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3D-bioprinted microenvironments for sweat gland regeneration

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Burns & Trauma 2022年第1期10卷 796-804页

作者： Wei Song Bin Yao Dongzhen Zhu Yijie Zhang Zhao Li Sha Huang xiaobing fu Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing 100853P.R.China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing 100048P.R.China Department of Cardiac Surgery and Department of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510100China

The development of 3D bioprinting in recent years has provided new insights into the creation of in vitro microenvironments for promoting stem cell-based *** glands(SGs)are mainly responsible for thermoregulation and are a highly differentiated organ with limited regenerative *** studies have focused on stem cell-based therapies as strategies for repairing SGs after deep dermal *** this review,we highlight the recent trend in 3D bioprinted native-like microenvironments and emphasize recent advances in functional SG regeneration using this ***,we discuss five possible regulatory mechanisms in terms of biochemical factors and structural and mechanical cues from 3D bioprinted microenvironments,as well as the most promising regulation from neighbor cells and the vascular microenvironment.

关键词： 3D bioprinting Microenvironment Sweat glands regeneration Stem cells

新一代皮肤再生:生物材料和生物工程的机遇和挑战

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Science Bulletin 2023年第16期68卷 1722-1725页

作者：彭雨姜玉峰付小兵 Key Laboratory of Tissue Repair and Regeneration PLA General HospitalBeijing 100037China School of Medicine Nankai UniversityTianjin 300071China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijing 100039China

Skin regeneration is a critical area of focus in modern medicine due to its potential to repair or replace damaged skin tissue resulting from various causes,including trauma,burns,chronic wounds,and genetic disorders[1].The global burden of skin-related health issues is substantial,with an estimated 1.5 billion people worldwide suffering from chronic skin conditions,and a significant proportion of these individuals require advanced treatments for skin regeneration[2].In China,skin diseases account for approximately20%of all outpatient visits to hospitals[3].

关键词： replace 生物工程 Skin

Review of current progress in the structure and function of Smad proteins

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Chinese Medical Journal 2002年第3期115卷 446-450页

作者：陈伟付小兵盛志勇解放军第304医院全军创伤修复重点研究室北京100037

PURPOSE: To review the recent developments in the structure and function of Smad proteins. DATA SOURCES: Both Chinese- and English-language literatures were searched using MEDLINE/CD-ROM (1997 - 2000) and the Index of Chinese-Language Literature (1997 - 2000). STUDY SELECTION: Data from published articles about TGF-beta signal transduction in recent domestic and foreign literature were selected. DATA EXTRACTION: Data were mainly extracted from 22 articles which are listed in the reference section of this review. RESULTS: Smad proteins mediate signal transduction induced by the TGF-beta superfamily. Based on their structural and functional properties, Smad proteins are divided into three groups. The first group, receptor-regulated Smads (R-Smads), are phosphorylated by activated type I receptors and form heteromeric complexes with the second group of Smads, common mediator Smads (Co-Smads). These Smad complexes translocate into the nucleus to influence gene transcription. Inhibitory Smads (I-Smads) are the third group and these antagonize the activity of R-Smads. In the nucleus, Smads can directly contact Smad-binding elements (SBE) in target gene promoters. Through interaction with different transcription factors, transcriptional co-activators or co-repressors, Smads elicit different effects in various cell types. The aberrance of Smad proteins has been noted in several human disorders such as fibrosis, hypertrophic scarring and cancer. CONCLUSION: The structure of Smads determines their function as transcriptional factors which translocate signals from the cell surface to the nucleus where Smads regulate TGF-beta superfamily-dependent gene expression.

关键词： DNA-Binding Proteins Humans Research Support, Non-U.S. Gov't Signal Transduction Smad Proteins Trans-Activators Transcription Factors Transforming Growth Factor beta

Wound healing center establishment and new technology application in improving the wound healing quality in China

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Burns & Trauma 2020年第1期8卷 67-70页

作者： xiaobing fu Wound Healing Unit Medical Innovation Department and the Fourth Medical CenterPLA General Hospital and PLA Medical College28 Fu Xian RoadHaidian DistrictBeijing 100853China

Wound healing,tissue repair and regenerative medicine are in great demand,and great achievements in these fields have been *** recent years,many of these successes have benefitted patients,especially in the field of chronic skin ***,perfect tissue repair and regeneration of damaged tissues and organs are still great challenges in the management of trauma and *** this paper,the main achievements in wound healing,tissue repair and regeneration in China are reviewed and the establishment of wound healing centers and new technology application in improving wound healing quality in patients in China is highlighted.

关键词： Trauma Wound healing Tissue repair Wound healing center

Growth factor regulatory system:a new system for not truly recognized organisms

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Science China(Life Sciences) 2020年第3期63卷 443-446页

作者： Jian Xiao Zhuofeng Lin Hua Qin Zhilong Zheng Fanghua Gong Yanlong Liu Xiaokun Li xiaobing fu Molecular Pharmacology Research Center School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325027China Wound Healing and Cell Biology Laboratory Institute of Basic Medical SciencesPLA General Hospital and PLA Medical CollegeBeijing 100853China Key Laboratory of Tissue Repair and Regeneration of PLA and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationFourth Medical Center of PLA General HospitalBeijing 100048China

Growth,development,aging,and disease occurrence in organisms,especially animals or Homo sapiens,are regulated by different regulatory systems in *** nervous,endocrine,metabolic,and immune systems are the traditional biological systems essential for the growth,development,and metabolism of the *** systems maintain a balance and precisely biologically regulate every aspect of life activities under normal ***,in abnormal situations,owing to endogenous or exogenous attack,these regulatory systems result in dysfunction,subsequently leading to illness or injury(Muggianu et al.,2018).In the classical neuroendocrine regulatory system,Cushing’s syndrome is defined as a series of abnormal clinical symptoms with chronic overproduction of glucocorticoids in the adrenal *** clinical manifestations are“moon face”and“buffalo hump,”involving blood circulation,bone metabolism,and gonadal function,among *** addition,severe trauma or burn leads to an imbalanced immune regulatory system,resulting in excessive inflammatory reactions and ***,an independent or cooperative regulation of multiple regulatory systems is critical in maintaining the body’s homeostasis,healthy development,and growth.

关键词： system metabolism maintain

糖尿病足溃疡合并下肢血管病变的外科诊疗全国专家共识(2024版)

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中华烧伤与创面修复杂志 2024年第3期40卷 206-220页

作者：中国老年医学学会烧创伤分会中华医学会烧伤外科学分会中国医师协会创面修复专业委员会胡大海黄跃生付小兵郭光华王克甲石文龙陶克不详空军军医大学第一附属医院全军烧伤中心烧伤与皮肤外科西安710032 南方科技大学医院创面修复科南方科技大学医学院创面修复与再生医学研究所深圳518055 解放军总医院医学创新研究部创伤修复与组织再生研究中心北京100853 南昌大学第一附属医院烧伤整形与创面修复医学中心空军军医大学第一附属医院全军烧伤中心空军军医大学第一附属医院甲乳血管外科温州医科大学附属第一医院创面修复与再生医中心创面修复科

糖尿病足溃疡合并下肢血管病变具有发病率高、愈合缓慢、预后差的特点,如不经规范治疗易导致截肢甚至危及生命。针对合并下肢血管病变的治疗对改善糖尿病足溃疡的愈合进程至关重要,在临床实践中逐渐得到重视。近年来,关于糖尿病足溃疡... 详细信息

糖尿病足溃疡合并下肢血管病变具有发病率高、愈合缓慢、预后差的特点,如不经规范治疗易导致截肢甚至危及生命。针对合并下肢血管病变的治疗对改善糖尿病足溃疡的愈合进程至关重要,在临床实践中逐渐得到重视。近年来,关于糖尿病足溃疡合并下肢血管病变的临床研究已见诸多报道,为了进一步规范临床诊疗,由中国老年医学学会烧创伤分会、中华医学会烧伤外科学分会、中国医师协会创面修复专业委员会牵头的专家组共同审议并编写了《糖尿病足溃疡合并下肢血管病变的外科诊疗全国专家共识(2024版)》。该共识以文献证据为基础,内容涵盖了糖尿病足溃疡合并下肢血管病变的疾病特征、临床诊疗循证证据以及新技术和新治疗方法的应用,旨在为临床工作者提供关于糖尿病足溃疡合并下肢血管病变最佳筛查和诊疗方法的明确指导,希望为从事糖尿病足创面治疗的医务人员提供规范性的临床实践依据。

关键词：糖尿病足糖尿病血管病变外周动脉疾病微循环截肢术创面修复专家共识

从第一个用于创烧伤治疗的基因工程国家一类新药研发与转化应用看创烧伤治疗“中国方案”的创立

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中华烧伤与创面修复杂志 2022年第1期38卷 4-8页

作者：付小兵李校堃解放军总医院医学创新研究部创伤修复与组织再生研究中心北京100853 解放军总医院第四医学中心全军创伤修复与组织再生重点实验室北京100048 温州医科大学药学院

创新与转化应用是近年来国内科学界反复讨论的重要话题。本文系统回顾生长因子研发和在我国创烧伤治疗中的应用过程及基于具有中国特色的创面治疗学科体系建设过程中形成创烧伤治疗“中国方案”的感悟和体会。希望这些弥足珍贵的历程能... 详细信息

创新与转化应用是近年来国内科学界反复讨论的重要话题。本文系统回顾生长因子研发和在我国创烧伤治疗中的应用过程及基于具有中国特色的创面治疗学科体系建设过程中形成创烧伤治疗“中国方案”的感悟和体会。希望这些弥足珍贵的历程能够对同行,特别是对青年一代具有一定的借鉴和启示作用。

关键词：创伤和损伤烧伤基因工程生长因子

TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA

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Science China(Life Sciences) 2020年第1期63卷 80-91页

作者： Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang xiaobing fu Tianjin Medical University Tianjin 300070China Key Laboratory of Tissue Repair and Regeneration of PLA and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationFourth Medical Center of General Hospital of PLABeijing 100048China School of Medicine Nankai UniversityTianjin 300052China Wound Healing and Cell Biology Laboratory Institute of Basic Medical SciencesGeneral Hospital of PLABeijing 100853China

An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further ***,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency *** elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation *** of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m *** expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland *** finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional ***,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine.

关键词： MSCs sweat gland cells differentiation TNF-α Nanog m6A FTO

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再生医学在战创伤早期救治中的作用及展望

中华烧伤与创面修复杂志 2023年第5期39卷 411-416页

作者：田光磊程飚付小兵解放军总医院第四医学中心全军创伤修复与组织再生重点实验室北京100048 解放军南部战区总医院烧伤整形外科广州510010

再生医学在战创伤修复中已取得巨大突破,展现出广阔前景,但其在战创伤早期救治中的应用方法尚不够明确。战创伤早期的救治需严格控制出血、补充大量血液、减轻酸中毒、纠正低体温和改善凝血功能障碍。该文将从生物工程化血液、止血材料... 详细信息

再生医学在战创伤修复中已取得巨大突破,展现出广阔前景,但其在战创伤早期救治中的应用方法尚不够明确。战创伤早期的救治需严格控制出血、补充大量血液、减轻酸中毒、纠正低体温和改善凝血功能障碍。该文将从生物工程化血液、止血材料的研发、炎症/感染控制与免疫调控、重要脏器的保护、军事医学研究模型建立、生物传感器与药物的研发以及干细胞库在国防医学中再生与组织工程的预防式应用等方面概括再生医学在战创伤早期救治中的作用,希望有助于提高战创伤整体救治水平。

关键词：再生医学创伤和损伤军事医学