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Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

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Journal of Sport and Health Science 2021年第2期10卷 122-130页

作者： Eric R.Munoz Jaclyn B.Caccese Brittany E.Wilson Kyle t.Shuler Fernando V.Santos Carolina t.Caban John J.Jeka Dianne Langford matthew B.Hudson Department of Kinesiology and Applied Physiology University of DelawareNewarkDE 19713USA School of Health and Rehabilitation Sciences The Ohio State University College of MedicineColumbusOH 43210USA Department of Neuroscience Lewis Katz School of MedicineTemple UniversityPhiladelphiaPA 19140USA

Background:Considering the potential cumulative effects of repetitive head impact(HI)exposure,we need sensitive biomarkers to track shortand long-term *** small extracellular vesicles(sEVs)(traffic biological molecules throughout the body and may have diagnostic value as biomarkers for *** purpose of this study was to identify the microRNA(miRNA)profile in circulating sEVs derived from human plasma following repetitive HI ***:Healthy adult(aged 18-35 years)soccer players were randomly assigned to one of 3 groups:the HI group performed 10 standing headers,the leg impact group performed 10 soccer ball trapping maneuvers over 10 min,and the control group did not participate in any soccer *** was collected before testing and 24 h afterward,and sEVs were isolated and characterized via nanoparticle tracking ***-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs,and candidate microRNAs were analyzed via quantitative polymerase chain *** silico target prediction was performed using targetScan(Version 7.0;***)and miRWalk(http://***/)programs,and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney(HEK)293t/17 ***:Plasma sEV concentration and size were not affected across time and group following repetitive HI *** 24 h,the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p,miR-423-5p,and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p,miR-144-5p,miR-221-5p,and *** of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA *** our knowledge,miR-7844-5p is a previously unknown *** identified 8 miR-7844-5p mRNA targets:protein phosphatase 1 regulatory inhibitor subunit 1B(PPP1R1B),LIM and senescent cell antigen-like domains 1(LIMS1),au

关键词： Biomarker Concussion MicroRNA Repetitive head impact exposure Soccer heading

Energy exchange between charged relativistic fluids in f(t)gravity

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Communications in theoretical Physics 2024年第10期76卷 106-118页

作者： Z Yousaf U A Khokhar Nasser Bin turki t Suzuki Department of Mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan Department of Mathematics College of ScienceKing Saud UniversityPO Box 2455Riyadh11451Saudi Arabia Department of Regional Management Faculty of ManagementFukushima CollegeFukushima 960-0181Japan

this study focuses on the effects of a polytropic fluid on a charged gravitational source within f(t)gravity,where t is the torsion *** investigate how the electromagnetic field affects the flow of energy in spherically symmetric and static celestial objects that contain relativistic *** using the gravitational decoupling technique,we analyze the effects of polytropic fluid on the dynamics of the gravitational source,accompanied by the matching of the interior geometry with an exterior at the hypersurfaceΣ.Finally,with the help of the tolmanⅡV solution,we observe the conduct of energy conditions with the existence of charge using f(t)field equations and got the intended outcomes.

关键词： complexity hydrodynamics anisotropy self-gravitating systems energy exchange

High-throughput predictions of metal-organic framework electronic properties:theoretical challenges,graph neural networks,and data exploration

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npj Computational Materials 2022年第1期8卷 1053-1062页

作者： Andrew S.Rosen Victor Fung Patrick Huck Cody t.O’Donnell matthew K.Horton Donald G.truhlar Kristin A.Persson Justin M.Notestein Randall Q.Snurr Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Miller Institute for Basic Research in Science University of CaliforniaBerkeleyBerkeleyCA94720USA Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Chemical and Biological Engineering Northwestern UniversityEvanstonIL60208USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN37831USA Energy technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Chemistry Chemical Theory Centerand Minnesota Supercomputing InstituteUniversity of MinnesotaMinneapolisMN55455USA Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

With the goal of accelerating the design and discovery of metal–organic frameworks(MOFs)for electronic,optoelectronic,and energy storage applications,we present a dataset of predicted electronic structure properties for thousands of MOFs carried out using multiple density functional *** to more accurate hybrid functionals,we find that the widely used PBE generalized gradient approximation(GGA)functional severely underpredicts MOF band gaps in a largely systematic manner for semi-conductors and insulators without magnetic ***,an even larger and less predictable disparity in the band gap prediction is present for MOFs with open-shell 3d transition metal *** regards to partial atomic charges,we find that different density functional approximations predict similar charges overall,although hybrid functionals tend to shift electron density away from the metal centers and onto the ligand environments compared to the GGA point of *** more significant differences in partial atomic charges are observed when comparing different charge partitioning *** conclude by using the dataset of computed MOF properties to train machine-learning models that can rapidly predict MOF band gaps for all four density functional approximations considered in this work,paving the way for future high-throughput screening *** encourage exploration and reuse of the theoretical calculations presented in this work,the curated data is made publicly available via an interactive and user-friendly web application on the Materials Project.

关键词： charges electronic centers

Chaotic movement of vortices in superconductors of high-t_c superconducting maglev system at a high speed

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Journal of Modern transportation 2012年第2期20卷 70-75页

作者： H.t. LIN Department of Information Management Department of Electrical Engineering Cheng Shiu University Taiwan China

Vortex motion in superconductors of high-to superconducting maglev system is studied by a computational simulation. the vortex system is treated in a similar fashion, as a system where defects are arranged in periodic arrays and driven by an alternating current （AC） field. Computational simulation reveals that due to the high nonlinearity of the vortex-defect interaction, the system shows typical chaotic characters. Effects of the vortex-vortex coupling, the driving frequency, and the vortex viscosity on the vortex motion have been studied to reveal the interaction between the spatial and temporal chaos. It is found that the mean-field approach is a good approximation to describe the vortex motion in one dimensional vortex system under an AC driving field. the vortex motion under the damping mode is a kind of self-organized motion. Lastly, the spatial chaos can dominate the chaotic behavior of the system.

关键词： superconductors vortex motion spatial chaos temporal chaos

Evaluation of periglacial landforms and formation of soil properties on the Mount Honaz,SW türkiye

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Journal of Mountain Science 2024年第9期21卷 3047-3067页

作者： SERİN Soner UNCU Levent DEDE Volkan tÜRKEŞMurat Institute of Social Sciences İstanbul Universityİstanbul 34119Türkiye Department of Geography BilecikŞeyh Edebali UniversityBilecik 11234Türkiye Department of Geography Ardahan UniversityArdahan 75002Türkiye Center for Climate Change and Policy Studies Boğaziçi Universityİstanbul 34342Türkiye

the main aim of this study is to explain periglacial processes on the summits of Mount Honaz(2571 m a.s.l.),define periglacial landforms,and determine the relationships between morphometric features and topographic *** circles,stony earth circles,non sorted steps,and non sorted stripes were identified on the summits of Mount ***'s correlation coefficient(r)and linear regression analyses were performed by taking metric measurements from 125 periglacial landforms to describe their morphometric features(length,width,height)of periglacial landforms and explain the relationships between them and topographic factors(elevation,slope).to explain the relationships between periglacial landforms and soil properties,soil samples from 11 periglacial landforms were taken and *** landforms,which continue to develop on the summits of Mount Honaz today,have been evaluated with present climate *** of soil samples indicates a notable impact of parent material on the genesis of periglacial *** high ratio of organic matter in mud circle and non sorted step landforms and the high lime ratio in stony earth circle landforms prove a strong relationship between the formation mechanisms of landforms and the soil ***,it is consistent with the findings obtained from the analysis that severe periglacial processes and washing and scavenging events are experienced more on the northern slopes.

关键词： Periglacial processes and geomorphology Soil analysis Morphometric analysis Mount Honaz türkiye

Contemporary's economics /

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Skeletal stem cells in bone development,homeostasis,and disease

2007年

作者： Downey matthew t.

来源：畅想之星图书光盘版（南... 评论

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Protein & Cell 2024年第8期15卷 559-574页

作者： Guixin Yuan Xixi Lin Ying Liu matthew B.Greenblatt Ren Xu the First Affliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cell State Key Laboratory of Cellular Stress BiologySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361005China Xiamen Key Laboratory of Regeneration Medicine Fujian Provincial Key Laboratory of Organ and Tissue RegenerationOrgan Transplantation InstituteSchool of MedicineXiamen UniversityXiamen 361102China Department of Pathology and Laboratory Medicine Weill Cormell Medical CollegeNew YorkNY 10065USA Research Division Hospital for Special SurgeryNew YorkNY10065USA

tissue-resident stem cells are essential for development and repair,and in the skeleton,this function is fulfilled by recently identified skeletal stem cells(SSCs).However,recent work has identified that SSCs are not monolithic,with long bones,craniofacial sites,and the spine being formed by distinct stem *** studies have utilized techniques such as fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing to investigate the involvement of ssCs in bone development,homeostasis,and *** investigations have allowed researchers to map the lineage commitment trajectory of ssCs in different parts of the body and at different time ***,recent studies have shed light on the characteristics of ssCs in both physiological and pathological *** review focuses on discussing the spatiotemporal distribution of ssCs and enhancing our understanding of the diversity and plasticity of ssCs by summarizing recent discoveries.

关键词： skeletal stem cells bone development endochondral ossification intramembranous ossification lineage tracing

the utility of point-of-care ultrasound in the assessment of volume status in acute and critically ill patients

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World Journal of Emergency Medicine 2019年第4期10卷 232-238页

作者： Ali Pourmand matthew Pyle David Yamane Kazi Sumon Sarah E.Frasure Department of Emergency Medicine George Washington University School of Medicine and Health Sciences

BACKGROUND:Volume resuscitation has only been demonstrated to be effective in approximately fifty percent of *** remaining patients do not respond to volume resuscitation and may even develop adverse outcomes(such as acute pulmonary edema necessitating endotracheal intubation).We believe that point-of-care ultrasound is an excellent modality by which to adequately predict which patients may benefi t from volume *** RESOURCES:We performed a search using PubMed,Scopus,and *** following search terms were used:fluid responsiveness,ultrasound,non-invasive,hemodynamic,fluid challenge,and passive leg *** was given to clinical trials and review articles that were most relevant to the topic of assessing a patient’s cardiovascular ability to respond to intravenous fl uid administration using ***:Point-of-care ultrasound can be easily employed to measure the diameter and collapsibility of various large vessels including the inferior vena cava,common carotid artery,subclavian vein,internal jugular vein,and femoral *** parameters are closely related to dynamic measures of fluid responsiveness and can be used by providers to help guide fluid resuscitation in critically ill ***:Ultrasound in combination with passive leg raise is a non-invasive,costand time-effective modality that can be employed to assess volume status and response to fluid *** sonographic studies have focused on the evaluation of large veins such as the inferior vena cava,and internal jugular vein.A number of recently published studies also demonstrate the usefulness of evaluating large arteries to predict volume status.

关键词： Stroke volume Fluid responsiveness Ultrasound Non-invasive Hemodynamic

Predicting carbon nanotube forest attributes and mechanical properties using simulated images and deep learning

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npj Computational Materials 2021年第1期7卷 1214-1224页

作者： taher Hajilounezhad Rina Bao Kannappan Palaniappan Filiz Bunyak Prasad Calyam matthew R.Maschmann Mechanical&Aerospace Engineering University of MissouriColumbiaMOUSA Electrical Engineering and Computer Science University of MissouriColumbiaMOUSA

Understanding and controlling the self-assembly of vertically oriented carbon nanotube(CNt)forests is essential for realizing their potential in myriad *** governing process–structure–property mechanisms are poorly understood,and the processing parameter space is far too vast to exhaustively explore *** overcome these limitations by using a physics-based simulation as a high-throughput virtual laboratory and image-based machine learning to relate CNt forest synthesis attributes to their mechanical *** CNtNet,our image-based deep learning classifier module trained with synthetic imagery,combinations of CNt diameter,density,and population growth rate classes were labeled with an accuracy of>91%.the CNtNet regression module predicted CNt forest stiffness and buckling load properties with a lower root-mean-square error than that of a regression predictor based on CNt physical *** results demonstrate that image-based machine learning trained using only simulated imagery can distinguish subtle CNt forest morphological features to predict physical material properties with high *** paves the way to incorporate scanning electron microscope imagery for high-throughput material discovery.

关键词： carbon properties overcome