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A simulation study on spatial and time resolution for a cost-effective positron emission particle tracking system

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Particuology 2024年第5期88卷 312-322页

作者： Josephine Oppotsch Matthias Steinke Miriam Fritsch fritz-Herbert Heinsius Thomas Held Nikoline Hilse Viktor Scherer Ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

This work is the second part of a simulation study investigating the processing of densely packed and moving granular assemblies by positron emission particle tracking (PePT).Since medical positron emission tomography (PeT) scanners commonly used for PePT are very expensive,a PeT-like detector system based on cost-effective organic plastic scintillator bars is being developed and tested for its *** this context,the spatial resolution of a resting positron source,a source moving on a freely designed model path,and a particle motion given by a discrete element method (DeM) simulation is studied using Monte Carlo simulations and the software toolkit *** not only extended the simulation and reconstruction to a moving source but also significantly improved the spatial resolution compared to previous work by adding oversampling and iteration to the reconstruction ***,in the case of a source following a trajectory developed from DeM simulations,a very good resolution of about 1 mm in all three directions and an average 3D deviation between simulated and reconstructed events of 2.3 mm could be ***,the resolution for realistic particle motion within the generic grate system (which is the test rig for further experimental studies) is well below the smallest particle *** simulation of the dependence of the reconstruction accuracy on tracer particle location revealed a nearly constant efficiency within the entire detector system,which demonstrates that boundary effects can be neglected.

关键词： Positron emission particle tracking Monte Carlo method Time-of-flight Plastic scintillators Silicon photomultipliers(SiPMs)

A simulation study for a cost-effective PeT-like detector system intended to track particles in granular assemblies

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Particuology 2024年第1期84卷 117-125页

作者： Josephine Oppotsch Antonios Athanassiadis Miriam Fritsch fritz-Herbert Heinsius Thomas Held Nikoline Hilse Viktor Scherer Matthias Steinke Ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

Since many industrial applications rely on the processing of densely packed and moving granular ma-terial,obtaining bulk internal information on the particle movement inside the reactors is of great *** information can be delivered by Positron emission Particle Tracking(PePT).By marking pellets with a positron-emitting radioisotope,the position of these tracer particles can be determined via the time-of-flight differences of the emitted gamma-ray *** current paper proposes a PeT-like detector system based on cost-effective organic plastic scintillators instead of the more common but expensive inorganic *** system is currently under construction and was tested for its resolution and efficiency in this simulation *** Monte Carlo simulations and the software toolkit Geant4,three different geometries(an empty glass box,a generic grate system,and a cubic box of 1 m3 completely filled with pellets)were investigated,leading to a spatial resolution in the millimeter range and an efficiency,defined as the ratio of reconstructed decay locations to simulated decays,of 2.7%,1.4%,and 0.3%.

关键词： Positron emission particle tracking Geant4 Monte Carlo method Time-of-flight Plastic scintillators Silicon photomultipliers(SiPMs)

Modern internet search analytics and thyroidectomy:What are patients asking?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 49-58页

作者： Neeraj Suresh Christian fritz emma De Ravin Karthik Rajasekaran Department of Otorhinolaryngology–Head&Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives:Thyroidectomy is among the most commonly performed head and neck surgeries,however,limited existing information is available on topics of interest and concern to *** Design:***:***:A search engine optimization tool was utilized to extract metadata on Google‐suggested questions that“People Also Ask”(PAA)pertaining to“thyroidectomy”and“thyroid surgery.”These questions were categorized by Rothwell criteria and topics of *** Journal of the American Medical Association(JAMA)benchmark criteria enabled quality ***:A total of 250 PAA questions were ***‐oriented PAA questions describing what to expect during and after the surgery on topics such as postoperative management,risks or complications of surgery,and technical details were significantly less popular among the“thyroid surgery”group(Pespectively).PAA questions about scarring and hypocalcemia were nearly threefold more popular than those related to pain(335 and 319 vs.113 combined search engine response page count,respectively).The overall JAMA quality score remained low(2.50±1.07),despite an increasing number of patients searching for“thyroidectomy”(r(77)=0.30,P=0.007).Conclusions:Patients searching for the nonspecific term“thyroid surgery”received a curated collection of PAA questions that were significantly less likely to educate them on what to expect during and after surgery,as compared to patients with higher health literacy who search with the term“thyroidectomy.”This suggests that the content of PAA questions differs based on the presumed health literacy of the internet user.

关键词： information quality online health education search analytics thyroid surgery thyroidectomy

Isolated traumatic orbital floor fracture:An analysis of the National Trauma Data Bank

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 187-192页

作者： emma De Ravin D Katherine Xu Christian fritz Harman S.Parhar Karthik Rajasekaran Department of Otorhinolaryngology Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives:To date,no study provides a comprehensive analysis of traumatic orbital floor fractures across the United *** aimed to characterize patient demographics,injury-related variables,and operative management in this ***:The National Trauma Data Bank was queried for open or closed orbital floor fractures from 2008 to *** data were ***:Overall,148,592 orbital floor fractures were identified,with 142,577(95.9%)closed-and 6158(4.1%)open-type fractures.A total of 106,243(71.5%)patients were male and the median patient age was 41 *** majority of patients(79.2%)had abbreviated injury scale scores of≤2,indicating minor/moderate *** mechanism of injury(MOI)differed by gender,with the most frequent being unarmed fights in men(34.3%)and falls in women(14.0%).There were 29,600 patients(19.9%)with isolated orbital floor(I-OF)*** MOI most strongly associated with operative intervention of with I-OF fractures were penetrating injuries caused by a firearm(odds ratio[OR]:2.91;95%confidence interval[CI]:1.62–5.20)and cuttings/piercings(OR:2.17;95%CI:1.29–3.65).Conclusion:This large epidemiological study reveals that orbital floor fractures tend to present with minor or moderate injuries and are more likely to require operative intervention in setting of firearm or cut/pierce injuries.

关键词： epidemiology National Trauma Data Bank orbital fracture risk factors trauma

Forecasting tropical cyclone coastal and marine hazards and impacts

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Tropical Cyclone Research and Review 2024年第1期13卷 1-14页

作者： Nadao Kohno Cody fritz Monica Sharma Robbie Berg Diana Greenslade Devon Telford Sakeasi Rabitu P.L.N.Murty M.Mohapatra Maria Cristina C.Uson Japan Meteorological Agency TokyoJapan National Hurricane Center MiamiUSA India Meteorological Department New DelhiIndia Bureau of Meteorology MelbourneAustralia environment and Climate Change Canada QuebecCanada Fiji Meteorological service NadiFiji Philipine Atmospheric Geophysical and Astronomical Services AdministrationQuezon CityPhilippines

The report highlights the signiﬁcant progress over various regions with respect to understanding of coastal hazards,numerical modeling techniques and the generation&dissemination of coastal hazard warnings and *** developments over various regions in the globe during 2014–18 have been discussed in this report as presented during 10th session of International Workshop on Tropical Cyclones(IWTC-X)at Bali,*** speciﬁcally,various regions have started to confront the uncertainty that cannot be removed from TC analyses and forecasts and further communicate those hazards within the context of risk[probabilistic]based *** also includes impact-based forecasts such as communicating coastal inundation information relative to total water level instead of storm surge,speciﬁcally(i.e.,anomaly from as-tronomical tide and waves).Lastly,updates to model grid conﬁguration,model resolution,and coupled dynamical systems continue to resolve the costal hazards more *** approaches have likely helped reduce loss of life relative to historical ***,regions agree that the generation and dissemination of coastal hazard information still need to be improved in view of growing population along the coast and thus increased exposure of life to coastal hazard.

关键词： Coastal inundation Storm surge Probabilistic forecast

香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant ecology 2024年第1期17卷 165-171页

作者： Monique Silva Costa Thaís Jorge de Vasconcellos Claudio sergio Lisi Arno fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

Ca^(2+) binding to the C_(2)e domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. fritz be.se.e. Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerearLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DeRDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of excellence(MBexC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

Influence of 3d transition-metal substitution on the oxygen reduction reaction electrocatalysis of ternary nitrides in acid

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Nano Research 2019年第9期12卷 2307-2312页

作者： Kevin e. fritz Yichen Yan Jin Suntivich Department of Material Science and engineering Cornell UniversityIthacaNew York 14850USA Kavli Institute at Cornell for Nanoscale Science IthacaNew York 14850USA

The development of non-precious,acid-stable,oxygen reduction reaction(ORR)electrocatalysts can significantly aid the commercialization of proton exchange membrane fuel cells(PeMFCs).We report a survey of the ORR electrocatalysis on 3d metal substituted(M=Mn,Fe,Co)molybdenum and tungsten nitrides in acidic *** find that molybdate catalysts are more active than tungstates,with the specific activity depending on the chemistry of the substituted 3d *** both families,more electronegative 3d metals led to higher ORR activity(i.e.,Co>Fe>Mn).We attribute this result to the ability of the more electro negative 3d metal to withdraw electro ns from the Mo-or W-based active sites,effectively oxidizing the metal centers of the *** on our observation,future nitride ORR electrocatalysts can be further optimized by oxidizing the Mo sites further by,for example,addi ng eve n more electro negative dopa nt metals or in corporati ng anion vaca ncies.

关键词： nitrides electrocatalysis fuel cells oxygen reduction

Organorhenium(Ⅶ) oxides

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Rare Metals 2006年第Z1期25卷 411-421页

作者： KüHN fritz e. JAIN Kavita R. Department für Chemie der Technischen Universitt München Lichtenbergstrasse 4 D-85747 Garching bei München Germany

Methyltrioxorhenium (MTO) and its derivatives were utilized as catalysts for a broad variety of organic reactions after the discovery of an easy synthetic access way to this class of compounds. Among the numerous characterization techniques, 17O-NMR spectroscopy and vibrational spectroscopy were exemplary discussed. The immobilization of MTO and its derivatives is of significant current interest as is the synthesis of chiral derivatives.

关键词： catalysis epoxidation immobilization olefination rhenium