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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping Guo yan-Mei Lu Bei-lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Pfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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润滑油摩擦系数的不确定度初步研究

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机械研究与应用 2015年第3期28卷 35-37页

作者：张娟林福严国家知识产权局专利局专利审查协作江苏中心江苏苏州215163 中国矿业大学(北京)机电与信息工程学院北京100083

润滑油的摩擦系数的精确测试对节能减排及设备寿命有重要影响。针对目前常用的润滑剂摩擦因数四球测定标准方法误差较大问题,利用不确定度理论对摩擦系数测量的影响因素进行了分析,并使用改进的MS-800四球试验机,对某润滑油在特定的实... 详细信息

润滑油的摩擦系数的精确测试对节能减排及设备寿命有重要影响。针对目前常用的润滑剂摩擦因数四球测定标准方法误差较大问题,利用不确定度理论对摩擦系数测量的影响因素进行了分析,并使用改进的MS-800四球试验机,对某润滑油在特定的实验条件下进行实验,实验表明其摩擦系数的不确定度均能控制在5%之内。

关键词：润滑油四球试验机摩擦系数不确定度

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机器人化采煤设备系统及控制模式探讨

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煤炭科学技术 2010年第8期38卷 97-99,103页

作者：林福严张运九薛光辉中国矿业大学(北京) 北京100083

机器人化采煤设备是煤矿机械研究的重要方向,因此,基于逻辑机器人的概念,建立了一个由矿长、队长、操作工等机器人和可控设备组成的机器人化采煤设备系统模型,设计了一个网络化的机器人化采煤设备系统控制方案,该方案的通信主干线采用... 详细信息

机器人化采煤设备是煤矿机械研究的重要方向,因此,基于逻辑机器人的概念,建立了一个由矿长、队长、操作工等机器人和可控设备组成的机器人化采煤设备系统模型,设计了一个网络化的机器人化采煤设备系统控制方案,该方案的通信主干线采用高速以太网连接,地面上有多台远程逻辑机器人,它们分别按各自的职责对远程设备进行操作,井下每台设备都有一个支持网络的本地机器人,直接对设备进行操作和控制。

关键词：采煤设备机器人化逻辑机器人以太网控制模式

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： yan Zhao Qiang Yuan Liting yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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《伤寒杂病论》汤剂服量探讨

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上海中医药杂志 2010年第11期44卷 18-21页

作者：杨琳傅延龄北京中医药大学基础医学院北京100029

整理《伤寒杂病论》汤剂服量情况,总结出其日服次数有日一服、日二服、日三服、顿服、日夜连服、日五服、日六服、日十服、少少频服等9种情况,以日三服占多数,这一服量方法较现代多用"每日一剂,每剂分早晚服二次"更为合理;每次服量有1升... 详细信息

整理《伤寒杂病论》汤剂服量情况,总结出其日服次数有日一服、日二服、日三服、顿服、日夜连服、日五服、日六服、日十服、少少频服等9种情况,以日三服占多数,这一服量方法较现代多用"每日一剂,每剂分早晚服二次"更为合理;每次服量有1升、1.5升、8合、7合、6合、5合、8.3合、6.7合、7.5合等。张仲景对服量的控制方法有"缩短服药间隔时间,不效加量""以知为度、逐渐变量""中病即止,不必尽剂"几种,充分体现"随症施量"原则。

关键词：《伤寒杂病论》服量随症施量文献研究

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某新能源车型电动转向泵绝缘故障分析

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汽车电器 2021年第12期 79-80,83页

作者：付燕林胡胜云江铃汽车股份有限公司江西南昌330001

电动汽车助力转向泵是汽车配件领域中发挥着重要作用的配件之一,对于汽车的转向工作起着极为重要的操控作用,驱动汽车转向轮实现转向功能。在新能源车型中,转向泵工作时受高压驱动,针对新能源车型转向泵常见的绝缘故障,查找原因,并提出... 详细信息

电动汽车助力转向泵是汽车配件领域中发挥着重要作用的配件之一,对于汽车的转向工作起着极为重要的操控作用,驱动汽车转向轮实现转向功能。在新能源车型中,转向泵工作时受高压驱动,针对新能源车型转向泵常见的绝缘故障,查找原因,并提出整改措施,模拟故障发生的工况,设计试验验证,通过优化设计,解决原设计缺陷,最后成功实施有效的解决方案。

关键词：电动转向泵绝缘故障新能源

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