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SIRT and Its Unresolved Problems—Is Imaging the Solution? A Review

Journal of Cancer Therapy 2016年第7期7卷 505-518页

作者： franziska schulz Michael Friebe Department of Medical Engineering Otto-von-Guericke University Magdeburg Germany

Selective Internal Radiation Therapy (SIRT) is used as a treatment option for unresectable liver tumors. In SIRT, microspheres, which have a radioactive substance as an integral component, are placed via image guided catheters into the hepatic artery. The ionizing radiation is directly delivered to the tumor. Currently used commercially available microspheres are based on Yttrium 90, a β-emitter, which has been shown to be safe and to produce good clinical results. The technical features of Y90, their applications and their limitations are presented. Image guidance and intraoperative depiction of Yttrium 90 microspheres are restricted, which is currently one of the main limitations in SIRT. Therapy planning and control is currently based on pre- and post-operative images to evaluate the placement of the microspheres respectively. Holmium 166, another possible nuclide integrated into the microspheres emits a higher amount of secondary γ-radiation (Bremsstrahlung) than Yttrium 90. This enables an improved depiction of the microspheres inside the patient during and immediately after application, but comes with other shortfalls. Imaging of delivery and verification of the microsphere placement could solve many of the identified problems with SIRT. The different technologies are reviewed and an outlook in future developments is given particularly on image guidance and therapy control.

关键词： Selective Internal Radiation Therapy (SIRT) Radioembolization Yttrium 90 Holmium 166 Liver Tumors

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Stroke-like onset of brain stem degeneration presents with unique MRI sign and heterozygous NMNAT2 variant:a case report

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Translational Neurodegeneration 2016年第1期5卷 181-185页

作者： Alexander schulz franziska Wagner Martin Ungelenk Ingo Kurth Christoph Redecker Hans Berger Department of Neurology Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Genetics and Program in Cellular Neuroscience Neurodegeneration and RepairYale University School of MedicineNew HavenCT 06510USA Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University JenaJena 07743Germany Institute of Human Genetics Uniklinik RWTH AachenAachen 52074Germany

Background:Acute-onset neurodegenerative diseases in older patients are rare clinical cases,especially when the degeneration only affects specific regions of the nervous *** neurological disorders have been described in which the degeneration of brain parenchyma originates from and/or primarily affects the brain *** diagnosis in these patients,however,is often complicated due to a poor understanding of these diseases and their underlying *** presentation:In this manuscript we report on a 73-year-old female who had experienced a sudden onset of complex neurological symptoms that progressively worsened over a period of 2 *** evaluation had suggested a MRI-negative stroke as underlying *** combination of patient’s medical history,clinical examination and exceptional pattern of brain stem degeneration presenting as“kissing swan sign”in MR imaging was strongly suggestive of acute onset of Alexander’s *** leukoencephalopathy is caused by GFAP(glial fibrilary acidic protein)gene mutations and may present with brain stem atrophy and stroke-like onset of symptoms in elderly ***,a pathognomonic GFAP gene mutation could not be identified by Sanger ***:After an extended differential diagnosis and exclusion of other diseases,a definite diagnosis of the patient’s condition presently remains ***,whole-exome sequencing performed from patient’s blood revealed 12 potentially disease-causative heterozygous variants,amongst which several have been associated with neurological disorders in vitro and in vivo–in particular the axon degeneration-related NMNAT2 gene.

关键词： Brain stem atrophy Dementia Alexander’s disease Whole-exome sequencing Kissing swan sign NMNAT2 Axon degeneration

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三牙融合的双侧乳中切牙：临床病程及治疗

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中国口腔医学继续教育杂志 2009年第2期12卷 19-21页

作者： Nelly schulz-Weidner franziska Ansari Viola Mueller-Lessmann Willi-Eckhard Wetzel 马超（译）王琪（审）不详北京协和医院口腔科正畸科 100730

罕见的牙齿发育异常如融合牙或牙双生常引发与之相关的临床问题。本病例展示了1例罕见的双侧上颌乳中切牙、乳侧切牙及多生乳切牙之间的融合。该患者为4岁小男孩．泰国人。口内检查发现由于根尖部骨质溶解导致脓肿和瘘管形成．采取开髓... 详细信息

罕见的牙齿发育异常如融合牙或牙双生常引发与之相关的临床问题。本病例展示了1例罕见的双侧上颌乳中切牙、乳侧切牙及多生乳切牙之间的融合。该患者为4岁小男孩．泰国人。口内检查发现由于根尖部骨质溶解导致脓肿和瘘管形成．采取开髓引流作为应急处理，由于其预后不确定，只能将其拔除。为了重建其功能，改善美观及发音．应用丙烯酸支托义齿修复。

关键词：牙齿融合牙根尖周病变语音重建牙齿复杂解剖三牙融合

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