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Heat Transfer and Flow Structure of a Turbine blade's Air-cooled leading edge Considering Different Hole Shapes and Additional Flow Angles

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Journal of Thermal Science 2024年第4期33卷 1421-1442页

作者： QIN Runxuan ZHOU Xun WANG Songtao CAI le School of energy Science and engineering Harbin Institute of TechnologyHarbin150001China

A numerical study is conducted to elucidate the impact of hole shapes and additional flow angles on the flow structure of the coolant and temperature field in the leading edge area of the gas turbine *** typical hole shapes are considered for the Ge-e3 *** impact of the additional flow angle(e)within each hole shape on the temperature field is *** results indicate that for the leading edge area and suction surface,the fan-shaped hole case performs best in decreasing temperatures,with a decrease of about 43 *** is mainly due to the fact that the fan-shaped hole has the maximum expansion in hole spanwise *** the pressure surface,the console hole case performs best in decreasing temperatures,with a maximum reduction of about 47.2 *** influence of e on the surface temperature at leading edge area varied between the different hole *** the cylinder hole and console hole,the e=-20°case has the lowest area-averaged *** both the fan-shaped hole and the 7-7-7 shaped hole are expansion holes,the pattern of variation of the leading edge area temperature with increasing e is similar for the fan-shaped hole case and 7-7-7 shaped hole *** e=20°case shows the lowest spanwise-averaged temperature near the hole outlet,and the e=-20°case shows the lowest spanwise-averaged temperature further downstream.

关键词： film cooling Ge-e3 turbine rotor blade conjugate heat transfer leading edge

Neg-entropy Mechanism as a Target for Natural Medicines

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engineering 2024年第7期38卷 11-12页

作者： Tian-le Gao Hui-Hui Guo Jian-Dong Jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

effectiveness of ivermectin mass drug administration in the control of soil-transmitted helminth infections in endemic populations: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第1期13卷 1-15页

作者： brandon le Naomi e.Clarke Nicolas legrand Susana Vaz Nery The Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

background Current soil-transmitted helminth(STH)control guidelines endorse the use of albendazole or meben-dazole for school-based targeted preventive chemotherapy(PC),yet their reduced efficacy against Strongyloides sterc-oralis and Trichuris trichiura presents significant *** evidence indicates that community-wide PC[or mass drug administration(MDA)]using ivermectin,commonly used in other neglected tropical disease(NTD)control programs,may play an important role in controlling these *** conducted a systematic review and meta-analysis to evaluate the effectiveness of ivermectin PC in reducing STH prevalence in endemic *** We searched Pubmed,eMbASe,and Web of Science on February 14,2023,for studies that investigated the effectiveness of ivermectin PC,either alone or in combination with other anthelmintic drugs,on STH infec-tions,and provided a measure of STH prevalence before and after *** calculated pooled prevalence reductions for each STH using random-effects *** protocol is available on PROSPeRO(registration number CRD42023401219).Results A total of 21 were eligible for the systematic review,of which 15 were eligible for *** studies delivered ivermectin through *** pooled prevalence reduction of *** following MDA with ivermec-tin alone was 84.49%(95%CI:54.96-94.66)across five studies and 81.37%(95% CI:61.62-90.96)across seven studies with or without *** prevalence reduction of *** was 49.93%(95%CI:18.23-69.34)across five studies with ivermectin alone,and 89.40%(95%CI:73.66-95.73)across three studies with the addition of *** was high heterogeneity for all syntheses(I^(2)>65%).Conclusions This study underscores the key role of ivermectin-based MDA in addressing limitations in current global STH guidelines in terms of limited efficacy against *** and *** on these findings,revising inter-national STH guidelines to include i

关键词： Soil-transmitted helminths Ivermectin Albendazole Mass drug administration Preventive chemotherapy

A Novel Supercapacitor Degradation Prediction Using a 1D Convolutional Neural Network and Improved Informer Model

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Protection and Control of Modern Power Systems 2024年第4期9卷 51-68页

作者： Hao Zhang Zhenxiao yi le Kang yi Zhang Kai Wang the College of Materials Science and engineering Xi’an University of Science and Technol-ogyXi’an 710054China the School of electrical engineering Qingdao UniversityQingdao 266071China the School of energy Sciences and engineering Nanjing Tech UniversityNanjing 211816China

Safety and reliability are crucial for the next-generation supercapacitors used in energy storage systems,while accurate prediction of the degradation trajectory and remaining useful life(RUL)is essential for analyzing degradation and evaluating performance in energy storage *** study proposes a novel data processing and improved one-dimensional convolutional neural network(1D CNN)-informer framework for robust RUL *** data preprocessing,all data from two structures are adjusted to a unified format,and cross-entropy loss is used to couple the 1D CNN and ***,the minimum-maximum feature scaling method is used for normalization to accelerate the training process in reaching the minimum cost function.A relative position encoding algorithm is introduced to improve the Informer model,enabling it to better learn the sequence relationships between data and effectively reduce prediction *** data in dif-ferent working conditions are used to validate the proposed *** with other existing methods,the maximum root mean square error is reduced by 32.71%,the mean absolute error is reduced by 28.50%,and R^(2) is increased by 4.79%.The strategy considers the complementarity between two single models,which can extract features and enrich local details,as well as enhance the model’s global perception *** experimental results demonstrate that the proposed model achieves high-precision and robust RUL prediction,thereby pro-moting the industrial application of supercapacitors.

关键词： Supercapacitors remaining useful life convolution neural network transformer informer

Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

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Acta Pharmaceutica Sinica b 2024年第2期14卷 437-454页

作者： Jiamei le.yilong Chen Wei yang Ligong Chen Jianping ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter *** transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and *** actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUT4), glucose reabsorption(e.g., SLC5A2/SGLT2), thermogenesis(e.g., SLC25A7/UCP-1), and ATP production(e.g., SLC25A4/ANT1 and SLC25A5/ANT2). The activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(T2DM). Notably, SLC5A2 has emerged as a valid drug target for T2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for T2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1b1/OATP1b1) and metformin(SLC22A1-3/OCT1-3 and SLC47A1, 2/MATe1, 2). by consolidating insights into the biological activities and clinical relevance of SLC transporters in T2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis Polymorphisms

A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang Xue Gisèle Krysztofiak yangang Ren Min Cai Patrick Mercier Frédéric le Fur Corinne Robin benoit Grosselin Véronique Daele Max RMcGillen yujing Mu Valéry Catoire Abdelwahid Mellouki Laboratoire de Physique et Chimie de l’environnement et de l’espace(LPC2e) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research Centre for eco-environmental Sciences Chinese Academy of SciencesBeijing 100085China Lig’Air-Association de surveillance de la qualitéde l’air en région Centre-Val de Loire Saint-Cyr-en-Val 45590France Mohammed V University RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(Loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as eF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and bC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFeD and FINN)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality emission factor emission inventory VOLTAIRe supersite

enhancement of mechanical properties of GTAW joints for ZC63 magnesium alloy by post-weld heat treatment

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Journal of Materials Science & Technology 2024年第2期169卷 251-263页

作者： Weiyang Zhou Qichi le.ye Shi Qiyu Liao Tong Wang Qi Zou Clodualdo Aranas Jr Key Lab of electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Key Laboratory of Lightweight Structural Materials Liaoning ProvinceNortheastern UniversityShenyang 110819China School of Materials Science and engineering Northeastern UniversityShenyang 110819China Department of Mechanical engineering University of New BrunswickFrederictonE3B 5A3New BrunswickCanada

To further improve the microstructure and mechanical properties of gas tungsten arc welded(GTAW)welded joints for ZC63 magnesium alloy,post-weld heat treatment is carried *** is found that the majority of the MgZnCu phase in the fusion zone(FZ)is dissolved in theα-Mg matrix under suitable heat treatment *** remainder is diffusely distributed as rods or granules at the grain *** excessive heat treatment temperature(460℃)leads to abnormal grain growth(AGG)in the *** substructure gradient between the abnormally grown grains and the surrounding small grains pro-vides the driving force for ***,the dissolution of the MgZnCu phase weakens the hindering effect of the second phase on grain boundary migration,setting the stage for *** addition,the detri-mental impact of the continuous MgZnCu phase on the mechanical properties of the welded joint is also lessened by its *** ultimate tensile strength(UTS),yield strength(yS)and elongation(eL)of the welded joints are 255 MPa,119 MPa and 27.0%,respectively,under the post-weld heat treatment process of 440℃×12 *** welding coefficient of the welded joint reaches 97.0%,satisfying the service criteria set forth by the mechanical properties of the welded joints.

关键词： GTAW FZ Heat treatment AGG Mechanical properties

experimental measurements of gamma-photon production and estimation of electron/positron production on the PeTAL laser facility

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Matter and Radiation at extremes 2024年第5期9卷 32-47页

作者： F.brun L.Ribotte G.boutoux X.Davoine P.e.Masson-Laborde y.Sentoku N.Iwata N.blanchot D.batani I.Lantuéjoul L.lecherbourg b.Rosse C.Rousseaux b.Vauzour D.Raffestin e.D’Humières X.Ribeyre Centre Lasers Intenses et Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance CeA DAMCESTAF-33116 Le BarpFrance CeA DAMDIFF-91297 ArpajonFrance CeA LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute of Laser engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article reports the first measurements of high-energy photons produced with the high-intensity PeTawatt Aquitaine Laser(PeTAL)*** experiments were performed during the commissioning of the *** laser had an energy of about 400 J,an intensity of 8×10^(18)W cm^(−2),and a pulse duration of 660 fs(FWHM).It was shot at a 2 mm-thick solid tungsten *** high-energy photons were produced mainly from the bremsstrahlung process for relativistic electrons accelerated inside a plasma generated on the front side of the *** paper reports measurements of electrons,protons and *** electrons up to35 MeV with a few-MeV temperature were recorded by a spectrometer,called SeSAMe(SpectreÉlectronS Angulaire MoyenneÉnergie).K-and L-shells were clearly detected by a photon spectrometer called SPeCTIX(Spectromètre PetalàCristal en TransmIssion pour le rayonnnement X).High-energy photons were diagnosed by CRACC-X(Cassette de RAdiographie Centre Chambre-rayonnement X),a bremsstrahlung *** cannon analysis is strongly dependent on the hypothesis adopted for the spectral *** shapes can exhibit similar reproductions of the experimental *** eliminate dependence on the shape hypothesis and to facilitate analysis of the data,simulations of the interaction were *** model the mechanisms involved,a simulation chain including hydrodynamic,particle-in-cell,and Monte Carlo simulations was *** simulations model the preplasma generated at the front of the target by the PeTAL laser prepulse,the acceleration of electrons inside the plasma,the generation of MeV-range photons from these electrons,and the response of the detector impacted by the energetic photon *** this work enabled reproduction of the experimental *** high-energy photons produced have a large emission angle and an exponential distribution *** addition to the analysis of the photon spectra,positron production was also ***,if high

关键词： process. positron hypothesis

CpG Island Definition and Methylation Mapping of the T2T-yAO Genome

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Genomics, Proteomics & bioinformatics 2024年第2期22卷 69-79页

作者： Ming Xiao Rui Wei Jun yu Chujie Gao Fengyi yang le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Precisely defining and mapping all cytosine(C)positions and their clusters,known as CpG islands(CGIs),as well as their methylation status,are pivotal for genome-wide epigenetic studies,especially when population-centric reference genomes are ready for timely ***,we first align the two high-quality reference genomes,T2T-yAO and T2T-CHM13,from different ethnic backgrounds in a base-by-base fashion and compute their genome-wide density-defined and position-defined ***,by mapping some representative genome-wide methylation data from selected organs onto the two genomes,we find that there are about 4.7%–5.8%sequence divergency of variable categories depending on quality *** among the divergent sequences are mostly associated with neurological ***,CGIs associated with the divergent sequences are significantly different with respect to CpG density and observed CpG/expected CpG(O/e)ratio between the two ***,we find that the T2T-yAO genome not only has a greater CpG coverage than that of the T2T-CHM13 genome when whole-genome bisulfite sequencing(WGbS)data from the european and American populations are mapped to each reference,but also shows more hyper-methylated CpG sites as compared to the T2T-CHM13 *** study suggests that future genome-wide epigenetic studies of the Chinese populations rely on both acquisition of high-quality methylation data and subsequent precision CGI mapping based on the Chinese T2T reference.

关键词： T2T-yAO Position-defined CpG island Density-defined CpG island DNA methylation Genome analysis