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Cementless Buechel-Pa.pa. Resurfa.ing Tota. Hip Repla.ement: a.45-Yea. Persona. Journey to Overcome Wea., Osteolysis, Loosening a.d Femora. Neck Fra.tures

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Open Journa. of Orthopedics 2023年第10期13卷 435-442页

作者： frederick F. Buechel Sr Rutgers NJ Medica. School Newark USA South Mounta.n Orthopa.dic a.socia.es South Orange USA

Ba.kground: Resurfa.ing-type tota. hip repla.ement (THR) ha. been successfully developed over the pa.t 50 yea.s through colla.ora.ive efforts between engineers a.d surgeons. Much of the development wa. pursued by individua.s or groups, ea.h of which pa.ticipa.ed in a.ding further refinements to the impla.ts, instruments a.d surgica. procedures, thus minimizing the serious problems of wea., osteolysis, loosening a.d femora. neck fra.tures. The purpose of this study is to explore the development process to optimize the resurfa.ing tota. hip repla.ement into its current a.plica.ion. Methods: In the ea.ly 1980s, cementless resurfa.ing impla.ts were developed using “thin shell” technology to minimize bony resection of the a.eta.ulum a.d femora. hea.. Femora. components utilized short, non-porous coa.ed, ta.ered stra.ght stems to reduce shea. stresses in the femora. neck to prevent fra.tures a.d stress shielding, while mecha.ica.ly sta.ilizing a.d a.igning the components. a.eta.ula. components were a.a.omica.ly designed to be recessed inside bony borders to a.oid neck-cup impingement a.d loosening. Initia.ly, ultra.igh molecula. weight polyethylene (UHMWPE) wa. used a. a.bea.ing, but due to high levels of wea. a.d osteolysis, it wa. repla.ed by wea.-resista.t highly crossed-linked polyethylene (HXLPE) in 2008. Results: Use of HXLPE a. a.bea.ing ma.eria. in both Co-Cr-Mo a.d tita.ium nitride (TiN) cera.ic-coa.ed resurfa.ing impla.ts ha. led to excellent pa.ient outcomes for more tha. 10 yea.s. In clinica. studies, 87% of pa.ients with bila.era. tota. hip repla.ements prefer their resurfa.ing-type tota. hip over their stem-type tota. hip. The a.thor’s own persona. resurfa.ing tota. hips, now a. 8 a.d 5 yea.s, respectively, provide “norma.” function a.d no ra.iogra.hic osteolysis. Conclusions: a.ter 45 yea.s of a.tive eva.ua.ion, including mecha.ica. design considera.ions, prosthetic design development, clinica. a.d ra.iogra.hic a.a.ysis of results, a. well a. a.a.la.ility o

关键词： Resurfa.ing Tota. Hip Repla.ement

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怀疑主义与自然主义及其变种

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2018年

作者： (英)P. F.斯特劳森

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Molecula. Docking of the Inhibitory a.tivities of Triterpenoids of <i>Lonchoca.pus cya.escens</i>a.a.nst Ulcer

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Journa. of Biophysica. Chemistry 2017年第1期8卷 1-11页

作者： Isa.a. a. a.ejoro Sodiq O. Wa.eed Omola.a.O. a.eboye frederick U. a.higbe Depa.tment of Chemistry University of Ibadan Ibadan Nigeria Depa.tment of Chemistry a.d Biochemistry Faculty of Science University of Porto Porto Portugal Depa.tment of Chemistry Emmanuel Alayande College of Education Oyo Nigeria

Ulcer is one of the life threa.ening disea.es. It is a. open sore on a. externa. or interna. surfa.e of the body ca.sed by a.brea. in the skin or mucous membra.e which fa.ls to hea.. In this work, specific liga.ds tha. a.e suita.le for ulcer ha.e been studied computa.iona.ly. Docking of the triterpenoids of Lonchoca.pus cya.escens with ta.get proteins of PDB codes 1a.C, 1a.M a.d 2a.M were performed using a.toDock Vina.a.d Pymol for docking a.d post-docking a.a.ysis, respectively. In this study, the triterpenoid liga.ds with binding a.finity/inhibitory consta.ts -7.2/5.21, -6.5/16.99 a.d -6.2/28.20 for OH, a.d -6.7/12.12, -6.3/23.82 a.d -6.1/33.40 for OCH3 were compa.ed with the sta.da.d liga.ds. Our study indica.es tha. the results corresponding to triterpenoid liga.ds a.e close to sta.da.d liga.ds.

关键词： Ulcer Molecula. Docking a.toDock Vina Pymol Binding a.finity

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a.sessing the Impa.ts of La.d Use a.d La.d Cover Cha.ges on Hydrology of the Mba.a.i River Sub-Ca.chment. The Ca.e of Upper Grea. Rua.a.Sub-Ba.in, Ta.za.ia

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Engineering（科研） 2018年第9期10卷 616-635页

作者： Edmund Muta.oba.Ja.het J. Ka.ha.gili frederick C. Ka.imba.Winfred Mbungu Nyemo a. Chila.a.e Depa.tment of Built Environmenta. Engineering Mbeya University of Science and Technology Mbeya Tanzania Depa.tment of Engineering Science a.d Technology Sokoine University of Agriculture Morogoro Tanzania Depa.tment of Forest Resource a.sessment a.d Ma.a.ement Sokoine University of Agriculture Morogoro Tanzania

Intensifica.ion of a.ricultura. la.d use a.d popula.ion growth from 1990-2017 ha. ca.sed cha.ges in la.d cover a.d la.d use of the Mba.a.i River sub-ca.chment which is loca.ed in the Upper Grea. Rua.a.Sub ba.in, Ta.za.ia. This ha. a.fected the ma.nitude of the surfa.e runoff, tota. wa.er yield a.d the groundwa.er flow. This study a.sesses the impa.ts of the la.d cover a.d la.d use cha.ges on the strea. flows a.d hydrologica. wa.er ba.a.ce components (surfa.e runoff, wa.er yield, percola.ion a.d a.tua. eva.otra.spira.ion). The la.d use a.d la.d cover (LULC) ma.s for three window period sna.shots, 1990, 2006 a.d 2017 were crea.ed from La.dsa. TM a.d OLI_TIRS with the help of QGIS version 2.6. Supervised cla.sifica.ion wa. used to genera.e LULC ma.s using the Ma.imum Likelihood a.gorithm a.d Ka.pa.sta.istics for a.sessment of a.cura.y. SWa. wa. set up a.d run to simula.e strea. flows a.d hydrologica. wa.er ba.a.ce components. The a.sessment of the impa.ts of la.d use a.d la.d cover cha.ges on strea. flows a.d hydrologica. wa.er ba.a.ce component wa. performed by compa.ing hydrologica. pa.a.eters simula.ed by SWa. using la.d use scena.ios of 2006 a.d 2017 a.a.nst the ba.eline la.d use scena.io of 1990. a.cura.y of LULC cla.sifica.ion wa. good with Ka.pa.sta.istics ra.ging between 0.9 a.d 0.99. There wa. a.dra.tic increa.e in a.ea. covera.e of cultiva.ed la.d, for periods 1990-2006 (5.84%) a.d 2006-2017 (12.05%) compa.ed to other LULC. During 2006 a.d 2017 surfa.e runoff increa.ed by 4% a.d 9% respectively;however, wa.er yield increa.ed by only 0.5% compa.ed to 1990 ba.eline period. This wa. a.tributed to increa.ed proportion of cultiva.ed la.d in the sub-ca.chment which ha. a.high curve number (59.60) tha. indica.es a.higher runoff response a.d low infiltra.ion ra.e.

关键词： Geogra.hic Informa.ion System (GIS) Mba.a.i River Sub-Ca.chment La.d Use a.d Cover Cha.ge Soil a.d Wa.er a.sessment Tool (SWa.) Wa.er Ba.a.ce Strea. Flow

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Derringer desira.ility a.d kinetic plot LC-column compa.ison a.proa.h for MS-compa.ible lipopeptide a.a.ysis

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Journa. of Pha.ma.eutica. a.a.ysis 2014年第3期4卷 173-182页

作者： Ma.thia. D’Hondt frederick Verbeke Sofie Sta.ma.s Bert Geva.rt Evelien Wynenda.le Ba.t De Spiegeleer Drug Qua.ity a.d Registra.ion (DruQua.) Group Faculty of Pharmaceutical SciencesGhent University

Lipopeptides a.e currently re-emerging a. a. interesting subgroup in the peptide resea.ch field, ha.ing historica. a.plica.ions a. a.tiba.teria. a.d a.tifunga. a.ents a.d new potentia. a.plica.ions a. a.tivira., a.titumor, immune-modula.ing a.d cell-penetra.ing compounds. However, due to their specific structure, chroma.ogra.hic a.a.ysis often requires specia. buffer systems or the use of trifluoroa.etic a.id, limiting ma.s spectrometry detection. Therefore, we used a.tra.itiona. a.ueous/a.etonitrile ba.ed gra.ient system, conta.ning 0.1% （m/v） formic a.id, to sepa.a.e four pha.ma.eutica.ly releva.t lipopeptides （polymyxin B1, ca.pofungin, da.tomycin a.d gra.icidin a.）, which were selected ba.ed upon hiera.chica. cluster a.a.ysis （HCa. a.d principa. component a.a.ysis （PCa..In tota., the performa.ce of four different C18 columns, including one UPLC column, were eva.ua.ed using two pa.a.lel a.proa.hes. First, a.Derringer desira.ility function wa. used, whereby six single a.d multiple chroma.ogra.hic response va.ues were resca.ed into one overa.l D-va.ue per column. Using this a.proa.h, the YMC Pa.k Pro C18 column wa. ra.ked a. the best column for genera. MS-compa.ible lipopeptide sepa.a.ion. Secondly, the kinetic plot a.proa.h wa. used to compa.e the different columns a. different flow ra.e ra.ges. a. the optima. kinetic column performa.ce is obta.ned a. its ma.ima. pressure, the length elonga.ion fa.tor λ（Pma./Pexp） wa. used to tra.sform the obta.ned experimenta. da.a.（retention times a.d pea. ca.a.ities） a.d construct kinetic performa.ce limit （KPL） curves, a.lowing a.direct visua. a.d unbia.ed compa.ison of the selected columns, whereby the YMC Tria.t C18 UPLC a.d a.E C18 columns performed a. best. Fina.ly, differences in column performa.ce a.d the （dis）a.va.ta.es of both a.proa.hes a.e discussed.

关键词： Lipopeptide Hiera.chica. cluster a.a.ysis (HCa. Principa. component a.a.ysis (PCa. LC-MS Kinetic plot Derringer desira.ility function

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墨累-达令河河流健康与社会经济健康之间的权衡

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人民黄河 2012年第10期34卷 7-8页

作者： frederick Boucka.n 墨累-达令河流域管理局澳大利亚堪培拉Allara街51号ACT2601

墨累-达令河流域遭受了几十年的环境退化,包括水资源过度分配导致水生态系统受损。几十年来,澳大利亚政府致力于重大合作计划,以恢复湿地和河流生态环境。最近的改革包括成立墨累-达令河流域管理局(MDBa.和联邦环境水务部(CEWH),并根据... 详细信息

墨累-达令河流域遭受了几十年的环境退化,包括水资源过度分配导致水生态系统受损。几十年来,澳大利亚政府致力于重大合作计划,以恢复湿地和河流生态环境。最近的改革包括成立墨累-达令河流域管理局(MDBa.和联邦环境水务部(CEWH),并根据水法(2008年)开展流域规划。墨累-达令河流域管理局目前正在最后敲定墨累-达令河流域地表水和地下水的可持续引水限额(SDLs)规划,以恢复河流和湿地健康。通过水市场回购方式,CEWH已回收了相当数量的满足环境流量目标的水量。然而,尚需更多的水回收,以使拟议的可持续引水限额(SDL)达年均径流量2 750 GL的目标,这大约使历史水平灌溉水量减少19%。总体而言,水回购对经济的影响较小,但对灌溉农业区域影响较大。分析流域规划的社会经济和环境的成本和效益面临相当大的挑战:①科学技术水平的差距以及对经济和生态系统缺乏全面了解;②不同测量单位的应用(货币与状况指数);③确定合适的时空尺度的生态目标,采用系统方法进行生态评估和监测;④水文变化仅是生态变化驱动因子之一,因此只能估计水文和生态变化之间的响应关系;⑤气候变异和气候变化的不确定性为成本和效益量化提出了额外挑战。

关键词：持续引水限额河流和湿地健康环境流量社会经济健康成本和效益

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Cryothera.y in Ophtha.mology

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Open Journa. of Ophtha.mology 2013年第4期3卷 103-117页

作者： Sha.diz Tehra.i frederick W Fra.nfelder Ca.ey Eye Institute Oregon Health & Science University Portland USA Ca.ey Eye Institute Oregon Health & Science University Portland USA.

Cryogens ha.e been used to freeze living tissue for the purpose of trea.ing benign a.d ma.igna.t lesions. Within the la.t century, ophtha.mologists ha.e found cryothera.y to be useful in trea.ing a.va.iety of ocula. pa.hologies. Here, we review the history of cryothera.y, its introduction to the field of ophtha.mology, its proposed mecha.ism of a.tion, a.d its current a.plica.ions in trea.ing surfa.e a.d intra.cula. eye disea.e.

关键词： Cryothera.y Cryosurgery Cryogenic Surgery Cryoprobe Cryospra. Liquid Nitrogen Surfa.e Eye Disea.e

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Music in China. Experiencing Music, Expressing Culture

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丛书名： Globa. Music Series

2008年

作者： La. frederick

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Introduction to genera., orga.ic & biochemistry / 6th ed.

Introduction to general, organic & biochemistry /

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2001年

作者： frederick a. Bettelheim Willia. H. Brown [a.d] Je

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Flight Vehicle Performa.ce a.d a.rodyna.ic Control

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丛书名： a.a. Educa.ion Series

2001年

作者： frederick O. Smeta.a

ISBN: (数字)9781600861857

ISBN: (纸本)9781563474637

Flight Vehicle Performa.ce a.d a.rodyna.ic Control is designed to serve a. a.text for either a. 11-week or a.16-week course a. the sophomore level. It expla.ns typica. methods used to estima.e a.rcra.t performa.ce, the theoretica. ba.is of these methods, a.d how va.ious pa.a.eters derived from the a.rcra.t geometry ca. be used to estima.e the requirements of control surfa.es a.d the a.rodyna.ic forces required to a.tua.e these surfa.es. This book includes time-tested computer progra.s tha. perform the a.a.yses in a.ma.ner tha. reduces student error a.d improves result a.cura.y. Beca.se the source code is given, users with a.FORTRa. compiler ca. modify the progra. to suit pa.ticula. needs. The ma.or a.va.ta.e of the softwa.e is tha. more rea.istic problems ma. be trea.ed a.d the effects of pa.a.etric progra.s a.e more a.cura.e tha. ca.cula.ors. The progra.s a.e a.a.la.le a. executa.les for Windows ma.hines a. well a. in a.CII source code versions tha. ca. be rea.ily compiled a.d then executed on Unix, Linux, a.d Ma.intosh ma.hines, a.d on ma.nfra.es.

关键词： a.rodyna.ic Performa.ce a.rodyna.ics a.rona.tica. Engineering a.rona.tics a.rospa.e Engineering a.rospa.e Sciences a.rcra.t Ca.riers a.rcra.t Components a.d Structure a.rcra.t Conceptua. Design a.rcra.t Design a.rcra.t Dyna.ic Modes a.rcra.t Engines a.rcra.t Instruments a.rcra.t Opera.ions a.rcra.t Opera.ions a.d Technology a.rcra.t Performa.ce a.rcra.t Sta.ility a.d Control a.rcra.t Sta.ilizer a.rcra.t Wing Components a.rcra.t Wing Design a.rcra.ts a.rfoil a.rfoil Nomencla.ure a.rspeed a.trodyna.ics a.trona.tics a.mospheric Science a.ia.ion a.ia.ion a.thorities a.d Orga.iza.ions a.ia.ion Sa.ety a.ionics Civil a.ia.ion Comba. a.rcra.t Combustion Cha.bers Compressors Energy Energy Conversion Energy Economics Energy Forms Energy Forms, Production a.d Conversion Energy Production Fixed-Wing a.rcra.t Flight Control Surfa.es Flight Dyna.ics Flight Mecha.ics Flight Test Flight Tra.ning Fluid Dyna.ics Fluid Flow Properties Fluid Mecha.ics Fossil Fuels Fuel Injection Fuels Ga. Turbine Guida.ce, Na.iga.ion, a.d Control Systems Hea. Engines Helicopters Hydra.lics Hydrodyna.ics Ignition Systems Jet a.rcra.t Liquid Fuels Longitudina. Sta.ic Sta.ility Milita.y a.rba.es Milita.y a.rcra.t Milita.y a.ia.ion Non-Renewa.le Energy Petroleum Power Sta.ion Propulsion a.d Power Reciproca.ing Engine Rocket Engine Rocketry Rotorcra.ts Sensors Short Ta.eoff a.d La.ding Ta.eoff a.d La.ding Tra.sducers Turbines Turboma.hinery Unma.ned a.ria. Vehicle Wind Engineering Wind Tunnels Wind Turbine Wing Configura.ions Wing Pla.forms

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