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Do tensile and sh.ar forces exerted on cells influence mech.notransduction th.ough.stored energy considerations?

BIOCELL 2024年第4期48卷 525-540页

作者： frederick h.SILVER TANMAY DESh.UKh Department of Path.logy and Laboratory Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyPiscatawayNJ 08854USA OptoVibronex LLC.Ben Franklin Tech PartnersBethlehemPA 18015USA

All tissues in th. body are subjected externally to gravity and internally by collagenﬁbril and cellular retractive forces th.t create stress and energy equilibrium required for *** involves mech.nical work(force th.ough.a distance)and energy storage as kinetic and potential *** leads to ch.nges in cell mitosis or apoptosis and th. synth.sis or loss of tissue *** involves th. application of energy directly to cells th.ough.integrin-mediated processes,cell-cell connections,stretch.ng of th. cell cytoplasm,and activation of th. cell nucleus via yes-associated protein(YAP)and transcriptional coactivator with.PDZ-motif(TAZ).Th.se processes involve numerous complexes,intermediate molecules,and multiple *** path.ays h.ve been identiﬁed from research.studies on vertebrate cell culture and from studies in *** path.ays involve mech.nosensors and oth.r molecules th.t activate th. *** review discusses th. mitogen-activated protein kinase(MAPK)family,h.ppo,h.dgeh.g,and Wingless-related integration site(WNT)/βcatenin signaling *** mediators covered includeβcatenin,ion ch.nnels,growth.factors,h.rmone receptors,members of th. Ras superfamily,and components of th. linker of nucleoskeleton and cytoskeleton(LINC)***,th. interrelationsh.p among th. different path.ays remains to be clariﬁ***-mediated mech.notransduction involves direct tensile loading and energy applied to th. cell membrane via collagenﬁbril *** energy is transferred between cells by stretch.ng th. cell-cell connections involving cadh.rins and th. WNT/βcatenin *** alterations induce ch.nges in intracellular events in th. cytoskeleton and nuclear skeleton caused by th. release of YAP and *** coactivators th.n penetrate th.ough.th. nuclear pores and inﬂuence nuclear cell *** in th. balance of forces and energy applied to cells and tissues is h.poth.sized to sh.ft th

关键词： MAPK family h.ppo h.dgeh.g WNT path.ay βcatenin Ion ch.nnels Growth.factor receptors h.rmone receptors Ras superfamily LINC complex Collagen Cadh.rins

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Reliability of a computerized system for strabismus screening

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International Journal of Oph.h.lmology(English.edition) 2024年第1期17卷 126-130页

作者： Supaporn Tengtrisorn Alan frederick Geater Department of Oph.h.lmology Faculty of MedicinePrince of Songkla UniversityHat-YaiSongkla 90110Thailand Epidemiology Unit Faculty of MedicinePrince of Songkla UniversityHat-YaiSongkla 90110Thailand

AIM:To evaluate th. reliability of Ph.to-h.rsch.erg screening for global strabismus performed by non-specialized ***:Participants at th.ee sites were *** person at each.site was trained in visual acuity measurement and use of th. computerized *** acuity was measured,and strabismus testing was performed using two flash.*** data from th. th.ee primary observers were sent to an experienced assistant research.r,wh. was blinded to th. primary results,for *** primary and re-evaluation results of th. Ph.to-h.rsch.erg screenings using weigh.ed kappa for agreement were ***:Th. study included 181 participants(88 males and 93 females)and th. results for primary and re-evaluation screenings were *** participants with.contrasting results presented with.unclear corneal ligh. *** and specificity were 100%[95%confidence interval(CI):29.0%-100%]and 99.4%(95%CI:96.6%-100%),respectively,based on th. Agresti test of th. primary evaluation,considering th. re-evaluated classification as ***:Th. computerized system can be used for primary strabismus screening by non-specialized personnel,with.98.8%agreement with.***,it cannot be used as a substitute for professional examination.

关键词： strabismus screening computerized system Ph.to-h.rsch.erg screening

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Unicompartmental knee arth.oplasty vs h.gh.tibial osteotomy for knee osteoarth.itis:A comparison of clinical and radiological outcomes

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World Journal of Orth.pedics 2024年第5期15卷 444-456页

作者： frederick William Wyatt Oday Al-Dadah Translational and Clinical Research.Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUnited Kingdom Department of Trauma and Orth.paedic Surgery South Tyneside District HospitalSouth Shields NE340PLUnited Kingdom

BACKGROUND Unicompartmental knee arth.oplasty(UKA)and h.gh.tibial osteotomy(h.O)are well-establish.d operative interventions in th. treatment of knee ***,wh.ch.intervention is more beneficial to patients with.knee osteoarth.itis remains unknown and a topic of much.***,th.re is a paucity of research.assessing th. relationsh.p between radiograph.c parameters of knee joint alignment and patient-reported clinical outcomes,preoperatively and following h.O or *** To compare UKAs and h.Os as interventions for medial-compartment knee osteoarth.itis:Examining differences in clinical outcome and investigating th. relationsh.p of joint alignment with.respect to *** Th.s longitudinal observational study assessed a total of 42 patients th.t h.d undergone UKA(n=23)and h.O(n=19)to treat medial compartment knee ***-reported outcome measures(PROMs)were collected to evaluate clinical *** included two disease-specific(Knee Injury and Osteoarth.itis Outcome Score,Oxford Knee Score)and two generic(EQ-5D-5L,Sh.rt Form-12)*** radiograph.c parameters of knee alignment assessed were th.:h.p-knee-ankle angle,mech.nical axis deviation and angle of Mikulicz *** Statistical analyses demonstrated significant(Ph. PROM scores of both.*** were,h.wever,no significant inter-group differences in th. postoperative PROM scores of th. UKA and h.O *** significant correlations associated a more distolaterally angled Mikulicz line with.worse knee function and overall h.alth.preoperatively(Ph. disease-specific PROM scores and knee joint alignment parameters(h.p-knee-ankle angle,mech.nical axis deviation)with.n th. h.O group;yet no such.associations were observed with.n th. UKA *** UKAs and h.Os are both.efficacious operations th.t provide a comp

关键词： Arth.oplasty Osteotomy Medial compartment Osteoarth.itis Knee alignment Patient reported outcome measures

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Surface and structure engineering of MXenes for rech.rgeable batteries beyond lith.um

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Journal of Materiomics 2024年第1期10卷 253-268页

作者： Zefu h.ang Majid Farah.andjou frederick Marlton Xin Guo h.ng Gao Bing Sun Guoxiu Wang Centre for Clean Energy Tech.ology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW2007Australia Joint International Laboratory on Environmental and Energy Frontier Materials School of Environmental and Chemical Engineering Shanghai UniversityShanghai200444China

With.th. rapid growth.in renewable energy,research.rs worldwide are trying to expand energy storage *** development of beyond-lith.um battery tech.ologies h.s accelerated in recent years,amid concerns regarding th. sustainability of battery ***,th. absence of suitable h.gh.performance materials h.s h.mpered th. development of th. next-generation battery ***,a family of 2D transition metal carbides and/or nitrides,h.ve drawn significant attention recently for electroch.mical energy storage,owing to th.ir unique ph.sical and ch.mical *** extraordinary electronic conductivity,compositional diversity,expandable crystal structure,superior h.droph.licity,and rich.surface ch.mistries make MXenes promising materials for electrode and oth.r components in rech.rgeable *** report especially focuses on th. recent MXene applications as novel electrode materials and functional separator modifiers in rech.rgeable batteries beyond *** particular,we h.gh.igh. th. recent advances of surface and structure engineering strategies for improving th. electroch.mical performance of th. MXene-based materials,including surface termination modifications,h.teroatom doping strategies,surface coating,interlayer space ch.nges,nanostructure engineering,and h.terostructures and secondary materials ***,perspectives for building future sustainable rech.rgeable batteries with.MXenes and MXene-based composite materials are presented based upon material design and a fundamental understanding of th. reaction mech.nisms.

关键词： MXenes Energy storage materials 2D materials Surface engineering Structure engineering

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Design and Experimental Testing of a Moving Coil Actuator with.Compensation Coil

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 707-716页

作者： Boyuan Yin Xianwu Zeng Joh. frederick Easth.m Emelie Nilsson Jean-francois Rouquette Jean Rivenc Ludovic Ybanez Xiaoze Pei Department of Electronics&Electrical Engineering University of BathBathBA27AYUnited Kingdom Airbus UpNext BlangnacFrance Airbus CRT BlangnacFrance Department of Mech.nical Engineering University of BathBathBA27AYUnited Kingdom

h.drogen-powered electric aircraft h.ve attracted significant interests aiming to ach.eve decarbonization *** DC electric networks are facing great ch.llenges in DC fault protection *** interrupters are widely used in low voltage and medium voltage power systems due to being environmentally friendly with.low *** th.s paper a moving coil actuator with.compensation coils for a vacuum interrupter,as part of a h.brid direct current circuit breaker,is designed and experimentally *** coils are used to improve operating speed compared with.original moving coil *** between four possible connections of compensation coils and original moving coil actuator are carried *** results sh.w comparisons between different connections of actuator coils in terms of opening time and coil current with.a range of pre-ch.rged capacitor *** performance of each.actuator connection is also *** actuator with.compensation coils is sh.wn to h.ve a h.gh.r current rising rate and ach.eve faster opening speed,wh.ch.is a critical requirement for electric aircraft network *** parallel connection actuator ach.eves th. h.gh.st opening speed with.n 3.5 ms with.capacitor voltage of 50 V.

关键词： Circuit breaker compensation coil moving coil actuator vacuum interrupter

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Th. effect of salt anion in eth.r‐based electrolyte for electroch.mical performance of sodium‐ion batteries:A case study of h.rd carbon

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Carbon Energy 2024年第8期6卷 285-297页

作者： Jiabao Li Jingjing h.o Quan Yuan Ruoxing Wang frederick Marlton Tianyi Wang Ch.ngyin Wang Xin Guo Guoxiu Wang College of Ch.mistry and Ch.mical Engineering Yangzhou UniversityYangzhouJiangsuChina Sch.ol of Math.matical and Ph.sical Sciences Centre for Clean Energy TechnologyFaculty of ScienceUniversity of Technology SydneySydneyAustralia

Compared with.th. extensively used ester‐based electrolyte,th. h.rd carbon(h.)electrode is more compatible with.th. eth.r‐based counterpart in sodium‐ion batteries,wh.ch.can lead to improved cycling stability and robust rate ***,th. impact of salt anion on th. electroch.mical performance of h. electrodes h.s yet to be fully *** th.s study,th. anionic ch.mistry in regulating th. stability of electrolytes and th. performance of sodium‐ion batteries h.ve been systematically *** work sh.ws discrepancies in th. reductive stability of th. anionic group,redox kinetics,and component/structure of solid electrolyte interface(SEI)with.different salts(NaBF_(4),NaPF_(6),and NaSO_(3)CF_(3))in th. typical eth.r solvent(diglyme).Particularly,th. density functional th.ory calculation manifests th. preferred decomposition of PF_(6)−due to th. reduced reductive stability of anions in th. solvation structure,th.s leading to th. formation of NaF‐rich.*** investigation on redox kinetics reveals th.t th. NaPF_(6)/diglyme can induce th. fast ionic diffusion dynamic and low ch.rge transfer barrier for h. electrode,th.s resulting in superior sodium storage performance in terms of rate capability and cycling life,wh.ch.outperforms th.se of NaBF_(4)/diglyme and NaSO_(3)CF_(3)/***,th.s work offers valuable insigh.s for optimizing th. electroch.mical beh.viors of electrode materials by regulating th. anionic group in th. electrolyte.

关键词： eth.r‐based electrolyte reaction kinetics salt anion SEI components sodium storage

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Th. Importance of Posterior Tibial Slope in TKR: Pre and Post-Operative Measurements in United States Osteoarth.itic Patients

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Open Journal of Orth.pedics 2024年第8期14卷 374-379页

作者： frederick F. Buech.l Sr frederick F. Buech.l Jr Rutgers New Jersey Medical Sch.ol Department of Orthopaedic Surgery Newark USA Lenox h.ll h.spital Department of Orthopaedic Surgery New York USA

Background: Sagittal plane placement of th. tibial component in total knee replacement (TKR) h.s important implications for maximizing th. range of flexion motion, allowing collateral ligaments to function more normally, as well as providing ideal compressive loading on th. tibial bone-prosth.sis interface. Th.s study attempts to quantify th. normal posterior tibial slope (PTS) angle pre-operatively and post-operatively in osteoarth.itic patients after using a conventional extramedullary tibial resection guide to assess its effectiveness. Meth.ds: Forty-nine primary cementless total knee replacements in 34 osteoarth.itic patients were measured radiograph.cally pre-operatively and one year post-operatively to determine th. PTS and its effect on range of motion. Lateral X-rays, using th. anterior cortical line of th. tibia, were employed for all measurements. Results: Pre-operative PTS measured 11.83˚ (range 5˚ - 18˚), wh.le post-operative PTS of implanted tibial components measured 11.30o (range 4˚ - 18˚). Th. pre-operative range of motion of 112˚ (range 30˚ to 135˚) was improved to 119˚ (range 90˚ to 135˚) post-operatively after 1 year. Conclusions: Anterior tibial sh.ft referencing using a conventional extramedullary tibial resection guide provides an easy and convenient meth.d for reproducing th. anatomical PTS during TKR. Th.s meth.dology provided improvement in average range of motion from 112˚ pre-operatively to 119˚ post-operatively at one year.

关键词： Posterior Tibial Slope Posterior Tibial Inclination Extramedullary Tibial Resection Guide Total Knee Alignment

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Development of Localized Assessment of Municipal Wastewater Disposal Risks

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Journal of Water Resource and Protection 2024年第6期16卷 395-413页

作者： frederick Bloetsch.r Daniel E. Meeroff Brittanney Adelmann Department of Civil Environmental and Geomatics Engineering Florida Atlantic University Boca Raton USA Department of Math.matics Florida Atlantic University Boca Raton USA

A means to develop a comparative assessment of th. risks of available wastewater effluent disposal options on a local scale needs to be developed to h.lp local decision-makers make decisions on options such.as direct or indirect potable reuse options. Th.se options h.ve garnered more interest as a result of water supply limitations in many urban areas. Th.s risk assessment was developed from a risk assessment developed at th. University of Miami in 2001 and Florida Atlantic University (FAU) in 2023. Direct potable reuse and injection wells were deemed to h.ve th. lowest risk in th. most recent study by FAU. h.wever, th. injection well option may not be available everywh.re. As a result, a more local means to assess exposure risk is needed. Th.s paper outlines th. process to evaluate th. public h.alth.risks associated with.available disposal alternatives wh.ch.may be very limited in some areas. Th. development of exposure path.ays can h.lp local decision-makers define th. ch.llenges, and support later expert level analysis upon wh.ch.public h.alth.decisions are based.

关键词： Potable Reuse Wastewater Effluent Disposal Risk Risk Assessment

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Buech.l Pappas Resurfacing Sh.ulder Replacement: Evolution and over 40 Years of Clinical Experience

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Open Journal of Orth.pedics 2024年第5期14卷 218-228页

作者： frederick F. Buech.l Mich.el J. Pappas Rutgers NJ Medical Sch.ol Newark NJ USA South.Mountain Orth.paedic Associates South Orange NJ USA New Jersey Institute of Tech.ology Newark NJ USA

Background: Early exploration of th. semi constrained “Floating-Socket” total sh.ulder replacement (TSR) in 1974 led to a proliferation of various unconstrained designs th.t allowed resection or retention of th. h.meral h.ad, depending upon th. path.logical process involved. Degenerative glenoh.meral arth.itis with.mild to moderate involvement of subch.ndral bone allowed for a resurfacing option, wh.le severe h.meral h.ad involvement required a partial or full h.meral h.ad replacement attach.d to an intramedullary stem for fixation. All components evolved from cemented to cementless application by 1982. Th. purpose of th.s paper is to describe th. progression of Buech.l-Pappas (B-P) sh.ulder replacement development from th. early 1970’s in both.cemented and cement less applications. Meth.ds: Clinical evaluations of “Floating-Socket” TSR, followed by B-P stem-type, resurfacing types, bipolar-type and revision components, all of wh.ch.comprise th. B-P Sh.ulder Replacement System, were performed over a 49-year period. Results: “Floating-Socket” implants improved th. results of simple, constrained ball-in-socket designs, but generally failed by glenoid component loosening in both.ch.mpanzee and h.man applications. Unconstrained resurfacing-type components, both.anatomical h.meral h.ad and full proximal h.meral components, were quite successful, with.minimal failures observed in long-term studies. Bipolar salvage implants, used for severe proximal deficiencies, revisions and massive rotator cuff arth.opath., were also very successful;providing overh.ad range of motion in many patients. Conclusions: Resurfacing h.miarth.oplasty, in patients with.intact or repairable rotator cuff mech.nisms, gave th. most satisfactory results and were th. least tech.ically complicated to perform, requiring minimal instrumentation. Resurfacing of full proximal h.meral deficiencies, using femoral resurfacing components, gave similar clinical results to more complex semi-constrained devices,

关键词： Total Sh.ulder Replacement Resurfacing Sh.ulder Replacement

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Estimating th. subsolar magnetopause position from soft X-ray images using a low-pass image filter

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Earth.and Planetary Ph.sics 2024年第1期8卷 173-183页

作者： h.angpyo Kim h.unju K.Connor Jaewoong Jung Brian M.Walsh.David Sibeck Kip D.Kuntz frederick S.Porter Catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Mich.el Collier Space Research.Institute Austrian Academy of Sciences8042 GrazAustria Geoph.sical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Fligh. Center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Ph.sics Boston UniversityBostonMassachusetts 02215USA Department of Ph.sics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA h.ward University WashingtonDC 20059USA

Th. Lunar Environment h.liosph.ric X-ray Imager(LEXI)and Solar wind Magnetosph.re Ionosph.re Link Explorer(SMILE)missions will image th. Earth.s dayside magneto pause and cusps in soft X-rays after th.ir respective launch.s in th. near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt th. success of th.se scientific missions,it is critical to develop tech.iques th.t extract th. magnetopause locations from th. observed soft X-ray *** th.s research.we introduce a new geometric equation th.t calculates th. subsolar magnetopause position(RS)from a satellite position,th. look direction of th. instrument,and th. angle at wh.ch.th. X-ray emission is *** assumptions are used in th.s meth.d:(1)Th. look direction wh.re soft X-ray emissions are maximized lies tangent to th. magnetopause,and(2)th. magnetopause surface near th. subsolar point is almost sph.rical and th.s RSis nea rly equal to th. radius of th. magneto pause *** create synth.tic soft X-ray images by using th. Open Geospace General Circulation Model(OpenGGCM)global magnetoh.drodynamic model,th. galactic background,th. instrument point spread function,and Poisson *** th.n apply th. fast Fourier transform and Gaussian low-pass filte rs to th. synth.tic images to re move noise and obtain accurate look angles for th. soft X-ray pea *** th. filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using th. OpenGGCM subsolar magnetopause location as ground *** meth.d estimates RS with.an accuracy ofh.n th. solar wind density exceeds>10 *** accuracy improves for greater solar wind densities and during south.ard interplanetary magnetic *** meth.d ca ptures th. magnetopause motion during south.a rd interplaneta ry magnetic field ***,th. tech.ique will enable quantitative analysis of th. magnetopause motion and h.lp reveal th. daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXI SMILE

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