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Colloidal(Gd0.98Nd0.02)2O3 nanothermometers operating in a cell culture medium within the first and second biological windows

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Journal of Rare Earths 2020年第5期38卷 483-491页

作者： m.l.Debasu H.Oliveira J.Rocha l.D.Carlos Department of Physics CICECO-Aveiro Institute of MaterilsUniversidade de Aveiro3810-193AveiroPortugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversidade de Aveiro3810-193AveiroPortugal Department of Biology CESAMLaboratory of Biotechnology and CytomicsUniversidade de Aveiro3810-193AveiroPortugal

Non-contact,self-referenced and near-infrared luminescent nanothermometers have been recognized as emerging tools in the fields of nanomedicine and nanotechnology due to their great capability of precise temperature readout at the nanoscale and real-time deep-tissue ***,the development of multifunctional and biocompatible luminescent nanothermometers operating within the optically transparent biological windows with high thermal sensitivity(>2.0%/K)remains ***,we present(Gd0.98Nd0.02)2O3 nanothermometers operated effectively within the first and second biological windows upon continuous-wave laser diode excitation at 808 *** thermometric parameters are defined by the relative changes in the emission intensities originating from the two Stark components of the 4 F3/2 level(R2 and R1)to the 4 I9/2(900-1000 nm),4 I11/2(1035-1155 nm)and 4 I13/2(1300-1450 nm)*** thermo metric parameters are evaluated for colloidal samples in a cell culture medium and powder samples,and the highest thermal sensitivity(2.18%/K at 298 K)is attained for the former in the first biological window(both the excitation and emission in the 800-965 nm range).The repeatability and temperature uncertainty are 99%and 1.2 K,*** nanothermometers are biocompatible with human mNT-1 melanoma and HaCaT cells for 24 h of exposure and nanoparticle concentration up to 0.400 mg/ml,showing their potential for applications in nanomedicine,e.g.,intracellular imaging and temperature mapping.

关键词： Gd2O3 Nd3^+-doped nanoparticles luminescent nanothermometry Thermal sensitivity Cytotoxicity of nanoparticles Rare earths

Resistance of full-scale beams against close-in *** modeling and field tests

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Defence Technology（防务技术） 2024年第10期40卷 35-47页

作者： A.Prado A.Alañón R.Castedo A.P.Santos l.m.lópez m.Chiquito m.Bermejo C.Oggeri Escuela Politécnica Superior dé Avila Universidad de SalamancaÁvila05003Spain E.T.S.I.minas y Energía Universidad Politecnica de MadridMadrid28003Spain Department of Engineering Aviation and TechnologySaint Louis UniversityMadrid28003Spain Department of Environment Land and Infrastructure Engineering(DIATI)Politecnico di TorinoTorino10129Italy

This paper explores the performances of a finite element simulation including four concrete models applied to a full-scale reinforced concrete beam subjected to blast loading. Field test data has been used to compare model results for each case. The numerical modelling has been, carried out using the suitable code lS-DYNA. This code integrates blast load routine(CONWEP) for the explosive description and four different material models for the concrete including: Karagozian & Case Concrete, Winfrith, Continuous Surface Cap model and Riedel-Hiermaier-Thoma models, with concrete meshing based on 10, 15, and 20 mm. Six full-scale beams were tested: four of them used for the initial calibration of the numerical model and two more tests at lower scaled distances. For calibration, field data obtained employing pressure and accelerometers transducers were compared with the results derived from the numerical simulation. Damage surfaces and the shape of rupture in the beams have been used as references for comparison. Influence of the meshing on accelerations has been put in evidence and for some models the shape and size of the damage in the beams produced maximum differences around 15%. In all cases, the variations between material and mesh models are shown and discussed.

关键词： Blast test Numerical simulation lS-DYNA Concrete model mesh effect Full-scale beams

Toward developing Ti alloys with high fatigue crack growth resistance by additive manufacturing

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Journal of materials Science & Technology 2023年第1期132卷 166-178页

作者： F.Wang l.m.lei X.Fu l.Shi X.m.luo Z.m.Song G.P.Zhang Shenyang National laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AECC Commercial Aircraft Engine Co. Ltd.Shanghai 201306China

Fatigue crack growth behaviors were investigated by three-point bending tests for TA19 alloy fabricated by laser metal deposition and four kinds of heat-treated *** crack growth resistance of the TA19 samples in the near-threshold regime and Paris regime was evaluated through the experimental characterization and theoretical analysis of the interaction between fatigue crack andα/βphase inter-face,columnar prior-βgrain boundary and colony *** results show that in the near-threshold regime,the fatigue crack propagation threshold and resistance increase with the increase of widths of lamellarαp phases and colonies,and the decrease of the number ofαlaths with an angle(ϕ)relative to the applied stress direction ranging from 75°to 90°.In the Paris regime,the fatigue cracking path can be deflected at colony boundaries or columnar prior-βgrain *** larger the deflection angle,the more tortuous the cracking path and the lower the fatigue crack growth *** angle(γ)of the columnar prior-βgrain growth direction relative to the build direction affects not onlyϕof differentαvariants,but also the fatigue cracking path deflection angle(θij)at columnar prior-βgrain *** optimal combination ofγ=0°-15°-0°-15°for several adjacent columnar prior-βgrains is derived from the theoretical analysis,and that can effectively avoidϕbeing in the range from 75°to 90°and makeθij as large as *** findings provide a guide for the selection of scanning strategies and process parameters to additively manufacture Ti alloys with high fatigue damage tolerance.

关键词： Ti alloy Fatigue crack growth Additive manufacturing Phase interface Grain boundary

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser mulla Yousef Katib Asim m Almughamsi Duaa S Alkhayat mohamed mosaad Samir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNm staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/ml, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

The C–V and G/ω–V Electrical Characteristics of ^(60)Co γ-Ray Irradiated Al/Si_(3)N_(4)/p-Si (mIS) Structures

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Chinese Physics letters 2013年第7期30卷 193-197页

作者： S.Zeyrek A.Turan m.m.Bülbül Department of Physics Faculty of Arts and SciencesDumlupınar University43100KütahyaTurkey Department of Physics Faculty of SciencesGazi University06500BeşevlerAnkaraTurkey

The influence of ^(60)Co(γ-ray)irradiation on the electrical characteristics of Al/Si_(3)N_(4)/p-Si(mIS)structures is investigated using capacitance-voltage(C–V)and conductance-voltage(G/ω–V)*** mIS structures are exposed to a ^(60)Coγradiation source at a dose of 0.7 kGy/h,with a total dose range of 0–100 *** C–V and G/ω–V properties are measured before and after ^(60)Coγ-ray irradiation at 500 kHz and room *** is found that the capacitance and conductance values decrease with the increase in the total dose due to the irradiation-induced defects at the *** results also indicate thatγradiation causes an increase in the barrier height ФB,Fermi energy EF and depletion layer width W_(D).The interface state density(N_(ss)),using the Hill–Coleman method and dependent on radiation dose,is determined from the C–V and G/ω–V measurements and decreases with an increase in the radiation *** decrease in the interface states can be attributed to the decrease in the recombination centers and the passivation of the Si surface due to the deposition insulator layer(Si_(3)N_(4)).In addition,it is clear that the acceptor concentration NA decreases with increasing radiation *** profile of series resistance Rs for various radiation doses is obtained from forward and reverse-biased C–V and G/ω–V measurements,and its values decrease with increasing radiation dose,while it increases with increasing voltage in the accumulation region.

关键词： capacitance interface attributed

li(2p←2s)+Na(3s)pressure broadening in the far-wing and line-core profiles

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Chinese Physics B 2022年第7期31卷 247-254页

作者： F Talbi N lamoudi l Reggami m T Bouazza K Alioua m Bouledroua Physics Department Badji Mokhtar UniversityB.P.12Annaba 23000Algeria laboratoire de Physique des Rayonnements Badji Mokhtar UniversityB.P.12Annaba 23000Algeria laboratoire d’Etude des Surfaces et Interfaces de la matiere Solide(lESImS) Badji Mokhtar UniversityB.P.12 Annaba 23000Algeria laboratoire lAmA Laboratoire des Materiaux Avances(LAMA)Badji Mokhtar UniversityB.P.12 Annaba 23000Algeria laboratoire de Physique de la matiere et du Rayonnement lPmR Universite Cherif MessaidiaB.P.1553Souk-Ahras 41000Algeria

This work reports pressure-broadening line-wing and line-core of the lithium li(2p←2s)resonance line perturbed by ground sodium Na(3s)*** far-wing regions,the calculations are performed quantum-mechanically and are intended to examine the photoabsorption coefficients at diverse *** results show the existence of three satellites,in the blue wing near the wavelengths 470 nm and in the red wing around 862 nm and 1070 *** the line-core region,by adopting the simplified Baranger model,the line-width and line-shift rates are determined,and their variation law with temperature is *** published data were found to compare these results with.

关键词： pressure broadening line-core broadening far-wing spectra photoabsorption

The skeleton gets a （reproductive） life

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Asian Journal of Andrology 2011年第5期13卷 651-652页

作者： Charles m Allan David l Handelsman ANZAC Research Institute Concord Hospital Universityof Sydney Sydney NSW 2139 Australia

To most well-informed scientists who do not work on bone, the idea that bones determine anything other than your posture and location for the miseries of arthritis would come as quite a surprise. It would be like imagining that the walls of our home played something more than a passive role in the complexities of the lives conducted within. Yet something precisely as radical as that is what Karsenty and his colleagues boldly imagined,1 and then provocatively established in a series of studies over the past decade.20steocalcin （OCN） is a vitamin K- dependent peptide hormone secreted by the bone-formine osteoblasts.

关键词： Transcription

Revision of the genus Inouenola lászló,Ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry Research 2015年第2期26卷 457-467页

作者： Gyula m.lászló Gábor Ronkay lászló Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola la′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

NUmERICAl SImUlATION OF SUCCINONITRITE DENDRITIC GROWTH IN A FORCED FlOW

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Acta metallurgica Sinica(English letters) 2008年第6期21卷 444-450页

作者： Z. Chen C.l. Chen l.m. Hao School of Science Department of Applied Physics Shaanxi Key Laboratory of Condensed Matter Structures and Properties Northwestern Polytechnical University Xi＇an 710072 China School of Science Xi＇an University of Science ＆ Technology Xi＇an 710054 China

Numerical simulation based on phase field method is performed to describe solidification process of pure material in a free or forced flow. The evolution of the interface is showed, and the effects of mesh grid and flow velocity on succinonitrite shape are studied. These results indicate that crystal grows into an equiaxial dendrite in a free flow and into an asymmetrical dendritic in a forced flow. With increasing flow velocity, the upstream dendritic arm tip grows faster and the downstream arm grows slower. However, the evolution of the perpendicular tip has no significant change. In addition, mesh grid has no influence on dendritic growth shape when mesh grid is above 300×300.

关键词： Phase field method Forced flow Dendritic Succinonitrite Tip velocity