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Modern internet search analytics and thyroidectomy:What are patients asking?

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 49-58页

作者： Neeraj Suresh christian fritz Emma De Ravin Karthik Rajasekaran Department of Otorhinolaryngology–Head&Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaPennsylvaniaUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives:Thyroidectomy is among the most commonly performed head and neck surgeries,however,limited existing information is available on topics of interest and concern to *** Design:***:***:A search engine optimization tool was utilized to extract metadata on Google‐suggested questions that“People Also Ask”(PAA)pertaining to“thyroidectomy”and“thyroid surgery.”These questions were categorized by Rothwell criteria and topics of *** Journal of the American Medical Association(JAMA)benchmark criteria enabled quality ***:A total of 250 PAA questions were ***‐oriented PAA questions describing what to expect during and after the surgery on topics such as postoperative management,risks or complications of surgery,and technical details were significantly less popular among the“thyroid surgery”group(P<0.001,P=0.005,and P<0.001,respectively).PAA questions about scarring and hypocalcemia were nearly threefold more popular than those related to pain(335 and 319 vs.113 combined search engine response page count,respectively).The overall JAMA quality score remained low(2.50±1.07),despite an increasing number of patients searching for“thyroidectomy”(r(77)=0.30,P=0.007).Conclusions:Patients searching for the nonspecific term“thyroid surgery”received a curated collection of PAA questions that were significantly less likely to educate them on what to expect during and after surgery,as compared to patients with higher health literacy who search with the term“thyroidectomy.”This suggests that the content of PAA questions differs based on the presumed health literacy of the internet user.

关键词： information quality online health education search analytics thyroid surgery thyroidectomy

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Isolated traumatic orbital floor fracture: An analysis of the National Trauma Data Bank

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世界耳鼻咽喉头颈外科杂志英文版 2024年第3期10卷 187-192页

作者： De Ravin Emma Xu Katherine fritz christian S. Parhar Harman Rajasekaran Karthik Department of Otorhinolaryngology Head and Neck Surgery University of Pennsylvania Philadelphia Pennsylvania USA Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA Leonard Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania USA

Objectives: To date, no study provides a comprehensive analysis of traumatic orbital floor fractures across the United States. We aimed to characterize patient demographics, injury-related variables, and operative management in this ***: The National Trauma Data Bank was queried for open or closed orbital floor fractures from 2008 to 2016. Clinical data were ***: Overall, 148,592 orbital floor fractures were identified, with 142,577 (95.9%) closed- and 6158 (4.1%) open-type fractures. A total of 106,243 (71.5%) patients were male and the median patient age was 41 years. The majority of patients (79.2%) had abbreviated injury scale scores of ≤2, indicating minor/moderate injury. Fracture mechanism of injury (MOI) differed by gender, with the most frequent being unarmed fights in men (34.3%) and falls in women (14.0%). There were 29,600 patients (19.9%) with isolated orbital floor (I-OF) fractures. The MOI most strongly associated with operative intervention of with I-OF fractures were penetrating injuries caused by a firearm (odds ratio [OR]: 2.91; 95%confidence interval [CI]: 1.62–5.20) and cuttings/piercings (OR: 2.17; 95%CI: 1.29–3.65).Conclusion: This large epidemiological study reveals that orbital floor fractures tend to present with minor or moderate injuries and are more likely to require operative intervention in setting of firearm or cut/pierce injuries.

关键词： epidemiology National Trauma Data Bank orbital fracture risk factors trauma

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利用运算法则提升发动机效率

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软件 2010年第1期31卷 24-26页

作者： christian fritz 美国国家仪器(NI)有限公司

当电机效率低下又无法更换时，可以使用基于FPGA设备的先进控制技术提高能源效率。

关键词：发动机效率运算法则先进控制技术电机效率能源效率 FPGA

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虚拟原型技术与机电一体化设计结合

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中国电子商情 2010年第11期 44-45页

作者： Javier Gutierrez christian fritz Stephen Endersby 美国国家仪器公司 Dassault Systemes SolidWorks公司

用户总是要求我们提高所设计的机械的性能，同时减少资金成本。为了达到这两个矛盾的目标，我们将注意力放到在机械设计方面有巨大潜力的机电一体化上。本文着重展示了使用嵌入式分析工具的现代计算机辅助设计（CAD）系统如何实现机电... 详细信息

用户总是要求我们提高所设计的机械的性能，同时减少资金成本。为了达到这两个矛盾的目标，我们将注意力放到在机械设计方面有巨大潜力的机电一体化上。本文着重展示了使用嵌入式分析工具的现代计算机辅助设计（CAD）系统如何实现机电一体化设计。

关键词：一体化设计机电一体化虚拟原型计算机辅助设计技术机械设计资金成本分析工具

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App-based assessment of memory functions in patients after transfemoral aortic valve replacement

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老年心脏病学杂志:英文版 2023年第9期20卷 664-672页

作者： Jonathan Nübel Michael Hauptmann Julika Schön Georg fritz christian Butter Anja Haase-Fielitz Department of Cardiology University Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Biostatistics and Registry Research Brandenburg Medical School Theodor FontaneNeuruppinGermany Faculty of Health Sciences(FGW) Joint Faculty of the University of Potsdamthe Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-SenftenbergCottbusGermany Anesthesia and Intensive Care University Hospital Ruppin Brandenburg(ukrb)Brandenburg Medical School(MHB)Theodor FontaneNeuruppinGermany Department of Anesthesiology Intensive Care and Pain TherapyUniversity Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Social Medicine and Health System Research Otto von Guericke University MagdeburgGermany

BACKGROUND Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve *** safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and *** clinical practice,comprehensive cognitive testing is difficult to ***-assisted digital applications may help to optimize diagnosis and *** Neurocognitive function was assessed by validated psychometric tests using“Δelta-App”,which uses artificial intelligence and computational linguistic methods for extraction and *** function was assessed using the‘Consortium to Establish a Registry for Alzheimer’s Disease’(CERAD)word list and digit span task(DST)before TAVR and before hospital *** study is registered in the German Register of Clinical Trials(https://***/search/de/trial/DRKS00020813).RESULTS From October 2020 until March 2022,141 patients were enrolled at University Hospital Heart Centre *** age was 81±6 years,42.6%were *** between the pre-and post-interventional test was on average 6±3 *** function before TAVR was found to be below average in relation to age and educational *** pre-post TAVR comparison showed significant improvements in the wordlist repeat,P<0.001 and wordlist recall test of CERAD,P<*** were no changes in the digital span *** Despite impaired preoperative memory function before TAVR,no global negative effect on memory function after TVAR was *** improvements shown in the word list test should be interpreted as usual learning effects in this task.

关键词： patients impaired valve

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An inflammatory subtype of pancreatic ductal adenocarcinoma is associated with poor prognosis and increased perioperative mortality

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Journal of Pancreatology 2019年第3期2卷 107-112页

作者： Benzing christian Klein fritz Pelzer Uwe Sinn Marianne Pratschke Johann Bahra Marcus Campus Charité-Mitte and Campus Virchow Klinikum Charité-Universitätsmedizin BerlinBerlinGermany Department of Hematology Oncology and Tumor ImmunologyCharité-Universitätsmedizin BerlinBerlinGermany

Pancreatic ductal adenocarcinoma(PDAC)is a malignancy characterized by an aggressive tumor *** present analysis seeks to identify and analyze a cohort that meets criteria for"inflammatory"PDAC(IPDAC).All patients who underwent a curative resection for PDAC at our institution between 1989 and 2015 were included in the retrospective *** with histological proven adenocarcinoma and elevated C-reactive protein(CRP)(≥6 mg/L)serum concentrations,but no other suspicion of infection were *** provide a matched control group with normal CRP serum levels from the same patient ***-six(6.8%)of 532 patients meet our criteria for an IPDAC group ***-hospital(30 days)mortality was 13.9%in the IPDAC group vs 0%in the control group(P=.020).Median follow-up was 183.8 months(standard deviation[SD]=53.3,range 14.3-285.4).Median overall survival was 8.5 months(SD=16.8,range 0.3-89.6)in the IPDAC group and 24.8 months(SD=19.4,range 0.7-80.4)in the control group(P=.002).Patients indicating an IPDAC in our cohort had a significantly and clinical meaningful decreased overall survival and a higher perioperative morbidity and mortality.

关键词： Cholangitis CRP Inflammatory carcinoma PDAC

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An evidenced-based diagnostic tool for superior semicircular canal dehiscence syndrome

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中华耳科学杂志:英文版 2023年第4期18卷 230-234页

作者： christian G.fritz Garrett G.Casale Lulia A.Kana Robert S.Hong Michigan Ear Institute Farmington HillsMichiganUSA Department of OtorhinolaryngologyeHead&Neck Surgery University of PennsylvaniaPhiladelphiaPAUSA Department of OtolaryngologyeHead and Neck Surgery Wayne State UniversityDetroitMIUSA

Purpose:To construct a symptoms-based prediction tool to assess the likelihood of superior canal dehiscence(SSCD)on high-resolution *** and methods:Mathematical modeling was employed to predict radiologic evidence of SSCD at a tertiary neurotology referral ***:A total of 168 patients were included,of which 118 had imaging-confirmed *** univariate analysis significant predictors of SSCD presence were:sound/pressure-induced vertigo(p?0.006),disequilibrium(p?0.008),hyperacusis(p?0.008),and autophony(p?0.034).Multivariate analysis enabled a 14-point symptom-weighted tool to be developed,wherein a score of6 raised the suspicion of SSCD(70%likelihood of being present),R2?***:The likelihood of SSCD on CT scan can be determined with a high degree of certainty based on symptoms recorded at *** the evidenced-based diagnostic tool validated herein,a score6 with any symptom combination justifies ordering a CT scan.

关键词： Clinical predictors Diagnostic tool SSCD Superior semicircular canal dehiscence Third window

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Development of a Full Parameterized FE-modeling Tool for Efficient Vibration Investigations on End Windings of Turbo- and Hydro-Generators

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Journal of Energy and Power Engineering 2013年第8期7卷 1496-1504页

作者： Bemd Schlegl christian Scheinecker Andreas Marn fritz Neumayer Mario Himmelreich Franz Heitmeir Machine Dynamics and Acoustics Department Andritz Hydro GmbH Weiz 8160 Osterreich Institutfiir Thermische Turbomaschinen und Maschinendynamilq Technische Universitat Graz Graz 8010 Osterreich

End windings of generators are excited to vibrations due to electromagnetic forces which can cause severe damage and noise. To avoid this, it is important to predict the natural frequencies and modes of the end windings with finite elements. Due to the complex structure and unknown boundary conditions, the conventionally calculation of stator end windings has been very difficult and time consuming up to now. This paper describes the development of a full parameterized modeling tool, which allows a quick calculation of natural frequencies during the design phase of the generator. To keep the computing time low, it is important to find a way to get exact calculation results without detailed modeling of all pans. Additionally, special attention was paid to the active part, which has been replaced by spring-damper elements, and the determination of their stiffness via experimental modal analysis combined with finite element calculations.

关键词： Electrical machines end windings finite element method generators hydro generator power generation vibrationproblems.

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Role of nuclear factor kappa B in central nervous system regeneration

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Neural Regeneration Research 2014年第7期9卷 707-711页

作者： christian Engelmann Falk Weih Ronny Haenold Leibniz Institute for Age Research-fritz Lipmann Institute

Activation of nuclear factor kappa B （NF-κB） is a hallmark of various central nervous system （CNS） pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-~B in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a trans- dominant negative mutant of its upstream regulator IκBa, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular pro- gram in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury.

关键词： nuclear factor kappa B RelA p65 p50 central nervous system injury axonal regeneration neural regeneration

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Accelerating materials-space exploration for thermal insulators by mapping materials properties via artificial intelligence

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npj Computational Materials 2023年第1期9卷 1204-1215页

作者： Thomas A.R.Purcel Matthias Scheffler Luca M.Ghiringhelli christian Carbogno The NOMAD Laboratory at fritz-Haber-Institut der Max-Planck-Gesellschaft and IRIS-Adlershof of the Humboldt-Universität zu Berlin Faradayweg 4-6D-14195 BerlinGermany Physics Department and IRIS Adlershof Humboldt Universität zu Berlin BerlinGermany

Reliable artificial-intelligence models have the potential to accelerate the discovery of materials with optimal properties for various applications,including superconductivity,catalysis,and *** in this field are often hindered by the scarcity and quality of available data and the significant effort required to acquire new *** such applications,reliable surrogate models that help guide materials space exploration using easily accessible materials properties are urgently ***,we present a general,data-driven framework that provides quantitative predictions as well as qualitative rules for steering data creation for all datasets via a combination of symbolic regression and sensitivity *** demonstrate the power of the framework by generating an accurate analytic model for the lattice thermal conductivity using only 75 experimentally measured *** extracting the most influential material properties from this model,we are then able to hierarchically screen 732 materials and find 80 ultra-insulating materials.

关键词： artificial thermal properties

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