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Circulatory responses to nasotracheal intubation： comparison of GlideScope videolaryngoscope and Macintosh direct laryngoscope

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Chinese Medical Journal 2008年第14期121卷 1290-1296页

作者： xue fu-shan li Xuan-ying liu Qian-jin liu He-ping YANG quan-yong XU Ya-chao liAO Xu liu Yi Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China Department of Anesthesiology Washington University School of Medicine 660 S. Euclid Ave St. Louis MO USA Xinxiang Medical College Xinxiang Henan 453003 China

Background The GlideScope videolaryngoscope （GSVL） has been shown to have no special advantage over the Macintosh direct laryngoscope （MDL） in attenuating the circulatory responses to orotracheal intubation, but no study has compared the circulatory responses to nasotracheal intubation （NTI） using the two devices. This prospective randomized clinical study was designed to determine whether there was a clinically relevant difference between the circulatory responses to NTI with the GSVL and the MDL. Methods Seventy-six adult patients were randomly allocated equally to the GSVL group and the MDL group. After induction of anesthesia, NTI was performed. Non-invasive blood pressure （BP） and heart rate （HR） were recorded before induction （baseline values） and immediately before intubation （post-induction values）, at intubation and every minute for a further five minutes. During the observation, times required to reach the maximum values of systolic BP （SBP） and HR, times required for recovery of SBP and HR to postinduction values and incidence of SBP and HR percent changes 〉 30% of baseline values were also noted. The product of HR and systolic BP, i.e. rate pressure product （RPP）, and the areas under SBP and HR vs. time curves （AUGsBP and AUGHR） were calculated. Results The NTI with the GSVL resulted in significant increases in BP, HR and RPP compared to postinduction values, but these circulatory changes did not exceed baseline values. BPs at all measuring points, AUGSBP, maximum values of BP and incidence of SBP percent increase 〉 30% of baseline value during the observation did not differ significantly between groups. However, HR and RPP at intubation and their maximum values, AUGHR and incidence of HR percent increase 〉 30% of baseline value were significantly higher in the MDL group than in the GSVL group. Times required for recovery of SBP and HR to postinduction values were significantly longer in the MDL group than in the GSVL group. Conclusions The presso

关键词： GlideScope videolaryngoscope Macintosh direct laryngoscope nasotracheal intubation circulatory responses airway management

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Half-lives of Low-Lying Isomeric States in ^(169)Ta

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Chinese Physics Letters 1998年第2期15卷 92-94页

作者： ZHANG Yu-hu ZHAO Qing-zhong ZHU Shao-fei XU Hu-shan ZHOU Xiao-hong GUO Ying-xiang LEI xiang-guo lu Jun GOU quan-bu liu Zhong jin Han-juan luO Yi-xiao SUN xiang-fu ZHU yong-tai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000

Two low-lying isomeric states in 169Ta have been identified via ^(159)Tb(l6O,6nγ)^(169)Ta *** half-lives are measured to be 28±5ns for the 9/2^(-)level and 17±4 ns for the 5/2^(-)level by using the delayedγ-γcoincidence *** two isomeric states are considered to be the bandheads with 9/2-[514]and 1/2-[541]configurations,*** neutron quasiparticle configuration for the ground state of ^(169)W is discussed.

关键词： reaction. method.

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-lian Zhou Guan-Nan Bai Shu-Xian li Dan Xu li-Na Chen Xing Chen Xiao-Yan dong Hong-Min fu Zhou fu Chuang-li Hao Jian-Guo Hong En-Mei liu Han-Min liu Xiao-Xia lu Zheng-Xiu luo Lan-Fang Tang Man Tian yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-lin Zhang De-Yu Zhao Shun-Ying Zhao Guo-Hong Zhu Ying-xue Zou quan lu Yuan-Yuan Zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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Continuous intravenous infusion of recombinant human endostatin using infusion pump plus chemotherapy in non-small cell lung cancer

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World Journal of Clinical Cases 2022年第4期10卷 1164-1171页

作者： Zhi-quan Qin Si-fu Yang Yun Chen Chao-jin Hong Tong-Wei Zhao Guo-Rong Yuan liu Yang liang Gao Xiao Wang li-Qin lu Department of Medical Oncology Zhejiang Provincial People’s Hospital(People’s Hospital of Hangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND lung cancer is one of the deadliest cancers in the world with the highest incidence and mortality rate among all ***-small cell lung cancer(NSCLC)accounts for approximately 80%of primary lung ***,efficacy and safety of the current regimens for NSCLC is ***,there has been an increasing urgency for development of potential therapeutic therapies for *** To investigate the therapeutic outcomes and safety of continuous intravenous infusion of recombinant human endostatin(Rh-endostain)using an infusion pump in retreated advanced *** Patients with retreated advanced NSCLC who were admitted to Zhejiang Provincial People's Hospital from October 2017 to April 2019 were *** patients received continuous intravenous infusion of Rh-endostain using an infusion *** response rate(ORR),clinical benefit rate(CBR),median progression-free survival(mPFS),and incidences of adverse events(AEs)were analyzed after *** A total of 45 patients with retreated advanced NSCLC were included,and all of them were *** these patients,ORR was 22.2%,CBR was 84.4%,and mPFS was 5.3 *** following AEs were observed,decreased hemoglobin(34 cases,75.6%),nausea/vomiting(32 cases,71.1%),elevated transaminase(24 cases,53.3%),leukopenia(16 cases,35.6%),thrombocytopenia(14 cases,31.1%),and constipation(1 case,3.4%).None of the patients had leukopenia,nausea/vomiting,and constipation of grade III and *** The patients showed improved adherence to 5-d continuous intravenous infusion of Rh-endostain using an infusion *** efficacy and safety of this treatment regimen were achieved in retreated advanced NSCLC.

关键词： Non-small cell lung cancer Chemotherapy Recombinant human endostatin Continuous intravenous infusion

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利用种间杂交途径向栽培稻转移非AA组野生稻有利基因的研究进展

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中国水稻科学 2007年第6期21卷 559-566页

作者：傅雪琳卢永根刘向东李金泉华南农业大学广东省植物分子育种重点实验室广东广州510642

利用种间有性杂交向栽培稻转移非AA组野生稻有利基因的研究在三个方面取得进展,即单体异附加系的培育、渗入系的建立以及有利性状的遗传及基因定位。栽培稻与非AA组野生稻种间杂交存在严重的生殖障碍,表现在不可交配性和杂种不育性两个... 详细信息

利用种间有性杂交向栽培稻转移非AA组野生稻有利基因的研究在三个方面取得进展,即单体异附加系的培育、渗入系的建立以及有利性状的遗传及基因定位。栽培稻与非AA组野生稻种间杂交存在严重的生殖障碍,表现在不可交配性和杂种不育性两个方面,这是限制非AA组野生稻有利基因转移的"瓶颈"。传统的有性杂交手段和生物技术相结合是克服种间生殖障碍,提高非AA组野生稻有利基因育种利用效率的可行途径。

关键词：栽培稻非AA组野生稻种间杂交单体异附加系渗入系基因定位生殖障碍

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Novel and favorable genomic regions for spike related traits in a wheat germplasm Pubing 3504 with high grain number per spike under varying environments

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Journal of Integrative Agriculture 2017年第11期16卷 2386-2401页

作者： CHEN Dan WU Xiao-yang WU Kuo ZHANG jin-peng liu Wei-hua YANG Xin-ming li Xiu-quan lu Yu-qing li li-hui National Key Facility for Crop gene Resources and genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural Sciences Biotechnology and Germplasm Resources Institute Yunnan Academy of Agricultural Sciences/Key Laboratory of Southwestern Crop Gene Resources and Germplasm InnovationMinistry of Agriculture/Scientific Observation for Rice Germplasm Resources of YunnanMinistry of Agriculture/Yunnan Provincial Key Laboratory of Agricultural Biotechnology

Grain number per spike （GNPS） is a major factor in wheat yield breeding. A new wheat germplasm Pubing 3504 shows superior features in spike traits. To elucidate the genetic basis of spike and yield related traits in Pubing 3504, 282 F2：3 families were generated from the cross Pubing 3504xjing 4839, and seven spike and yield related traits, including GNPS, spike length （SL）, kernel number per spikelet （KPS）, spikelet number per spike （SNS）, thousand-grain weight （TGW）, spike number per plant （SNP）, and plant height （HT） were investigated. Correlation analysis indicated significant positive correlations between GNPS and spike-related traits, including KPS, SNS, and SL, especially KPS. A genetic map was constructed using 190 polymorphic simple sequence repeat （SSR）, expressed sequence tag （EST）-SSR, and sequence- tagged-site （STS） markers. For the seven traits measured, a total of 37 quantitative trait loci （QTLs） in a single-environment analysis and 25 QTLs in a joint-environment analysis were detected. Additive effects of 70.3% （in a single environment） and 57.6% （in a joint environment） of the QTLs were positively contributed by Pubing 3504 alleles. Five important genomic regions on chromosomes 1A, 4A, 4B, 2D, and 4D could be stably detected in different environments. Among these regions, the marker interval Xmag834-Xbarc83 on the short arm of chromosome 1A was a novel important genomic region that included QTLs controlling GNPS, KPS, SNS, TGW, and SNP with stable environmental repeatability. This genomic region can improve the spike trait and may play a key role in improving wheat yield in the future. We deduced that this genomic region was vital to the high GNPS of Pubing 3504.

关键词： wheat high GNPS germplasm QTL mapping genomic region

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genetic characteristics of a wheat founder parent and a widely planted cultivar derived from the same cross

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Journal of Integrative Agriculture 2018年第4期17卷 775-785页

作者： CHANG li-fang li Hui-hui WU Xiao-yang lu Yu-qing ZHANG jin-peng YANG Xin-ming li Xiu-quan liu Wei-hua li li-hui National Key Facility for gene Resources and genetic Improvement/Key Laboratory of Crop Germplasm Utilization Ministry of Agriculture/Institute of Crop Sciences Chinese Academy of Agricultural Sciences

Founder parents have contributed significantly to the improvement of wheat breeding and production. In order to investigate the genetic characteristics of founder parents and widely planted cultivars, Mazhamai(M), Biyumai(B) and six sibling lines(BM1–6) derived from the cross M×B were phenotyped for eight yield-related traits over multiple years and locations and genotyped using the the wheat 90 K single nucleotide polymorphism(SNP) assay. BM4 has been used as a founder parent, and BM1 has been widely planted, whereas BM2, 3, 5, and 6 have not been used extensively for breeding or planting in China. Phenotypic comparisons revealed that BM4 and BM1 displayed a better overall performance than the other sibling lines. BM1 showed higher thousand-grain weight than BM4, whereas BM4 exhibited lower coefficient of variation for most of the yield-related traits across different years and locations, indicating that BM4 was widely adaptable and more stable in different environments. SNP analysis revealed that BM4 and BM1 inherited similar proportions of the M genome but are dissimilar to BM2, 3, 5, and 6. Both BM1 and BM4 have specific alleles that differ from the other BM lines, and most of these alleles are concentrated in specific chromosomal regions that are found to associate with favorable QTLs, these SNPs and their surrounding regions may carry the genetic determinants important for the superior performance of the two lines. But BM4 has more genetic diversity than BM1 with more specific alleles and pleiotropic regions, indicating that the genome of BM4 may be more complex than the other sibling lines and has more favorable gene resources. Our results provide valuable information that can be used to select elite parents for wheat and self-pollinating crop breeding.

关键词： wheat founder parents widely planted cultivars SNP

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Reduction of Efficiency Droop and Modification of Polarization Fields of InGaN-Based Green light-Emitting Diodes via Mg-Doping in the Barriers

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Chinese Physics Letters 2013年第8期30卷 129-131页

作者： ZHANG Ning liu Zhe SI Zhao REN Peng WANG Xiao-dong FENG xiang-Xu dong Peng DU Cheng-Xiao ZHU Shao-Xin fu Bing-Lei lu Hong-Xi li jin-Min WANG Jun-Xi Research and Development Center for Semiconductor lighting Chinese Academy of SciencesP.O.Box 912Beijing 100083

We demonstrate that the Mg-doping in barriers can partially screen the polarization fields of InGaN-based green light-emitting *** photocurrent spectra show that the Mg-doping samples have smaller polarization fields and the blue shift of the peak with increasing current is *** reduction of polarization fields can be attributed to the screening of the impurity holes generated by the Mg atoms in the *** efficiency droop is sensitive to the Mg-doping concentration in barriers,while the sample with Mg concentration of 5×10^(19) cm^(-3) exhibits the lowest efficiency degradation of 12.4%at a high injection current.

关键词： polarization Efficiency doping

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Identification and genetic analysis of multiple P chromosomes of Agropyron cristatum in the background of common wheat

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Journal of Integrative Agriculture 2018年第8期17卷 1697-1705页

作者： CHEN Hong-xin HAN Hai-ming li Qing-feng ZHANG jin-peng lu Yu-qing YANG Xin-ming li Xiu-quan liu Wei-hua li li-hui National Key Facility for Crop gene Resources and genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China College of Agronomy Northwest A&F UniversityYangling 712100P.R.China

Agropyron cristatum, a wild relative of common wheat(Triticum aestivum L.), provides many desirable genetic resources for wheat improvement, such as tolerance to cold, drought, and disease. To transfer and utilize these desirable genes, in this study, two wheat-A. cristatum derivatives II-13 and II-23 were identified and analyzed. We found that the number of root tip cell chromosomes was 44 in both II-13 and II-23, but there were four and six P genome chromosomes in II-13 and II-23, respectively, based on genomic in situ hybridization(GISH). The chromosome configurations of II-13 and II-23 were both 2 n=22 II by the meiotic analysis of pollen mother cells(PMCs) at metaphase I, indicating that there were two and three pairs of P chromosomes in II-13 and II-23, respectively. Notably, wheat chromosome 7 D was absent in derivative line II-13 while II-23 lacked chromosomes 4 B and 7 A based on SSR analysis combining fluorescence in situ hybridization(FISH) analysis with p As1 and p Sc119.2 as probes. Chromosomes 2 P and 7 P were detected in both II-13 and II-23. Another pair of P genome chromosomes in II-23 was determined to be 4 P based on expressed-sequences tags-sequence tagged sites(EST-STS) markers specific to A. cristatum and FISH with probes p Ac TRT1 and p Acp CR2. Overall, these results suggest that II-13 was a 7 P(7 D) substitution line with one pair of additional 2 P chromosomes and II-23 was a multiple 4 P(4 B), 7 P(7 A) substitution line with one pair of additional 2 P chromosomes. Moreover, we obtained six alien disomic addition lines and five alien disomic substitution lines by backcrossing. These new materials will allow desirable genes from A. cristatum to be used in common wheat.

关键词： common wheat Agropyron cristatum derivatives in situ hybridization molecular markers

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Nested-PCR assay for detection of Schistosoma japonicum infection in domestic animals

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Infectious Diseases of Poverty 2017年第1期6卷 754-760页

作者： Xin Zhang Chuan-Chuan He jin-Ming liu Hao li Ke lu Zhi-Qiang fu Chuan-Gang Zhu Yi-Ping liu Lai-Bao Tong De-bao Zhou li Zha Yang Hong Ya-Mei jin Jiao-Jiao lin Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Animal ParasitologyMinistry of AgricultureShanghai 200241People’s Republic of China Anhui Center for Animal Disease Control and Prevention HefeiPeople’s Republic of China Wangjiang county Center for Animal Husbandry and Veterinary Bureau AnqingPeople’s Republic of China dongzhi county Center for Animal Husbandry and Veterinary Bureau ChizhouPeople’s Republic of China Huangshan Center for Animal Disease Control and Prevention Huangshan 341000People’s Republic of China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious and Zoonosea YangzhouJiangsu province 225009People’s Republic of China

Background:Schistosomiasis japonica is a common *** animals are the primary source of infection and play an important role in disease *** prevalence and infectivity of this disease in domestic animals in China have significantly decreased and,for this reason,diagnostics with a higher sensitivity have become increasingly *** was reported that polymerase chain reaction(PCR)-based methods could be used to detect schistosome infection in humans and animals and presented a high sensitivity and *** present study aimed to develop a PCR-based method for detection of Schistosoma japonicum infection in domestic ***:A specific nested-PCR assay was developed to detect *** infection in domestic animals via amplification of a 231-bp DNA fragment of retrotransposon *** developed assay was first used in sera and dry blood filter paper(DBFP)from goats and buffaloes at different time points of ***,78 DBFPs from 39 artificially-infected bovines at 14 and 28 days post-infection and 42 DBFPs from schistosome-negative bovines from the city of Huangshan in the Anhui province were used to evaluate the diagnostic ***,this assay was used to detect *** infection in domestic animals in dongzhi and Wangjiang ***:The expected PCR product was detected in eggs and adult worms of *** and blood samples from ***-infected goats and water buffaloes,but not from Fasciola and Haemonchus contortus *** nested-PCR assay could detect the target *** DNA in DBFPs from goats and buffaloes after day 3 *** sensitivity in buffaloes at 14 and 28 days post-infection was 92.30%(36/39)and 100%(39/39),*** specificity was 97.60%(41/42).The positivity rates in dongzhi and Wangjiang counties were 6.00%and 8.00%in bovines and 22.00%and 16.67%in goats,*** positivity rates in goats in both counties were higher than those in bovines wit

关键词： Schistosomiasis Domestic animals Nested-PCR Diagnosis

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