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国外医学.外科学分册 1982年第6期09卷 343-344页

作者： freeman r. 沈家宜

“澳大利亚抗原”及其伴随的病象,激起医学界的广泛关注,从而引起许多不必要的惊慌。虽然急性乙型肝炎的高度传染性已经得到公认,但随着经验的积累,发现带乙型肝炎表面抗原(HBsAg)人的传染性比患急性乙型肝炎者要小得多。

关键词：乙型肝炎血清乙肝病毒性肝炎 HBsAg 病人手术心内直视

迟发性直立性低血压:立位耐受不良的常见原因

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 9-10页

作者： Gibbons C.H. freeman r. 郭俊 Dr.Autonomic and Per.pher.l Ner.e Labor.tor. Department of NeurologyBeth Israel Deaconess Medical Center1 Deaconess RoadBostonMA 02215United States

OBJECTIVE:To investigate the pr.valence,symptoms,and neur.physiologic featur.s of delayed or.hostatic hypotension(OH).METHODS:Blood pr.ssur.s(BP)wer. measur.d at 1minute inter.als on 230 patients dur.ng 60°head-up tilt for.45 minutes and standing for.5 *** was defined as a sustained fall in BP(≥20 mm Hg systolic or.≥10 mm Hg diastolic)and delayed OH as a sustained BP fall occur.ing beyond 3 minutes of standing or.upr.ght tilt table ***-to-beat BP,tests of car.iovagal function,and sympathetic-adr.ner.ic function wer. ***:Of patients with OH,only 46%had OH within 3 minutes of head up tilt;15%had OH between 3 and 10 minutes;and 39%had OH only after.10 minutes of tilt table *** magnitude and the tempor.l distr.bution of the BP fall did not differ.between those with and without symptoms of or.hostatic *** with OH beyond 10 minutes tended to be younger.p r.BP falls dur.ng phase II of the Valsalva maneuver.p r.ater.phase IV over.hoot(p r.hostatic hypotension occur.ed in 54%of our.tested population and was associated with milder.abnor.alities of sympathetic adr.ner.ic function,suggesting this disor.er.may be a mild or.ear.y for. of sympathetic adr.ner.ic failur..

关键词：直立性低血压迟发性立位耐受

黄斑中心凹处视网膜前膜剥离术后出现的非进展性中心凹外视网膜裂孔

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 19-20页

作者： Kozak I. freeman W. r. 王文军(译) Jacobs r.tina Center Shiley Eye Center University of California San Diego San Diego CA United States 不详

PUr.OSE:To r.por. an extr.foveal poster.or.r.tinal hole after.sur.ical r.moval of foveal epir.tinal ***:Obser.ational case ***:We descr.be two patients who under.ent vitr.ctomy sur.er. with an epir.tinal membr.ne *** months after.vision impr.ving sur.er.,a small r.tinal hole outside the macular.ar.a ***:Fundus photogr.phy and optical coher.nce tomogr.phy showed a full-thickness r.tinal holewith a sur.ounding cuff of subr.tinal fluid smaller.than descr.bed in stage III or.IV macular.*** hole has been stable in shape and dimension,has not pr.gr.ssed to r.tinal detachment,and is not associated with an epir.tinal membr.ne;the fluid is not impinging on the macular.***:Asymptomatic full-thickness extr.foveal r.tinal holes,which do not pr.gr.ss to neur.sensor. detachment,can develop after.epir.tinal membr.ne *** appear.stable and have substantially smaller.cuffs of subr.tinal fluid than typical macular.holes.

关键词：视网膜裂孔视网膜前膜中心凹外膜剥离术黄斑区进展性光学相干断层成像视网膜下液

Cosmic-r.y exposur. age of Mar.ian meteor.te Gr. 99027

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Science China Ear.h Sciences 2007年第10期50卷 1521-1524页

作者： D. FABEL r. Br.WN S. freeman Depar.ment of Geogr.phical and Ear.h Sciences University of Glasgow Glasgow G12 8QQ Scotland UK Scottish Univer.ities Envir.nmental r.sear.h Centr. Rankine Avenue Scottish Enterprise Technology Park East Kilbride G75 0QF Scotland UK

We have deter.ined the concentr.tions of 10Be and 26Al in Gr. 99027 r.cover.d by the 16th Chinese Antar.tic expedition team, which ar. 14.1 ± 0.6 dpm/kg and 67.5 ± 3.4 dpm/kg, r.spectively. Fr.m the concentr.tion of 10Be, we calculate a cosmic-r.y exposur. age of 4.4 ± 0.6 Ma for.Gr. 99027. The concentr.tion of 26Al is too high compar.d to the 10Be exposur. age, indicating extr. pr.duction fr.m solar.r.y. The exposur. ages, petr.logic and geochemical char.cter.stics of mantle-der.ved Mar.ian meteor.tes Gr. 99027, LEW 88516, Y-793605, NWA 1950 and ALHA77005 ar. ver. similar. suggesting that these meteor.tes most pr.bably wer. ejected fr.m Mar. in the same impact event.

关键词： Gr. 99027, Mar.ian meteor.te, cosmic r.y, exposur. age, Mar.

The ubiquitin ligase Siah2 is r.vealed as an accomplice of the andr.gen r.ceptor.in castr.tion r.sistant pr.state cancer

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Asian Jour.al of Andr.logy 2013年第4期15卷 447-448页

作者： Michael r.freeman r.sear.h Division of Cancer.Biology and Ther.peutics Departments of Surgery Medicine and BiomedicalSciences Cancer Biology Program Samuel OschinComprehensive Cancer Institute Los Angeles CA90048 USA

The andr.gen r.ceptor.（Ar. r.mains the pr.mar. molecular.tar.et for.r.state cancer.（PCa） tr.atment and for.development of novel ther.pies. Pr.filing and other.analyses of human pr.state adenocar.inoma have shown that the Ar.is still functional dur.ng latestage disease in the absence of cir.ulating hor.one fol lowing castr.tion ther.py. The molecular.mechanisms that oper.te dur.ng this ＇cas tr.tion r.sistant＇ phase ar. still not well under.tood. Qi et al. have now implicated the ubiquitin ligase Siah2 as an impor.ant mediator.of Ar.action in castr.tion r.sis tant pr.state cancer.（Cr.C）. Siah2 was found to tar.et r.pr.ssed Ar.chr.matin complexes for.degr.dation, r.sulting in activation of Ar.egulated genes involved in tumor.cell pr.lifer.tion, cell motility and lipid metabolism. The author. show a r.quir.ment for.Siah2 activity for.PCa cell gr.wth under.conditions of low andr.gen, and also that tar.eting Siah2 r.sults in tumor.gr.wth suppr.ssion under.castr.te conditions. These findings identify a new mechanism of Ar.r.gulation in pr.gr.ssing disease as well as a novel enzymatic tar.et for.ther.peutic inter.ention. The Ar.is a wellstudied hor.one r.ceptor.that belongs to the lar.e nuclear.r.ceptor.gene super.amily. Ar.is activated by andr.gen binding （pr.ncipally 5：~dihydr.testoster.ne, 5DHT）, which elicits changes in Ar.r.sident cytosolic complexes, tr.nslocation of the r.ceptor.to cell nuclei, for.ation of multipr.tein tr.nscr.ptional complexes onchr.matin, and activation or.r.pr.ssion of gene expr.ssion. Exper.ments with in vivo model systems have pr.vided evidence that vir.ually all physiologic pr.cesses affected by andr.gens r.quir. the Ar.as a mediator.of molecular.effects at the gene level.1 Ar.is widely expr.ssed beyond the r.pr.ductive systems and is believed to play impor.ant r.les in sever.l nonr.pr.ductive tissues, including muscle and br.in. The fact that PCa gr.wth is initially dependent on the pr. sence of andr.gens in the cir.ulation, and that pr.stat

关键词： ligase r.vealed accomplice

Like mother. like daughter. her.tability of female r.char.son＇s gr.und squir.el Ur.citellus r.char.sonii cor.isol str.ss r.sponses

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Cur.ent Zoology 2018年第2期64卷 153-163页

作者： Kevin r. BAIr.S-NOVAK Calen r.r.AN Angela r. freeman W. Gar. ANDEr.ON James F, HAr. Depar.ment of Biological Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 Canada Depar.mentof Biology University of Saskatchewan Saskatoon S7N 5E2 Saskatchewan Canada Depar.ment ofAnthr.pology Northwestern University Evanston 60208 Illinois USA Depar.ment of Biological Sciences Kent State University Kent 44242 Ohio USA

Activation of the hypothalamic-pituitar.-adr.nal （HPA） axis liber.tes glucocor.icoids, which pr.vides an acute indication of an individual＇s r.sponse to str.ssor.. The her.tability of the str.ss r.sponse in wild mammals, however. r.mains poor.y documented. We quantified the cor.isol str.ss r.sponse of female r.char.son＇s gr.und squir.els （r.Ss） to handling and physical r.str.int, testing for. （1） the effects of individual age, time of day, and sample latency; （2） r.peatability within individuals; （3） nar.ow-sense her.tability; and （4） differ.nces among individuals owing to potential genetic and/or.envir.nmental effects. We detected a positive linear.r.lationship between baseline plasma cor.isol （BL-cor.isol） concentr.tion and str.ss-induced plasma cor.isol （Sl-cor.isol） concentr.tion that defined each individual＇s cor.isol str.ss r.sponse. BL-cor.isol, SI-cor.isol, and str.ss r.sponse did not differ.accor.ing to the time the sample was taken, or.by subject age. Cor.isol str.ss r.sponse was highly r.peatable within individuals, had a mother.offspr.ng her.tability of h2 =0.40 ± 0.24 （mean ±SE）, full-sibling her.tability of h2s = 0.37 ± 0.71, and half-sibling her.tabil- ity of hHS^2 = 0.75 ± 1.41. Str.ss r.sponses of sibling gr.ups, immediate-family gr.ups, and squir. r.ls within a given ar.a did not differ. wher.as those of individuals fr.m mor. distantly r.lated matr.lines did. Our.r.sults highlight the natur.l var.ability in HPA axis r.activity among individuals by quantifying both BL- and SI-cor.isol levels, demonstr.te par.ial her.tability of the str.ss r.sponse that is not attr.butable to envir.nmental var.ation, and suggest that at least par. of an indi- vidual＇s str.ss r.sponse can be accounted for.by differ.nces in matr.lineal histor..

关键词： glucocor.icoids gr.und squir.el her.tability hypothalamic-pituitar.-adr.nal axis r.activity str.ss r.sponse.

L-DOPS治疗自身免疫性自主神经病变患者的难治性直立性低血压

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 48-48页

作者： Gibbons C.H. Ver.ino S.A. Kaufmann H. freeman r. 陈海 Autonomic and Per.pher.l Ner.e Labor.tor. Department of Neurology Beth Israel Deaconess Medical Center 1 Deaconess Road Boston MA 02215 United States.Dr

The author. r.por. a 46-year.old woman with antibodies to the nicotinic acetylcholine r.ceptor.(NiAchr. of the autonomic ganglia. She pr.sented with sever. or.hostatic intoler.nce r.fr.ctor. to tr.atment with midodr.ne, fludr.cor.isone, er.thr.poietin, vasopr.ssin, salt, and fluid loading. Addition of L-thr.o-3,4-dihidr.xyphenylser.ne (L-DOPS) substantially impr.ved blood pr.ssur. and or.hostatic toler.nce. L-DOPS may benefit patients with sever. or.hostatic intoler.nce and be par.icular.y effective in patients with ganglionic NiAchr.antibodies.

关键词：直立性低血压患者 L-DOPS

糖尿病周围神经病变患者催汗与伤害感受器轴突反射的差异损伤

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 32-32页

作者： Ber.hoff M. Kilo S. Hilz M.J. freeman r. 李青波 Depar.ment of Neur.logy Beth Israel Deaconess Medical Center Harvard Medical School 1 Deaconess Road Boston MA 02215 United States Dr.

It is not known whether.C- fiber.functional subclasses ar. differ.ntially affected by diabetes mellitus or.whether.the patter.s of C- fiber.dysfunction ar. differ.nt between type 1 and type 2 diabetes. We ther.for. examined effer.nt sympathetic sudomotor.and pr.mar. affer.nt nociceptor.C- fiber.function in diabetic patients. Acetylcholine (10% ) was used to evoke C- fiber.(axon- r.flex)mediated r.sponses. The nociceptor.(flar.) r.sponse was measur.d using a laser.Doppler.device. The sudomotor.r.sponse was quantified with silastic impr.nts. The nociceptor.C- fiber. mediated flar. r.sponse was r.duced in type 2 diabetic patients (P r.to contr.ls in type 1 diabetic patients. The sympathetic C- fiber. mediated r.sponses, including sweat volume (P r.of activated sweat glands (P = 0.003), wer. incr.ased in patients with type 1 diabetes. Ther. also was a tr.nd towar. a lar.er.axon- r.flex sweat ar.a in patients with type 1 diabetes (P = 0.09). No differ.nces in these sweat r.sponses wer. found in patients with type 2 diabetes compar.d to contr.ls. These findings suggest that the functional abnor.alities in diabetic per.pher.l neur.pathy ar. not homogeneous and that C- fiber.subclasses ar. differ.ntially affected in type 1 and 2 diabetes mellitus.

关键词：感受器神经纤维神经末梢神经元糖尿病患者轴突反射差异

Even-odd har.onics gener.ted fr.m above-thr.shold ionization

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Fr.ntier. of physics 2014年第1期9卷 69-73页

作者： Dong-Sheng Guo Jing-Tao Zhang Zhen-r.ng Sun Jin T. Wang Ju Gao Zhi-Wei Sun r. r. freeman State Key Labor.tor. of Pr.cision Spectr.scopy Department of Physics East China Normal University Shanghai 200062 China Depar.ment of Physics Southern University Baton Rouge LA 70813 USA State Key Labor.tor. of High Field Laser.Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China Jingpin Opto-Electr.nic Co. Jiangsu FOHO Science Park Fenhu Town Wujiang 215211 China Key Labor.tor. of Micr.gr.vity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China Depar.ment of Physics Ohio State University Columbus OH 43210 USA

We ar. r.por.ing a theor.tical pr.diction： The photoelectr.ns for.ing above-thr.shold-ionization （ATI） peaks emit both even and odd har.onics. These har.onics exhibit plateau and cut-off featur.s similar.to those o... 详细信息

关键词： str.ng-field laser.physics above-thr.shold inoization high har.onic gener.tion evenodd har.onics nonper.ur.ative quantum electr.dynamics

高分辨光学相干断层成像术对棉絮状白斑进行活体组织学观察

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 16-16页

作者： Kozak I. Bar.sch D. -U. Cheng L. freeman W. r. 曹绪胜(译) Jacobs r.tina Center University of California San Diego Shiley Eye Center San Diego CA United States 不详

PUr.OSE:To pr.vide optical char.cter.stics of cotton-wool spots(CWS)on optical coher.nce tomogr.phy(OCT)and scan the r.tina after.CWS have ophthalmoscopically ***:Obser.ational case ***:We studied four.eyes of four.patients with r.tinopathy due to human immunodeficiency vir.s(HIV)and *** Str.tusOCT Model 3000 in single-line mode was used for.imaging of acute and r.solved CWS and adjacent nor.al *** fundus photogr.phy ser.ed as a template for.OCT scanning in localization of *** tissue r.flectivity images wer. ***:Ther. wer. differ.nces in r.flectivity of nor.al r.tina,the r.tina in the ar.a of active CWS,and the r.tina in the same ar.a after.CWS has *** str.king was that the OCT documented a per.istent focal ar.a of hyper.eflectivity in the ar.a of the r.solved CWS,indicative of r.tinal gliosis that could be ***:CWS show a hyper.r.flective patter. on OCT that per.ists even after.they become ophthalmoscopically invisible.

关键词：光学相干断层成像术组织学观察白斑高分辨视网膜组织人类免疫缺陷病毒活体 CT扫描