检索结果-南通市图书馆

Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity

引用

Eye and Vision 2021年第3期8卷 203-213页

作者： Robert Herber Lutz E.Pillunat frederik raiskup Department of Ophthalmology University Hospital Carl Gustav CarusUniversitätsklinikum Carl Gustav Carus an der Technischen Universität DresdenFetscherstraße 74TU 01307 DresdenGermany

Background:To investigate machine-learning(ML)algorithms to differentiate corneal biomechanical properties between different topographical stages of keratoconus(KC)by dynamic Scheimpflug tonometry(CST,Corvis ST,Oculus,Wetzlar,Germany).In the following,ML models were used to predict the severity in a training and validation ***:Three hundred and eighteen keratoconic and one hundred sixteen healthy eyes were included in this monocentric and cross-sectional pilot *** corneal response(DCR)and corneal thickness related(pachymetric)parameters from CST were chosen by appropriated selection techniques to develop a ML *** stage of KC was determined by the topographical keratoconus classification system(TKC,Pentacam,Oculus).Patients who were classified as TKC 1,TKC 2 and TKC 3 were assigned to subgroup mild,moderate,and advanced *** patients were classified as TKC 1-2,TKC 2-3 or TKC 3-4,they were assigned to subgroups according to the normative range of further corneal indices(index of surface variance,keratoconus index and minimum radius).Patients classified as TKC 4 were not included in this study due to the limited amount of *** discriminant analysis(LDA)and random forest(RF)algorithms were used to develop the classification *** were divided into training(70%of cases)and validation(30%of cases)***:LDA model predicted healthy,mild,moderate,and advanced KC eyes with a sensitivity(S_(n))/specificity(S_(p))of 82%/97%,73%/81%,62%/83%and 68%/95%from a validation dataset,*** the RF model,a S_(n)/S_(p) of 91%/94%,80%/90%,63%/87%,72%/95%could be reached for predicting healthy,mild,moderate,and advanced KC eyes,*** overall accuracy of LDA and RF was 71%and 78%,*** accuracy for KC detection including all subgroups of KC severity was 93%in both ***:The RF model showed good accuracy in predicting healthy eyes and various stages of *** accuracy was superior with respec

关键词： Artificial intelligence Corneal biomechanics Corvis ST Grading Keratoconus Machine learning

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long term results of accelerated 9mW corneal crosslinking for early progressive keratoconus:the Siena Eye-Cross Study 2

引用

Eye and Vision 2021年第1期8卷 154-165页

作者： Cosimo Mazzotta frederik raiskup Farhad Hafezi Emilio A Torres-Netto Ashraf Armia Balamoun Giuseppe Giannaccare Simone Alex Bagaglia Departmental Ophthalmology Unit USL Toscana Sud-EstCampostaggiaSienaItaly Siena Crosslinking Center 53035MonteriggioniSienaItaly Department of Ophthalmology C.G.Carus University HospitalDresdenGermany ELZA Institute DietikonSwitzerland Medical Faculty University of GenevaGenevaSwitzerland Roski Eye Institute University of Southern CaliforniaLos AngelesCAUSA Department of Ophthalmology University of WenzhouWenzhouChina Department of Ophthalmology Federal University of Sao PauloSao PauloBrazil Ashraf Armia Eye Clinic and Al Watany Eye Hospital Watany Research and Development CentreCairoEgypt Department of Ophthalmology University Magna Graecia of CatanzaroCatanzaroItaly

Purpose:To assess clinical results of the 9 mW/5.4 J/cm^(2) accelerated crosslinking(ACXL)in the treatment of progressive keratoconus(KC)over a span of 5 ***:The prospective open non-randomized interventional study(Siena Eye-Cross Study 2)included 156 eyes of 112 patients with early progressive KC undergoing the Epi-Off 9 mW/5.4 J/cm^(2) ACXL at the Siena Crosslinking Centre,*** mean age was 18.05±5.6 *** 20-min treatments were performed using the New KXL I(Avedro,Waltham,USA),10 min of 0.1%HPMC Riboflavin soaking(VibeX Rapid,Avedro,Waltham,USA)and 10 min of continuous-light UV-A *** distance visual acuity(UDVA),corrected distance visual acuity(CDVA),Kmax,coma,minimum corneal thickness(MCT),surface asymmetry index(SAI),endothelial cell count(ECC)were measured,and corneal OCT ***:UDVA and CDVA improved significantly at the 3rd(P=0.028),Δ+0.17 Snellen lines and 6th postoperative month,respectively(P<0.001),Δ+0.23 Snellen *** improved at the 6th postoperative month(P=0.03),Δ−1.49 diopters from the baseline ***,coma aberration value improved significantly(P=0.004).A mild temporary haze was recorded in 14.77%of patients without affecting visual acuity and without persistent *** OCT revealed a mean demarcation line depth at 332.6±33.6μ***:The 5-year results of Epi-Off 9 mW/5.4 J/cm^(2) ACXL demonstrated statistically significant improvements in UCVA and CDVA,corneal curvature and corneal higher-order aberrations which confers a long-term stability for progressive *** on the results of the Siena Eye-Cross Study 2,the 9 mW/5.4 J/cm^(2) ACXL is a candidate to be the natural evolution of Epi-Off CXL treatment for the management of early progressive corneal ectasia,and thus optimize clinic workflow.

关键词： Crosslinking Keratoconus Accelerated crosslinking Epi-off Dresden accelerated protocol 9mW crosslinking CXL ACXL

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：