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Geometrical Evaluation of Cervical Cells. Fractal and Euclidean Diagnostic Methodology of Clinical Application

Journal of Biosciences and Medicines 2018年第3期6卷 111-122页

作者： Javier Rodriguez Velasquez Miguel Sanchez Cardenas freddy Andres barrios Arroyave Yolanda Soracipa Munoz Insight Group Research Center of the Clinica del CountryBogotaColombia Research and Social Projection.the Health Sexual and Reproductive Research GroupUniversidad el BosqueBogotaColombia Sexual and Reproductive Health Universidad el Bosque BogotaColombia Epidemiology and Biostatistics CES UniversityMedellinColombia Epidemiology and Biostatistics Research Group CES University and GISCO(Health and Community Research Group)Fundacion Universitaria Autonoma de las AmericasPereiraColombia

Background: The concomitant use of fractal and Euclidian measurements has led to the development of new methodologies of cell evaluation, including a diagnosis of cervical cells that set up differences between normality and various degrees of lesion, to carcinoma. Aim: To confirm the diagnostic capacity of the methodology based on fractal and Euclidian geometry for the mathematical diagnosis through a blind study of normal cells and with different types of lesion, as atypia of undetermined significance (ASCUS), low grade squamous intra-epithelial lesion (LGSIL) and high grade squamous intra-epithelial lesion (HGSIL). Methods: 100 cells of Papanicolaou tests were analyzed and divided into 4 groups according to conventional parameters: 25 normal, 25 ASCUS, 25 LGSIL and 25 HGSIL. By means of the Box-counting Fractal Space, we calculated the fractal dimension and occupying spaces of the border and surface in pixels of the cell nucleus and cytoplasm. The diagnostic parameters of the previously developed methodology were applied and compared with the conventional diagnosis, setting up sensibility, specificity, negative likelihood ratio and Kappa coefficient. Results: The values of the occupation of the border and surface of the cell nucleus and cytoplasm were consistent with the values found by the diagnostic methodology previously found. The subtraction of the nucleus and cytoplasm frontiers presented values between: 189 and 482 for normality;159 and 432 for ASCUS;126 to 401 for LGSIL and 39 to 122 for HGSIL. A sensitivity and specificity of 100%, and a Kappa coefficient of 1 were obtained. Conclusions: The capacity of the methodology to diagnose quantitatively the different stages in the evolution of the cervical cells observed in Papanicolaou tests was confirmed, from normality to HGSIL.

关键词： Fractals Cervical Cancer Cytology Mathematics

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Planar matrices and arrays of Feynman diagrams

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Communications in Theoretical Physics 2024年第3期76卷 15-32页

作者： freddy Cachazo Alfredo Guevara Bruno Umbert Yong Zhang Perimeter Institute for Theoretical Physics WaterlooON N2L 2Y5Canada Department of Physics and Astronomy University of WaterlooWaterlooON N2L 3G1Canada CECs Valdivia y Departamento de Física Universidad de ConcepciónCasilla 160-CConcepciónChile Center for the Fundamental Laws of Nature Society of Fellows and Black Hole InitiativeHarvard UniversityCambridgeMA 02138United States of America Department of Applied Mathematics Western UniversityLondonON N6A 5B7Canada CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China

Recently,planar collections of Feynman diagrams were proposed by Borges and one of the authors as the natural generalization of Feynman diagrams for the computation of k=3 biadjoint *** collections are one-dimensional arrays of metric trees satisfying an induced planarity and compatibility *** this work,we introduce planar matrices of Feynman diagrams as the objects that compute k=4 biadjoint *** are symmetric matrices of metric trees satisfying compatibility *** introduce two notions of combinatorial bootstrap techniques for finding collections from Feynman diagrams and matrices from *** applications of the first,we find all 693,13612 and 346710 collections for(k,n)=(3,7),(3,8)and(3,9),*** applications of the second kind,we find all90608 and 30659424 planar matrices that compute(k,n)=(4,8)and(4,9)biadjoint amplitudes,*** an example of the evaluation of matrices of Feynman diagrams,we present the complete form of the(4,8)and(4,9)biadjoint *** also start a study of higher-dimensional arrays of Feynman diagrams,including the combinatorial version of the duality between(k,n)and(n-k,n)objects.

关键词： Feynman diagrams biadjoint amplitudes tropical Grassmannian

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Influence of BPPV and Meniere's Disease on Cognitive Abilities: A Questionnaire-Based Study

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Journal of Otology 2024年第1期19卷 10-18页

作者： Rohit Bhattacharyya Animesh Barman freddy Antony All India Institute of Speech and Hearing MysoreMysuruIndia

The vestibular system connects the inner ear to the midbrain and subcortical structures and can affect cognition. Patients with vertigo often experience cognitive symptoms such as attention deficits, memory problems, and spatial perception difficulties. This study aimed to explore the cognitive impairments associated with Benign paroxysmal positional vertigo(BPPV) and Meniere's Disease(MD). A non-experimental group comparison design was used with 107 participants divided into three groups: Group I(clinically normal), Group II(BPPV), and Group III(MD). Participants completed a questionnaire with 10 cognition-related questions, and their responses were scored. The data were found to be non-normally distributed. The analysis revealed a significant difference in scores between Group I and both Group II and Group III. Chi-square tests showed that the responses to cognition-related questions varied among the groups, with Group II exhibiting more cognitive problems. Associated conditions like hypertension, diabetes, and hearing loss did not significantly influence the responses within each group. This study suggests a significant relationship between cognitive problems and patients with BPPV and MD. However, there was no association found between the cognitive problems experienced in BPPV and MD patients. These findings align with previous research indicating that vestibular disorders can lead to deficits in spatial memory, attention, and other cognitive functions. By understanding the link between cognition and vestibular disorders, we can improve diagnosis and rehabilitation services to enhance the quality of life for these patients.

关键词： BPPV Meniere's disease Cognition Questionnaire

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Physical Mathematical Evaluation of the Cardiac Dynamic Applying the Zipf-Mandelbrot Law

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Journal of Modern Physics 2015年第13期6卷 1881-1888页

作者： Javier Oswaldo Rodríguez Signed Esperanza Prieto Sandra Catalina Correa Fernán Mendoza Giora Weiz María Yolanda Soracipa Nelly Velásquez Juan Mauricio Pardo Miguel Martínez freddy barrios Insight Research Group Bogotá Colombia Clínica del Country Research Center Bogotá Colombia Fundación Clínica Abood Shaio Bogotá Colombia Universidad el Bosque Bogotá Colombia Columbia University Medical Center Cardiology Shaare Zedek Medical Center Jerusalem Israel Hospital Universitario Mayor Méderi Bogotá Colombia Physiology Medicine Faculty Universidad Nacional de Colombia Bogotá Colombia

Introduction: The law of Zipf-Mandelbrot is a power law, which has been observed in natural languages. A mathematical diagnosis of fetal cardiac dynamics has been developed with this law. Objective: To develop a methodology for diagnostic aid to assess the degree of complexity of adult cardiac dynamics by Zipf-Mandelbrot law. Methodology: A mathematical induction was done for this;two groups of Holter recordings were selected: 11 with normal diagnosis and 11 with acute disease of each group, one Holter of each group was chosen for the induction, the law of Zipf-Mandelbrot was applied to evaluate the degree of complexity of each Holter, searching similarities or differences between the dynamics. A blind study was done with 20 Holters calculating sensitivity, specificity and the coefficient kappa. Results: The complexity grade of a normal cardiac dynamics varied between 0.9483 and 0.7046, and for an acute dynamic between 0.6707 and 0.4228. Conclusions: A new physical mathematical methodology for diagnostic aid was developed;it showed that the degree of complexity of normal cardiac dynamics was higher than those with acute disease, showing quantitatively how cardiac dynamics can evolve to acute state.

关键词： Heart Rate Cardiovascular Diseases Zipf-Mandelbrot Law Complexity Grade

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Impact of data balancing a multiclass dataset before the creation of association rules to study bacterial vaginosis

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Intelligent Medicine 2024年第3期4卷 188-199页

作者： freddy de la Cruz-Ruiz Juana Canul-Reich Rafael Rivera-López Erick de la Cruz-Hernández Academic Division of Science and Technology of the Information Juárez Autonomous University of TabascoLa Esmeralda DistrictTabascoMexico Department of Systems National Technological Institute of MexicoTechnological Institute of VeracruzVeracruzMexico Multidisciplinary Academic Division of Comalcalco Juárez Autonomous University of TabascoTabascoMexico

Background Bacterial vaginosis is a polymicrobial syndrome in which the homeostasis exerted by the Latobacillus species that protect the vaginal mucosa has been *** study explored the data balancing process with the intention of improving the quality of association *** article aimed to balance the unbalanced multiclass dataset to improve association rule *** A dataset with 201 observations and 58 variables was analyzed.A preconstructed dataset was *** authors collected the data between August 2016 and October 2018 in Tabasco,*** study population comprised sexually active women ages 18 to 50 who underwent gynecological inspection at the infectious and metabolic diseases research laboratory at the Universidad Juarez Autonoma de *** determine the best κ-value,the random-forest algorithm was used and the balancing was performed with the synthetic minority over-sampling technique(SMOTE),random over-sampling examples(ROSE),and adaptive syntetic sampling approach for imbalanced learning(ADASYN)*** Apriori algorithm created the rules and to select rules with statistical significance,the ***(),***(),and ***()functions and quality metric Fisher’s exact tes were *** biological validation was carried out by the expert(bacteriologist).Results The ADASYN algorithm at K=9 the out of the bag(OOB)error was zero,this was the best𝐾-*** the balancing process the ADASYN algorithm show best the *** the dataset balanced with ADASYN,the apriori algorithm created the association rules and the selection with the quality metric Fisher’s exact test,and the biological validation reported 13 ***-bacteria Atopobium vaginae,Gardnerella vaginalis,Megasphaera filotipo 1,Mycoplasma hominis and Ureaplasma parvum were detected by the apriori algorithm from the balanced *** Balancing may improve the creation of association rules to efficiently model the bacteria that cause bac

关键词： Bacterial vaginosis Data balancing Random forest Synthetic minority over-sampling technique

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Characterisation of Human-Wildlife Conflicts around the Kahuzi-Biega National Park, Eastern Democratic Republic of Congo

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Journal of Environmental Protection 2024年第3期15卷 343-356页

作者： Basubi Muke Matthieu Vwima Stany Ayagirwe Basengere Rodrigue Mushagalusa freddy Benjamin-Fink Nicole Bobo Kadiri Serge Faculty of Agricultural and Environmental Sciences Evangelical University in Africa Bukavu Congo Wildlife and Protected Areas Laboratory Forestry and Wood Technology Department of Forestry University of Dschang Dschang Cameroon Faculty of Economics and Management Sciences Evangelical University in Africa Bukavu Congo Conservation beyond Borders Organization Minnetonka USA

The history of mankind contains so many illustrations of well-classified and violent struggles against various animals over crop production in agricultural fields, attacks on human life or competition in order to have access to certain natural resources. The aim of this study is to characterise the human-wildlife conflicts that occur around the KBNP, especially with regard to primates. Surveys were carried out in 260 households selected using the snowball method. The results showed that human-wildlife conflicts around the KBNP are characterised by the destruction of crops in riparian fields by monkeys, chimpanzees and gorillas, the destruction of houses, physical attacks and zoonoses. Despite the conservation and protection measures for wildlife and local populations put in place by the Park’s managers, conflicts between local populations and the Park’s wild animals are still visible. These conflicts lead to the detention of wild animals by local people roaming in the villages and to poaching on the Park’s boundaries. The weakness of the community management policy on the part of the park managers and the resentment of the indigenous peoples towards the restriction of their access to natural resources are the major constraints on the sustainable management of conflicts between the local populations and the wild animals in the KBNP. The strategies for the sustainable resolution of human-wildlife conflicts around the KBNP must be geared towards and integrated into a community conservation approach.

关键词： Community Conservation Human-Wildlife Conflict Kahuzi-Biega National Park

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Profile of Multidrug Resistant Bacteria in Bukavu Hospitals and Antimicrobial Susceptibility to Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis and Staphylococcus aureus

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Advances in Microbiology 2024年第4期14卷 209-225页

作者： Christian Ahadi Irenge freddy Bikioli Patient Birindwa Mulashe Félicien Mushagalusa Kasali Patient Wimba Aksanti Lwango Yves Coppieters Justin Ntokamunda Kadima Department of Pharmacy and Public Health Official University of Bukavu Bukavu Democratic Republic of the Congo Department of Tropical Medecine Faculty of Medecine University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Microbiology Faculty of Medicine Official University of Bukavu Bukavu Democratic Republic of the Congo Department of Medical Biology Higher Institute of Medical Technics Bukavu Democratic Republic of the Congo School of Public Health Free University of Bruxelles Bruxelles Belgium School of Medicine College of Medicine and Health Sciences University of Rwanda Huye Rwanda

Objective: To evaluate the spread of Multidrug-Resistant (MDR) bacterial infections in Bukavu hospitals and test antimicrobial susceptibility patterns of some isolates to usual marketed antibiotics. Methods: The prevalence of MDR strains was determined by using general antimicrobial susceptibility data collected from 3 hospital laboratories. The susceptibility of some isolates to usual antibiotics was processed by agar diffusion method with standard E. coli ATCC8739 and standard antibiotics discs as controls. The tested antibiotics were ampicillin, ceftriaxone, gentamicin, chloramphenicol and ciprofloxacin. Results: At the 3 hospitals, 758 tests were realized in urine, pus, stool, FCV, blood, LCR, split and FU specimens;46 strains were unidentified and 712 strains were identified. Of 712 identified strains, 223 (31.4%) were MDR or XDR strains including Escherichia coli, Klebsiella pneumoniae, Enterobacter, Proteus mirabilis, Salmonella enterica, Pseudomonas aeruginosa, Citrobacter freundii, Morganella morganii, Enterococcus faecalis and E. faecium, Neisseria gonorrohoae, Staphylococcus aureus, coagulase-negative, staphylococci, Streptococcus pneumoniae and Streptococcus pyogenes. Of the infected patients, 36 (21.5%) children were under 16 years and 188 (78.5%) adults were predominately women (58.5%). The susceptibility test showed that all strains but S. aureus were resistant to ampicillin and amoxicillin and ciprofloxacin. Gentamicin, ceftriaxone, and chloramphenicol remain partially active (27% - 80%) against P. mirabilis, E. coli and P. aeruginosa. The resistance is more likely related to strain mutation than to pharmaceutical quality of the antibiotics prescribed. Conclusion: Both data from hospital laboratories and in vitro post-testing findings confirmed the ongoing elevated prevalence of MDR strains in Bukavu. The causes of antibiotic misuse and socio-economic determinants of the phenomenon of resistance should be scrutinized in order to take adequate strateg

关键词： Prevalence Antimicrobials Multi-Resistance Bacterial Sensitivity Bukavu DRC

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An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina Yat Wa Liu Lin Yang Man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu freddy Man-Hin Lam Daihai He Lei Yang Yan Li Gilman Kit-Hang Siu Stefanos Tyrovolas Yao Jie Xie David Man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence

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Rationale of a Cross Sectional Analytic Study on Determinants of Recurrent Preeclampsia at University Clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France)

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 824-831页

作者： Mushengezi Amani Dieudonné Sengeyi Muela Andy Mbangama Mokambanda Cynthia Awena Goy Sambwa Christian Kelele Nkongolo freddy Muamba Banza Jésual Lotoy Otem Christian Ndesanzim Department of Obstetrics and Gynecology University Clinics of Kinshasa Kinshasa Democratic Republic of Congo

Research Background: Pre-eclampsia is one of main causes of materno-foetal mortality and morbidity worldwide, with a prevalence of 3% - 7%. Although considered a primiparous condition, it can nevertheless recur. Several factors appear to be associated with risk of recurrence of pre-eclampsia, such as the term of delivery of previous pregnancy, severity of disease, the existence of co-morbidities and the inter-genital space. Purpose: The aim of our study will be to analyse and identify in a population of pregnant women with a history of preeclampsia risk factors associated with occurrence of recurrent preeclampsia at University clinics of Kinshasa (Democratic Republic of Congo) and at Victor Dupouy Hospital Center (France). Methods: In this study, pregnant women with an history of preeclampsia who will give birth between November 2018 and October 2024 at University Clinics of Kinshasa (UCK) and Victor Dupouy Hospital Center (VDHC) will be included. This will be a cross-sectional analytical study, data from previous and subsequent pregnancies will be studied. Expected Result: The prevalence of recurrent preeclampsia in the study population will be determined. And we will highlight the factors that will determine the recurrence of preeclampsia by analysing the risk factors. Conclusion: Knowledge of the factors associated with recurrent preeclampsia could be an excellent tool for predicting and preventing the disease.

关键词： Recurrent Pre-Eclampsia Risk Factor Determinants

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Role of bioengineering structures made of willow cuttings in marly sediment trapping: assessment of three real-size experiments in the Southern French Alps

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Journal of Mountain Science 2018年第2期15卷 225-236页

作者： freddy REY Univ.Grenoble Alpes Irstea Grenoble

Improving knowledge on the ability of bioengineering structures made of willow cuttings to enhance efficient and sustainable sediment trapping in marly gullies in the Southern French Alps under a mountainous Mediterranean climate, to decreasesediment trapped per experiment, the mean annual values reached 0.25, 0.14 and 0.08 m3 yr-1 in experiments C, A and B, respectively. Maximum values for one structure reached 1.94 m3 per year in experiment C. The significance of the volumes ofsediment yield at their outlets, is a key issue today for the international scientific community working in geosciences and ecology. This study therefore aims to assess three real-size experiments(A, B and C) carried out between 2003 and 2013 in this environment. A total of 157 bioengineering structures using purple and white willow(Salix purpurea and Salix incana)cuttings – which have been shown to resprout and survive more than 2 years after their installation,corresponding to brush layers with brush mats on wooden sills(BLM), 1.2 m wide and 2 m long,installed on the floors of 33 experimental marly gullies, were monitored. The results showed that sediment trapping occurred upstream of the vegetation barriers from the 1 st year *** the depth of sediment trapped per experiment, the mean annual values reached 11.2 cm yr-1 after 3 years in experiment A, 7.7 cm yr-1 after 2–4 years in experiment C and 5.1 cm yr-1 after 5 years in experiment B. Occasionally, BLMs showed that they could trap up to 16 and 15 cm yr-1 in experiments A and C, respectively. Considering the volumes oftrapped sediment and the sustainability of sediment trapping are discussed, and rules for bioengineering strategies are proposed.

关键词： Erosion Marly gully Vegetation barriers Ecological engineering Salix

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