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Fully On-Chip Integrated Photodetector Front-End Dedicated to Real-Time Portable Optical Brain Imaging

Optics and Photonics Journal 2012年第4期2卷 300-313页

作者： Ehsan Kamrani frederic lesage Mohamad Sawan Electrical Engineering Department Ecole Polytechnique Montreal Canada

Optical brain imaging using functional near infra-red spectroscopy (fNIRS) offers a portable and noninvasive tool for monitoring of blood oxygenation. In this paper we have introduced a new miniaturized photodetector front-end on achip to be applied in a portable fNIRS system. It includes silicon avalanche photodiodes (SiAPD), Transimpedance amplifier (TIA) front-end and Quench-Reset circuitry to operate in both linear and Geiger modes. So it can be applied for both continuous-wave fNIRS (CW-fNIRS) and also single-photon counting. Proposed SiAPD exhibits high-avalanche gain (>100), low-breakdown voltage ( V) and high photon detection efficiency accompanying with low dark count rates. The proposed TIA front-end offer a low power consumption ( mW), high-transimpedance gain (up to 250 MV/A), tunable bandwidth (1 kHz - 1 GHz) and very low input and output noise (~few fA/√Hz and few μV/√Hz). The Geiger-mode photon counting front-end also exhibits a controllable hold-off and rest time with an ultra fast quench-reset time (few ns). This integrated system has been implemented using submicron (0.35 μm) standard CMOS technology.

关键词： Biochip Analog CMOS Integrated Circuit Trans-Impedance Amplifier fNIRS Brain Imaging Medical Imaging Optical Sensors

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Validation of the General <i>Health Questionnaire</i>(GHQ-12) adapted to a work-related context

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Open Journal of Preventive Medicine 2011年第2期1卷 44-48页

作者： Francois-Xavier lesage Sonia Martens-Resende frederic Deschamps Sophie Berjot 不详

Introduction: The aim of this study is to test the factorial structure and the internal consistency of the 12-items General Health Questionnaire adapted to work-related psychological distress (GHQW). Methods: A validated French version of the GHQ-12 was used and transformed to remind of the occupational context. A sample of 1014 workers completed the GHQW. Internal consis- tency was assessed by Cronbach’s α coefficient. The factorial structure was extracted with an exploratory factorial analysis (EFA). Results: The EFA run on the data yield to a one- factor structure explaining 60.5% of the total variance of the scale. The Cronbach’s alpha showed a very good internal consistency of the scale (α = 0.94). Conclusion: The findings support that the GHQW is a reliable and valid instrument for measuring work-related psychological distress in workers. This work-related version could find some applications in epide-miological research at work, in the study of psychosocial risk factors and in the occupational health physi- cian’s daily activity.

关键词： Occupational Health Mental Health Questionnaires Factor Analysis Statistical General Health Ques-tionnaire Validity

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