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孕29周伴胁腹痛的子宫后壁囊肿

世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 61-61页

作者： frei k.a. Duwe D.G. Bonel H.M. 王伟华 Dr.Department of Obstetrics University Hospital Inselspital Bern Effingerstrasse 102 3010 Bern Switzerland

BACkGROUND: Uterine sacculation is a rare complication of pregnancy and may cause substantial peripartal morbidity. CASE: A possible diagnosis of posterior uterine sacculation was raised when a 34-year-old Gravida 1 Para 1 presented with bilateral flank pain at 29 weeks. Sonographic and magnetic resonance imaging findings confirmed the diagnosis and demonstrated bilateral dilated renal pelvises. Bilateral nephrostomas were placed, offering the patient considerable relief. A healthy female newborn was delivered by cesarean at 34+1/7 weeks. Operative findings confirmed the posterior sacculation of the uterus. CONCLUSION: Early diagnosis of sacculation of the uterus is necessary to limit maternal and fetal morbidity and mortality. For a detailed evaluation of the pelvic anatomy, we recommend the use of magnetic resonance imaging in the third trimester.

关键词：子宫后壁胁腹妊娠晚期妊娠并发症肾盂扩张围生期子宫囊早期诊断肾孔

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Late biliary complications in human alveolar echinococcosis are associated with high mortality

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World Journal of Gastroenterology 2014年第19期20卷 5881-5888页

作者： Pascal frei Benjamin Misselwitz Meher k Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried kuno Lehmann Rudolf W Ammann Stephan R Vavricka Division of Gastroenterology and Hepatology University Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois1011 LausanneSwitzerland Swiss Hepato-Pancreatico-Biliary and Transplantation Center Department of SurgeryUniversity Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Stadtspital Triemli8063 ZurichSwitzerland

AIM: To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis (AE) under long-term chemotherapy with benzimidazoles.

关键词： Alveolar echinococcosis Biliary strictures Biliary cirrhosis Cholangitis Cholestatic liver disease Chronic liver disease Complications Echinococcal cysts Prognosis

Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize

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Molecular Plant 2017年第10期10卷 1357-1360页

作者： Pengfei Leng Qing Ji Torben Asp Ursula k. frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt National Maize Improvement Center China Agricultural University Beijing 100193 China Department of Agronomy Iowa State University Ames IA 50011 USA Department of Molecular Biology and Genetics Aarhus University Forsegsvej 14200 Slagelse Denmark National key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Institute of Agricultural Sciences Molecular Plant Breeding ETH Zurich Universitaetstrasse 2 8092 Zurich Switzerland USDA Agricultural Research Service Corn Soybean and Wheat Quality Research Unit and Department of Plant Pathology Ohio State University Wooster OH 44691 USA Maize Research Institute Sichuan Agricultural University Chengdu 611130 China School of Life Sciences Guizhou Normal University Laboratory of Plant Physiology and Developmental Regulation Guiyang 550000 China

Dear Editor,Sugarcane mosaic virus （SCMV） causes severe viral diseases in maize worldwide （Fuchs and Gruntzig, 1995）, resulting in significant losses in grain and forage yield in susceptible cultivars of maize and related crops. The most promising solution is to cultivate resistant varieties, which contribute to sustainable crop production. Two epistatically interacting major SCMV resistance loci （Scmvl and Scmv2） are required to confer complete resistance against SCMV in the resistant nearisogenic line F7RPJRR （the letters left of the slash refer to the genotype at Scmv2 on chromosome 3 and those on the right refer to the genotype at Scmvl on chromosome 6, with R indicating a resistance allele and S a susceptibility allele）（Xing et al., 2006）.

关键词： Auxin Binding Protein 1 Reinforces Resistance Sugarcane Mosaic Virus Maize

ITPk1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis.

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Molecular Plant 2021年第11期14卷 1864-1880页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert k.Harmel Philipp Gaugler Verena Gaugler Michael frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehl Department of Plant Nutrition Institute of Crop Science and Resource ConservationRheinische Friedrich-Wilhelms-Universitat Bonn53115 BonnGermany Department of Chemistry and Pharmacy and CIBSS-Centre for Integrative Biological Signalling Studies Albert-Ludwigs University Freiburg79104 FreiburgGermany Medical Research Council Laboratory for Molecular Cell Biology(MRC-LMCB) University College LondonLondon WC1E 6BTUK Department of Biochemistry Indian Institute of ScienceBengaluruKarnataka 560012India Leibniz-Forschungsinstitut fur Molekulare Pharmakologie 13125 BerlinGermany Department of Chemistry Humboldt Universitat zu Berlin12489 BerlinGermany Institute of Agronomy and Crop Physiology Justus-Liebig University Giessen35392 GiessenGermany Department of Physiology&Cell Biology Leibniz-lnstitute of Plant Genetics and Crop Plant Research06466 GaterslebenGermany

In plants, phosphate (Pi) homeostasis is regulated by the interaction of PHR transcription factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. Here, we combined different methods to obtain a comprehensive picture of how inositol (pyro)phosphate metabolism is regulated by Pi and dependent on the inositol phosphate kinase ITPk1. We found that inositol pyrophosphates are more responsive to Pi than lower inositol phosphates, a response conserved across kingdoms. With CE-ESI-MS we could separate different InsP7 isomers in Arabidopsis and rice, and identify 4/6-InsP7 and a PP-InsP4 isomer hitherto not reported in plants. We found that the inositol pyrophosphates 1/3-InsP7, 5-InsP7 and InsP8 increase severalfold in shoots after Pi resupply and that tissue-specific accumulation of inositol pyrophosphates relies on ITPk1 activities and MRP5-dependent InsP6 compartmentalization. Notably, ITPk1 is critical for Pi-dependent 5-InsP7 and InsP8 synthesis in planta and its activity regulates Pi starvation responses in a PHR-dependent manner. Furthermore, we demonstrate that ITPk1-mediated conversion of InsP6 to 5-InsP7 requires high ATP concentrations and that Arabidopsis ITPk1 has an ADP phosphotransferase activity to dephosphorylate specifically 5-InsP7 under low ATP. Collectively, our study provides deeper insights into Pi-dependent changes in nutritional and energetic states with the synthesis of regulatory inositol pyrophosphates.

关键词： diphosphoinositol pentakisphosphate kinase inositol 1,3,4-trisphosphate 5/6-kinase 1 inositol phosphates inositol pyrophosphates phosphate homeostasis phosphate signaling

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高增压汽油机动力总成系统的整体优化

汽车与新动力 2012年第1期44卷 11-14页

作者： Berns S Benninger k kulzer A frei R 范明强不详

目前,降低燃油耗乃至达到法规所规定的二氧化碳排放限值是动力总成创新的主要推动力,这促使研发人员需根据不同的汽车市场和发动机等级采用不同的解决方案。除了在极度小型化的情况下,采取一些机内措施以获得可靠的燃烧过程之外,还讨论... 详细信息

目前,降低燃油耗乃至达到法规所规定的二氧化碳排放限值是动力总成创新的主要推动力,这促使研发人员需根据不同的汽车市场和发动机等级采用不同的解决方案。除了在极度小型化的情况下,采取一些机内措施以获得可靠的燃烧过程之外,还讨论了选择哪种变速箱方案及不同的混合动力结构型式。Bosch公司为汽油机动力总成系统在沟通内燃机、变速箱和电子控制3个主要领域方面起到了桥梁作用。

关键词：动力总成燃油耗二氧化碳排放模拟计算高增压汽油机变速箱电动化

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Bcl-2 over-expression inhibits pentachlorophenol metabolite-induced apoptosis in NIH3T3 cells: a possible mechanism for tumor promotion

丛书名：《瑞士史》

1988年

作者：（瑞士）弗　雷（frei D.）刘文立译

弗雷(1940- ),苏黎世大学讲授政治科学并担任瑞士国际研究院的领导工作:本书探讨了导致瑞士中立的地理、历史环境、瑞士中立的特点、瑞士中立在当代世界的意义等问题。

ISBN: (纸本)7562201471

关键词：对外政策地点:瑞士

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Bcl-2 over-expression inhibits pentachlorophenol metabolite-...

急性缺血性卒中的血管内治疗：神经介入外科学学会实践标准委员会的报告

The 5th Congress of Toxicology in Developing Countries

作者： B.-Z. Zhu Y-P. Lin M.-C. Yang B. frei M.-H. Pan J.-k. Lin Y.-J. Wang Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA College of Medicine National Cheng Kung University Tainan Taiwan ROC College of Medicine National Cheng Kung University Tainan Taiwan ROC Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA College of Medicine National Taiwan University Taipei Taiwan ROC College of Medicine National Taiwan University Taipei Taiwan ROC College of Medicine National Cheng Kung University Tainan Taiwan ROC

＜正＞ Tetrachlorohydroquinone （TCHQ） is a major metabolite of the widely used wood preservative pentuchlorophenol （PCP）. Recenlly, we found that TCHQ was a promoter in a mouse skin carcinogenesis model. However, the mechanism is still not clear. In this study, we showed that over-expression of Bcl-2 effectively suppresses TCHQ-induced apoptosis in NIH3T3 cells, as evideuced by mot-

关键词：

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国际脑血管病杂志 2012年第12期20卷 905-912页

作者： k.a.Black.a. P M Meyers T A Abruzzo F C Alberquerque D Fiorella J Fraser D frei C D Gandhi D V Heck J A Hirsch D P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) 代表神经介入外科学学会南京大学医学院临床学院南京军区南京总医院神经内科 210002

目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会（American Heart Association，AHA）以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上，进行系统的文献回顾以评估支持急性缺血性... 详细信息

目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会（American Heart Association，AHA）以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上，进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。

关键词：急性缺血性卒中血管内治疗委员会神经介入外科学标准学会美国心脏协会

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瑞士苏黎世Hardbrücke车站更新

建筑技艺 2011年第2期17卷 218-219页

作者： Hannes Henz Roger frei Frank Wie-Yang Chen Marc Holle Fabian Hrmann Jrn küsters Claudia Meier Mathias Müller Daniel Niggli Marcellus Schwarz Basil Spiess Nina Strck WGG Schnetzer Puskas 朱晓琳 EM2N Architekten

Hardbrücke车站位于瑞士的苏黎世,用于Hardbrücke火车站的更新费用约为3350000瑞士法郎,总建筑面积5650m2.建筑师试图以选择性的干预手段赋予车站一种新的身份,使人们能够很容易地找到车站所在的方位,同时增加车站站前空间的吸引力.

关键词：苏黎世 cke 车站 Hardbr 瑞士

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