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Profile of People Living with HIV after 24 Week. of Treatment with Dolutegravir in k.nshasa

Advances in Infectious Diseases 2023年第4期13卷 660-674页

作者： Berry I. Bongenya Benoit O. k.bengele Marie-Thérèse A. S. Sombo Guy M. M. Bumok. Hippolyte N. T. Situak.banza fridolin k. k. kodondi Gauthier k. Mesia Mariano M. Lusak.banza Jean Marie N. k.yembe Baudouin B. Buassa Richard L. k.lala Erick.N. k.mangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo Focus HIV/AIDS Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Biochemistry Laboratory Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clinical Pharmacology Unit Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Introduction: The sixth month appointment (M6) is crucial because at the start of the ART course, it is an indicator of the prognosis of the evolution of care and decision-mak.ng on the continuity of treatment. Objective: The objective of this study is therefore to present the profile of People Living with HIV under treatment with Dolutegravir 6 months after starting ART in k.nshasa. Methods: The present study is a cross-sectional view at M6 of a prospective cohort to determine the profile of People Living with HIV (PLHIV) after 6 months of ARV Treatment (ART) in k.nshasa, DRC. During the M6 appointment, from April to August 2022, a sample of 5 ml of blood was tak.n for the various analyzes from all HIV patients included. The collection of sociodemographic data as well as biological and clinical data was carried out under the same conditions as at inclusion. The parameters recorded during M6 were: age, sex, and religion, level of study, marital status, profession, socio-economic level, height, weight, Body Mass Index (BMI), clinical profile, opportunistic infections as well as biochemical and molecular assessment. Results: In M6, 62 patients were registered including 38 women (61.3%), thus giving a sex ratio of 1.58 in favor of women. Fifty-seven (57) patients did not respond to the appointment, representing a loss rate of 47.89%. The most common age group is between 36 and 45 years old with 16 patients (26.7%). The mean age was 42.4 ± 13.3 years. The mean weight was 60.5 ± 15.4 k. with a mean BMI of 22.6 ± 5.8 k./m2. Thirty-four (34) patients (61.82%) were in Clinical Stage 3. Thirty-six (36) patients (67.92%) had a normal clinical condition. The most common opportunistic infections among patients in M6 were: sk.n pruritus (25.8%), dermatitis (22.6%) and rash (21%). The mean values of biochemical parameters of patients in M6 were within normal ranges. The median VL value was 2.92 log10 RNA copies/ml with 17.75% of patients experiencing major failure of f

关键词： Profile PLHIV 6 Months of ART Dolutegravir k.nshasa

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Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in the Dolutegravir Era in k.nshasa, Democratic Republic of Congo

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World Journal of AIDS 2023年第3期13卷 95-115页

作者： Berry I. Bongenya Benoit O. k.bengele Marie-Thérèse A. S. Sombo Guy M. M. Bumok. Hippolyte N. T. Situak.banza fridolin k. k. kodondi Gauthier k. Mesia Mariano M. Lusak.banza Jean Marie N. k.yembe Georges L. Mvumbi Baudouin B. Buassa Richard L. k.lala Erick.N. k.mangu Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo “HIV/AIDS Focus” Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Laboratory of Biochemistry Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Clinical Pharmacology Unit Department of Pharmacology Faculty of Medicine and Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service of Molecular Biochemistry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Back.round: For several decades, the introduction of AntiRetrovirals (ARVs) has improved the symptomatology of People Living with HIV (PLHIV), a spectacular reduction in morbidity and mortality, an improvement in life expectancy and quality of life of PLHIV. Objective: The objective of this study was to determine the profile of PLHIV initiating AntiRetroViral Treatment (ART) in the era of Dolutegravir in k.nshasa. Methods: Cross-section of a prospective cohort to determine the profile of PLHIV initiating ART in k.nshasa. The inclusions were from October 04, 2021 to February 15, 2022. Confirmation of the diagnosis was carried out by Nested PCR. The inclusion criteria were: being at least 18 years old, confirmed HIV positive, naïve to ART, consenting and having signed an informed consent. The parameters of interest followed for the present study were: age, sex, religion, level of study, marital status, occupation, height, weight, body mass index (BMI), the clinical profile, the opportunistic infections as well as the para-clinical assessment (biochemistry and molecular biology). Results: 67 (56.3%) women and 52 (43.7%) men were included, thus 119 patients, all confirmed positive for HIV by Nested PCR on the gag, pol and env regions. The average age of the patients included is 39.87 ± 12.36 years and the most represented age group is that of 36 to 45 years with 37 patients (31.9%). The average height was 1.66 ± 0.08 meters, with an average weight of 56.41 ± 13.30 k., giving an average Body Mass Index (BMI) of 21.54 ± 5.17 k./m2. The majority of patients were married (46.1%), of Protestant religion (70.7%), with secondary education (66.7%), and work.ng in the informal sector (29.4%). 49 patients (41.5%) were in clinical stage 3 and 55 patients (47.0%) had a normal clinical status. Malaria (45.4%) and tuberculosis (29.4%) were the most common Opportunistic Infections. The mean values of the patients’ assessed biochemical parameters were within the ranges. The

关键词： Profile PLHIV Starting of ART Dolutegravir k.nshasa

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Assessment of Membrane Erythrocyte Cholesterol Level in Sick.e Cell Disease

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Journal of Biosciences and Medicines 2020年第11期8卷 16-22页

作者： J. A. N. Mwelo Z. Diak.ese L. Diyi O. Nzingula N. Misengabu G. Ink.laba M. Luvandu k. k. kodondi Laboratory of Biochemistry-Hematology Faculty of Pharmaceutical Sciences University of Kinshasa (UNIKIN) Kinshasa DR Congo Institute for Research in Health Sciences (IRSS) Kinshasa DR Congo Higher Institute of Medical Sciences (ISTM) Nutrition Section Kinshasa DR Congo

Objective: The aim of this study was to assess the level of erythrocyte membrane cholesterol in sick.e cell patients, which is one of the essential parameters of membrane fluidity that contributes to understanding the hemolytic state of the erythrocyte. Methods: We work.d with blood specimens from 20 controls and 50 sick.e cell patients. The blood count and the isoelectric focusing (IEF) were performed on the samples in order to select them. The titration of the erythrocyte membrane cholesterol was made after washing and lysing the erythrocytes with the hemolyzing solution (EDTA, 2 Mercapto-Ethanol, NADP, NaOH). The cholesterol level was assessed by the enzymatic colorimetric method. The results were analyzed by Student’s test. Results: We work.d with 16 control subjects with a hemoglobin status and a normal hemogram. The evaluation of the erythrocyte membrane cholesterol level of the samples allows us to define the reference interval (α = 0.05) at 17.55 ± 3.83 mg of cholesterol/g of hemoglobin. The erythrocyte membrane cholesterol levels of sick.e cell patients found in this study were 11.58 ± 2.98 mg cholesterol/g of hemoglobin. In this study, 38 sick.e cell patients (76%) were found with a low erythrocyte membrane cholesterol level compared to the reference interval. Statistical analysis showed that there was a significant difference (α = 5%) between the erythrocyte membrane cholesterol level of normal subjects and sick.e cell patients. Conclusion: Most of the sick.e cells patients had a decreased erythrocyte membrane cholesterol level. This reduces the membrane fluidity mak.ng the erythrocyte membrane rigid and more fragile. This may be one of the factors responsible for the lyses of erythrocytes.

关键词： Cholesterol Membrane Fluidity Sick.e Cell Anemia Erythrocytes

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