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Disaster Risk Management Th.ough.th. Design Safe Cyberinfrastructure

International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-Paul Pinelli Maria Esteva Ellen M.Rath.e David Rouech. Scott J.Brandenberg Gilberto Mosqueda Jamie Padgett frederick h.an Department of Mech.nical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses th. ch.llenges of supporting integrative data-driven research.in natural h.zards *** is an end-to-end data management,communications,and analysis platform wh.re users collect,generate,analyze,curate,and publish.large data sets from a variety of sources,including experiments,simulations,field research.and post-disaster *** ach.eves key objectives th.ough.(1)integration with.h.gh.performance and cloud-computing resources to support th. computational needs of th. regional risk assessment community;(2)th. possibility to curate and publish.diverse data structures emph.sizing relationsh.ps and understandability;and(3)facilitation of real time communications during natural h.zards events and disasters for data and information *** resultant services and tools sh.rten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of th. *** summarizes its design principles,arch.tecture,and *** focus is on case studies to sh.w th. impact of Design Safe on th. disaster risk *** Next Generation Liquefaction project collects and standardizes case h.stories of earth.uake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with.th. *** can correlate in Design Safe building dynamic ch.racteristics based on data from building sensors,with.observed damage based on ground motion *** groups upload,curate,and publish.wind,seismic,and coastal damage data th.y gath.r during field reconnaissance missions,so th.se datasets are available sh.rtly after a *** a part of th. education and community outreach.efforts of Design Safe,training materials and collaboration space are also offered to th. disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural h.zard data management

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Activation of Defense Response Path.ays by OGs and Fig22 Elicitors in Arabidopsis Seedlings

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Molecular Plant 2008年第3期1卷 423-445页

作者： Carine Denoux Roberta Galletti Nicole Mammarella Suresh.Gopalan Danièle Werck Giulia De Lorenzo Simone Ferrari frederick M. Ausubel Julia Dewdney Department of Genetics Harvard Medical School and Department of Molecular Biology Massachusetts General Hospital 185 Cambridge St Simches 7700Boston MA 02114 USA Institut de Biologie Moleculaire des Plantes CNRS Universite Louis Pasteur. Strasbourg France Dipartimento di Biologia Vegetale University di Roma 'La Sapienza' Piazzale Aldo Moro 5 00185 Rome. Italy

We carried out transcriptional profiling analysis in 10-d-old Arabidopsis th.liana seedlings treated with.oligogalacturonides （OGs）, oligosacch.rides derived from th. plant cell wall, or th. bacterial flagellin peptide Fig22, general elicitors of th. basal defense response in plants. Alth.ugh.detected by different receptors, both.OGs and Fig22 trigger a fast and transient response th.t is both.similar and compreh.nsive, and ch.racterized by activation of early stages of multiple defense signaling path.ays, particularly JA-associated processes. h.wever, th. response to Fig22 is stronger in both.th. number of genes differentially expressed and th. amplitude of ch.nge. Th. magnitude of induction of individual genes is in both.cases dose-dependent, but, even at very h.gh.concentrations, OGs do not induce a response th.t is as compreh.nsive as th.t seen with.Fig22. Wh.le h.gh.doses of eith.r microbe-associated molecular pattern （MAMP） elicit a late response th.t includes activation of senescence processes, SA-dependent secretory path.ay genes and PR1 expres- sion are substantially induced only by Fig22. Th.se results suggest a lower th.esh.ld for activation of early responses th.n for sustained or SA-mediated late defenses. Expression patterns of amino-cyclopropane-carboxylate synth.se genes also implicate eth.lene biosynth.sis in regulation of th. late innate immune response.

关键词： Fig22 唇形科种子活化作用

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Quality evaluation of synth.tic quorum sensing peptides used in R&D

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Journal of Ph.rmaceutical Analysis 2015年第3期5卷 169-181页

作者： frederick Verbeke Evelien Wynendaele Sarah.Braet Matth.as D'h.ndt Bart De Spiegeleer Drug Quality and Registration(DruQuaR) Group Faculty of Pharmaceutical SciencesGhent University

Peptides are becoming an important class of molecules in th. ph.rmaceutical field. Closely related peptide-impurities in peptides are inh.rent to th. synth.sis approach.and h.ve demonstrated to potentially mask biomedical experimental results. Quorum sensing peptides are attracting h.gh.interest in R＆D and th.refore a representative set of quorum sensing peptides, with.a requested purity of at least 95.0%, was evaluated for th.ir purity and nature of related impurities. In-h.use quality control （QC） revealed a large discrepancy between th. purity levels as stated on th. supplier＇s certificate of analysis and our QC results. By using our QC analysis flowch.rt, we demonstrated th.t only 44.0% of th. peptides met th. required purity. Th. main compound of one sample was even found to h.ve a different structure compared to th. desired peptide. We also found th.t th. majority of th. related impurities were lacking amino acid（s） in th. desired peptide sequence. Relying on th. certificates of analysis as provided by th. supplier migh. h.ve serious consequences for peptide research. and peptide-research.rs sh.uld implement and maintain a th.rough.in-h.use QC.

关键词： Quorum sensing peptides Quality Impurity profiling

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基于PFC2D的砂土原生各向异性微观机理数值试验

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岩土工程学报 2017年第3期39卷 518-524页

作者：张坤勇李威罗兴军 Ch.RKLEY Nai frederick 河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 江苏省岩土工程技术工程研究中心(河海大学) 江苏南京210098 中国建筑西南勘察设计研究院有限公司四川成都610084

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增... 详细信息

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增量,得到不同沉积条件下不同加载方向上砂土试样宏观应力应变曲线和力学参数。数值试验结果显示,重力沉积步数对颗粒微观长轴定向排列、平均配位数有显著影响;初步建立了砂土微观结构变化和宏观应力应变曲线及力学参数的联系;分析了砂土试样表现出的宏观原生各向异性力学特性与内部颗粒结构的关系。

关键词：离散元砂土原生各向异性微观结构

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Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)

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Genomics, Proteomics & Bioinformatics 2003年第4期1卷 247-262页

作者： Raymond Kin h. h.i Raymond Tsz Yeung Wong Ch. Wai Yip frederick Ch. Ch.ng Leung Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.

Th. sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted th. establish.ent of a global scientific network subsuming most of th. traditional rivalries in th. competitive field of virology. With.n month. of th. SARS outbreak, collaborative work revealed th. identity of th. disastrous path.gen as SARS-associated coronavirus (SARS-CoV). h.wever, alth.ugh.th. rapid identifi-

关键词： severe acute respiratory syndrome SARS-CoV genome ph.logenetics h.man leukocyte antigen (h.A) system molecular epidemiology

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Applicability of Mean Field Approximation to Numerical Experiments of Th.rmal Convection during th. Cooling Period of Lake Biwa

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Journal of Energy and Power Engineering 2013年第12期7卷 2220-2226页

作者： Takash. h.soda frederick Malembeka Department of Urban Management Graduate School of Engineering Kyoto Universi~ Kyoto 615-8540 Japan Department of Civil Engineering Arusha Technical College Arusha 296 Tanzania

Th.s paper describes th. applicability of a stoch.stic model to th. numerical experiments of th.rmal convection carried out under th. condition of th. north.rn part of Lake Biwa, Sh.ga Prefecture, Japan. It was sh.wn in th. previous study th.t th. temporal ch.nges of vertical water temperature distributions during th. cooling period between September and February can be reproduced by a simple 3D-CFD model. It was also pointed out th.t th. spatial distributions of cooled water body sinking to th. bottom due to water surface cooling represent similar features of forest gap distribution, wh.ch.can be clarified by a stoch.stic model. Th. basic features of numerical experiments on th.rmal convection such.as th. spatial distribution of cooled water body are firstly sh.wn with.several cooling rates at water surface. Th.n, a stoch.stic model, wh.ch.was originally introduced to explain forest gap dynamics, is sh.wn with.its MFA （mean field approximation） as first approximation of stoch.stic model. It is pointed out th.ough.th. comparison of th.oretical results by MFA with.tuned model constants to numerical experiments th.t MFA with.some refinement can be applicable to reproduce th. basic features of simulated results to some extent, alth.ugh.furth.r investigations are required to clarify th. applicability of th. model to more detailed mech.nism of th.rmal convection such.as size distribution of cooled water body, ph.se ch.nge of flow pattern, etc..

关键词： Th.rmal convection lake h.drodynamics Lake Biwa stoch.stic model.

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Mapping of QTLs and candidate genes associated with.multiple ph.notypic traits for h.anglongbing tolerance in citrus

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h.rticultural Plant Journal 2023年第4期9卷 705-719页

作者： Ming h.ang Mikeal L. Roose Qibin Yu Ed Stover David G. h.ll Zh.nao Deng frederick G.Gmitter Jr. Key Laboratory of Plant h.rmones and Development Regulation of Ch.ngqing College of Life SciencesChongqing UniversityChongqing 401331China Citrus Research.and Education Center University of FloridaLake AlfredFL 33850United States Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521United States United States h.rticultural Research.Laboratory Agricultural Research ServiceUnited States Department of AgricultureFort PierceFL 34945United States Gulf Coast Research.and Education Center University of FloridaWimaumaFL 33598United States

h.anglongbing(h.B)is th. most devastating disease for citrus *** Liberibacter asiaticus(C Las),vectored by Asian citrus psyllid(ACP,Diaph.rina citri Kuwayama),is th. most common path.gen causing th. *** citrus varieties are h.gh.y susceptible to h.B,wh.reas trifoliate orange(Poncirus trifoliata)is considered h.gh.y tolerant to *** F1 segregating population and th.ir parent trifoliate orange and sweet orange,wh.ch.h.d been exposed to intense h.B pressure for th.ee years,was evaluated for disease symptoms,ACP colonization,C Las titer and tree vigor repeatedly for two to th.ee *** orange and sweet orange sh.wed significant differences for most of th. ph.notypic traits,and th. F1 population exh.bited a large variation.A h.gh.density SNP-based genetic map with.1402 markers was constructed for trifoliate orange,wh.ch.exh.bited h.gh.synteny and h.gh.coverage of its reference genome.A total of 26 quantitative trait locus(QTLs)were identified in four linkage groups LG-t6,LG-t7,LG-t8 and LG-t9,of wh.ch.four QTL clusters exh.bit a clear co-localization of QTLs associated with.different *** genome-wide analysis of gene expression in response to C Las infection in‘Flying Dragon’and‘Larger-Flower DPI-50-7’trifoliate orange,85 differentially expressed genes were found located with.n th. QTL *** th.m,seven genes were classified as defense or immunity protein wh.ch.exh.bited th. h.gh.st transcriptional ch.nge after C Las *** results indicate a quantitative genetic nature of h.B tolerance and identified candidate genes th.t sh.uld be valuable for search.ng for genetic solutions to h.B th.ough.breeding or genetic engineering.

关键词： Candidatus liberibacter QTL mapping Ph.notyping F1 population Poncirus Citrus

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Resistance switch.ng for RRAM applications

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Science Ch.na(Information Sciences) 2011年第5期54卷 1073-1086页

作者： Ch.N frederick T. LEE h.ngYuan h.U YenYa Ch.N PangSh.u LIU Wenh.ing TSAI Ch.nh.n Sh.U Sh.h.h.uan TSAI MingJinn Nanoelectronic Tech.ology Division Electronics and Optoelectronics Research Laboratories Industrial Technology Research Institute (ITRI) Department of Ch.mical and Materials Engineering Ming Shin University of Science and Technology

Resistive random access memory (RRAM or ReRAM) is a non-volatile memory (NVM) tech.ology th.t consumes minimal energy wh.le offering sub-nanosecond switch.ng. In addition, th. data stability against h.gh.temperature and cycling wear is very robust, allowing new NVM applications in a variety of markets (au- tomotive, embedded, storage, RAM). Based on sudden conduction th.ough.oxide insulators, th. ch.racteristics of RRAM tech.ology h.ve still yet to be fully described. In th.s paper, we present our current understanding of th.s very promising tech.ology.

关键词： random access memory storage oxide breakdown oxygen vacancies

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Cementless Buech.l-Pappas Resurfacing Total h.p Replacement: A 45-Year Personal Journey to Overcome Wear, Osteolysis, Loosening and Femoral Neck Fractures

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Open Journal of Orth.pedics 2023年第10期13卷 435-442页

作者： frederick F. Buech.l Sr Rutgers NJ Medical Sch.ol Newark USA South.Mountain Orth.paedic Associates South Orange USA

Background: Resurfacing-type total h.p replacement (Th.) h.s been successfully developed over th. past 50 years th.ough.collaborative efforts between engineers and surgeons. Much.of th. development was pursued by individuals or groups, each.of wh.ch.participated in adding furth.r refinements to th. implants, instruments and surgical procedures, th.s minimizing th. serious problems of wear, osteolysis, loosening and femoral neck fractures. Th. purpose of th.s study is to explore th. development process to optimize th. resurfacing total h.p replacement into its current application. Meth.ds: In th. early 1980s, cementless resurfacing implants were developed using “th.n sh.ll” tech.ology to minimize bony resection of th. acetabulum and femoral h.ad. Femoral components utilized sh.rt, non-porous coated, tapered straigh. stems to reduce sh.ar stresses in th. femoral neck to prevent fractures and stress sh.elding, wh.le mech.nically stabilizing and aligning th. components. Acetabular components were anatomically designed to be recessed inside bony borders to avoid neck-cup impingement and loosening. Initially, ultrah.gh.molecular weigh. polyeth.lene (Uh.WPE) was used as a bearing, but due to h.gh.levels of wear and osteolysis, it was replaced by wear-resistant h.gh.y crossed-linked polyeth.lene (h.LPE) in 2008. Results: Use of h.LPE as a bearing material in both.Co-Cr-Mo and titanium nitride (TiN) ceramic-coated resurfacing implants h.s led to excellent patient outcomes for more th.n 10 years. In clinical studies, 87% of patients with.bilateral total h.p replacements prefer th.ir resurfacing-type total h.p over th.ir stem-type total h.p. Th. auth.r’s own personal resurfacing total h.ps, now at 8 and 5 years, respectively, provide “normal” function and no radiograph.c osteolysis. Conclusions: After 45 years of active evaluation, including mech.nical design considerations, prosth.tic design development, clinical and radiograph.c analysis of results, as well as availability o

关键词： Resurfacing Total h.p Replacement

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怀疑主义与自然主义及其变种

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2018年

作者： (英)P. F.斯特劳森

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