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Effects of Histotripsy on Local tumor Progression in an in vivo Orthotopic Rodent Liver tumor Model

Biomedical Engineering Frontiers 2020年第1期1卷 50-63页

作者： tejaswi Worlikar Mishal Mendiratta-Lala Eli Vlaisavljevich Ryan Hubbard Jiaqi Shi timothy L.Hall Clifford S.Cho fred t.lee Joan Greve Zhen Xu Department of Biomedical Engineering University of MichiganAnn ArborMichigan 48109USA Division of Abdominal Radiology University of MichiganAnn ArborMichigan 48109USA Department of Biomedical Engineering and Mechanics Virginia Polytechnic Institute and State UniversityBlacksburgVirginia 24061USA Department of Pathology University of MichiganAnn ArborMichigan 48109USA Department of Surgery University of MichiganAnn ArborMichigan 48109USA Department of Surgery VA Ann Arbor Healthcare SystemAnn ArborMichigan 48105USA Department of Radiology University of WisconsinMadisonWisconsin 53705USA

Objective and Impact *** is the first longitudinal study investigating the effects of histotripsy on local tumor progression in an in vivo orthotopic,immunocompetent rat hepatocellular carcinoma(HCC)*** is the first noninvasive,nonionizing,nonthermal,mechanical ablation technique using ultrasound to generate acoustic cavitation to liquefy the target tissue into acellular debris with millimeter ***,histotripsy has demonstrated in vivo ablation of noncancerous liver ***.N1-S1 HCC tumors were generated in the livers of immunocompetent rats(n=6,control;n=15,treatment).Real-time ultrasound-guided histotripsy was applied to ablate either 100%tumor volume+up to 2 mm margin(n=9,complete treatment)or 50-75%tumor volume(n=6,partial treatment)by delivering 1-2 cycle histotripsy pulses at 100 Hz PRF(pulse repetition frequency)with p−≥30 MPa using a custom 1 MHz *** were monitored weekly using MRI(magnetic resonance imaging)for 3 months or until tumors reached~25 *** revealed effective post-histotripsy reduction of tumor burden with near-complete resorption of the ablated tumor in 14/15(93.3%)treated *** showedtumoral,fibrous tissue at the treatment site at 3 *** with increased tumor burden(3/6 control and 1 partial treatment)were euthanized early by 2-4 *** 3 other controls,histology revealed fibrous tissue at original tumor site at 3 *** was no evidence of histotripsy-induced off-target tissue *** and partial histotripsy ablation resulted in effective tumor removal for 14/15 rats,with no evidence of local tumor progression or recurrence.

关键词： repetition debris cavitation

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General Compartmental Epidemic Models

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Chinese Annals of Mathematics,Series B 2010年第3期31卷 289-304页

作者： fred BRAUER Department of Mathematics University of British Columbia

the age of infection approach introduced by Kermack and Mckendrick in 1927 gives a unified way of describing and analyzing a variety of epidemic models, including models with multiple stages, treatment, and heterogeneous mixing. the author gives a description of the main results for such models, emphasizing the use of the final size relation to estimate the size of the epidemic.

关键词： Epidemic models treatment models Basic reproduction number Final size relation

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Focal distance tabu search

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Science China(Information Sciences) 2021年第5期64卷 5-16页

作者： fred GLOVER Zhipeng Lü Meta-Analytics Inc. School of Computer Science and technology Huazhong University of Science and Technology

Focal distance tabu search modifies a standard tabu search algorithm for binary optimization by augmenting a periodic diversification step that drives the search away from a current best(or elite) solution until the objective function deteriorates beyond a specified threshold or until attaining a lower bound on the distance from the originating solution. the new augmented algorithm combines the threshold and lower bound approaches by introducing an initial focal distance for the lower bound which is updated when the diversification step is completed. However, rather than terminating the diversification step at the customary completion point, focal distance tabu search(tS) retains the focal distance bound through additional search phases designed to improve the objective function, drawing on a strategy proposed with strategic *** algorithm realizes this strategy by partitioning the variables into two sets which are managed together with an abbreviated tabu search process. An advanced version of the approach drives the search away from a collection of solutions rather than a single originating solution, introducing the concept of a signature solution to guide the search. the method can be employed to augment a variety of other metaheuristic algorithms such as those using threshold procedures, late acceptance hill climbing, iterated local search, breakout local search, GRASP, and path relinking.

关键词： tabu search diversification strategic oscillation adaptive partitioning metaheuristics

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CREAtING BALANCED AND CONNECtED CLUStERS tO IMPROVE SERVICE DELIVERY ROUtES IN LOGIStICS PLANNING

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Journal of Systems Science and Systems Engineering 2010年第4期19卷 453-480页

作者： Buyang CAO fred GLOVER Esri Inc. 380 New York Street CA 92373 USA Opttek Systems Inc. 2241 17th Street Boulder CO 80302 USA

A challenging problem in real world logistics applications consists in planning service territories for customer deliveries, in contexts where customers must be clustered into groups that satisfy various conditions such as balance and connectivity. In this paper we propose new algorithms for producing such clusters based upon special procedures for exploiting thiessen polygons. Our methods are able to handle multiple criteria for balancing the clusters, such as the number of customers in each cluster, the service revenue in each cluster, or the delivery/pickup quantity in each cluster. Computational results demonstrate the efficacy of our new procedures, which are able to assist users to plan service personal service territories and vehicle routes more efficiently.

关键词： Clustering K-means logistics routing thiessen polygon

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Benefits of High-voltage SiC-based Power Electronics in Medium-voltage Power-distribution Grids

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Chinese Journal of Electrical Engineering 2021年第1期7卷 1-26页

作者： fred Wang Shiqi Ji Department of Electrical Engineering and Computer Science The University of TennesseeTN 37996USA Oak Ridge National Lab Oak RidgeTN 37830USA Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

Medium-voltage(MV)power electronics equipment has been increasingly applied m distnbution grids,and high-voltage(HV)silicon carbide(SiC)power semiconductors have attracted considerable attention in recent *** paper first overviews the development and status of HV SiC power ***,MV power-converter applications in distribution grids are summarized and the benefits of HV SiC in these applications are ***,including conventional and asynchronous microgrids,that can fully demonstrate the benefits of HV SiC power semiconductors are selected to investigate the benefits of HV SiC in detail,including converter-level benefits and system-level ***,an asynchronous microgrid power-conditioning system(PCS)prototype using a 10 kV SiC MOSFEt is presented.

关键词： Silicon carbide power semiconductor distribution grid asynchronous microgrid power-conditioning system

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Universal optimality of digital nets and lattice designs

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Science China Mathematics 2009年第11期52卷 2309-2320页

作者： HICKERNELL fred J Department of Applied Mathematics Illinois Institute of Technology

this article considers universal optimality of digital nets and lattice designs in a regression model. Based on the equivalence theorem for matrix means and majorization theory,the necessary and sufficient conditions for lattice designs being φp-and universally optimal in trigonometric function and Chebyshev polynomial regression models are obtained. It is shown that digital nets are universally optimal for both complete and incomplete Walsh function regression models under some specified conditions,and are also universally optimal for complete Haar wavelet regression models but may not for incomplete Haar wavelet regression models.

关键词： Chebyshev polynomial Haar wavelet trigonometric function Walsh function 62K15 62K10

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Internet literacy

Internet literacy

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2006年

作者： fred t. Hofstetter

来源：畅想之星图书光盘版（南... 评论

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基于分布式最大功率跟踪的光伏系统输出特性分析

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电工技术学报 2015年第24期30卷 127-134页

作者：王丰孔鹏举 fred C.lee 卓放西安交通大学电气工程学院西安710049 iWatt公司加州美国95008 弗吉尼亚理工大学弗吉尼亚州美国24060

分布式最大功率跟踪(DMPPt)光伏系统可以有效地抑制实际环境中因为光照不均影响所造成的产电率下降的问题。以DMPPt的光伏系统为研究对象,针对多个分布式最大功率跟踪模块组网的优化问题,基于系统静态输出特性对多个光伏优化模块级联的... 详细信息

分布式最大功率跟踪(DMPPt)光伏系统可以有效地抑制实际环境中因为光照不均影响所造成的产电率下降的问题。以DMPPt的光伏系统为研究对象,针对多个分布式最大功率跟踪模块组网的优化问题,基于系统静态输出特性对多个光伏优化模块级联的结构进行了分析,提出了一种新型的DMPPt光伏系统结构。通过分析和研究,阐明了光照条件、系统结构及单个光伏优化模块本身限压值、限流值等参数与光伏阵列最大输出功率之间的关系。所提出的新型DMPPt光伏系统结构可以保证在不同的光照条件下每块光伏板都可以工作在各自的最大功率点,该结构有效地提高了光伏阵列在失配问题下产电率,并且适用于高电压母线系统。最后搭建了实验平台,通过硬件实验平台验证了所提出的新型DMPPt光伏系统结构对光伏系统产电率的优化效果。

关键词：分布式最大功率跟踪光伏光照不均结构优化

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嵌入式智能光伏模块的最大功率输出统一控制

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中国电机工程学报 2013年第21期33卷 81-89,196页

作者：王丰吴新科 fred C.lee 卓放西安交通大学电气工程学院陕西省西安市710049 浙江大学电气工程学院杭州省浙江市310058 Virginia Polytechnic Institute and State University VA U.S. 24060

传统的太阳能系统经常会因为实际应用环境中的不匹配问题和光照不均现象而影响效率。分布式最大功率跟踪(distributed max power point tracking,DMPPt)概念的提出有效地抑制了这种影响。在分布式最大功率跟踪的基础上,该文提出一种嵌... 详细信息

传统的太阳能系统经常会因为实际应用环境中的不匹配问题和光照不均现象而影响效率。分布式最大功率跟踪(distributed max power point tracking,DMPPt)概念的提出有效地抑制了这种影响。在分布式最大功率跟踪的基础上,该文提出一种嵌入式智能光伏模块(sub-panel MPPt converter,SPMC),利用非隔离的DC-DC变换器替代传统太阳能板接线盒中的旁路二极管,通过输出侧统一的最大功率计算单元对输入侧进行的指令信号控制,可以有效地消除太阳能板因为不匹配问题所带来的能量损失。文中首先对所提出智能光伏模块的拓扑结构进行分析、比较。然后以BUCK型的嵌入式智能光伏模块提出统一输出最大功率跟踪控制策略,这种控制策略在保证输出功率最大化的前提下,优化了系统模块,有效降低了系统控制复杂度和装置成本。最后,文章通过实验验证了所提出的概念和控制方法。

关键词：分布式最大功率跟踪光伏 DC-DC变换器统一输出控制

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A methodology for simulating 2D shock-induced dynamic stall at flight test-based fluctuating freestream

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Chinese Journal of Aeronautics 2019年第10期32卷 2223-2238页

作者： Khider AL-JABURI Daniel FESZtY fred NItZSCHE Department of Mechanical and Aerospace Engineering Carleton University

A comprehensive methodology for simulating 2 D dynamic stall at fluctuating freestream is proposed in this paper.2 D CFD simulation of a SC1095 airfoil exposed to a fluctuating freestream of Mach number 0.537±0.205 and Reynolds number 6.1×10~6(based on the mean Mach number)and undergoing a 10°±10°pitch oscillation with a frequency of 4.25 Hz was *** conditions were selected to be representative of the flow experienced by a helicopter rotor airfoil section in a real-life fast forward *** constant freestream dynamic stall as well as fluctuating freestream dynamic stall simulations were conducted and *** methodology was carefully validated with experimental data for both transonic flow and dynamic stall under fluctuating ***,the results suggest that the fluctuating freestream alters the dynamic stall mechanism documented for constant freestream in a major way,emphasizing that inclusion of this effect in the prediction of dynamic stall related rotor loads is imperative for rotor performance analysis and blades design.

关键词： Mach fluctuation Pitching airfoil Shock-induced dynamic stall transonic flow Unsteady freestream velocity

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