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Water-soluble chitosan nanoparticles as a novel carrier system for protein delivery

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Chinese Science Bulletin 2007年第7期52卷 883-889页

作者： WANG chun fu Xiong yang LianSheng School of Light Industry and Food Sciences South China University of Technology Guangzhou 510640 China

High MW chitosan (CS) solutions have already been proposed as vehicles for protein delivery. The aim of the present work is to investigate the potential utility of water-soluble chitosan (WSC) as vehicles to load and deliver proteins. WSC nanoparticles (WSC NP) with various formations were prepared based on ionic gelation of WSC with pentasodium tripolyphosphate (TPP) anions. Bovine serum albumin (BSA) was used as a model protein drug incorporated into the WSC nanoparticles. Blank and BSA-loaded WSC nanoparticles were examined and determined to have a spherical shape with diameters between 35―190 nm, and zeta potential between 35―42 mV. FTIR confirmed that the tripolyphosphoric groups of TPP linked to the ammonium groups of WSC in the nanoparticles. Some factors affecting delivery properties of BSA have been investigated. Altering the concentration of BSA from 0.05 to 1 mg/mL enhanced the loading capacity of BSA but decreased loading efficiency simultaneously. Also, with the introduction of poly ethylene glycol (PEG), BSA release accelerated. Nanoparticle preparation from WSC with various deacetylation degrees (DDs) from 72.6% to 90% and MWs ranging from 3.5 to 15.8 kDa promoted loading efficiency and decreased the release rate. These results indicate that WSC nanoparticles are promising carriers for protein delivery.

关键词：水溶性壳聚糖纳米颗粒蛋白质输送载体系统药物赋形剂

Conversion hip arthroplasty for failed nailing of intertrochanteric fracture: Reflections on some important aspects

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World Journal of Orthopedics 2024年第10期15卷 997-1000页

作者： fu-chun yang Department of Orthopedic Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

In this editorial,I present my comments on the article by Solarino et *** hip arthroplasty,which is an optional salvage procedure performed following unsuccessful fixation of intertrochanteric femur fractures in elderly pati-ents,entails more complex processes and higher rates of operative complications than primary ***,it is important to consider the appropriateness of the primary treatment choice,as well as the adequacy of nailing fixation for intertrochanteric *** article briefly analyzes the possible factors contributing to the nailing failure of intertrochanteric fractures and attempts to find corresponding countermeasures to prevent fixation *** also analyzes the choice of treatment between nailing fixation and primary arthroplasty for intertrochanteric fractures.

关键词： Intertrochanteric femur fracture Femoral nailing fixation Primary hip arthroplasty Conversion hip arthroplasty Failed internal fixation Treatment reflection

Isolated cryptococcal osteomyelitis of the ulna in an immunocompetent patient:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6617-6625页

作者： Jing-Long Ma Liang Liao Tao Wan fu-chun yang Department of Orthopedic Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi ProvinceChina Guangxi Key Laboratory of Regenerative Medicine Department of OrthopedicsThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi ProvinceChina

BACKGROUND Cryptococcal osteomyelitis is a bone infection caused by *** an opportunistic infection,bone cryptococcosis usually occurs in patients with immunodeficiency diseases or in those undergoing immunosuppressive therapy and often displays characteristics of disseminated *** cryptococcal osteomyelitis is extremely unusual in immunocompetent *** pathogenic fungus often invades vertebrae,femur,tibia,rib,clavicle,pelvis,and humerus,but the ulna is a rare *** SUMMARY A 79-year-old woman complaining of chronic pain,skin ulceration and a sinus on her right forearm was admitted,and soon after was diagnosed with cryptococcal osteomyelitis in the right ***,she was also found to have apparently normal *** treatment with antifungal therapy combined with surgery debridement,the patient’s osteomyelitis healed with a satisfactory *** Although rare,cryptococcal osteomyelitis should be considered in the differential diagnosis of osteolytic lesions even in immunocompetent patients,and good outcomes can be expected if early definitive diagnosis and etiological treatment are established.

关键词： Cryptococcus neoformans Osteomyelitis Isolated lesions Ulna Immunocompetence Case report

Assessment of clinical outcomes of advanced hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 155-162页

作者： Kang-Jie Chen fu-chun yang Yun-Sheng Qin Jing Jin Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

Background: Low resectability and poor survival outcome are common for hilar cholangiocarcinoma(HCCA), especially in advanced stages. The present study was to assess the clinical outcome of advanced HCCA, focusing on therapeutic modalities, survival analysis and prognostic ***: Clinical data of 176 advanced HCCA patients who had been treated in our hospital between January 2013 and December 2015 were analyzed retrospectively. Prognostic effects of clinicopathological factors were explored by univariate and multivariate analysis. Survival predictors were evaluated by the receiver operating characteristic(ROC) ***: The 3-year overall survival rate was 13% for patients with advanced HCCA. Preoperative total bilirubin(P = 0.009), hepatic artery invasion(P = 0.014) and treatment modalities(P = 0.020) were independent prognostic factors on overall survival. A model combining these independent prognostic factors(area under ROC curve: 0.748; 95% CI: 0.678–0.811; sensitivity: 82.3%, specificity: 53.5%) was highly predictive of tumor death. After R0 resection, the 3-year overall survival was up to 38%. Preoperative total bilirubin was still an independent negative factor, but not for hepatic artery ***: Surgery is still the best treatment for advanced HCCA. Preoperative biliary drainage should be performed in highly-jaundiced patients to improve survival. Prediction of survival is improved significantly by a model that incorporates preoperative total bilirubin, hepatic artery invasion and treatment modalities.

关键词： Hilar cholangiocarcinoma Hepatic artery resection Preoperative biliary drainage Prognostic factors

Surgical treatment of an old avulsion fracture of the ischial tuberosity and ischial ramus: A case report

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World Journal of Orthopedics 2024年第1期15卷 94-100页

作者： Zi-Ru Chen Shi-Jie Liao fu-chun yang Department of Orthopedic Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Avulsion fracture of the ischial tuberosity is a relatively clinically rare type of trauma that is mainly incurred by adolescents during competitive sports *** to previous literature,the most commonly involved sports are soccer,sprinting,and gymnastics,in descending ***-induced avulsion fracture of the ischial tuberosity and ischial ramus is extremely clinically *** SUMMARY A case of a neglected avulsion fracture of the ischial tuberosity and ischial ramus was diagnosed in a young female dancer who complained of pain and restricted movement of her right *** stated that she had suffered the injury while performing a split leap during a dance performance 9 mo ***,she underwent surgery and obtained satisfactory treatment *** Early diagnosis of these fractures is important to ensuring early proper treatment towards a quicker *** old fractures with nonunion and chronic buttock pain,surgery is a preferred therapeutic choice with good treatment outcomes.

关键词： Ischial tuberosity Ischial ramus Avulsion fracture Delayed diagnosis Splitleap injury Case report

Reconstruction of large limb bone defects with a double-barrel free vascularized fibular graft

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Chinese Medical Journal 2008年第23期121卷 2424-2428页

作者： BI Zheng-gang HAN Xin-guang fu chun-jiang CAO yang yang Cheng-lin Department of Orthopedics First Hospital Harbin Medical University Harbin Heilongjiang 150001 China

Background The use of a free, vascularized fibular graft is an important technique for the reconstruction of large defects in long bones. The technique has many advantages in strong, tubular bones; a more reliable vascular anatomy with a large vascular diameter and long pedicle is used, minimizing donor-site morbidity. Due to limitations in both fibular anatomy and mechanics, they cannot effectively be used to treat large limb bone defects due to their volume and strength. Methods From 1990 to 2001, 16 clinical cases of large bone defects were treated using vascularized double-barrel fibular grafts. Patients were evaluated for an average of 10 months after surgery.Results All the patients achieved bony union; the average bone union took 10 months post surgery, and no stress fractures occurred. Compared with single fibular grafts, the vascularized double-barrel fibular grafts greatly facilitate bony union and are associated with fewer complications, suggesting that the vascularized double-barrel fibular graft is a valuable procedure for the correction of large bone defects in large, long bones in addition to enhancing bone intensity. Conclusions The vascularized double-barrel fibular graft is superior to the single fibular graft in stimulating osteogenous activity and biological mechanics for the correction of very large bone defects in large, long bones. Free vascutarized folded double-barrel fibular grafts can not only fill up large bone defects, but also improve the intensity margin. Therefore, this study also widens its application and enlarges the treatment targets. However, in the case of bone deformability, special attention should be paid to bone fixation and protection of donor and recipient sites.

关键词： fibula graft double bone loss

财产权利的客体——清代妇女婚姻地位的实例考析

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华中科技大学学报（社会科学版） 2007年第6期21卷 38-42页

作者：付春杨武汉大学法学院湖北武汉430074

基于对大量清代婚姻案例的考察,解析当时妇女的婚姻地位,有利于揭示其缺乏独立人格的事实,从而以实证的角度判读在婚姻伦理掩盖下妇女作为财产权利客体的本质。

关键词：妇女婚姻财产权利

Should we initiate vasopressors earlier in patients with septic shock: A mini systemic review

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World Journal of Critical Care Medicine 2023年第4期12卷 204-216页

作者： Hang-Xiang Zhou chun-fu yang He-Yan Wang Yin Teng Hang-Yong He Department of Critical Care Medicine Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Critical Care Medicine The Sixth Hospital of GuiyangGuiyang 550002Guizhou ProvinceChina Department of Respiratory Medicine The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalBeijing 100020China Beijing Institute of Respiratory Medicine Beijing Chao-Yang HospitalBeijing 100020China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Chao-Yang HospitalBeijing 100020China

Septic shock treatment remains a major challenge for intensive care units,despite the recent prominent advances in both management and *** serve as a cornerstone of septic shock therapy,but there is still controversy over the timing of ***,it remains unclear whether vasopressors should be used early in the course of ***,we provide a systematic review of the literature on the timing of vasopressor *** was systematically identified through PubMed,Embase and Cochrane searching according to PRISMA *** studies met the eligibility criteria and were included in the *** pathophysiological basis for early vasopressor use was classified,with the exploration on indications for the early administration of mono-vasopressors or their combination with vasopressin or *** found that mortality was 28.1%-47.7%in the early vasopressors group,and 33.6%-54.5%in the control *** also investigated the issue of vasopressor ***,we acknowledged the subsequent challenge of administration of high-dose norepinephrine via peripheral veins with early vasopressor *** on the literature review,we propose a possible protocol for the early initiation of vasopressors in septic shock resuscitation.

关键词： Septic shock Resuscitation Vasopressor Norepinephrine Vasopressin Timing

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动态量化空间均衡模型的理论进展与中国应用

中国工业经济 2022年第9期 43-63页

作者：赵扶扬陈斌开傅春杨中央财经大学经济学院中国社会科学院大学经济学院

量化空间均衡是研究新发展格局和区域协调发展等中国重大议题的有力工具。相比于传统的实证方法或理论模型方法,其优势在于具备一般均衡效应,可进行丰富的反事实模拟和政策分析,匹配多维度数据并实现量化研究。近年来,随着量化空间均衡... 详细信息

量化空间均衡是研究新发展格局和区域协调发展等中国重大议题的有力工具。相比于传统的实证方法或理论模型方法,其优势在于具备一般均衡效应,可进行丰富的反事实模拟和政策分析,匹配多维度数据并实现量化研究。近年来,随着量化空间均衡在多领域的深入应用和交叉融合,这一研究范式呈现出“动态化”拓展的重大特征。动态量化空间均衡模型可应用于宏观经济学、金融经济学、环境经济学、房地产经济学等多个研究领域,拓展了这些领域的研究范式和研究视角。本文首先对动态量化空间均衡文献进行综述,详细梳理和讨论了现有理论框架、技术难点和研究议题;进一步地,将这一框架应用于中国宏观经济的空间动态模拟,展示了建模、算法、数据匹配和模拟等过程,分析了空间均衡视角为传统宏观范式提供的理论启示,以及为构建新发展格局提供的政策含义;最后,展望了动态量化空间均衡在诸多中国本土问题上的广阔应用前景。

关键词：动态量化空间均衡维度诅咒中国应用新发展格局

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