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Off-Pump CABG for Mulitvessel Coronary Artery Disease-Safe Incorporation into Surgical Practice

Open Journal of Th.racic Surgery 2012年第3期2卷 78-86页

作者： Cath.rina Nesselmann Sadia Aftab Manikandan Ch.ndran fraser w. h. sutherland Anaesth.tic Department Royal Hospital for Sick Children Glasgow Scotland Department for Cardioth.racic Surgery Golden Jubilee National Hospital Glasgow Scotland Department of Cardiac Surgery University of Rostock Rostock Germany

Introduction: Since its revival tw. decades ago development of th. surgical tech.ique, along w.th.evidence and clinical outcomes of off-pump coronary artery bypass surgery (OPCAB) w.re brough. into focus. Meth.ds: w. report a single surgeon, single center experience of th. first 37 consecutive patients undergoing off-pump surgery. Patients w.re selected for OPCAB (study group) individually and match.d retrospectively to a control group of 113 patients performed over an identical time frame. Data w.re retrieved from a h.spital data base (TOMCAT). Results: Mean Logistic European System of Cardiac Operative Risk Stratification (EuroSCORE) w.s sligh.ly h.gh.r in th. off-pump group (3.8% versus 2.9%). One patient died during th. study and th.s w.s in th. off-pump CAB group (OPCAB-30 day mortality 2.7%). Operating time w.s sligh.ly sh.rter in th. off-pump group (3 h.urs 28 minutes versus 3 h.urs 49 minutes, p = 0.15). After exclusion of outliers, total h.spital stay w.s significantly sh.rter for off-pump cases (mean 6.8 days versus 8.37 days), w.ile Intensive Care Unit (ICU) stay (1.2 versus 1.4 days) and ventilation time w.re only sligh.ly sh.rter (9.35 h.urs versus 10.6 h.urs) for off-pump cases. Ch.st tube drainage w.s significantly low.r in th. off-pump group (484 ml versus 744 ml, p = 0.04) w.th.correspondingly sligh.ly low.r transfusion requirements and significantly increased disch.rge h.emoglobin concentrations in OPCAB. Th.re w.s one cerebrovascular accident (CVA) in th. off-pump group and none in th. on-pump group. Conclusion: In th.s study w. sh.w.sh.rt term outcomes for introduction of off-pump into surgical tech.ique. Length.of ICU stay, ventilation times, ch.st tube drainage, transfusion re0 quirements and pre-disch.rge h.emoglobin concentration all appeared superior in th. off pump group. Th. off-pump tech.ique w.s safely introduced into th. surgeon`s service w.th.relatively little mortality. Experience of surgeon w.s considered advantageous for fast adapti

关键词： Off-Pump Versus On-Pump Coronary Artery Bypass Grafting w.th.ut Cardiopulmonary Bypass Cardiac Surgery

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Manipulation of ph.tosensory and circadian signaling restricts ph.notypic plasticity in response to ch.nging environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： Martin w.lliam Battle Scott fraser Ew.ng Cath.yn Dickson Joseph.Obaje Kristen N.Edgew.rth.Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow.Matth.w.Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth.Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:Sch.ol of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit ph.notypic plasticity to adapt th.ir grow.h.and development to prevailing environmental *** of ligh. and temperature signals is aided by th. circadian system,w.ich.provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative grow.h.and flow.ring time)can vary w.dely depending on local environmental *** prevents accurate prediction of h.rvesting times and produces a variable *** th.s study,w. sough. to restrict ph.notypic plasticity and circadian regulation by manipulating signaling systems th.t govern plants'responses to environmental *** modeling of plant grow.h.and develop-ment predicted reduced plant responses to ch.nging environments w.en circadian and ligh. signaling path.0}ys w.re *** tested th.s prediction by utilizing a constitutively active allele of th. plant ph.toreceptor ph.toch.ome B,along w.th.disruption of th. circadian systemvia mutation of *** found th.t th.se manipulations produced plants th.t are less responsive to ligh. and temper-ature cues and th.s fail to anticipate *** engineered plants h.ve uniform vegetative grow.h.and flow.ring time,demonstrating h.w.ph.notypic plasticity can be limited w.ile maintaining plant *** h.s significant implications for future agriculture in both.open fields and controlled environments.

关键词： circadian developmental plasticity ph.notypic plasticity external coincidence ligh. temperature

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Modelling th. development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,grow.h.factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badw. B.Boumelh.m Stuart T.fraser Syamak Farajikh.h.Rach.l A.Sh.arberg Mich.el B.Morris Marcela M.M.Bilek Anyu Zh.ng Beh.am Akh.van Simon Fleming Maryanne Large Sch.ol of Ph.sics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia Sch.ol of Ch.mical and Biomolecular Engineering University of SydneyAustralia Sch.ol of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia Sch.ol of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia Sch.ol of Engineering University of NewcastleCallaghanNSW 2308Australia h.nter Medical Research.Institute(h.RI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such.as nerves,blood and lymph.tic vessels,and muscle fibres exh.bit longitudinal ge-ometries w.th.distinct cell types extending along both.th. length.and w.dth.of internal linear *** th.se th.ee-dimensional structures in vitro is ch.llenging:th. best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on th. signals received,h.lding great promise for regenerative ***,th. integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge th.s gap if th. appropriate signalling systems are incorporated into th. ***,w. h.ve taken a biomimicry approach.to generate longitudinal structures in *** th.s approach.mouse embryonic stem cells are directed to differentiate to specific cell types on th. surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to w.ich.w.th.lineage-specifying molecules h.ve been covalently *** demonstrate th. simplicity and utility of our meth.d for efficiently generating h.gh.yields of th. follow.ng cell types from th.se pluripotent stem cells:neurons,vascular endoth.lial cells,osteoclasts,adipocytes,and cells of th. eryth.oid,myeloid,and lymph.id *** arranged plasma-treated scaffolds w.th.differentiated cell types could ultimately serve as a means for th. repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Grow.h.factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attach.ent Polycaprolactone

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单分子结中的有机自由基

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Science Ch.na Materials 2024年第3期67卷 709-728页

作者：张雅琦邱仁慧屈恺张成 J.fraser Stoddart 陈洪亮 Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310021China Zh.jiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CentreZhejiang UniversityHangzhou 311215China Department of Ch.mistry and Innovation Center of Pesticide Research China Agricultural UniversityBeijing 100193China Department of Ch.mistry The University of Hong KongHong Kong SAR 999077China Sch.ol of Ch.mistry University of New South WalesSydneyNSW 2052Australia Beijing National Laboratory for Molecular Sciences Beijing 100871China

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可... 详细信息

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可以通过二聚、分子识别和机械互锁等分子间相互作用来构筑超分子器件.本文综述了空气稳定有机自由基在电子学及自旋电子学中的应用,通过详述其卓越的电磁性能来拓展启发分子设计的多样性.本综述还概述了超分子自由基的制备方法和相关性质的研究进展,拓宽了单分子研究的范围.此外,自由基介导的单分子反应是一个新兴的研究方向,本文也对该领域的未来发展方向进行了展望.通过阐明空气稳定有机自由基的应用潜力,本文将有望对分子电子学和自旋电子学的研究产生一定的指导意义.

关键词： air-stable radicals molecular electronics spintronics supramolecular devices

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Off-pump coronary artery bypass grafting versus optimal medical th.rapy alone：effectiveness of incomplete revascularization in h.gh.risk patients

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Journal of Geriatric Cardiology 2016年第1期13卷 23-30页

作者： Filippo Prestipino Cristiano Spadaccio Antonio Nenna fraser w. sutherland Gw.n w.Beattie Mario Lusini Francesco Nappi Massimo Ch.llo Department of Cardiovascular Surgery Universit&#224 Campus Bio-Medico di Roma Rome Italy Department of Cardioth.racic Surgery Golden Jubilee National Hospital Clydebank Glasgow UK Department of Cardiac Surgery Centre Cardiologique du Nord de Saint-Denis Paris France

BackgroundGeriatric patients w.th.multivessel coronary artery disease （CAD） are a ch.llenging group to treat; th.se cases elicit dis-cussion w.th.n h.art teams regarding th. actual benefit of undertaking major surgery on th.se patients and often lead to abandon th. surgical option. Percutaneous procedures represent an important option, but coronary anatomy may be unfavorable. Off-pump coronary artery bypass （OPCAB） provides good quality graft on left anterior descending （LAD） w.th.ut exposing th. patient to cardiopulmonary bypass, and migh. be th. ideal ch.ice in patients w.th.multiple comorbidities, not eligible to percutaneous or on-pump procedures. Th. objective of th.s study w.s to compare survival during a mid-term follow.up in h.gh.risk patients w.th.no percutaneous alternative, eith.r treated w.th.OPCAB or disch.rged in medical *** retrospectively evaluated from June 2008 to June 2013, 83 h.gh.risk patients w.th.multivessel CAD w.re included： 42 w.re treated w.th.incomplete off-pump revascularization using left internal mammary artery （LIMA） on LAD; 41 w.re disch.rged in optimal medical th.rapy （OMT）, h.ving refused surgery. Follow.up ended in March.2015, w.th.a teleph.nic interview. Primary endpoint w.s survival from all-cause mortality; secondary endpoints w.re survival from cardiac-related mortality and freedom from non-fatal major adverse cardiac events （MACEs）.ResultsDuring follow.up, 11 death. in OPCAB group and 27 death. in OMT group occurred. Death.w.s due to cardiac factors in 6 and 15 patients, respectively. MACEs w.re observed in 6 patients in OPCAB group and in 4 patients in OMT group. w.th.regards to survival from all-cause mortality, patients w.o underw.nt OPCAB survived more th.n th.se dis-ch.rged in OMT （Log Rank ＆lt; 0.001）, and OMT group carries a propensity score-adjusted h.zard ratio of 3.862 （P ＆lt; 0.001）. w.th.regards to survival from cardiac-related events, patients w.o underw.nt OPCAB survived more th.n th.se disch.rged

关键词： Coronary artery disease Myocardial revascularization Off-pump coronary artery bypass Survival analysis

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Micro-Ph.toluminescence Confocal Mapping of Single V-Grooved GaAs Quantum w.re

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Ch.nese Ph.sics Letters 2006年第12期23卷 3341-3344页

作者：黄少华陈张海柏利慧沈学础 h. h. Tan L. Fu M. fraser C. Jagadish Department of Ph.sics and National Key Laboratory for Surface Ph.sics Fudan University Shanghai 200433 Department of Electronic Material Engineering Research School of Ph3~sical Science and Engineering Australian National University Canberra ACT 0200 Australia

w. perform th. micro-ph.toluminescence measurement at low.temperatures and a scanning optical mapping w.th.h.gh.spatial resolution of a single V-grooved GaAs quantum w.re modified by th. selective ion-implantation and rapid th.rmally annealing. w.ile th. mapping sh.w. th. luminescences respectively from th. quantum w.res and from quantum w.ll areas betw.en quantum w.res in general, th. micro-ph.toluminescence at liquid h. temperatures reveals a plenty of spectral structures of th. PL band for a single quantum w.re. Th. spectral structures are attributed to th. inh.mogeneity and non-uniformity of both.th. space structure and compositions of real w.res as w.ll as th. defects nearby th. interface betw.en quantum w.re and surrounding quantum w.ll structures. All th.se make th. excitons farth.r localized in quasi-zero-dimensional quantum potential boxes related to th.se non-uniformity and/or defects. Th. results also demonstrate th. ability of micro-ph.toluminescence measurement and mapping for th. ch.racterization of both.opto-electronic and structural properties of real quantum w.res.

关键词： GROw.h

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Teach.ng teach.rs

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作者： James w. fraser and Lauren Lefty.

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Dynamic compressive beh.viour of Ti-6Al-4V alloy processed by electron beam melting under h.gh.strain rate loading

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Advances in Manufacturing 2015年第3期3卷 232-243页

作者： A.Moh.mmadh.sseini S.h.Masood D.fraser M.Jah.di Department of Mech.nical and Product Design Engineering Faculty of ScienceEngineering and TechnologySwinburne University of Technology Commonw.alth.Scientific and Industrial Research.Organisation

Th.s paper documents an investigation into th. compressive deformation beh.viour of electron beam melting （EBM） processing titanium alloy （Ti-6A1-4V） parts under h.gh.strain loading conditions. Th. dynamic compression tests w.re carried out at a h.gh.strain rate of over 1 × 10^3/S using th. split h.pkinson pressure bar （Sh.B） test system and for comparison th. quasi-static tests w.re performed at a low.strain rate of 1×10^-3/s using a numerically controlled h.draulic materials test system （MTS） testing mach.ne at an ambient temperature. Furth.rmore, microstructure analysis w.s carried out to study th. failure mech.nisms on th. deformed samples. Th. Vickers micro-h.rdness values of th. samples w.re measured before and after th. compression tests. Th. microstructures of th. compressed samples w.re also ch.racterized using optical microscopy. Th. particle size distribution and ch.mical composition of pow.er material, w.ich.migh. affect th. mech.nical properties of th. specimens, w.re investigated. In addition, th. numerical simulation using commercial explicit finite element softw.re w.s employed to verify th. experimental results from Sh.B test system.

关键词： Additive manufacturing Electron beam melting (EBM) Titanium alloys Split h.pkinson

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Adsorption of As on h.droxy-Fe-montmorillonite complexes

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Science Ch.na Earth.Sciences 2005年第12期48卷 2155-2165页

作者： Donald G. fraser Department of Earth.Sciences Oxford University Parks Road Oxford OX1 3PR UK

Arsenate h.s h.gh.affinity for soluble h.droxy-Fe species and Fe-oxyh.droxide pre-cipitates. In addition, th. h.drolysis of Fe(III) and th. grow.h.of th. initially precipitated Fe(III) ph.ses are strongly influenced by th. presence of montmorillonite. In th.s paper, th. adsorption of As onto various h.droxy-Fe-montmorillonite (h.F-M) complexes w.s studied. Th.ee systems of samples w.re prepared by mixing montmorillonite, h.droxy-Fe and arsenate in different se-quences: (1) Prior mixing of montmorillonite and h.droxy-Fe before th. addition of arsenate; (2) prior mixing of h.droxy-Fe and arsenate before th. addition of montmorillonite; and (3) prior mixing of montmorillonite and arsenate before th. addition of h.droxy-Fe. For each.system, th. effects of ph. ionic strength. temperature, initial Fe and As concentrations and adsorption dura-tion on th. overall uptake of As by h.F-M complexes w.re studied. Results sh.w.d th.t th. up-take of As increased w.th.increasing ph. temperature, initial Fe concentration and adsorption duration, and decreased w.th.increasing ionic strength.and initial As concentration to different extents for th. th.ee systems. Th. variation of th. As uptake of h.F-M complexes w.th.ph.in th. range of study is opposite to th.t reported previously for Fe-O-h.systems in th. absence of montmorillonite and similar to th.t reported for montmorillonite in th. absence of h.droxy-Fe. Th. marked influence of ionic strength.on th. As uptake of h.F-M complexes indicates th.t outer-sph.re complexation plays an important role. Th.s is quite different from th. adsorption of As on th. surface of eith.r Fe-oxyh.droxides or montmorillonite alone in w.ich.inner-sph.re complexation dominates. Under all experimental conditions, th. h.F-M complexes studied dis-played a very strong affinity for As, among w.ich.system 2 h.d th. h.gh.st As adsorption capac-ity and system 1 th. low.st. Th. auth.rs attribute th.s to th. differences in mixing sequence w.ich.resulted in more h.

关键词： h.droxy-Fe, montmorillonite, complex, arsenate adsorption.

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Proximal gastric motility in critically ill patients w.th.type 2 diabetes mellitus

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w.rld Journal of Gastroenterology 2007年第2期13卷 270-275页

作者： Nam Q Nguyen Robert J fraser Laura K Bryant Marianne Ch.pman Rich.rd h.h.llow.y Department of Gastroenterology Hepatology and General Medicine Royal Adelaide Hospital South Australia Investigation and Procedures Unit Repatriation General Hospital South.Australia Anaesth.sia and Intensive Care Royal Adelaide Hospital South Australia

AIM： To investigate th. proximal gastric motor response to duodenal nutrients in critically ill patients w.th.longstanding type 2 diabetes ***： Proximal gastric motility w.s assessed （using a barostat） in 10 critically ill patients w.th.type 2 diabetes mellitus （59±3 years） during tw. 60-min duodenal infusions of Ensure （1 and 2 kcal/min）, in random order, separated by 2h.fasting. Data w.re compared w.th.15 non-diabetic critically ill patients （48 ± 5 years） and 10 h.alth. volunteers （28 ±3 years）. RESULTS： Baseline proximal gastric volumes w.re similar betw.en th. th.ee groups. In diabetic patients, proximal gastric relaxation during I kcal/min nutrient infusion w.s similar to non-diabetic patients and h.alth. controls. In contrast, relaxation during 2 kcal/ min infusion w.s initially reduced in diabetic patients （P 〈 0.05） but increased to a level similar to h.alth. h.mans, unlike non-diabetic patients w.ere relaxation w.s impaired th.ough.ut th. infusion. Duodenal nutrient stimulation reduced th. fundic w.ve frequency in a dose-dependent fash.on in both.th. critically ill diabetic patients and h.alth. subjects, but not in critically ill patients w.th.ut diabetes. Fundic w.ve frequency in diabetic patients and h.alth. subjects w.s greater th.n in non-diabetic ***： In patients w.th.diabetes mellitus, proximal gastric motility is less disturbed th.n nondiabetic patients during critical illness, suggesting th.t th.se patients may not be at greater risk of delayed gastric emptying.

关键词： Proximal gastric function Diabetes mellitus type 2 Critical illness Enteral nutrition

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