检索结果-南通市图书馆

Survival Rate and Factors Influencing It in Triptorelin-Castrated Metastatic Prostate Cancer Patients

Open Journal of Urology 2024年第3期14卷 160-172页

作者： Sossa Jean Vissoh Gilvias Yevi dodji Magloire Inès Hodonou fred Avakoudjo déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Bénin

Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. Still, chemical androgen deprivation therapy is not always available and not every patient can afford it. Thus, it will be interesting to evaluate the results of that therapy in the country. Objective: To analyze the survival rate and factors influencing it in metastatic prostate cancer patients who underwent triptorelin-based androgen deprivation therapy at the former Military Teaching Hospital of Cotonou from January 1, 2012, to december 31, 2022. Patients and Method: Metastatic prostate cancer patients received intragluteal injections of triptorelin 11.25 mg every 3 months. We retrospectively collected follow-up data from the patients’ medical records. By means of the software StataTM version 15, we performed a descriptive analysis of qualitative data. We used Kaplan-Meir method to estimate the overall survival rate in the whole cohort and in specific subgroups of patients. We compared survival rates by using the log-rank test. Results: 68 metastatic prostate cancer patients aged 47-86 years (mean = 69.9) with initial PSA ranging from 24.25 to 6334 ng/mL (mean = 666.1) started triptorelin-based castration. The tumor grade in 21 (33.3%), 14 (22.2%), 15 (23.8), 8 (12.7%), and 5 (7.9%) patients was respectively ISUP grade groups 5, 4, 3, 2, and 1. 15 (22.1%), 4 (5.9%), 2 (2.9%), 1 (1.5%), 11 (16.2%), and 7 (10.3%) patients respectively had hypertension, diabetes mellitus, peptic ulcer, asthma, unilateral or bilateral hydronephrosis, and paralysis. The mean nadir PSA level was 22.5 ng/mL (range: 0.01-220.25). The mean time to nadir PSA level was 8.9 months (range: 3-57). The overall survival rate was 42.6%. There was no significant survival difference between age groups (p = 0.475), relating to the presence of diabetes or hypertension (p = 0.757) or to the presence of paralysis or hydronephrosis (p = 0.090). The initial PSA level exert

关键词： Metastatic Prostate Cancer Androgen deprivation Therapy Overall Survival PSA Nadir

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Results of an Eight Year Long Practice of Saline Bipolar Transurethral Resection of Prostate

引用

Open Journal of Urology 2024年第4期14卷 189-196页

作者： Sossa Jean Mangoue Moube Ariane Landry Yevi dodji Inès Magloire Hodonou fred Avakoudjo déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Open prostatectomy has long been the only prostatic bladder outlet obstruction’s surgery available in Benin. It is prone to postoperative bleeding and infections and is not suitable for prostate cancer-induced bladder outlet obstruction. Objective: To evaluate the first results of endoscopic surgery of prostatic bladder outlet obstruction in our environment. Patients and Method: We conducted an observational study of saline bipolar transurethral resection of prostate (B-TURP) at the former Military Teaching Hospital of Cotonou. We retrospectively collected the data from patients’ medical records from November 17, 2014, to September 7, 2022. We used Excel 2019 to make a descriptive analysis of the data. Results: Saline B-TURP was performed in 60 consecutive patients. Their mean age was 69.1 years (range: 48-85). The procedure was indicated in 22 (36.7%), 32 (53.3%), 3 (5%), and 3 (5%) patients, respectively for acute urinary retention, chronic urinary retention, obstructive renal failure, and unresponsiveness to alpha-blockers. 35 patients (58.3%) had prostate cancer (PCa). 25 patients (41.7) had benign prostate hyperplasia (BPH). No patient got a blood transfusion. The duration of postoperative hospitalization was 3 days (88.3%) to 5 days (11.7%). 5 patients (8.3%), i.e., 3 BPH and 2 prostate cancer patients got preoperative urinary tract infection. The causative bacteria were Escherichia coli in 3 patients (60%), Klebsiella pneumoniae in 2 patients (40%), and multi-resistant Acinetobacter as a metachronous infection to Escherichia coli in 1 patient (20%). All the infections were associated with indwelling Foley catheter. 7 patients (11.7%), i.e., 3 BPH and 4 prostate cancer patients, got a second resection to recover full spontaneous micturition. Prostate size was available in the medical record of 21 BPH patients and 15 prostate cancer patients. Prostate size ranged from 22 to 123 g with a mean value of 61.1 g in BPH patients, and from 34 to 180 g with

关键词： Saline B-TURP BPH Prostate Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards standardizing retinal optical coherence tomography angiography:a review

引用

Light(Science & Applications) 2022年第4期11卷 520-541页

作者： danuta M.Sampson Adam M.dubis fred K.Chen Robert J.Zawadzki david d.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at Moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania

引用

Infectious diseases of Poverty 2014年第1期3卷 440-448,439页

作者： Humphrey d Mazigo david W dunne Safari M Kinung’hi fred Nuwaha department of Medical Parasitology and Entomology School of MedicineCatholic University of Health and Allied SciencesP.O.Box 1464MwanzaTanzania department of disease Control and Environmental Health School of Public HealthCollege of Health SciencesMakerere UniversityP.O.Box 7072KampalaUganda department of Pathology Division of Microbiology and ParasitologyCambridge UniversityTennis Court RoadCambridge CB21QPUK National Institute for Medical Research Mwanza Research CentreP.O.Box 1462 MwanzaTanzania

Background:Animal studies have demonstrated that functional immune responses,as determined by the levels of Cd4+cell counts and anti-schistosome antibodies responses,determine the efficacy of *** on this evidence,it has been hypothesised that the immunodeficiency effects of the human immunodeficiency virus(HIV)-1 infection may affect the efficacy of praziquantel in co-infected human ***,the present study assessed the efficacy of praziquantel by comparing parasitological cure rates and the reduction in infection intensity in HIV-1 seronegative individuals infected with *** and HIV-1 seropositive individuals co-infected with ***,following treatment with a single oral dose of ***:This was a prospective longitudinal study which included,at baseline,555 *** infected adults aged 21-55 years,who were either co-infected or not with HIV-1 and who lived in fishing villages along Lake Victoria in Northwest *** individuals were treated with a single oral dose of praziquantel(40 mg/kg)and,at 12 weeks,single stool samples were obtained and examined for *** eggs using the Kato-Katz *** prick and venous blood samples were collected for HIV-1 screening and Cd4+cell ***:The parasitological cure rate did not differ significantly from the HIV-1 serostatus(P=0.12):among the co-infected individuals,the cure rate was 48.3%(14/29),and among the individuals infected only with ***,the cure rate was 62.6%(329/526).The egg reduction rate did not vary with the HIV-1 serostatus(P=0.22):77.22%for HIV-1 seronegative and 75%for HIV-1 seropositive *** level of Cd4^(+) cell counts(median 228 cells/μL:range 202-380 cells)did not influence the cure rate(P=0.23)or the reduction in the intensity of the infection(P=0.37).Conclusion:The HIV-1 infection per se or its moderate immunodeficiency effects,demonstrated by the range of Cd4^(+) cell counts observed in co-infected individuals,d

关键词： HIV-1 S.mansoni Co-infection Praziquantel Efficacy Tanzania

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anthropometric and Physical Performance Profiles of High School Age American Football Players: 11th and 12th Grade Japanese Athletes

引用

Journal of Science in Sport and Exercise 2023年第1期5卷 25-33页

作者： daichi Yamashita Shota Yamaguchi fred Ariel Hernandez Yasuhiro Yuasa depart of Sports Science Japan Institute of Sports Sciences3-15-1NishigaokaKita-kuTokyo 115-0056Japan Institute of Physical Education Keio University4-1-1HiyoshiKanagawa 223-8521Japan department of Anthropology University of California-Irvine3203 Social&Behavioral Sciences GatewayIrvineCalifornia 92697-5100USA Faculty of Sports and Health Science department of Sports Science Daito Bunka University1-9-1 TakashimadairaItabashi-kuTokyo 175-8571Japan

Purpose To compare anthropometric and physical performance profiles of Japanese 11th and 12th grade American football players within each positional *** Fifty-two 11th and 12th grade American football players from two Japanese high schools participated in the study during the summer pre-season *** performed anthropometric(height and body mass)and physical(vertical jump,broad jump,40-yard dash,pro-agility shuttle 4-kg medicine ball chest throw,front throw,and back throw)*** jump momentum and 10-yard sprint momentum were also calculated by multiplying the velocity and body *** were divided into two groups by playing positions:skill players and *** Skill players in the 12th grade were better at medicine ball chest throw(d=0.73,P=0.04)and vertical jump momen-tum(d=0.75,P=0.03)than those in the 11th ***,there were no differences in any measurements(P>0.05)between linemen from the two *** The current study suggests that upper and lower body absolute power and momentum production can be improved for skill players even over 17 years *** the other hand,body size and speed,attributes that did not change between 11th and 12th grades,seem to be essential talent identification criteria in the current *** study is needed to monitor longitudinal performance improvements in implementing talent development programs by focusing on the quality of speed,agility and power development at the youth level.

关键词： Cross-sectional study Physical fitness profile Talent identification Talent development Long-term athletic development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Response of Solanum tuberosum to Myzus persicae infestation at different stages of foliage maturity

引用

Insect Science 2014年第6期21卷 727-740页

作者： Adriana E. Alvarez Anahi M. Alberti d'Amato W. fred Tjallingii Marcel dicke Ben Vosman Laboratory of Entomology Wageningen University 6700 EH Wageningen Plant Breeding Wageningen UR 6700 AA Wageningen EPG systems 6703CJ Wageningen the Netherlands

Young leaves of the potato Solanum tuberosum L. cultivar Kardal contain resistance factors to the green peach aphid Myzuspersicae （Sulzer）（Hemiptera： Aphididae） and normal probing behavior is impeded. However, M. persicae can survive and reproduce on mature and senescent leaves of the cv. Kardal plant without problems. We compared the settling ofM. persicae on young and old leaves and analyzed the impact of aphids settling on the plant in terms of gene expression. Settling, as measured by aphid numbers staying on young or old leaves, showed that after 21 h significantly fewer aphids were found on the young leaves. At earlier time points there were no difference between young and old leaves, suggesting that the young leaf resistance factors are not located at the surface level but deeper in the tissue. Gene expression was measured in plants at 96 h postinfestation, which is at a late stage in the interaction and in compatible interactions this is long enough for host plant acceptance to occur. In old leaves of cv. Kardal （compatible interaction）, M. persicae infestation elicited a higher number of differentially regulated genes than in young leaves. The plant response to aphid infestation included a larger number of genes induced than repressed, and the proportion of induced versus repressed genes was larger in young than in old leaves. Several genes changing expression seem to be involved in changing the metabolic state of the leaf from source to sink.

关键词： cdNA microarrays green peach aphid insect-plant interactions potato

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conquering Headache : An Illustrated Guide to Understanding the Treatment and Control of Headache 4th

引用

2003年

作者： Rapoport, Alan M. Sheftell, fred d. Tepper, Stewart J.

Includes index.

ISBN: (纸本)9781550092332;9780585489216

Includes index.

关键词： Headache--Popular works

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

A Panorama of the Urological diseases at the Former Military Teaching Hospital of Cotonou

引用

Open Journal of Urology 2023年第5期13卷 143-150页

作者： Jean Sossa Lionelle Fanou Yao Félicien Hounto dodji Magloire Inès Yevi fred Jean-Martin Hodonou déjinnin Josué Georges Avakoudjo Clinique Universitaire d’Urologie-Andrologie (CUUA) Centre National Hospitalier et Universitaire Hubert Koutoucou Maga (CNHU-HKM) Cotonou Benin

Background: Urological care has been advancing quickly over the last ten years in Benin. In order to conveniently support that trend towards better urological care standards, decision-makers need sound data on urological diseases in the country. Objective: To determine the prevalence of urological diseases in the former Military Teaching Hospital of Cotonou. Patients and Method: We retrospectively collected the urological diseases that the institution had managed from January 2012 to december 2020. We used Excel© 2010 and SPSS© to analyze the collected data. Results: 4244 patients, i.e. 3717 males (87.58%) and 527 females (12.42%) were managed during the study period. The main diseases diagnosed were benign prostatic hyperplasia (32.61%, n = 1384), erectile dysfunction (10.44%, n = 443), chronic prostatitis (5.94%, n = 252), prostate cancer (4.03%, n = 171), and ejaculatory disorders (3.44%, n = 146). In patients ≤ 15 years, predominant diseases were peritoneal vaginal canal (15.9%, n = 43), circumcision (15.6%, n = 42), testicular dystopia (10.7%, n = 29), hydrocele (7.8%, n = 21), and hypospadias (5.6%, n = 15). Wilms tumor (1.9%, n = 5) was the first cancer, testicular (0.4%, n = 1) and para-testicular (0.4%, n = 1) tumors were the next. In patients > 15 and ≤40 years, the main diseases were infertility (14.1%, n = 189), chronic prostatitis (12.9%, n = 173), erectile dysfunction (10.1%, n = 135), ejaculatory disorders (6.2%, n = 83), genital infections (6.2%, n = 83) and urinary stone (4.9%, n = 66). The first cancer was kidney cancer (0.97%, n = 13) followed by bladder cancer (0.3%, n = 4) and testicular tumor (0.3%, n = 4). In patients >40 years, the most prevalent diseases were BPH (52.0%, n = 1370), erectile dysfunction (11.7%, n = 308), prostate cancer (6.5%, n = 171), inguinal hernia (5.1%, n = 134), and urinary stone (3.9%, n = 102). Prostate cancer is the first cancer;the next were bladder (0.95%, n = 25) and kidney (0.68%, n = 18) c

关键词： Urological diseases Former Military Teaching Hospital of Cotonou

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of thermal treatment and fermentation by lactic acid bacteria on sorghum metabolite changes, their antioxidant and antidiabetic activities

引用

Food Bioscience 2022年第1期45卷 284-292页

作者： fred Kwame Ofosu Fazle Elahi Eric Banan-Mwine daliri Sang-Ik Han deog-Hwan Oh department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheonGangwon-do24341South Korea department of Southern Area Crop Science NICS Upland Crop Breeding Res.Div.Gyeongsangnaam-do50424South Korea department of Biological Models Life Sciences CenterVilnius UniversityLithuania

This study evaluated the impact of thermal treatment and lactic acid bacteria fermentation of sorghum on the antioxidant,antidiabetic,nutritional and metabolite *** cooking and pressurized cooking improved the antioxidant capacity compared to *** of wet cooked(H95F)and pressurized cooked samples(H121F)further enhanced the ABTS and dPPH antioxidant capacity by 2.4 and 2.0 times;and 1.5 and 1.8 times higher than raw,*** acidilactici OHFR1 fermentation of sorghum M20 genotype after wet cooking at 60℃,80℃ and 95℃ significantly decreasedα-glucosidase inhibition to 39.1%,40.6% and 46.4%,respectively,compared to raw(51.6%).However,α-glucosidase inhibition significantly increased to 70.1% after pressurized cooking and ***,28 metabolites including phenolic compounds,amino acids and their derivatives,peptides and microbial metabolites were identified in sorghum M20 using UHPLC-Q-TOF-MS/MS non-targeted approach after *** to the raw sorghum sample,wet cooking and pressurized cooking resulted in 9 differential metabolites *** after wet and pressurized cooking resulted in 4 and 14 differential metabolites,respectively,compared to the *** findings confirm the potential of thermal treatment and fermentation to significantly modify sorghum bioactive components and their use as functional ingredients in the management of diabetes.

关键词： Whole sorghum grain Cooking Fermentation Antioxidant capacity Antidiabetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of Comorbidities in the Urological Patients at the Former Military Teaching Hospital of Cotonou

引用

Open Journal of Urology 2023年第11期13卷 476-483页

作者： Sossa Jean Fanou Lionelle Hounto Yao Félicien Yevi dodji Magloire Inès Hodonou fred Martin Avakoudjo déjinnin Josué Georges Clinique Universitaire d’Urologie-Andrologie Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Comorbidities are additive diseases and care burdens in urological patients. determining the epidemiologic profile of comorbidities in urological patients in our setting may help us to better the management of urological disease. Objective: To evaluate the prevalence of comorbidities in urological patients. Patient and Method: We collected comorbidity, urological disease and demographic data in all urological patients managed at the former Military Teaching Hospital of Cotonou from January 1, 2012, to december 31, 2020. We used the software R 4.2.2 to perform descriptive and bi-varied data analysis. Student’s t test was used to compare means. Results: The prevalence of comorbidities was 14.2%, i.e., 601 comorbidity-affected among 4242 patients. The comorbidities predominantly affected men: the sex ratio was 13:1. The presence of comorbidity was correlated with patients’ age (p dities observed in the 601 affected patients were hypertension (84.5%), diabetes (26.5%), asthma (2%), and heart failure (1.2%). Hypertension (p = 0.001) and asthma (p = 0.030) were correlated with age. No comorbidity was associated with gender. The comorbidities’ prevalence was highest in patients aged 40 - 80 years who presented urological diseases such as BPH (68.9%), Erectile dysfunction (Ed) and ejaculatory disorders, overactive bladder (OAB) and neurogenic lower urinary tract dysfunction (LUTd), renal cyst (5%), inguinal hernia (4.2%), urinary stones (2.8%), and prostate cancer (2.3%). Conclusion: The comorbidities’ prevalence was 14.2% in the urological patients. The main comorbidities were hypertension (84.5%) and diabetes mellitus (26.5%).

关键词： Comorbidity Urological Patients Prevalence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：