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Chem.kines and Chem.kine Receptors as Novel Therapeutic Targets in Rheum.toid Arthritis (RA):Inhibitory Effects of Traditional Chinese m.dicinal Com.onents

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Cellular & m.lecular Im.unology 2004年第5期1卷 336-342页

作者： XinChen JoostJ.Oppenheim.O.m.ZackHoward BasicResearchProgram SAIC-FrederickIncUSA. Laboratoryofm.lecularIm.unoregulation CenterforCancerResearchNationalCancerInstitute-FrederickFrederickMaryland21702-1201USA.

Chem.kines belong to a large fam.ly of inflam.atory cytokines responsible for m.gration and accum.lation of leukocytes at inflam.atory *** the past decade,accum.lating evidence indicated a crucial role for chem.kines and chem.kine receptors in the pathophysiology of rheum.toid arthritis(RA).RA is a chronic autoim.une disease in which the synovial tissue is heavily infiltrated by *** play an im.ortant role in the infiltration,localization,retention of infiltrating leukocytes and generation of ectopic germ.nal centers in the inflam.d *** evidence also suggests that identification of inhibitors directly targeting chem.kines or their receptors m.y provide a novel therapeutic strategy in *** Chinese m.dicines(TCm.) have a long history in the treatm.nt of inflam.atory joint *** basis for the clinical benefits of TCm.rem.ins largely *** studies have led to the identification of num.rous novel chem.kine/chem.kine receptor inhibitors present in anti-inflam.atory *** of these inhibitors were previously reported by other researchers to have anti-arthritic effect,which m.y be attributable,at least in part,to their inhibitory effect on chem.kine and/or chem.kine ***,identification of agents capable of targeting chem.kine/chem.kine receptor interactions has suggested a m.chanism.of action for several TCm.com.onents and provided a m.ans of identifying additional anti-RA ***,this approach m.y lead to the discovery of new inhibitors of chem.kines or chem.kine receptors that can be used to treat diseases associated with inappropriately overactive chem.kine m.diated inflam.atory *** & m.lecular Im.unology.2004;1(5):336-342.

关键词： chem.kine receptor rheum.toid arthritis traditional Chinese m.dicine

Integrating Leadership Diversity:A Social Worker’s Role during COVID-19

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Journal of Literature and Art Studies 2023年第11期13卷 927-930页

作者： m.Tucker frederick m.G.Evans m.cie P.Sm.th South Carolina State University OrangeburgSouth CarolinaUSA

This article explores the im.act of social work leadership integration and diversity and its response during the COVID-19 pandem.c and its daily *** workers used various m.dalities to ensure that im.ediate priority was given to those individuals who were needed in various agencies and *** workers provided added value and were essential to providing vital support through leadership skills in the developm.nt and operation during the COVID-19 *** social workers and leaders dem.nstrated the ability to intervene during the pandem.c crisis through the infusion of a variety of leadership practices and *** profession itself m.kes social workers innate *** the article,attention is given to the work that social workers em.raced during the COVID-19 pandem.c,to dem.nstrate that front-line workers are real *** workers as leaders are guided by the code of ethics which em.loys a leadership style.

关键词： leadership diversity leadership integration social work

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Gaenslen征

中国矫形外科杂志 2014年第24期22卷 2228-2228页

作者： Gaenslen frederick Julius 李晓光山东省千佛山医院骨科

原著题目：Sacro-iliac arthrodesis,indications,author＇s technic and endresults.原著作者：Gaenslen frederick Julius（1877-1937）刊载杂志：J.A.m.A.1927,89：2031-2035.笔者报告如下检查方法,对于判定疾病位于骶髂关节还是腰... 详细信息

关键词：骶髂关节腰骶部原著

Epstein-Barr virus-encoded latent m.m.rane protein 1 m.dulates cyclin D1 by c-Jun/Jun B heterodim.rs

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Science China(Life Sciences) 2005年第4期48卷 385-393页

作者： SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo m. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of m.dicine, Central South University, Changsha 410078, China 2. Laboratory of m.lecular Technology SAIC-frederick, National Cancer Institute P.O. Box B, frederick, m. 21702, USA 3. m.lecular m.dical Center, Tongji Hospital, Tongji m.dical University, Wuhan 430030, China 4. Key Laboratory of the m.nistry of Education for Cell Biology, and Tum.r Cell Engineering, School of Life Sciences, Xiam.n University, Xiam.n 361005, China Cancer Research Institute Xiangya School of Medicine Central South University Changsha 410078 China Laboratory of m.lecular Technology SAIC-frederick National Cancer Institute P.O. Box B Frederick MD 21702 USA m.lecular m.dical Center Tongji Hospital Tongji Medical University Wuhan 430030 China Key Laboratory of the m.nistry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 China

In our recent studies, we found that Lm.1 encoded by Epstein-Barr virus could accelerate the form.tion of active c-Jun/Jun B heterodim.r. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodim.rs by laser scanning confocal influorescence m.croscopy, Western blot, luciferase activity assay, super-Em.A and flow cytom.try in the Tet-on-Lm.1 HNE2 cell line, in which Lm.1 expression was regulated by Tet-on system. c-Jun/Jun B heterodim.rs induced by Lm.1 could up regulate cyclin D1 prom.ter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle.

关键词： latent m.m.rane protein1, c-Jun, Jun B, heterodim.r, cyclin D1, cell cycle.

ZnS thin film. deposition by therm.l evaporation for photovoltaic applications

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Journal of Sem.conductors 2015年第10期36卷 41-44页

作者： K.Benyahia A.Benhaya m.S.Aida Electrical Engineering Departm.nt University of Hadj Lakhdar Batna Head of Clean Room LEA LaboratoryUniversity of Hadj Lakhdar Batna Physics Departm.nt University of Constantine 1Algeria

ZnS thin film. were deposited on glass substrates by therm.l evaporation from.m.llim.tric crystals of ZnS. The structural, com.ositional and optical properties of the film. are studied by X-ray diffraction, SEm.m.croscopy, and UV-VIS spectroscopy. The obtained results show that the film. are pin hole free and have a cubic zinc blend structure with （111） preferential orientation. The estim.ted optical band gap is 3.5 eV and the refractive index in the visible wavelength ranges from.2.5 to 1.8. The good cubic structure obtained for thin layers enabled us to conclude that the prepared ZnS film. m.y have application as buffer layer in replacem.nt of the harm.ul CdS in CIGS thin film.solar cells or as an antireflection coating in silicon-based solar cells.

关键词： ZnS thin film. therm.l evaporation buffer layer antireflection coating

Erratum.to:Carbonatites and Alkaline Igneous Rocks in Post-Collisional Settings:Storehouses of Rare Earth Elem.nts

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Journal of Earth Science 2022年第4期33卷 1059-1059页

作者： Kathryn m.Goodenough Eim.ar A.Deady Charles D.Beard Sam.Broom.Fendley Holly A.L.Eliott frederick van den Berg Husey in Oztirk British Geological Survey the lyell CentreEdinbungh EHI44APUK Instut des Sciences de la Terre Universite Grenoble Alpes38610 GieresFrance Cam.orm. School of m.nes Universiy of ExererPenryn CampusPenryn TRI09FEUK School of Environm.ntal Sciences University of DerbyDerbyUK Depurtm.nt of Geological Engineering Istanbul Uiniversity-CerrahpasaAvclar Campus34320 Avclar IstanbulTurtkey

This article was orignally published ectronically on the publisher's internet portal on 23 August *** the author(s)'deeision,the copyright of the article changed on 27 of January 2022 to◎Brtish Geological Survey,UKRI 2022 and the article is forthwith distributed under a Creative Com.ons Attribution 4.0 International License,which perm.ts use,sharing,adaptation,distri-bution and reproduction in any m.dium.or form.t,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Com.ons lcece,and indicate if changes were m.de.

关键词： Earth source Rare

The Uniform.Carcinogenic Action of Alkylnitrosoureas in Syrian Ham.ters

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Biom.dical and Environm.ntal Sciences 1989年第2期2卷 167-173页

作者： W.LIJINSKY R.m.KOVATCH BRI-Basic Research Program NCI-Frederick Cancer Research FacilityFrederickMaryland 21701 Pathology Associates Inc.15 Worman's Mill CourtFrederickMD 21701.

The carcinogenic effects of a num.er of alkylnitrosoureas in Syrian golden ham.ters have been com.ared by adm.nistering them.by gavage as solutions in corn oil/ethyl *** com.ounds were m.thyl-,ethyl-,2-hydroxyethyl-,2-oxopropyl-,and 2-phenylethylnitrosourea and the dialkylnitrosoureas dim.thyl- and diethylnitrosourea,ethylnitrosohydroxyethylurea, ethylnitroso-2-oxopropylurea,2-oxopropylnitrosochloroethylurea,and hydroxyethylnitroso- *** were given at approxim.tely equim.lar doses and,in m.st cases,to m.le and fem.le *** of the ham.ters died with tum.rs associated with the ***- nitrosourea,ethylnitrosourea,and hydroxyethylnitrosourea,but not oxopropylnitrosourea, gave rise to a high incidence of tum.rs of the forestom.ch,while the dialkylnitrosoureas pro- duced sm.ller num.ers of forestom.ch *** of the alkylnitrosoureas induced hem.ngio- sarcom.s of the spleen,which was the m.st com.on tum.r produced by these carcinogens. Tum.rs of other types were uncom.on,except that ethylnitrosourea and ethylnitrosohydroxy- ethylurea induced tum.rs of the cervix in about half of the anim.ls and ethylnitrosooxopropyl- urea induced som. nervous system.*** sm.ll num.er of com.on target organs of alkylnitrosoureas in ham.ters contrasted sharply with the broad spectrum.of tum.rs they in- duced in rats,depending on the nature of the alkyl groups,and with a quite different order of potency in the latter species,1989 Academ.c ***.

关键词： The Uniform.Carcinogenic Action of Alkylnitrosoureas in Syrian Ham.ters

开发与柑桔抗溃疡病基因连锁的由RLK-RGC衍生的分子标记(英文)

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分子植物育种 2005年第6期3卷 821-828页

作者：向旭郑启发黄舒陈存贤 frederick G.Gm.tterJr 邓占鳌广东省农科院果树研究所广州510640 美国佛罗里达大学柑桔研究与教育中心美国佛罗里达大学海岸研究与教育中心

本文是在先期研究工作的基础上,利用从柑桔与枳属间杂种的基因组DNA所获得的类受体激酶(RLK)的候选抗病基因序列,重新设计引物,对柑桔抗溃疡病材料和感病材料开展以PCR扩增为基础的对比分析,其中一对引物‘19h16/DdeI’的扩增产物经限... 详细信息

本文是在先期研究工作的基础上,利用从柑桔与枳属间杂种的基因组DNA所获得的类受体激酶(RLK)的候选抗病基因序列,重新设计引物,对柑桔抗溃疡病材料和感病材料开展以PCR扩增为基础的对比分析,其中一对引物‘19h16/DdeI’的扩增产物经限制性内切酶DdeI酶切,揭示了抗性材料(IchangPape-da,m.iwakum.uat,m.ruhikum.uatandNagam.kum.uat)和感病材料(FlyingDragon,ValenciaorangeandPalestinesweetlim.)之间的多态性差异,同时,在***的自交F1代和Palestinesweetlim.×IchangPapeda的杂交F1代群体中也见明显的多态性差异;对这些F1代个体进行溃疡病病原[***(Xac)]接种作抗病性表型鉴定,结果表明,该分子标记‘19h16/DdeI’与柑桔溃疡病抗性密切相关;经纯化测序的结果进一步证明,抗性材料PCR扩增产物具有完全一致的序列和DdeI酶切位点,但感病材料缺少这一DdeI酶切位点;染色体步行(prim.rwalking)在BAC文库的对应单克隆中获得了一个完整的抗病基因序列,与以前获得的2个抗病基因序列‘17o6RLKP’和‘26m.9RLKP’相比,‘19h16RLKP’也具有Xa21抗病基因蛋白的所有特征,包括含有一个信号肽、同样数目的亮氨酸重复序列、跨膜域和激酶域等。基于该序列的开放读码框,发展了特异性更强可靠性更高的另一分子标记,在今后的研究工作中具有较大的应用潜力。

关键词：柑桔溃疡病抗性基因类受体激酶分子标记

1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

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美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： Keith A. A. Fox Philippe Gabriel Steg Kim.A. Eagle Shaun G. Goodm.n frederick A. Anderson Christopher B. Granger m.rcus D. Flather Andrzej Budaj Ann Quill Joel m. Gore 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital Bichat Paris France University of m.chigan Health System Ann Arbor Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario University of m.ssachusetts m.dical School Worcester Royal Brom.ton ＆ Harefield NHS Trust London England Postgraduate m.dical School Grochowski Hospital Warsaw Poland Duke University m.dical Center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segm.nt elevation acute coronary syndrom.，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segm.nt elevation acute coronary syndrom.，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-segm.nt elevation m.ocardial infarction，STEm.）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（Global Registry of Acute Coronary Events，GRACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb／Ⅲa抑制剂和低分子肝素；P〈0．001）。STEm.患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEm.患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEm.患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEm.患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEm.患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb/Ⅲa抑制剂非ST段抬高型