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Buechel Pappas Resurfacing Shoulder Replacement: Evolution and over 40 Years of Clinical Experience

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Open journal of Orthopedics 2024年第5期14卷 218-228页

作者： frederick F. Buechel Michael j. Pappas Rutgers Nj Medical School Newark NJ USA South Mountain Orthopaedic Associates South Orange NJ USA New jersey Institute of Technology Newark NJ USA

Background: Early exploration of the semi constrained “Floating-Socket” total shoulder replacement (TSR) in 1974 led to a proliferation of various unconstrained designs that allowed resection or retention of the humeral head, depending upon the pathological process involved. Degenerative glenohumeral arthritis with mild to moderate involvement of subchondral bone allowed for a resurfacing option, while severe humeral head involvement required a partial or full humeral head replacement attached to an intramedullary stem for fixation. All components evolved from cemented to cementless application by 1982. The purpose of this paper is to describe the progression of Buechel-Pappas (B-P) shoulder replacement development from the early 1970’s in both cemented and cement less applications. Methods: Clinical evaluations of “Floating-Socket” TSR, followed by B-P stem-type, resurfacing types, bipolar-type and revision components, all of which comprise the B-P Shoulder Replacement System, were performed over a 49-year period. Results: “Floating-Socket” implants improved the results of simple, constrained ball-in-socket designs, but generally failed by glenoid component loosening in both chimpanzee and human applications. Unconstrained resurfacing-type components, both anatomical humeral head and full proximal humeral components, were quite successful, with minimal failures observed in long-term studies. Bipolar salvage implants, used for severe proximal deficiencies, revisions and massive rotator cuff arthropathy, were also very successful;providing overhead range of motion in many patients. Conclusions: Resurfacing hemiarthroplasty, in patients with intact or repairable rotator cuff mechanisms, gave the most satisfactory results and were the least technically complicated to perform, requiring minimal instrumentation. Resurfacing of full proximal humeral deficiencies, using femoral resurfacing components, gave similar clinical results to more complex semi-constrained devices,

关键词： Total Shoulder Replacement Resurfacing Shoulder Replacement

“国际中文教育‘电写转型’必要性与紧迫性”多人谈

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云南师范大学学报（对外汉语教学与研究版） 2024年第5期22卷 20-30页

作者：高正远莫大伟 frederick j.Poolea Liz Carter 密歇根州立大学美国密歇根州48824 首都师范大学北京100089 瓦萨学院美国纽约州12604

引言近几年来,“电写”(即“电子书写”,亦称“E-writing”)已成为国际中文教育界的热门课题之一。虽然迄今为止,业界学者和教师们对电写的认知和接受程度不尽相同,但无论是在国际研讨会议还是在相关的实证研究与教学实验中,电写无疑是... 详细信息

引言近几年来,“电写”(即“电子书写”,亦称“E-writing”)已成为国际中文教育界的热门课题之一。虽然迄今为止,业界学者和教师们对电写的认知和接受程度不尽相同,但无论是在国际研讨会议还是在相关的实证研究与教学实验中,电写无疑是中文教学界正在探讨、验证和争论的新型教学模式之一。

关键词：中文教育中文教学教学实验电子书写必要性与紧迫性接受程度实证研究新型教学模式

Hepatopancreatoduodenectomy for metastatic duodenal gastrointestinal stromal tumor

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Hepatobiliary & Pancreatic Diseases International 2006年第1期5卷 147-150页

作者： Charalabos Stratopoulos Zahir Soonawalla juan Piris Peter j friend Nuffield Department of Surgery and the Department of Cellular Pathology

BACKGROUND: Duodenal gastrointestinal stromal tumors, which are rare, comprise 3%-5% of all gastrointestinal stromai tumors. We present a case of a metastatic duodenal gastrointestinal stromal tumor that was successfully treated by simultaneous tight hemihepatectomy and pancreaticoduodenectomy. METHODS: A 50-year-old woman was admitted to our department for the treatment of a possible metastatic duodenal gastrointestinal stromal tumor (GIST). At laparotomy a large duodenal tumor was found displacing the head of the pancreas. A 3 cm in diameter lesion in the posterior aspect of segment Ⅷ of the liver was also noted. Simultaneous right hepatectomy and pancreaticoduodenectomy were performed. RESULTS: Histological examination revealed a high grade metastatic duodenal GIST strongly positive for c-kit, CD34, and vimentin. The patient had no additional therapy. A follow-up of 21 months showed that the patient is very well and there is no evidence of recurrent diseases. CONCLUSIONS: Malignant stromai tumors of the duodenum are rarely encountered. They are usually slow growing, and may be amenable to curative surgery, even after occurrence of metastases. Resection of localized liver metastasis is still advocated when feasible, since imatinib does not provide a complete or long-term response. Combined surgical resection is an efficacious treatment for patients with metastatic duodenal gastrointestinal stromal tumor.

关键词： duodenal neoplasms hepatectomy pancreaticoduodenectomy liver metastasis gastrointestinal stromal tumor

Designing Cyclopentapeptide Inhibitor of Neuraminidase H5N1 Virus Through Molecular and Pharmacology Simulations

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Tsinghua Science and Technology 2015年第5期20卷 431-440页

作者： Usman Sumo friend Tambunan Arli Aditya Parikesit Yossy Carolina Unadi Djati Kerami Bioinformatics Research Group Department of ChemistryFaculty of Mathematics and ScienceUniversity of Indonesia Mathematics Computation Research Group Department of MathematicsFaculty of Mathematics and ScienceUniversity of Indonesia

Highly Pathogenic Avian Influenza（HPAI） H5N1 has attracted much attention as a potential pandemic virus in humans, which makes death inevitable in humans. Neuraminidase（NA） has an important role in viral replication. Thus, it is an attractive target when designing anti-influenza virus drug. However, evolving viruses cause some anti-viral drugs to be ineffective, as they show resistance to them. Selection of peptides as drug candidates is important for the peptide-receptor activity and good selectivity. Cyclic bonds in the peptide ligand design aim to improve the stability of the system and remove the obstacles in drug metabolism. The design is based on the polarity of the ligand and amino acid residues in the active site of NA. The results are 4200 cyclic pentapeptides as potential lead compounds. Docking simulations were conducted using MOE 2008.10 and were screened based on the value of the binding energy（？Gbinding）. ADME-Tox prediction assay was conducted on the selected ***- and inter-molecular interactions, as well as changes in the form of bonds, were tested by molecular dynamics simulations at temperatures of 310 K and 312 K. The results of the docking simulations and toxicity prediction assay show that there are two ligands that have a residual interaction with the target protein： CLDRC and CIWRC. These two ligands have ？Gbindingvalues of –40.5854 and –39.9721 kcal/mol（1 kcal/mol = 4.18 k j/mol）. These ligands are prone to be mutagenic and carcinogenic, and they have a good oral bioavailability. The results show that the molecular dynamics of both ligand CLDRC and CIWRC are more feasible at the temperature of 312 K. At the end,both CIWRC and CLDRC ligands can be used as the drug candidates against H5N1 virus.

关键词： H5N1 neuraminidase cyclical pentapeptide molecular docking molecular dynamics

Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle

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journal of Animal Science and Biotechnology 2019年第4期10卷 1101-1107页

作者： Ibukun M.Ogunade jerusha Lay Kenneth Andries Christina j.Mc Manus frederick Bebe College of Agriculture Communities and the Environment Kentucky State University

Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated Holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina Hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, ***, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as Megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate < 0.01). Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation analysis of the DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate bindi

关键词： Functional potential Live yeast Rumen

Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep

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journal of Animal Science and Biotechnology 2015年第2期6卷 222-229页

作者： Laura D Brown Stephanie R Thorn Alex Cheung jinny R Lavezzi frederick C Battaglia Paul j Rozance Perinatal Research Center Division of Neonatology Department of Pediatrics University of Colorado Denver School of Medicine Center for Women’s Health Research University of Colorado Denver School of Medicine

Background： The importance of non-glucose carbohydrates, especially mannose and inositol, for normal development is increasingly recognized. Whether pregnancies complicated by abnormal glucose transfer to the fetus also affect the regulation of non-glucose carbohydrates is unknown. In pregnant sheep, maternal insulin infusions were used to reduce glucose supply to the fetus for both short （2-wk） and long （8-wk） durations to test the hypothesis that a maternal insulin infusion would suppress fetal mannose and inositol concentrations. We also used direct fetal insulin infusions （1-wk hyperinsulinemic-isoglycemic clamp） to determine the relative importance of fetal glucose and insulin for regulating non-glucose carbohydrates. Results： A maternal insulin infusion resulted in lower maternal （50%, P 〈 0.01） and fetal （35-45%, P 〈 0.01） mannose concentrations, which were highly correlated （r^2 = 0.69, P 〈 0.01）. A fetal insulin infusion resulted in a 50% reduction of fetal mannose （P 〈 0.05）. Neither maternal nor fetal plasma inositol changed with exogenous insulin infusions. Additionally, maternal insulin infusion resulted in lower fetal sorbitol and fructose （P 〈 0.01）. Conclusions： Chronically decreased glucose supply to the fetus as well as fetal hyperinsulinemia both reduce fetal non-glucose carbohydrates. Given the role of these carbohydrates in protein glycosylation and lipid production, more research on their metabolism in pregnancies complicated by abnormal glucose metabolism is clearly warranted.

关键词： Fructose Glucose Inositol Insulin Mannose Pregnancy

OCCURRENCE OF THE TERRESTRIAL AMPHIPOD TALITROIDES TOPITOTUM (BURT) ON HONG KONG ISLAND

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Zoological Systematics 1985年第1期 30-33页

作者： j.A.friend P.K.S.LAM Department of Zoology University of Hong Kong Western Australian Wildlife Research Centre

Amongst invertebrates from soil and leafmould recently collected in the grounds ofthe University of Hong Kong are specimens of a land-dwelling amphipod. This is thefirst published record of a terrestrial amphipod, or landhopper, from the Chinese re-gion. It is quite likely that further species exist in China, so we would like to draw theattention of Chinese biologists to the possibility that amphipods may be found in soilor leaf litter in this region. Talitroides topitotum (Burt) (figs. 1, 2).Talitrus (Talitropsis topitotum Burt 1934

关键词： ON HONG KONG ISLAND BURT OCCURRENCE OF THE TERRESTRIAL AMPHIPOD TALITROIDES TOPITOTUM

Disaster Risk Management Through the Design Safe Cyberinfrastructure

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International journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： jean-Paul Pinelli Maria Esteva Ellen M.Rathje David Roueche Scott j.Brandenberg Gilberto Mosqueda jamie Padgett frederick Haan Department of Mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

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如何为高校开放获取政策及服务制订方案

图书情报工作动态 2010年第5期 6-9页

作者： frederick friend Alma Swan 金学慧（编译）

1 OA开放获取（Opeia Access，OA）是一种及时免费获取同行评审文献的一种文献获取方式。虽然OA正在向图书章节、专题著作和科研数据等内容延伸，但根据定义，其适用对象主要还是期刊论文和同行评审的会议论文。本文阐述了怎样为一所大... 详细信息

1 OA开放获取（Opeia Access，OA）是一种及时免费获取同行评审文献的一种文献获取方式。虽然OA正在向图书章节、专题著作和科研数据等内容延伸，但根据定义，其适用对象主要还是期刊论文和同行评审的会议论文。本文阐述了怎样为一所大学的OA成本收益建模。

关键词：开放获取服务制文献获取方式政策高校 Access 同行评审免费获取