640China Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) Guangzhou 510640China Department of Food Science Stocking HallCornell UniversityIthaca 14853USA South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

In this study,the structural characters,antioxidant activities and bile acid-binding ability of sea buckthorn polysaccharides(HRPs)obtained by the commonly used hot water(HRP-W),pressurized hot water(HRP-H),ultrasonic(HRP-U),acid(HRP-C)and alkali(HRP-A)assisted extraction methods were *** results demonstrated that extraction methods had significant effects on extraction yield,monosaccharide composition,molecular weight,particle size,triple-helical structure,and surface morphology of HRPs except for the major linkage *** analysis showed that HRP-U with filamentous reticular microstructure exhibited better thermal *** HRP-A with the lowest molecular weight and highest arabinose content possessed the best antioxidant ***,the rheological analysis indicated that HRPs with higher galacturonic acid content and molecular weight showed higher viscosity and stronger crosslinking network(HRP-C,HRP-W and HRP-U),which exhibited stronger bile acid binding *** present findings provide scientific evidence in the preparation technology of sea buckthorn polysaccharides with good antioxidant and bile acid binding capacity which are related to the structure affected by the extraction methods.

关键词： Sea buckthorn Extraction method Structure Rheological properties Antioxidant activity Bile acid binding capacity

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Acetylene/argon mixture plasma to build ultrathin carbon bridge of CF_(x)/C/MnO_(2) for high-rate lithium primary battery

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Rare Metals 2024年第6期43卷 2574-2584页

作者： Da-Wei Zou Xing-Guang fu Gao-Bang Chen Yi-Fan liu bao-Shan Wu Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 31300lChina

Forming an ultrathin conducting layer on a fluorinated carbon(CFx)surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries(Li/CF_(x))remains a considerable challenge for achieving batteries with excellent rate ***,CFxwas modified by using acetylene/argon mixture plasma combined with MnO_(2)*** CF_(x)/C/MnO_(2)composite effectively reduced the voltage hysteresis and improved the electrochemical performance of Li/CF_(x).The excellent rate performance of CF_(x)/C/MnO_(2)was due to the high electrochemical activity provided by the atomicscale conductive carbon layer and ultrafine MnO_(2)*** with pristine CF_(x),the charge transfer resistance of the optimized CF_(x)/C/MnO_(2)decreased from 218.5 to 48.2Ω,the discharge rate increased from 2C to 10C,and the power density increased from 3.11 to 13.44 kW·g^(-1),The intrinsic reason for the enhanced rate performance was attributed to the fact that the ultrathin carbon layer acted as a conductive bridge to reduce the voltage hysteresis at the initial stage of the Li/CF_(x)discharge,and the high electrochemical activity of the ultrafine MnO_(2)particles provided a faster lithium-ion diffusion rate.

关键词： C_(2)H_(2)/Ar plasma Fluorinated carbon Lithium primary battery MnO_(2)

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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li bao Chuan-Zhi Chen Chang-Zhen Ren Ke-Yan Sun Hao liu Shao-Hua Song Zhi-Ren fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

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Fast and Adaptive Multi-Agent Planning under Collaborative Temporal Logic Tasks via Poset Products

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Research 2024年第2期2024卷 81-94页

作者： Zesen liu Meng Guo Weimin bao Zhongkui Li Deparment of Mechanics and Engineering Science College of EngineeringPeking UniversityBejing 0081 China Science and Technology Commission of China Aerospace Science and Technology Corporation Beijing 100048China

Efficient coordination and planning is essential for large-scale multi-agent systems that collaborate in a shared dynamic environment. Heuristic search methods or learning-based approaches often lack the guarantee on correctness and performance. Moreover, when the collaborative tasks contain both spatial and temporal requirements, e.g., as linear temporal logic (LTL) formulas, formal methods provide a verifiable framework for task planning. However, since the planning complexity grows exponentially with the number of agents and the length of the task formula, existing studies are mostly limited to small artificial cases. To address this issue, a new planning paradigm is proposed in this work for system-wide temporal task formulas that are released online and continually. It avoids two common bottlenecks in the traditional methods, i.e., (a) the direct translation of the complete task formula to the associated B點hi automaton and (b) the synchronized product between the B點hi automaton and the transition models of all agents. Instead, an adaptive planning algorithm is proposed, which computes the product of relaxed partially ordered sets (R-posets) on-the-fly and assigns these subtasks to the agents subject to the ordering constraints. It is shown that the first valid plan can be derived with a polynomial time and memory complexity with respect to the system size and the formula length. Our method can take into account task formulas with a length of more than 400 and a fleet with more than 400 agents, while most existing methods fail at the formula length of 25 within a reasonable duration. The proposed method is validated on large fleets of service robots in both simulation and hardware experiments.

关键词： hardware service system

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Improvement of Microstructure and Mechanical Properties of Rapid Cooling Friction Stir-welded A1050 Pure Aluminum

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 134-141页

作者：许楠 liu Lutao SONG Qining ZHAO Jianhua bao Yefeng College of Materials Science and Engineering Hohai UniversityChangzhou 213200China

Two-mm thick A1050 pure aluminum plates were successfully joined by conventional and rapid cooling friction stir welding(FSW), respectively. The microstructure and mechanical properties of the welded joints were investigated by electron backscatter diffraction characterization, Vickers hardness measurements, and tensile testing. The results showed that liquid CO_(2) coolant significantly reduced the peak temperature and increased the cooling rate, so the rapidly cooled FSW joint exhibited fine grains with a large number of dislocations. The grain refinement mechanism of the FSW A1050 pure aluminum joint was primarily attributed to the combined effects of continuous dynamic recrystallization, grain subdivision, and geometric dynamic recrystallization. Compared with conventional FSW, the yield strength, ultimate tensile strength, and fracture elongation of rapidly cooled FSW joint were significantly enhanced, and the welding efficiency was increased from 80% to 93%. The enhanced mechanical properties and improved synergy of strength and ductility were obtained due to the increased dislocation density and remarkable grain refinement. The wear of the tool can produce several WC particles retained in the joint, and the contribution of second phase strengthening to the enhanced strength should not be ignored.

关键词： aluminum alloy friction stir welding recrystallization microstructure mechanical properties

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Low-Complexity Reconstruction of Covariance Matrix in Hybrid Uniform Circular Array

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China Communications 2024年第3期21卷 66-74页

作者： fu Zihao liu Yinsheng Duan Hongtao Information School Communication University of ChinaBeijing 100024China Beijing Institute of Electronic System Engineering Beijing 100854China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China Beijing Radio Monitoring Station of State Radio Monitoring Center(SRMC) Beijing 100037China

Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital structure has been widely adopted to reduce the cost of radio frequency *** this situation, signals received at the antennas are unavailable to the digital receiver, and as a consequence, traditional sample average approach cannot be used for SCM reconstruction in hybrid multi-antenna systems. To address this issue, beam sweeping algorithm(BSA) which can reconstruct the SCM effectively for a hybrid uniform linear array, has been proposed in our previous works. However, direct extension of BSA to a hybrid uniform circular array(UCA)will result in a huge computational burden. To this end, a low-complexity approach is proposed in this paper. By exploiting the symmetry features of SCM for the UCA, the number of unknowns can be reduced significantly and thus the complexity of reconstruction can be saved accordingly. furthermore, an insightful analysis is also presented in this paper, showing that the reduction of the number of unknowns can also improve the accuracy of the reconstructed SCM. Simulation results are also shown to demonstrate the proposed approach.

关键词： hybrid array millimeter-wave spatial covariance matrix uniform circular array

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Diagnosis of the Kinetic Energy of the“21·7”Extreme Torrential Rainfall Event in Henan Province,China

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Advances in Atmospheric Sciences 2024年第1期41卷 73-83页

作者： Xiuping YAO Ruoying LI Xiaohong bao Qiaohua liu China Meteorological Administration Training Centre Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China College of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

An extreme torrential rain(ETR)event occurred in Henan Province,China,during 18-21 July *** on hourly rain-gauge observations and ERA5 reanalysis data,the ETR was studied from the perspective of kinetic energy(K),which can be divided into rotational wind(V_(R))kinetic energy(K_(R)),divergent wind kinetic energy(K_(D)),and the kinetic energy of the interaction between the divergent and rotational winds(K_(RD)).According to the hourly precipitation intensity variability,the ETR process was divided into an initial stage,a rapid increase stage,and maintenance *** showed that the intensification and maintenance of ETR were closely related to the upper-level K,and most closely related to the upperlevel K_(R),with a correlation coefficient of up to *** particular,the peak value of hourly rainfall intensity lagged behind the K_(R) by 8 ***,diagnosis showed that K transformation from unresolvable to resolvable scales made the ETR increase *** meridional rotational wind(u_(R))and meridional gradient of the geopotential(φ)jointly determined the conversion of available potential energy(APE)to K_(R) through the barotropic process,which dominated the rapid enhancement of K_(R) and then caused the rapid increase in *** transportation of K by rotational wind consumed K_(R),and basically offset the K_(R) produced by the barotropic process,which basically kept K_(R) stable at a high value,thus maintaining the ETR.

关键词： extreme torrential rain rotational kinetic energy kinetic energy generation and transport barotropic process

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Aptamer-Based Antibiotic Electrochemical Detection Platform Using Portable Plastic Gold Electrode and Multichannel Chip

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Chinese Journal of Chemistry 2024年第2期42卷 171-176页

作者： Yin bao Kaiwei Cai Yichen liu Bingling Li Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchunJilin 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China

The development of accurate,rapid and practical electrochemical sensing technology for antibiotic detection has an important application prospect in many fields such as food safety,environmental monitoring,medical and health *** this research,kanamycin specific DNA aptamer and its partially complementary short chain were self-assembled onto the surface of an integrated portable plastic gold electrode(PGE)by Au-s bond,and a simple kanamycin electrochemical biosensor interface was *** the same time,the epoxy resin channel layer was designed,and the auxiliary instrument was set up independently in the laboratory,which could help to measure and analyze eight groups of samples automatically in *** quantitative analysis results showed that in 20 min,the sensor had a good linear relationship between the peak current change of square wave voltammetry and the negative logarithm of kanamycin concentration when kanamycin concentration was in the range of 1-10o0μmol/L,and the detection limit could reach 0.40μmol/*** addition,the discrimination could be achieved within 5 min in the real-time analysis *** sensor had a simple construction method,good selectivity and stability,and could be used for rapid or real-time detection of kanamycin residues in actual water samples,which provided a new direction for the practical detection of kanamycin in environmental watersamples.

关键词： Biosensor Aptamer Antibiotics Electroanalysis DNA

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