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Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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GENOMICS PROTEOMICS & BIOINFORMATICS 2024年第2期22卷 qzae031页

作者： Li, Yanni van den Berg, Eline H. Kurilshikov, Alexander Zhernakova, Dasha, V Gacesa, Ranko Hu, Shixian Lopera-Maya, Esteban A. Zhernakova, Alexandra de Meijer, Vincent E. Sanna, Serena Dullaart, Robin P. F. Blokzijl, Hans Festen, Eleonora A. M. fu, jingyuan Weersma, Rinse K. Univ Groningen Univ Med Ctr Groningen Dept Gastroenterol & Hepatol NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Genet NL-9713 GZ Groningen Netherlands Tianjin Med Univ Tianjin Med Univ Gen Hosp Dept Gastroenterol & Hepatol Tianjin 300052 Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Inst Precis Med Guangzhou 510080 Peoples R China ITMO Univ Ctr Comp Technol Lab Genom Divers St Petersburg 199034 Russia Univ Groningen Univ Med Ctr Groningen Dept Pediat NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Surg Sect Hepatobiliary Surg & Liver Transplantat NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Endocrinol NL-9713 GZ Groningen Netherlands

Genetic susceptibility to metabolic associated fatty liver disease (MAFLD) is complex and poorly characterized. Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk factors. We performed genome-wide association study (GWAS) on two noninvasive definitions of hepatic fat content: magnetic resonance imaging proton density fat fraction (MRI-PDFF) in 16,050 participants and fatty liver index (FLI) in 388,701 participants from the United Kingdom (UK) Biobank (UKBB). Heritability, genetic overlap, and similarity between hepatic fat content phenotypes were analyzed, and replicated in 10,398 participants from the University Medical Center Groningen (UMCG) Genetics Lifelines Initiative (UGLI). Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci, including two novel genomic loci harboring CREB3L1 (rs72910057-T, P = 5.40E-09) and GCM1 (rs1491489378-T, P = 3.16E-09), respectively, as well as three previously reported loci: PNPLA3, TM6SF2, and APOE. GWAS of FLI in UKBB identified 196 genome-wide significant loci, of which 49 were replicated in UGLI, with top signals in ZPR1 (P = 3.35E-13) and FTO (P = 2.11E-09). Statistically significant genetic correlation (rg) between MRI-PDFF (UKBB) and FLI (UGLI) GWAS results was found (rg = 0.5276, P = 1.45E-03). Novel MRI-PDFF genetic signals (CREB3L1 and GCM1) were replicated in the FLI GWAS. We identified two novel genes for MRI-PDFF and 49 replicable loci for FLI. Despite a difference in hepatic fat content assessment between MRI-PDFF and FLI, a substantial similar genetic architecture was found. FLI is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction LIVER-DISEASE ASSOCIATION VARIANT LOCI SUSCEPTIBILITY PATHOGENESIS INSIGHTS TARGETS ENZYMES CONFERS

Mesoporous β-Co(OH)2 nanowafers and nanohexagonals obtained synchronously in one solution and their electrochemical hydrogen storage properties

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Progress in Natural Science:Materials International 2016年第6期26卷 555-561页

作者： Longqiang Wang jingyuan fu Yue Zhang Xiaoling Liu Yansheng Yin Lihua Dong Shougang Chen Institute of Materials Science and Engineering Ocean University of China College of Marine Science & Engineering Shanghai Maritime University

A water/oil two-phase solution strategy has been developed for the synthesis of various β-Co(OH)2nanostructures. More importantly, two different morphologies of β-Co(OH)2:mesoporous nanowafers and nanohexagons were successfully obtained through one reaction. furthermore, the special mesoporous of β-Co(OH)2nanowafers and nanohexagons exhibited excellent electrochemical hydrogen storage capacities and cycling stability. The maximum capacity reached 265.9 and 215.7 mA hg-1at room temperature, *** 70 cycles, the discharging capacities of the electrode still remain above 218.2 and 175.4 mA hg-1, which indicates that the as-prepared mesoporous β-Co(OH)2nanowafers have a strong resistance against oxidation and corrosion. These results indicates that the mesoporous β-Co(OH)2nanowafers and nanohexagons may be potentially applied for electrochemical hydrogen storage.

关键词： β-Co(OH)2 Nanowafers Nanohexagonals Electrochemical hydrogen storage

Effects of resonant magnetic perturbations on radial electric fields in DIII-D tokamak

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Plasma Science and Technology 2021年第10期23卷 137-149页

作者： jingyuan fu Pengfei LIU Xishuo WEI Zhihong LIN Nathaniel Mandrachia FERRARO Raffi NAZIKIAN fusion Simulation Center Peking UniversityBeijing 100871People's Republic of China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697United States of America Princeton Plasma Physics Laboratory PrincetonNJ 08543United States of America

Gyrokinetic simulations of DIII-D tokamak equilibrium find that resonant magnetic perturbation(RMP)drives a neoclassical non-ambipolar electron particle flux,which causes a rapid change of equilibrium radial electric fields consistent with experimental observations during the suppression of the edge localized mode(ELM).The simulation results provide a support for the conjecture that RMP-induced changes of radial electric fields lead to the enhanced turbulent transport at the pedestal top during the ELM suppression(Taimourzadeh et al 2019 ***59046005).furthermore,gyrokinetic simulations of collisionless damping of zonal flows show that resonant responses to the RMP decrease the residual level of the zonal flows and damp the geodesic acoustic mode.

关键词： resonant magnetic perturbation neoclassical transport zonal flow electric field

Pharmacomicrobiomics： a novel route towards personalized medicine？

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Protein & Cell 2018年第5期9卷 432-445页

作者： Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga jingyuan fu Departments of Genetics University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Paediatrics University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Gastroenterology & Hepatology University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Clinical Pharmacy & Pharmacology University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands Departments of Laboratory Medicine University Medical Center Groningen PO Box 30001 9700 RB Groningen The Netherlands K.G. Jebsen Coeliac Disease Research Centre Department of Immunology University of Oslo P.O. Box 1072 Blindern 0316 Oslo Norway

Inter-individual heterogeneity in drug response is a serious problem that affects the patient＇s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recog- nized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposi- tion （absorption, distribution, metabolism and excretion）. In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine.

关键词： gut microbiome drug metabolism personalized medicine

后金融危机时代科技型中小企业核心竞争力的打造——基于人力资源管理模式下的思考

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科技进步与对策 2009年第24期26卷 102-105页

作者：付景远聊城大学管理学院山东聊城252000

由于科技型中小企业具有高技术性、高成长性和高风险性等特点,加之目前竞争激烈,使科技型中小企业的发展存在很大的不确定性。金融危机过后如何尽快恢复实力、培育竞争优势,是目前科技型中小企业急需解决的问题。探讨了如何建立员工忠... 详细信息

由于科技型中小企业具有高技术性、高成长性和高风险性等特点,加之目前竞争激烈,使科技型中小企业的发展存在很大的不确定性。金融危机过后如何尽快恢复实力、培育竞争优势,是目前科技型中小企业急需解决的问题。探讨了如何建立员工忠诚、降低经营成本并打造核心竞争力的问题。

关键词：科技型企业核心员工员工流失核心竞争力

The dawn−dusk asymmetry in mesosphere and lower thermosphere temperature disturbances during geomagnetic storms at high latitude

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Earth and Planetary Physics 2024年第2期8卷 356-367页

作者： GuanChun Wei JianYong Lu Fen Tang jingyuan Li Meng Sun Institute of Space Weather School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China College of Information and Communication National University of Defense TechnologyWuhan 430019China

Utilizing observations by the Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)instrument,we quantitatively assessed the dawn-dusk asymmetry in temperature disturbances within the high-latitude mesosphere and lower thermosphere(MLT)during the main phase of geomagnetic storms in this *** analysis of five geomagnetic superstorm events indicated that during the main phase,negative temperature disturbances were more prevalent on the dawn side than on the dusk side in the high-latitude MLT *** of a statistical analysis of 54 geomagnetic storm events also revealed a notable disparity in temperature disturbances between the dawn and dusk *** high latitudes,38.2%of the observational points on the dawn side exhibited negative temperature disturbances(less than−5 K),whereas on the dusk side,this percentage was only 29.5%.In contrast,at mid-latitudes,these proportions were 34.1%and 36.5%,respectively,showing no significant *** also conducted a statistical analysis of temperature disturbances at different altitudes,which revealed an increase in the proportion of warming disturbances with ***,the proportion of cooling disturbances initially rose with altitude,reaching a peak around 105 km,and subsequently *** temperature disturbance differences could be explained by the day-night asymmetry in vertical wind disturbances during storm conditions.

关键词： dawn dusk asymmetry SABER(Sounding of the Atmosphere using Broadband Emission Radiometry) geomagnetic storms mesosphere and lower thermosphere

Optimizing electronic structure of Mo_(2)TiC_(2)T_(x) MXene through Nb doping for enhanced electrochemical performance

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Nano Research 2024年第8期17卷 7174-7181页

作者： jingyuan Zhao Wenzheng Yan Zhaoxi Liu Xiaobin Liu Yapeng Tian Xinwei Cui Henan Institute of Advanced Technology College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450003China College of Physics and Electronic Information Engineering Guilin University of TechnologyGuilin 514004China

MXene is a promising electrode material for both high volumetric capacitance and high-rate performance in ***,the current study has mainly focused on the monometallic element Ti_(3)C_(2)T_(x) MXene until now,while the bimetallic and multimetallic MXene have received comparatively less *** this work,we demonstrate that the electronic structure of the Mo_(2)TiC_(2)T_(x) MXene could be regulated by fine-tuning the content of doped Nb *** enhanced electron cloud density of surface–O termination and the electron spin of the Mo atoms in the Mo_(2)TiC_(2)T_(x) MXene,leads to the boost of electric double-layer capacitor(EDLC)and improvement of *** a consequence,the electrochemical performance of Nb-doped Mo_(2)TiC_(2)T_(x) MXene(Nb-0.3-MXene)demonstrates a capacitance of 398 F·cm^(−3),roughly doubling that of the pristine Mo_(2)TiC_(2)T_(x) MXene electrode at 197 F·cm^(−3) in the 3 M H_(2)SO_(4) *** the same time,the Nb-0.3-MXene could even maintain a capacitance of 82.75% at 200 mV·s−1,with high cyclic stability for 19,000 cycles at 10 A·g−***,Nb-0.3-MXene-based hybrid supercapacitors deliver a remarkable volumetric energy density of 48.1 W·h·L^(−1)at 230.7 W·L^(−1),and 34.4 W·h·L^(−1)at a high power density of 82.6 kW·L^(−1).There exists a balance between the volumetric capacitance and rate performance with different ratios of Nb atoms in the Nb-doped MXene due to the strong interaction between the Nb-doped MXene and the intercalated ***,optimizing the electronic structure of MXene through heteroatom doping is of great potential for enhanced supercapacitor performance.

关键词： niobium doping electronic structure Mo_(2)TiC_(2)T_(x)MXene electron spin rate performance volumetric capacitance

Science communication with science fiction movies

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The Innovation 2024年第2期5卷 17-18页

作者： Yuanzhuo Wang jingyuan Li Yuanhao Cui Department of Computer Science Beijing Technology and Business UniversityNo.33 Fucheng RoadHaidianBeijing 100048China Institute of Computing Technology Chinese Academy of SciencesNo.6 Kexueyuan South RoadHaidianBeijing 100190China School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyNo.1088 Xueyuan AvenueShenzhenGuangdong 518055China

“It is not as easy as it looks,”Holden Thorp,Science’s chief editor,commented at the end of 2021,when explaining new research findings of the COVID-19 pandemic to the public had encountered great difficulties.1 As a matter of fact,science communication has never been easy because serious scientific knowledge is prone to be boring rather than *** is only one atypical medium for science communication,i.e.,the science fiction movie(sci-fi movie for short),that has a huge amount of fans.

关键词： communication editor movie

Combining reinforcement learning with mathematical programming:An approach for optimal design of heat exchanger networks

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Chinese Journal of Chemical Engineering 2024年第5期69卷 63-71页

作者： Hui Tan Xiaodong Hong Zuwei Liao jingyuan Sun Yao Yang Jingdai Wang Yongrong Yang State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Heat integration is important for energy-saving in the process *** is linked to the persistently challenging task of optimal design of heat exchanger networks(HEN).Due to the inherent highly nonconvex nonlinear and combinatorial nature of the HEN problem,it is not easy to find solutions of high quality for large-scale *** reinforcement learning(RL)method,which learns strategies through ongoing exploration and exploitation,reveals advantages in such ***,due to the complexity of the HEN design problem,the RL method for HEN should be dedicated and designed.A hybrid strategy combining RL with mathematical programming is proposed to take better advantage of both *** insightful state representation of the HEN structure as well as a customized reward function is introduced.A Q-learning algorithm is applied to update the HEN structure using theε-greedy *** results are obtained from three literature cases of different scales.

关键词： Heat exchanger network Reinforcement learning Mathematical programming Process design