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Dynamic genetic features of eukaryotic plankton diversity in the Nakdong River estuary of Korea

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Chinese Journal of Oceanology and Limnology 2017年第4期35卷 844-857页

作者： Lee Jee eun CHUNG ik Kyo Lee Sang-Rae Division of earth environmental System Oceanography Major Pusan National University Marine Research Institute Pusan National University

estuaries are environments where freshwater and seawater mix and they display various salinity *** construction of river barrages and dams has rapidly changed these environments and has had a wide range of impacts on plankton *** understand the dynamics of such communities,researchers need accurate and rapid techniques for detecting plankton *** evaluated the diversity of eukaryotic plankton over a salinity gradient by applying a metagenomics tool at the Nakdong River estuary in *** samples were collected on three dates during summer and autumn of 2011 at the eulsukdo Bridge at the mouth of that *** the 18 S rDNA allowed us to analyze 456 clones and 122 *** sequences revealed various taxonomic groups and cryptic genetic variations at the intra-and inter-specific *** analyzing the same station at each sampling date,we observed that the phylotypes presented a salinity-related pattern of diversity in *** variety of species within freshwater samples reflected the rapid environmental changes caused by freshwater *** phylotypes accounted for the highest proportion of overall diversity in the seawater *** diatoms and dinoflagellates were observed in the freshwater,brackish and seawater *** biological data for species composition demonstrate the transitional state between freshwater and ***,this metagenomics information can serve as a biological indicator for tracking changes in aquatic environments.

关键词： 18S rDNA clone library metagenome estuary salinity gradient

Improvement of Shape Recognition Performance of Sendzimir Mill Control Systems Using echo State Neural Networks

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Journal of Iron and Steel Research International 2014年第3期21卷 321-327页

作者： Jung-hyun PARK Seong-ik HAN Jong-shik KIM School of Mechanical engineering Pusan National University School of electrical engineering Pusan National University

High rigidity twenty-high Sendzimir mills （ZRMs） are widely used for rolling stainless steels, silicon sheets, etc. A ZRM uses a small diameter work roll to produce massive rolling forces. Since a work roll with a small diameter can be bent easily, strips often have complex shapes with mixed quarter and deep edge waves in the shape of plates. In order to solve this problem, fuzzy neural network controls are generally used for shape： recognition in ZRM control systems. Among various neural network types, the multi-layer perceptron （MLP） is typically used in current ZRMs. However, an MLP causes the loss of a large amount of shape recognition data. To improve the shape recognition per- formance of ZRM control systems, echo state networks （eSNs） are proposed to be used. Through simulation re- sults, it is found that shape recognition performance could be improved using the proposed eSN method.

关键词： Sendzimir mill neural network multi-layer perceptron echo state network shape recognition

Alteration of the p53 gene during tree shrews' hepatocarcinogenesis

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Hepatobiliary & Pancreatic Diseases International 2003年第4期2卷 612-616页

作者： Young ik Lee Bioscience Research Division Korea Research Institute of Bioscience and Biotechnology P. O. Box 115 Yusong Taejon 305-600 South Korea

OBJeCTIVe: To detect the expression and variation of the p53 gene in hepatocarcinogenesis of tree shrews induced by hepatitis B virus (HBV) and aflatoxin B_1(AFB_1). MeTHODS: Tree shrews were divided into four groups: group A, infected with HBV and fed with AFB_1; group B, only infected with HBV; group C, fed with AFB_1 alone; and group D normal control. The tree shrews underwent liver biopsy every. 15 weeks. Liver and tumor tissues were detected by immunohistochemistry and molecular biotechnologies. ReSULTS: The incidence of hepatocellular carcinoma (HCC) was higher in group A (66.7%) than in groups B (0) and C (30%). HCC occurrence was earlier in group A than in group C (120.0±16.6 wk vs 153.3±5.8 wk, t=3.336, Ped p53 protein was not found in all groups before 75 weeks of experiment. At the 105th week, the expression rates of mutated p53 protein were 78.6%, 60.0% and 71.4% in groups A, B and C respectively, which were significantly higher than that in group D (10%) (X^2≥5.03, Pe p53 gene was detected in groups A and C. The mutational points of the p53 gene in liver cancer of tree shrews were at codon 275, 78 and 13. Nucleotide sequence and amino acids sequence of tree shrew's wild-type p53 were 91.7% and 93.4% in homology, compared with those of human p53, respectively. CONCLUSIONS: Remarkable synergistic effect on HCC exists between HBV and AFB_1. Mutated p53 protein expressed before occurrence of HCC promotes the development of HCC. HBV and AFB_1 may synergistically induce p53 gene mutation.

关键词： hepatocellular carcinom gene p53 hepatitis B virus aflatoxin B_1 tree shrew

Systematic study of(MoTa)_(x)NbTiZr medium-and high-entropy alloys for biomedical implants-In vivo biocompatibility examination

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Journal of Materials Science & Technology 2021年第19期78卷 183-191页

作者： Muhammad Akmal Ahtesham Hussain Muhammad Afzal Young ik Lee Ho Jin Ryu Department of Materials Science and engineering KAISTYuseongDaejeon 34141South Korea Lee's Biotech Co. Ltd.#415C-Dong13 Techno-4-roYuseong-guDaejeon34013South Korea Department of Mechanical engineering KAISTYuseongDaejeon34141South Korea Department of Nuclear and Quantum engineering KAISTYuseongDaejeon 34141South Korea

In this study,the application of medium-and high-entropy(Mo Ta)_(x)Nb Ti Zr alloys in biomedical implants was systematically *** alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties.A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta *** with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30%under *** nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system *** was surmised that the addition of Ta and Mo above a critical concentration(mole fraction=0.4)was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the ***,the(Mo Ta)_(0.2)Nb Ti Zr alloy is a potential structural material for biomedical implants because of its excellent strength and *** developed alloy was investigated for its corrosion properties and compared with commercial biomedical ***,the biocompatibility of the alloy was examined using an in vivo *** alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was *** alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response.

关键词： High-entropy alloys Medium-entropy alloys Biomedical applications In vivo Biocompatibility

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Microstructure and Mechanical Properties of TiB-Containing Al–Zn Binary Alloys

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Journal of Materials Science & Technology 2016年第7期32卷 653-659页

作者： Sang-Soo Shin Gil-Yong Yeom Tae-Yang Kwak ik-Min Park Department of Materials Science and engineering Pusan National University Busan 609-735 Republic of Korea Liquid Processing & Casting Technology R&BD Group Korea Institute of Industrial Technology Incheon 21999 Republic of Korea

The microstructure and mechanical properties of newly developed Al-35Zn cast alloys with TiB refiner addition were evaluated by X-ray diffractometry, optical microscopy, and scanning electron microscopy coupled with energy dispersive spectrometry. The microstructure of these alloys featured α-Al den- drites surrounded by AI-Zn （α ＋ rI） eutectic structures. After the addition of TiB refiner, the alloy grain sizes decreased, and its morphology abruptly changed from dendritic to equiaxed grains. Such an im- proved microstructure of the modified alloys was accompanied by a significant increase in the tensile strength and elongation percentage compared to those of the AI-Zn or Zn-Al-based alloys. The results showed that with the increase of TiB content up to 0.05%, the morphology of α-Al dendrites and α ＋ T1 phases changed from coarse dendrite and lamellar structures into independent and fine ones. Based on these results, the effect of TiB refiner addition on the microstructure and mechanical properties of the AI-35Zn binary alloys was investigated.

关键词： Al-Zn(-Cu) alloyeutectic structureHigh strengthTiB2

effect of Sub-T_g Annealing on the Corrosion Resistance of the Cu–Zr Amorphous Alloys

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Acta Metallurgica Sinica(english Letters) 2018年第3期31卷 273-280页

作者： Sang-Soo Shin Hong-Kyu Kim Jae-Chul Lee ik-Min Park Department of Materials Science and engineering Pusan National University Advanced Analysis Center Korea Institute of Science and Technology Department of Materials Science and engineering Korea University

Despite the economy of material cost and excellent toughness of Cu-based amorphous alloys,especially CusoZrso,their poor corrosion resistance to a chloride medium limits their widespread *** this study,corrosion tests were performed on the CusoZrso amorphous alloy with different degrees of short-range order,which were prepared by annealing below the glass transition temperature（Tg）.It was found that the corrosion resistance of amorphous alloys is improved to a significant level when the alloys were heated below *** studies showed that thermally activated relaxation process of created disorder,which occurs during sub-Tg annealing,is responsible for the improvement in the corrosion *** dynamics simulations performed on the Cu-Zr amorphous alloys demonstrated that the relaxation process of the alloys is associated with the formation of energetically stable icosahedra and icosahedron-like *** study highlights the effects of sub-Tg annealing on the improvement in the corrosion resistance of the amorphous alloys from the viewpoint the relaxation process of the short-range orders.

关键词： Amorphous alloys Corrosion Annealing Molecular dynamics electrochemical performance

Microstructure and Mechanical Properties of Mg-Al-Ca-Nd Alloys Fabricated by Gravity Casting

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Journal of Materials Science & Technology 2008年第1期24卷 85-88页

作者： Hyeon-Taek Son Jae-Seol Lee ik-Hyun Oh Chang-Seog Kang Korea Institute of Industrial Technology 1110-90ryong-dong Buk-gu Gwangju 500-480 South Korea

The aims of this study are to investigate the effects of Nd addition in the Mg-Al-Ca alloys on microstructure and mechanical *** of as-cast Mg-5Al-3Ca alloy containing Nd consists ofα-Mg matrix, eutectic phase and Al-Nd rich intermetallic *** Nd addition was increased,α-Mg matrix morphology was changed from dendritic to equiaxed grains and average value of grain size was *** addition to Mg-5Al-3Ca based alloys resulted in the formation of Al-Nd rich intermetallic compounds at grain boundary andα-Mg matrix *** these Al-Nd rich intermetallic compounds were dispersed *** these alloys,two kinds of eutectic phases were observed,*** irregular-shape structure at grain boundary and fine needle-shape structure in theα-Mg matrix *** is found that the ultimate strength showed the maximum value of 271 MPa at Mg-5Al-3Ca-2Nd alloy and elongation was decreased as the addition of Nd was increased.

关键词： Mg-AI-Ca alloy Neodymium (Nd) Rare earth element

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苯乙烯和叔丁氧羰氧苯乙烯的分散共聚合

应用化学 1994年第2期11卷 67-69页

作者：唐康泰 fre.,JMJ 中国科学院广州化学研究所

苯乙烯和叔丁氧羰氧苯乙烯在有机溶剂中分散共聚得到１．３～６．６μｍ均一尺寸聚合物粒子。考察了溶剂的溶度参数、反应温度、单体比和分散剂对生成粒子的影响，溶剂和生成的共聚物粒子的极性（溶度参数）相差越大导致位于尺寸减小；... 详细信息

苯乙烯和叔丁氧羰氧苯乙烯在有机溶剂中分散共聚得到１．３～６．６μｍ均一尺寸聚合物粒子。考察了溶剂的溶度参数、反应温度、单体比和分散剂对生成粒子的影响，溶剂和生成的共聚物粒子的极性（溶度参数）相差越大导致位于尺寸减小；反应温度较低时，得到的粒子尺寸亦较小。

关键词：苯乙烯叔丁氧羰氧苯乙烯聚合