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Experimental Study of 103Pd Stent Affecting Dynamic Equilibrium Between Proliferation and Apoptosis of Vascular Smooth Muscle Cells

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South China Journal of Cardiology 2006年第2期7卷 69-72页

作者： Liu Yingmei fu yuewu Wei Yulin Wu Wei Departme nt of Cardiology The Second Affiliated Hospital Sun Y at-sen University Guangzhou 510120 China Guangdong Provincial TCM Hospital Guangzhou 510120 China

Objectives By observing γ radioactive 103Pd stent affecting the proliferation and apoptosis of vascular smooth muscle cells （VSMCs） to explore the mechanism of radioactive stent preventing in-stent restenosis. Methods Fifty male New Zealand rabbits were randomized into stent group and 103Pd stent group. Control group was set up. The materials were harvested on 3, 7, 14, 28, 56 days after operation and the following investigations were carried out, including pathomorphology, immunohistochemistry, apoptosis （TUNEL） and in situs hybridization studies. Results ①The severity of the stenosis in 103Pd stent group was less than that of stent group. It was the most obvious on 56th day （P 〈 0.01）. ②The expression of PCNA of 103Pd stent group was lower than that of stent group on 3 to 28 days. It was the most obvious on 7th day, 16.35%±0.79% vs 24.36%±0.55% （P〈 0.01）. ②TUNEL method showed that the 103Pd stent group had much more apoptosis of VSMCs than that of stent group. The highest rate of apoptosis appeared on day 7, 14.72%±0.53% vs 12.42%±1.13% （P〈0.01）. ④ By calculating the ratio of PCNA/apoptosis （P：A）, a much lower ratio was seen in 103Pd-stent group than that of stent group at 3 to 28 days. There was significant statistic difference between two groups （P〈0.05）. ⑤For bcl-2/bax ratio, the result in 103Pd-stent group was lower than that of stent group at 3 to 28 days. It had significant statistic difference （P〈0.05）. Conclusions γ radioactive stent can inhibit the proliferation and accelerate apoptosis of injured media VSMCs. Also it can decrease the ratio of proliferation to apoptosis and relieve the severity of restenosis.

关键词： Radioisotope Stent Proliferation Apoptosis

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掺铒纳米晶与聚合物键合比例对光波导放大器增益性质的影响

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发光学报 2023年第4期44卷 678-684页

作者：唐迎李俊符越吾赵丹秦伟平吉林大学电子科学与工程学院集成光电子学国家重点实验室吉林长春130012

将掺铒纳米晶与甲基丙烯酸甲酯(MMA)单体共聚获得的复合聚合物可用作聚合物光波导放大器的增益介质。器件的增益性能与复合聚合物中的纳米粒子浓度密切相关。本文利用高温热分解法成功制备了尺寸均匀的β-NaLu_(50%)Y_(30%)F_(4)∶18%Yb... 详细信息

将掺铒纳米晶与甲基丙烯酸甲酯(MMA)单体共聚获得的复合聚合物可用作聚合物光波导放大器的增益介质。器件的增益性能与复合聚合物中的纳米粒子浓度密切相关。本文利用高温热分解法成功制备了尺寸均匀的β-NaLu_(50%)Y_(30%)F_(4)∶18%Yb^(3+),2%Er^(3+)纳米晶。纳米晶尺寸约16 nm,表面修饰有不饱和基团,因此可以与MMA共聚合得到纳米粒子-聚甲基丙烯酸甲酯(NPs-PMMA)纳米复合材料。通过将纳米粒子的掺杂浓度分别调整为0.1,0.15,0.25 mmol,制备了三组不同键合比例的复合聚合物。下转换发射光谱和透过光谱测试分析表明,随着键合的纳米晶浓度升高,复合聚合物发光强度逐渐提高,但近红外区的光透过率略微下降。使用这三组复合聚合物材料制备的倒脊型光波导放大器,在1550 nm处,器件的相对增益分别为3,3.46,5.61 dB,插入损耗分别为19.20,25.00,26.53 dB。该结果说明,虽然高掺杂浓度的稀土纳米晶造成了散射损耗增加,却有效地提高了增益介质在C波段的发光强度和器件的相对增益。在本文实验中,增加纳米晶浓度带来的增益提高优于散射损耗的增加。

关键词：掺铒纳米晶复合聚合物键合比例光波导放大器

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腹腔镜下右半结肠癌根治术的临床疗效

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华夏医学 2020年第4期33卷 104-106页

作者：卢文荣傅岳武龙门县人民医院外一科广东龙门516800

目的:探讨应用腹腔镜实施右半结肠癌根治术治疗的效果及对胃肠功能康复的影响。方法:60例结肠癌患者随机分为开腹组和腹腔镜组,每组30例,均实施右半结肠癌根治术治疗。比较两组患者手术疗效及预后。结果:开腹组总有效率为92.8%,腹腔镜... 详细信息

目的:探讨应用腹腔镜实施右半结肠癌根治术治疗的效果及对胃肠功能康复的影响。方法:60例结肠癌患者随机分为开腹组和腹腔镜组,每组30例,均实施右半结肠癌根治术治疗。比较两组患者手术疗效及预后。结果:开腹组总有效率为92.8%,腹腔镜组总有效率为93.7%,差异无统计学意义(P>0.05)。术后,腹腔镜组肠鸣音恢复时间、排气时间、胃管留置时间及正常进食时间明显短于开腹组,差异有统计学意义(P<0.05)。腹腔镜并发症发生率3.1%低于开腹组21.4%(P<0.05)。结论:应用腹腔镜实施右半结肠癌根治术治疗结肠癌具有疗效好、术后恢复快及并发症发生率低等优势。

关键词：腹腔镜右半结肠癌根治术结肠癌胃肠功能

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纳米金对荷结肠癌小鼠电刀手术前后细胞间黏附分子-1、转化生长因子-β的影响

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中华实验外科杂志 2017年第1期34卷 17-19页

作者：丁晖赵晓旭潘运龙覃莉傅岳武暨南大学附属第一医院普外科广州510630 暨南大学附属第一医院伽玛刀中心广州510630 暨南大学医学院组织胚胎学教研室广州510632

目的观察纳米金（AuNPs）对荷结肠癌小鼠电刀手术前后小鼠血清细胞间黏附分子-1（ICAM-1）、转化生长因子-β（TGF-β）的影响。方法实验分为不同浓度AuNPs处理组和生理盐水对照组，建立荷结肠癌小鼠模型后，各组均经尾静脉注射0.2 ml... 详细信息

目的观察纳米金（AuNPs）对荷结肠癌小鼠电刀手术前后小鼠血清细胞间黏附分子-1（ICAM-1）、转化生长因子-β（TGF-β）的影响。方法实验分为不同浓度AuNPs处理组和生理盐水对照组，建立荷结肠癌小鼠模型后，各组均经尾静脉注射0.2 ml相应的溶液，给药频率为2日1次，连续2周。然后经眶静脉取血，3 d后电刀手术切取各组小鼠移植瘤，检测移植瘤重量和抑瘤率。手术后3周经眶静脉取血，采用酶联免疫吸附试验（ELISA）法检测电刀手术前后小鼠血清ICAM-1、TGF-β浓度变化。结果手术前3 d各处理组荷结肠癌小鼠血清ICAM-1的浓度如下：空白对照组：（7.41±0.40） ng/ml，低浓度（2.5 μg/kg）AuNPs处理组：（5.32±0.35） ng/ml，高浓度（5.0 μg/kg）AuNPs处理组：（3.84±0.42） ng/ml（F＝125.302，P＝0.000）。手术后3周ICAM-1浓度为：假手术组：（15.46±1.71） ng/ml，单纯手术组：（3.44±0.37） ng/ml，低浓度（2.5 μg/kg） AuNPs＋手术组：（1.76±0.61） ng/ml，高浓度（5.0 μg/kg）AuNPs＋手术组：（0.92±0.33） ng/ml（F＝313.424，P＝0.000）。AuNPs对结肠癌小鼠血清TGF-β的影响与上述结果类似。此外，不同浓度AuNPs处理组结肠癌移植瘤重量及体积较空白对照组差异均有统计学意义（F＝106.125，P＝0.000），且呈剂量依赖关系。结论电刀手术前后AuNPs均能够降低荷结肠癌小鼠血清ICAM-1、TGF-β浓度，减小结肠癌小鼠移植瘤重量，发挥抗肿瘤作用。

关键词：结肠癌纳米金细胞间黏附分子-1 转化生长因子-β

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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黄芪四君子汤联合肠外营养支持促进胃癌患者术后恢复的研究

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广州中医药大学学报 2007年第6期24卷 459-461,465页

作者：傅岳武冯燕虹陈荣谭志健陈志强广州中医药大学第二附属医院外一科广州510120

【目的】观察黄芪四君子汤联合肠外营养支持对胃癌患者术后恢复的影响。【方法】将80例胃癌患者随机分为治疗组和对照组各40例。两组均于术后第3天开始给予肠外营养支持,治疗组在上述治疗基础上给予黄芪四君子汤内服。观察两组患者的肛... 详细信息

【目的】观察黄芪四君子汤联合肠外营养支持对胃癌患者术后恢复的影响。【方法】将80例胃癌患者随机分为治疗组和对照组各40例。两组均于术后第3天开始给予肠外营养支持,治疗组在上述治疗基础上给予黄芪四君子汤内服。观察两组患者的肛门恢复排气时间、切口感染率、生化指标和免疫指标。【结果】治疗组的肛门恢复排气时间为(2.40±0.33)d,对照组为(3.82±0.26)d,两组比较,差异有显著性意义(P0.05);两组比较,治疗组的前白蛋白水平的升高较对照组显著(P0.05),而对照组升高不明显(与术前比较,P<0.05)。【结论】黄芪四君子汤配合肠外营养支持能促进胃癌患者术后的恢复,改善机体的免疫状况,减少切口的感染率。

关键词：黄芪四君子汤肠外营养胃癌术后

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A bio-inspired optical imaging method for robotic perception in turbid water

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Science China Technological Sciences 2025年第1期 79-81页

作者： Xudong SUN Yafeng LI Peng LIN Xiaodi SHANG Xianping fu School of Information Science and Technology Dalian Maritime University College of Computer Science and Technology Qingdao University

In the realm of underwater robotics, optical imaging plays a pivotal role in many scientific researches. Due to the effects of absorption and scattering,images captured in turbid water are severely degraded. Therefore, enhancing the quality of underwater optical images stands paramount in ensuring the continued advancement and efficacy of underwater robots across its multifarious applications.

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Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan fu-Yong Jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li fu Tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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