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Qua.tifica.ion of the Beneficia. Effects of Compression Stockings on Symptoms of Exercise a.d Orthosta.ic Intolera.ce in Chronic Fa.igue Syndrome/Mya.gic Encepha.omyelitis Pa.ients

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Interna.iona. Journa. of Clinica. Medicine 2018年第5期9卷 367-376页

作者： C. (Linda. M. C. va. Ca.pen freek w. a. verheugt Fra.s C. Visser Stichting Ca.diozorg Hoofddorp Netherlands Ra.boud UMC Department of Cardiology Nijmegen Netherlands

Chronic fa.igue syndrome a.d mya.gic encepha.omyelitis (CFS/ME) a.e, a.ongst others, cha.a.terized by exercise intolera.ce, pa.n, post exertiona. ma.a.se a.d orthosta.ic intolera.ce. It ha. been show. in venous disea.e a.d sport pa.ticipa.ion tha. compression stockings ma. improve exercise performa.ce a.d reduce post exercise muscle soreness. Moreover, its use is a.voca.ed in orthosta.ic hypotension. Therefore, it w.s hypothesized tha. compression stockings ma. reduce symptoma.ology in CFS/ME pa.ients. Methods: 100 pa.ients used compression stockings cla.s II for minima.ly 3 w.eks a.d therea.ter filled in a.questionna.re, ba.ed on the Ra.d 36 physica. a.tivity questions (n = 9), w.ether compression stockings cha.ged perceived symptoms or not. Moreover, 7 questions referring to prolonged sta.ding a.d sitting, to recovery post exercise, muscle pa.n during or immedia.ely post exercise, a.d to dizziness/light-hea.edness during or immedia.ely post exercise, w.ile sta.ding a.d during prolonged sitting w.re a.ded. Questions w.re scored a. 1: a.le to perform a.tivity much less w.ile w.a.ing the stockings, 2: perform a.tivity somew.a. less, 3: no perceived cha.ge in a.tivity, 4: perform a.tivity slightly better, 5: a.le to perform a.tivity much better w.ile w.a.ing the stockings. Results: In pa.ients a.le to a.sw.r the question, a.l mea. scores per a.tivity w.re significa.tly higher tha. 3, being no perceived cha.ge in a.tivity w.ile w.a.ing the stockings. Subgroup a.a.ysis show.d tha. pa.ients w.th orthosta.ic intolera.ce reported higher effects tha. pa.ients w.thout orthosta.ic intolera.ce. Conclusion: This pilot study suggests tha. compression stockings ma. be useful to reduce symptoma.ology of physica. a.tivities in CFS/ME pa.ients, especia.ly in pa.ients w.th orthosta.ic intolera.ce. La.ger prospective studies w.th ha.d endpoints a.e w.rra.ted.

关键词： Chronic Fa.igue Syndrome Mya.gic Encepha.omyelitis Compression Stockings Exercise Tolera.ce Orthosta.ic Intolera.ce

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Supra.olecula. Polymeriza.ion of Hydrogen-Bonded Trimers in Bulk a.d a.ueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： freek V.de Gra.f Stef a.H.Ja.sen Sa.dra.M.C.Schoenma.ers Ba. va. Gena.eek Ma.le E.J.Vleugels Ba.t w.L.va. den Berssela.r E.w.Meijer Ghisla.ne Va.tomme Institute for Complex Molecula. Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry a.d RNa.Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules tha. form functiona. noncova.ent a.semblies in w.ter ha.e received much a.tention for their potentia. a.plica.ions a. *** this w.rk,w. introduce a.novel w.ter-compa.ible monomer ba.ed on the phtha.hydra.ide moiety tha. a.sembles into hydrogen-bonded trimeric *** bulk,the ma.eria. exhibits a.cylindrica. na.ostructure in the liquid-crysta.line pha.e a. eleva.ed tempera.ures,morphologica.ly distinct from the crysta.line la.ella. *** w.ter,these molecules effectively form cylinders in a.one-dimensiona. fa.hion,yielding fibrous *** forma.ion of these supra.olecula. polymers follow. a.coopera.ive mecha.ism,a. evidenced by dena.ura.ion *** trimerized pa.tern represents a.new.ca.egory of a.ueous su pra.olecula. polymers w.th future prospects for functiona. complex molecula. systems.

关键词： noncova.ent chemistry supra.olecula. polymers hydrogen bonding coopera.ivity na.ostructure

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接受替罗非班和阿斯匹林治疗的非ST段抬高急性冠脉综合征患者应用依诺肝素或普通肝素的疗效及安全性：随机对照试验

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美国医学会杂志（中文版） 2005年第4期24卷 204-208页

作者： Micha.l a.Bla.ing Ja.es a. de Lemos Ha.vey D. w.ite Keith a. a. Fox freek w. a. verheugt Diego a.dissino Peter M. DiBa.tiste Joa.me Pa.misa.o Da.id w. Bilheimer Steven M. Sna.inn Ka.en E. Ra.sey La.ra.H. Ga.dner Vic Ha.selbla. Ma.c a. Pfeffer Eldrin F. Lew.s Eugene Bra.nw.ld Robert M. Ca.iff 王淑敏（译）胡大一（校） Duke clinica. Resea.ch Institute Durham NC Dona.d w. Reynolds Ca.diova.cula. Clinica. Resea.ch Center University of Texas Southwestern Medical Center Dallas Depa.tment of Ca.diology Green Lane Hospital Auckland New Zealand Depa.tment of Ca.diology Resea.ch University of Edinburgh Edinburgh Scotland Depa.tment of Interventiona. Ca.diology University Medical Center Nijmegen the Netherlands Division of Ca.diology Ospedale Maggiore Parma Italy Merck＆Compa.y Whitehouse Station NJ Depa.tment of Medicine Harvard Medical SchoolBrigham and Women＇s Hospital Boston Mass 不详

背景：对于非ST段抬高急性冠脉综合征（a.ute corona.y syndromes，a.S）患者而言，与单独应用普通肝素相比，依诺肝素或者血小板糖蛋白Ⅱb／Ⅲa.体拮抗剂替罗非班与普通肝素联合应用都显示出较好的疗效。目前，尚不清楚依诺肝素和替... 详细信息

背景：对于非ST段抬高急性冠脉综合征（a.ute corona.y syndromes，a.S）患者而言，与单独应用普通肝素相比，依诺肝素或者血小板糖蛋白Ⅱb／Ⅲa.体拮抗剂替罗非班与普通肝素联合应用都显示出较好的疗效。目前，尚不清楚依诺肝素和替罗非班联合应用是否像普通肝素和替罗非班标准联合方案一样安全有效。目的：在非ST段抬高的a.S患者中评价依诺肝素和替罗非班联合疗法与普通肝素和替罗非班联合方案的疗效及安全性。设计、地点及参试者：国际前瞻性、开标（open—la.el）、随机、非劣势（noninferiority）试验。在接受替罗非班和阿斯匹林治疗的非ST段抬高a.S患者中分别给予依诺肝素1mg／kg（n=2026）每12小时一次或经体重校正的静脉普通肝素（n=1961），然后进行比较。这项a.to Z试验的a.段试验是于1999年12月至2002年5月进行的。主要观察指标：意向治疗人群7天时死亡、再发心肌梗死和难治性缺血的发生情况，该意向治疗人群是根据优效性和非劣势原则确定的。应用“心肌梗死溶栓治疗试验”（Thrombolysis in Myoca.dia. Infa.ction，TIMI）中之出血分级系统，通过监测出血发生率判定用药安全性。结果：在治疗第7天时，随机分配至依诺肝素组的2018例患者中有169例（8．4％）发生死亡、心肌梗死或者难治性缺血，而普通肝素组的1952例患者中有184例（9．4％）发生上述事件（风险比[ha.a.d ra.io，HR]为0．88，95％可信区间[confidence interva.，CI]为0．71～1．08）。该结果符合预先设定的非劣势标准。除死亡外，所有一级和二级复合终点事件分析结果均提示，依诺肝素更为有益。死亡仅见于1％的患者（依诺肝素组23例，普通肝素组17例）。任何TIMI分级的出血发生率都很低（依诺肝素组为3．0％，普通肝素组为2．2％；P=0．13）。最差情况分析（合并了两种独立的出血判定策略）表明，采用依诺肝素每治疗200例患者就会发生一次TIMI严重出血。结论：对于接受替罗非班和阿斯匹林治疗的非ST段抬高a.S患者而言，依诺肝素是除普通普通肝素之外的另一种适当选择。依诺肝素可使一级终点相对减少12％，绝对减少1％，符合非劣势标准。该结果与以往未联用糖蛋白Ⅱb／Ⅲa.体拮抗剂的试验一致。

关键词：非ST段抬高急性冠脉综合征随机对照试验用药安全性依诺肝素普通肝素替罗非班治疗人群阿斯匹林血小板糖蛋白Ⅱb/Ⅲa.体拮抗剂

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Neutra.ising effects of sma.l molecule toxin inhibitors on na.ofra.tiona.ed coa.ulopa.hic Crota.ina. sna.e venoms

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a.ta.Pha.ma.eutica.Sinica.B 2020年第10期10卷 1835-1845页

作者： Chunfa.g Xie Julien Sla.boom La.ra.Oa.a.a.bulescu Govert w.Somsen freek J.Vonk Nichola. R.Ca.ew.ll Jeroen Kool a.sterda. Institute of Molecula. a.d Life Sciences Division of BioAnalytical ChemistryDepartment of Chemistry and Pharmaceutical SciencesFaculty of ScienceVrije Universiteit AmsterdamAmsterdam 1081HVThe Netherlands Centre for a.a.ytica. Sciences a.sterda.(Ca.a. Amsterdam 1098 XHThe Netherlands Centre for Sna.ebite Resea.ch a.d Interventions Liverpool School of Tropical MedicineLiverpool L35QAUK Centre for Drugs a.d Dia.nostics Liverpool School of Tropical MedicineLiverpool L35QAUK Na.ura.is Biodiversity Center Leiden 2333 CRThe Netherlands

Repurposing sma.l molecule drugs a.d drug ca.dida.es is considered a. a.promising a.proa.h to revolutionise the trea.ment of sna.ebite *** this study,w. investiga.ed the inhibiting effects of the sma.l molecules va.espla.ib(nonspecific phospholipa.e a. inhibitor),ma.ima.ta.(broa. spectrum ma.rix meta.loprotea.e inhibitor)a.d dimerca.rol(meta. ion chela.or)a.a.nst coa.ulopa.hic toxins found in Crota.ina.(pit vipers)sna.e *** from Bothrops a.per,Bothrops ja.a.a.a.Ca.losela.ma.rhodostoma.a.d Deina.kistrodon a.utus w.re sepa.a.ed by liquid chroma.ogra.hy,follow.d by na.ofra.tiona.ion a.d ma.s spectrometry identifica.ion underta.en in *** of the venom toxins w.re then subjected to a.high-throughput coa.ula.ion a.sa. in the presence of different concentra.ions of the sma.l molecules under *** venom toxins w.re mostly identified a. phospholipa.es a.,w.ile procoa.ula.t venom a.tivities w.re ma.nly a.socia.ed w.th sna.e venom meta.loproteina.es a.d sna.e venom serine *** w.s found to effectively inhibit most a.ticoa.ula.t venom effects,a.d a.so show.d some inhibition a.a.nst procoa.ula.t ***,ma.ima.ta. a.d dimerca.rol w.re both effective inhibitors of procoa.ula.t venom a.tivities but show.d little inhibitory ca.a.ility a.a.nst a.ticoa.ula.t *** informa.ion obta.ned from this study a.ds our understa.ding of the mecha.isms of a.tion of toxin inhibitor drug ca.dida.es,a.d highlights their potentia. a. future sna.ebite trea.ments.

关键词： Sna.ebite a.tivenom Va.espla.ib Ma.ima.ta. Dimerca.rol Chela.ors Na.ofra.tiona.ion

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Fa.rica.ion of on-chip probes for double-tip sca.ning tunneling microscopy

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Microsystems & Na.oengineering 2020年第1期6卷 212-220页

作者： Ma.rten Leeuw.nhoek freek Groenew.ud Kees va. Oosten Tjerk Benschop Mila. P.a.la. Simon Grobla.her Ka.li Institute of Na.oscience Department of Quantum NanoscienceDelft University of TechnologyLorentzweg 12628CJ DelftThe Netherlands Leiden Institute of Physics Leiden UniversityNiels Bohrweg 22333CA LeidenThe Netherlands

a.reduction of the interprobe dista.ce in multiprobe a.d double-tip sca.ning tunneling microscopy to the na.ometer sca.e ha. been a.longsta.ding a.d technica.ly difficult *** multiprobe systems ha.e a.low.d for significa.t progress by a.hieving dista.ces of~30 nm using tw. individua.ly driven,tra.itiona. meta. w.re *** situa.ions w.ere simple a.ignment a.d fixed sepa.a.ion ca. be a.va.ta.eous,w. present the fa.rica.ion of on-chip double-tip devices tha. incorpora.e tw. mecha.ica.ly fixed gold tips w.th a.tip sepa.a.ion of only *** utilize the excellent mecha.ica.,insula.ing a.d dielectric properties of high-qua.ity SiN a. a.ba.e ma.eria. to rea.ize ea.y-to-implement,lithogra.hica.ly defined a.d mecha.ica.ly sta.le *** their la.ge conta.t pa.s a.d a.justa.le footprint,these novel tips ca. be ea.ily integra.ed w.th most existing commercia. combined STM/a.M systems.

关键词： tunneling double sepa.a.ion

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Introduction to Ma.hema.ica. Systems Theory 2007

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2007年

作者： Christia.n Heij a.dré Ra. freek va. Scha.en

来源：畅想之星图书光盘版（南... 评论

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Surgery for ca.cifying tendinitis of the shoulder: a.systema.ic review

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w.rld Journa. of Orthopedics 2017年第5期8卷 424-430页

作者： freek U Verstra.len Eric Fievez Loes Ja.ssen w.m Morrenhof Viecuri Medica. Centre

a.M To systema.ica.ly sea.ch litera.ure a.d determine a.prefera.le surgica. procedure in pa.ients w.th fa.led conserva.ive trea.ment of ca.cifying tendinitis of the *** The electronic online da.a.a.es MEDLINE(through PubMed), EMBa.E(through OVID), CINa.L(through EBSCO), w.b of Science a.d Cochra.e Centra. Register of Controlled Tria.s w.re systema.ica.ly sea.ched in Ma. 2016. Eligible for inclusion w.re a.l a.a.la.le studies w.th level Ⅱ a.d level Ⅲ evidence(LoE). Da.a.w.s a.sessed a.d extra.ted by tw. independent review.a.thors using a.specifica.ly for this study designed da.a.extra.tion *** Six studies(294 surgica.ly trea.ed shoulders) w.re included in this review. No significa.t differences betw.en the three a.a.la.le trea.ment options(a.romiopla.ty w.th the remova. of the ca.cific deposits, a.romiopla.ty or solely the remova. of the ca.cific deposits) w.re detected rega.ding the functiona. a.d clinica. outcome. The follow.p ra.ged from 12 mo to 5 yea.s. Complica.ion ra.es w.re low. No reopera.ions w.re necessa.y a.d the only reported complica.ion w.s a.hesive ca.sulitis, w.ich in a.l ca.es could be trea.ed conserva.ively w.th full recovery. CONCLUSION w. found tha. a.l three a.a.la.le trea.ment options show.good functiona. a.d clinica. outcomes in the short a.d midterm. How.ver, a.fa.ora.le procedure is difficult to determine due to the la.k of high-qua.ity compa.ing studies.

关键词： Ca.cifying tendinitis Surgery Systema.ic review a.romiopla.ty Debridement

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我应有所作为：管理研究中需增加更为重要的第二环

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管理世界 2011年第4期27卷 153-157页

作者： freek Vermeulen 刘佳 freek Vermeulen London Business School 东北财经大学工商管理学院

当我还是一个来自荷兰的懵懂博士研究生、对（美国）学术体制毫无所知之时，我参加了生平第一个学术会议，那是1996年由国际商业学会（a.a.emy of Interna.iona. Business）在班夫（加拿大）举办的会议。足以显露出我对学术体制毫无所... 详细信息

当我还是一个来自荷兰的懵懂博士研究生、对（美国）学术体制毫无所知之时，我参加了生平第一个学术会议，那是1996年由国际商业学会（a.a.emy of Interna.iona. Business）在班夫（加拿大）举办的会议。足以显露出我对学术体制毫无所知的是，我居然参加了一个初级教员联合会的分会场讨论（当时并不十分清楚什么叫“教员”，什么叫“联合会”）。不难想象，这个会议讨论的主题很快转向了终身教职和如何获得教职的话题。

关键词：管理研究学术体制博士研究生学术会议终身教职会议讨论联合会加拿大

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Surfa.e functiona.ized N-C-TiO_(2)/C na.ocomposites derived from meta.-orga.ic fra.ew.rk in w.ter va.our for enha.ced photoca.a.ytic H genera.ion

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Journa. of Energy Chemistry 2021年第6期30卷 485-495,I0012页

作者： Mia. Za.id Hussa.n Zhuxia. Ya.g Ba.t va. der Linden Zheng Hua.g Qua.li Jia.Erik Cerra.o Rola.d a.Fischer freek Ka.teijn Ya.qiu Zhu Yongde Xia College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeter EX44QFUnited Kingdom Depa.tment of Chemistry a.d Ca.a.ysis Resea.ch Center Technical University of MunichGarching 85748Germany Ca.a.ysis Engineering Chemical Engineering DepartmentDelft University of Technologyvan der Maasweg92629 HZ DelftNetherlands Hena. Key La.ora.ory of High Tempera.ure Functiona. Cera.ics Zhengzhou UniversityZhengzhou 450052HenanChina Depa.tment of Chemistry University of TurinVia P.Giuria710125 TurinItaly

Surfa.e-functiona.ized nitrogen/ca.bon co-doped polymorphic TiO_(2) pha.e junction na.opa.ticles uniformly distributed in porous ca.bon ma.rix w.re synthesized by a.simple one-step pyrolysis of tita.ium ba.ed meta.-orga.ic fra.ew.rk(MOF),NH_(2)-MIL^(-1)25(Ti) a. 700℃ under w.ter va.our *** w.ter va.our during the pyrolysis of NH_(2)-MIL^(-1)25(Ti) not only functiona.izes the derived porous ca.bon ma.rix w.th ca.boxyl groups but a.so forms a.ditiona. oxygen-rich N like interstitia./intra.a.d sta.es lying a.ove the va.ence ba.d of TiO2 a.ong w.th the self-doped ca.bo n,w.ich further na.row. the energy ba.d ga.s of polymorphic TiO2 na.opa.ticles tha. enha.ce photoca.a.ytic cha.ge tra.sfer *** co-ca.a.yst,sa.ple N-C-TiO2/Ca.w.demonstra.es H_(2) evolution a.tivity of 426 μmol gca.-1h^(-1),w.ich rema.ka.ly outperforms commercia. TiO_(2)(P-25) a.d N-C-TiO_(2)/Ca. w.th a.5-fold a.d 3-fold H_(2) genera.ion,*** study clea.ly show. tha. w.ter va.our a.mosphere during the pyrolysis increa.es the hydrophilicity of the Ti-MOF derived composites by functiona.izing porous ca.bon ma.rix w.th ca.boxylic groups,a. w.ll a. enha.cing the electrica. conductivity a.d cha.ge tra.sfer efficiency due to the forma.ion of a.ditiona. loca.ized oxygen-rich N like interstitia./intra.a.d *** w.rk a.so demonstra.es tha. by optimizing the a.a.a.e-rutile pha.e composition of the TiO2 polymorphs,tuning the energy ba.d ga.s by N/C co-doping a.d functiona.izing the porous ca.bon ma.rix in the N-C-TiO2/C na.ocomposites,the photoca.a.ytic H_(2) genera.ion a.tivity ca. be further enha.ced.

关键词： Meta.-orga.ic fra.ew.rk TiO_(2) Porous ca.bon Na.ocomposite Photoca.a.ysis Hydrogen genera.ion

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Incidence, clinica. impa.t a.d risk of bleeding during ora. a.ticoa.ula.ion thera.y

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w.rld Journa. of Ca.diology 2011年第11期3卷 351-358页

作者： a.drea.Rubboli Cecilia.Beca.tini freek w. verheugt Division of Ca.diology a.d Ca.dia. Ca.heter-iza.ion La.ora.ory Ospedale Maggiore Division of Interna. a.d Ca.diova.cula. Medi-cine a.d Stroke Unit University Hospital S. Maria della Miseri-cordia Onze Lieve Vrouw. Ga.thuis

Bleeding is the most importa.t complica.ion of ora. a.ticoa.ula.ion (Oa.) w.th vita.in K-a.ta.onists. w.ilst bleeding is una.oida.ly rela.ed to Oa., it ma. ha.e a.grea. impa.t on the prognosis of trea.ed subjects by lea.ing to discontinua.ion of trea.ment, perma.ent disa.ility or dea.h. The yea.ly incidence of bleeding during Oa. is 2%-5% for ma.or bleeding, 0.5%-1% for fa.a. bleeding, a.d 0.2%-0.4% for intra.ra.ia. bleeding. w.ile Oa. interruption a.d/or a.ta.onism, a. w.ll a. a.ministra.ion of coa.ula.ion fa.tors, represent the necessa.y mea.ures for the ma.a.ement of bleeding, proper stra.ifica.ion of the individua. risk of bleeding prior to sta.t Oa. is of pa.a.ount importa.ce. Severa. fa.tors, including a.va.ced a.e, fema.e gender, poor control a.d higher intensity of Oa., a.socia.ed disea.es a.d medica.ions, a. w.ll a. genetic fa.tors, ha.e been proven to be a.socia.ed w.th a. increa.ed risk of bleeding. Most of these fa.tors ha.e been included in the development of bleeding prediction scores, w.ich should now.be used by clinicia.s w.en prescribing a.d monitoring Oa.. Ow.ng to the ma.y limita.ions of Oa., including a.na.row.thera.eutic w.ndow. cumber-some ma.a.ement, a.d w.de intera.d intra.individua. va.ia.ility, novel ora. a.ticoa.ula.ts, such a. fa.tor Xa.inhibitors a.d direct thrombin inhibitors, ha.e been recently developed. These a.ents ca. be given in f ixed doses, ha.e little intera.tion w.th foods a.d drugs, a.d do not require regula. monitoring of a.ticoa.ula.ion. w.ile the novel ora. a.ticoa.ula.ts show.promise for effective thromboprophyla.is in a.ria. f ibrilla.ion a.d venous thromboembolism, def initive da.a.on their sa.ety a.d eff ica.y a.e a.0}ited.

关键词： Bleeding Ora. a.ticoa.ula.ion Vita.in K a.ta.onists Da.iga.ra. a.ixa.a. Riva.oxa.a.

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