检索结果-南通市图书馆

PPPM (Predictive, Preventive and Personalized Medicine) as a New Model of the National and International Healthcare Services and Thus a Promising Strategy to Prevent a Disease: From Basics to Practice

引用

International Journal of Clinical Medicine 2014年第14期5卷 855-870页

作者： I. A. Sadkovsky O. Golubnitschaja M. A. Mandrik M. A. Studneva H. Abe H. Schroeder E. N. Antonova F. Betsou T. A. Bodrova k. Payne S. V. Suchkov Department of Medicine Genetics and Comparative Pathology University of Alabama at Birmingham (UAB) Birmingham USA European Association for Predictive Preventive and Personalized Medicine (EPMA) Brussels EU Rheinische Friedrich-Wilhelms-University of Bonn Bonn Germany I.M. Sechenov First Moscow State Medical University Moscow Russia I.M. Sechenov First Moscow State Medical University Moscow Russia A.I. Evdokimov Moscow State Medical & Dental University Moscow Russia United Cultural Convention (UCC) Cambridge UK Institute of Population Health and Health Economics University of Manchester Manchester UK International Society for Personalized Medicine (ISPM) Tokyo Japan National research University “Higher School of Economics” Moscow Russia Université du Luxembourg and IBBL (Integrated BioBank of Luxembourg) Luxembourg EU

Nowadays the system of public health is constructed in such a manner so that its main objective is the recovery of an already sick person, while prediction and prevention receive little attention. Meanwhile the development of these aspects of medicine can lead to the ability to control morbidity among the population, to identify chronic and genetic diseases in the early stages of development, and thus to prevent their further progression. This will reduce traditionally high costs of sick people treatment and the number of disabled population, and improve the quality and duration of life. The elaboration of new fields of science that are working on the study and interpretation of data obtained during laboratory and clinical research, creation of new methods for diagnosis, prognosis and treatment, provides an opportunity now to implement a new strategy, called PPPM, and gets promising results, which should lead to further development of an existing medicine.

关键词： Predictive Preventive and Personalized Medicine Biomark.rs Subclinical Metabolomics Genomics Proteomics Bioinformatics Public Health Predisposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-energy laser facility PHELIX at GSI:latest advances and extended capabilities

引用

High Power Laser Science and Engineering 2024年第4期12卷 9-23页

作者： Zs.Major U.Eisenbarth B.Zielbauer C.Brabetz J.B.Ohland Y.Zobus S.roeder D.reemts S.kunzer S.Götte D.Neidherr J.Hornung P.kewes D.Schumacher D.Beck P.Hesselbach M.Malki P.Neumayer k.Weyrich A.Tauschwitz V.Bagnoud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Helmholtz-Institut Jena JenaGermany Laboratoire pour I’Utilisation des Lasers Intenses Ecole PolytechniquePalaiseau CedexFrance Institut für angewandte Physik Technische Universität DarmstadtDarmstadtGermany Institut für angewandte Physik Goethe-Universität FrankfurtFrankfurt am MainGermany

The high-energy/high-intensity laser facility PHELIX of the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt,Germany,has been in operation since ***,we review the current system performance,which is the result of continuous development and further *** its versatile frontend architecture,PHELIX can be operated in both long-and short-pulse modes,corresponding to ns-pulses with up to 1 kJ pulse energy and sub-ps,200 J pulses,*** the short-pulse mode,the excellent temporal contrast and the control over the wavefront make PHELIX an ideal driver for secondary sources of high-energy ions,neutrons,electrons and *** long-pulse mode is mainly used for plasma heating,which can then be probed by the heavy-ion beam of the linear accelerator of *** addition,PHELIX can now be used to generate X-rays for studying exotic states of matter created by heavy-ion heating using the ion beam of the heavy-ion synchrotron of GSI.

关键词： beam quality combined high-energy-laser heavy-ion experiments high-energy lasers high-intensity lasers temporal contrast

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

realizing Attosecond Core-Level X-ray Spectroscopy for the Investigation of Condensed Matter Systems

引用

Ultrafast Science 2023年第4期3卷 1-13页

作者： Adam M.Summers Stefano Severino Maurizio reduzzi Themistoklis P.H.Sidiropoulos Daniel E.rivas Nicola Di Palo Hung-Wei Sun Ying-Hao Chien Ik.r Leon Barbara Buades Seth L.Cousin Stephan M.Teichmann Tobias Mey klaus Mann Barbara keitel Elke Plonjes Dmitri k.Efetov Heinrich Schwoerere Jens Biegert ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 CastelldefelsBarcelonaSpain Linac Coherent Light Source SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA European XFEL Holzkoppel 422869 SchenefeldGermany Institut für Nanophotonik Göttingen e.V. Hans-Adolf-Krebs-Weg 137077 GöttingenGermany Deutsches Elek.ronen-Synchrotron Notkestraße 8522607 HamburgGermany Max-Planck-Institut für Struktur und Dynamik der Materie 22761 HamburgGermany ICrEA Pg.Lluís Companys 2308010 BarcelonaSpain

Unraveling the exact nature of nonequilibrium and correlated interactions is paramount for continued progress in many areas of condensed matter science. Such insight is a prerequisite to develop an engineered approach for smart materials with targeted properties designed to address standing needs such as efficient light harvesting, energy storage, or information processing. For this goal, it is critical to unravel the dynamics of the energy conversion processes between carriers in the earliest time scales of the excitation dynamics. We discuss the implementation and benefits of attosecond soft x-ray core-level spectroscopy up to photon energies of 600 eV for measurements in solid-state systems. In particular, we examine how the pairing between coherent spectral coverage and temporal resolution provides a powerful new insight into the quantum dynamic interactions that determine the macroscopic electronic and optical response. We highlight the different building blocks of the methodology and point out the important aspects for its application from condensed matter studies to materials as thin as 25 nm. Furthermore, we discuss the technological developments in the field of tabletop attosecond soft x-ray sources with time-resolved measurements at the near and extended edge simultaneously and investigate the exciting prospective of extending such technique to the study of 2-dimensional materials.

关键词： Attosecond Science Core-level x-ray Spectroscopy High Harmonic Generation X-ray Absorption Ultrafast solid-state dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

引用

Signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa ruhl Isabell Pink Jenny F.kiihne k.rstin Beushausen Jana keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk Institute of Transplant Immunology MHHDHanoverGermany Department of Pneumology MHHDHanoverGermany Department of Intensive Care Medicine University of ZurichCHZurichSwitzerland Division of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Department of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection Medicine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 rESIST MHHHanoverGermany German Center for Lung Diseases DZL/BrEATH MarburgGermany

The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SArS-CoV-2 *** define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering *** our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and *** patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and Nk cells and high levels of SArS-CoV-2-specific *** core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2型肌强直性营养不良的心源性猝死

引用

世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 45-45页

作者： Schoser B.G.H. rick.r k. Schneider-Gold C. 赵睿 friedrich Baur Institute Department of Neurology Ludwig Maximilians University Munich Ziemssenstr. 1a 80336 Munich Germany Dr.

Medical records and follow-up data were reviewed in 297 genetically proven myotonic dystrophy type 2 (DM2) patients. Patients were selected by the criteria of cardiac sudden death before age 45. Sudden death occurred in four patients, three of whom were cardiological asymptomatic, and one with a history of heart f ailure. Cardiac histopathology showed dilated cardiomyopathy in all, and conduct ion system fibrosis in two patients. Pathogenetic CCUG ribonuclear inclusions we re demonstrable in cardiomyocytes.

关键词：肌强直心源性猝死心衰病医疗记录基因诊断心肌病病理学检查赵睿心肌细胞包涵体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

极低出生体重婴儿脐动脉导管血液采集量和速度对脑血容量和氧合度的影响

引用

世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 7-7页

作者： roll C. Hüning B. kunicke M. 郭战宏 Vestische kinder-und Jugendklinik Datteln Universitt Witten/HerdeckeDr.-Friedrich-Steiner Str.545711 DattelnGermany

Aim:Blood sampling from umbilical artery catheters decreases cerebral blood volume and cerebral *** aim of this study was to assess the impact of sampling volume and ***:Forty-eight infants,median birthweight 965 g(480-1500 g),median gestational age 27 wk(23-34 wk),were studied during routine blood sampling from umbilical artery *** sampling procedure was performed following a strict protocol for draw-up volume(1.6 ml),sampling volume(1.7 ml or 0.2 ml),re-injection volume(1.6 ml)and flushing volume(0.6 ml),time of aspiration(40 s or 80 s),reinjection(30 s)and flushing(6 s).In each infant,sampling volume and aspiration time were subject to sequential variation in a randomized fashion(1.7 ml/40 s,1.7 ml/80 s,0.2 ml/30 s).Using near-infrared spectroscopy,changes in concentrations of cerebral oxygenated and deoxygenated haemoglobin were measured,and changes in cerebral blood volume and cerebral oxygenation were ***:During all three sampling procedures,oxygenated haemoglobin decreased significantly from baseline,whereas deoxygenated haemoglobin did not ***,a decrease in cerebral blood volume and cerebral oxygenation *** decrease was not affected significantly by extending the sampling time from 40 s to 80 s,whereas it was blunted by reducing the amount of blood ***:Blood sampling from umbilical artery catheters induces a decrease in cerebral blood volume and cerebral *** magnitude of the decrease depends on the blood volume withdrawn but not on sampling velocity.

关键词：极低出生体重婴儿脐动脉导管脑血容量采集量脑氧合血液速度血红蛋白浓度冲洗时间氧合血红蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

颈动脉血管成形和支架置入术后早期再狭窄的系统回顾

引用

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 61-61页

作者： Grschel k. rieck.r A. Schulz J.B. A. kastrup 李一明 Department of Neurology Friedrich-Schiller-Univ. of JenaErlangerAllee 10107747 JenaGermany Dr.

Back.round and Purpose:Carotid angioplasty and stenting(CAS) has emerged as a potential alternative to endarterectomy(CEA) for the treatment of carotid arter y disease. Aside from the periprocedural complication rates, the benefits of CAS will be affected by the incidence of recurrent carotid stenosis. Methods:We co nducted a systematic analysis of all peer-reviewed studies reporting on the rat e of restenosis (≥50%) after CAS based on duplex ultrasound or angiography tha t were published between January 1990 and July 2004. We identified 34 studies th at reported on a total of 4185 patients with a follow-up of 3814 arteries over a median of 13 months (range, 6 to 31 months).The ultrasound criteria and the lo wer thresholds for defining a recurrent stenosis were very heterogeneous. result s:The cumulative restenosis rates after 1 and 2 years were ≈6%and 7.5%in tho se studies, which used a lower restenosis threshold≥50%to 70%and ≈4%in the first 2 years after CAS in those studies, which used a lower restenosis threshol d > 70%to 80%.Conclusions:In reviewing the current literature, the early rest enosis rates after CAS compare well with those reported for CEA. However, this a nalysis of the peer-reviewed literature also indicates that the early restenosi s rates after CAS might be higher than previously suggested in observational sur ***, an active follow-up of all stented arteries seems to be warrant ed. Moreover, the bulk of endovascular data are derived from small studies with short follow-up periods so that the long-term durability of CAS still needs to be established in large trials. Ideally, these studies should use a clear and u niform definition of restenosis and identical follow-up schedules.

关键词：再狭窄支架置入术血管成形 restenosis endarterectomy carotid arteries 支架术 endovascular 围手术期并发症

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

身材矮小的父母所生的小于胎龄儿或足月儿婴儿期的发育减慢

引用

世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 23-23页

作者： Vlkl T.M.k. Haas B Beier C. H.G. Drr 朱新菊 Division of Pediatric Endocrinology Hospital for Children and Adolescents Friedrich-Alexander-University of ErlangenNuremberg Germany Dr.

Objective: We analyzed postnatal growth in children with familial short stature (FSS)with regard to small (SGA) or appropriate(AGA) for gestational age status at birth. Study design: We studied 96 otherwise healthy short-statured children (58 males;SGA: n = 41, AGA: n = 55). At least one of the parents was short-statured. Cross-sectional data for length/height and weight for the first 4 years of age were collected ***: AGA children had a mean length of 0.09 ±1.02 standard deviation score (SDS) at birth, -1.57 ±1.16 SDS after 1year of age, and -2.36 ±0.72 SDS after 4 years. SGA children had a mean length of -2.04 ±1.06 SDS at birth, -2.70 ±1.12 SDS at 1 year of age, and -3.05±0.86 SDS at 4 years. The loss of length SDS within the first 2 years of life was greater in AGA than in SGA children. SGA children were significantly shorter than AGA children at all of the study points (p ren with an FSS back.round born AGA show catch-down growth to their lower familial range during the first 2 years of life. SGA children did not catch up to their AGA peers at any time.

关键词：小于胎龄儿身材矮小婴儿期出生后家庭史生时族性研究设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

平面回波成像(EPI)和半傅里叶单激发扰相快速自旋回波(HASTE)扩散技术乳腺Mr(MrM)扩散-加权成像(DWI)的临床比较研究

引用

国际医学放射学杂志 2009年第5期32卷 505-505页

作者： P.A.T.Baltzer D.M.renz k.H.Herrmann M.Dietzel I.krumbein M.Gajda 秦乃姗 Institute of Diagnostic and Interventional radiology Friedrich-Schiller-University JenaErlanger Allee 10107740 JenaGermany

扩散加权成像（DWI）技术具有鉴别肿瘤良恶性的潜在能力。然而常规条件下使用DWI的诊断意义尚不明确。本研究以病灶可见度、表观扩散系数（ADC）的测量和病灶大小的估计为参数，比较了平面回波成像（EPI）和半傅里叶单激发扰相快速自旋... 详细信息

扩散加权成像（DWI）技术具有鉴别肿瘤良恶性的潜在能力。然而常规条件下使用DWI的诊断意义尚不明确。本研究以病灶可见度、表观扩散系数（ADC）的测量和病灶大小的估计为参数，比较了平面回波成像（EPI）和半傅里叶单激发扰相快速自旋回波（HASTE）2种技术的DWI。65例病人接受了EPI-DWI和HASTE-DWIMrM（1．5T）检查。

关键词：乳腺新生物 MrI 扩散加权成像敏感性和特异性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：