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Managing Health Risks during the Balkans Floods

American Journal of Climate Change 2017年第4期6卷 597-606页

作者： Vladimir Kendrovski franziska Matthies Goran Cerkez Maja Dragosavac Dragana Dimitrijevic Milan Rancic Elizabet Paunovic Oliver Schmoll Bettina Menne WHO Regional Office for Europe European Centre for Environment and Health Bonn Germany Freelance Consultant Feldafing Germany Federal Ministry of Health Sarajevo Bosnia and Herzegovina Croatian Institute of Emergency Medicine Zagreb Croatia Institute of Public Health of Serbia Belgrade Serbia

Floods have always had and will continue to have significant consequences for society. In May 2014, there was widespread flooding in the Balkans affecting Bosnia and Herzegovina, Croatia and Serbia. The aim of this article is to show that resilient and proactive health systems that anticipate needs and challenges are more likely to reduce risks and respond effectively during emergencies, saving lives and alleviating human suffering. The method draws on multiple sources of information, including a Balkan case study questionnaire survey with public health professionals involved in response to floods (n = 18) from three affected countries, and focus group discussion results (n = 43) presented at the meeting on “Prevention, preparedness and response to reduce or avoid health effects of flood events”, held in Bonn, Germany, in October 2015. The proposed range of measures to protect population health, organized around flood prevention, preparedness, response and recovery listed issues and considerations largely corresponds to the identified needs by Member State requests, following the Balkan country experiences. The consideration of lessons for early warning, preparedness and response and the integration of research results would lead to improved preparedness measures to better prevent flooding risks. Experiences in the WHO European Region point to a need to shift the emphasis from disaster response to long-term risk management.

关键词： Managing Flooding Health Risks Resilient Health System Balkans Population Health

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学历与一生的收入:德国最新的有关调查统计(上)

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应用型高等教育研究 2017年第4期2卷 83-88页

作者： Marc Piopiunik franziska Kugler Ludger Wβmann 陈颖 ifo研究所教育经济学中心德国慕尼黑81679 路德维希-马克西米利安-慕尼黑大学德国慕尼黑80539 奥斯纳布吕克应用科学大学

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度... 详细信息

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度人群进行分类并计算他们之间终生收入的差异。研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别,特别是职业培训和大学教育的不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。

关键词：教育教育收益职业教育高等教育

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High Response Rate to Second-Line Combination Antiangiogenic Chemotherapy in Patients with Metastatic Melanoma

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Journal of Cancer Therapy 2016年第12期7卷 908-918页

作者： Ozan Haase Ozan Angün Ewan A. Langan franziska Hübner Florian M. Vogt Christoph Thorns Detlef Zillikens Patrick Terheyden Department of Dermatology University of Lübeck Lübeck Germany Department of Radiology University of Lübeck Lübeck Germany Institute of Pathology Section for Hematopathology and Endocrine Pathology University of Lübeck Lübeck Germany

Objectives: Despite the array of new treatment strategies for the management of metastatic melanoma, the prognosis remains poor when immune checkpoint inhibition and targeted therapy options are exhausted. The antiangiogenic monoclonal antibody bevacizumab has documented its efficacy in the treatment of several solid tumors, when used in combination with standard chemotherapy. Phase II studies and case series have led to the speculation that it may also improve the prognosis when used in stage IV melanoma. Therefore, we investigated the influence of bevacizumab, combined with a platinum-based chemotherapy, in the treatment of melanoma and sought to identify prognostic factors affecting the response. Methods: Eight patients with metastatic melanoma, with documented progress after at least one previous therapy, received bevacizumab (5 mg/kg intravenously every two weeks) in combination with cisplatin (100 mg/m2 every four weeks) and carboplatin (200 mg/m2 every four weeks). The therapy was continued until renewed disease progression occurred. The response rate, progression-free and overall survival, and toxicity were evaluated. Results: We observed complete remission in two patients (25%) and partial response in an additional four patients. In one patient, the disease remained stable (total disease control rate of 87.5%). Only one patient (12.5%) had progressive disease. The median progression-free survival was 6 months (range 3 - 37 months). The median overall survival time was 15.5 months (range 6 - 77 months). Every patient experienced at least one adverse event of grade 3 - 4, most commonly bleeding associated with severe thrombocytopenia. Conclusion: Our observations indicate that bevacizumab, in combination with cisplatin and carboplatin, may represent an effective treatment option for patients with metastatic melanoma and disease progression.

关键词： Melanoma Cisplatin Carboplatin Bevacizumab Response Angiogenesis

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防止电化学腐蚀的有效方法新型预防失效的电中性材料

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汽车与配件 2018年第11期 60-62页

作者： franziska Munterer GünterPrautzsch Thilo Stier AKRO-PLASTIC GmbH AKRO-PLASTIC GmbH创新及销售事业部

电子产品的广泛应用丰富了我们生活。除了每天使用的智能手机和平板电脑，在其它的许多应用场合中也有电子产品的身影。在汽车领域，就能找到越来越多的集成电路（1C）。这些微型计算机不间断地运作，控制着许多功能，包括：座椅调整、... 详细信息

电子产品的广泛应用丰富了我们生活。除了每天使用的智能手机和平板电脑，在其它的许多应用场合中也有电子产品的身影。在汽车领域，就能找到越来越多的集成电路（1C）。这些微型计算机不间断地运作，控制着许多功能，包括：座椅调整、外后视镜定位、车窗升降器和雨刮器等，所有这些现代化车辆中的电动部件都是由小型计算机控制。

关键词：电化学腐蚀计算机控制电子产品微型计算机平板电脑智能手机集成电路座椅调整

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Manufacturing of Surface Nanostructured Fibers Featuring an Antibacterial Effect by Magnetic Field Transportation of Magnetite@Silver Core-Shell Nanoparticles

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Journal of Materials Science and Chemical Engineering 2017年第12期5卷 1-16页

作者： Roy Buschbeck franziska Lüttich Sebastian Spange Ronny Kocher Michael Roder Andreas Heft Bernd Grünler Arnd Schimanski Heinrich Lang Surface Engineering Innovent e.V.Technology DevelopmentJenaGermany Inorganic Chemistry Institute of ChemistryTechnischeUniversität ChemnitzChemnitzGermany

Magnetic core-shell nanoparticles of type Fe3O4@Ag were synthesized in gram scale following a combined co-precipitation phase-transfer method and afterwards, processed to nanoparticle polymer (polypropylene and polyamide) composites. These composites were used as sheath material for the fabrication of core-sheath fibers. During the melt spinning process, a magnetic field was applied around the roving, whereby the particles move in the still liquid sheath polymer towards the surface. The produced fiber materials were investigated by AFM showing a nanostructuring of the surface, which was indirectly confirmed by determination of a slight surface tension lowering. Nanoparticle movement was shown by cross-section SEM and EDX measurements. The antibacterial activity of the spun fibers was proven by contacting them with Escherichia coli. A long-term stability of this effect was observable by carrying out a standard washability test. In contrast to previous works this new approach uses no deposition technique to introduce surface changes. It rather applies a magnetic force to move appropriately equipped nanoparticles from the inside of the fiber to the surface. This leads in only one step to a strong superficial anchoring of the particles resulting in a unique combination of long-term stable antibacterial and improved anti-soiling effects.

关键词： Nanocomposites Polymer Fibers Core-Shell Nanoparticles Magnetic Field Treatment Nanostructured Surface

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Robotic Foregut Surgery: One Surgeon’s Experience with Nissen Fundoplication, Esophagomyotomy, and Hiatal Hernia Repair

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Surgical Science 2012年第1期3卷 1-9页

作者： franziska Huettner Robin A. Alley Jamie L. Doubet Michael J. Ryan Danuta I. Dynda David L. Crawford Department of Radiology University of Michigan Hospital Ann Arbor USA Division of Minimally Invasive Surgery Department of Surgery College of Medicine University of Illinois at Peoria Illinois Medical Center Peoria USA Division of Plastic Surgery Department of Surgery University of Alabama at Birmingham Birmingham UK

Purpose: The purpose of the study was to review a single surgeon, seven-year experience, using the Da Vinci Telerobotic system performing 124 foregut operations. Methods: Data review from 2002-2009 including 71 Nissen fundoplications, 26 esophagomyotomies, and 27 hiatal hernia repairs was performed. Parameters collected included gender, age, body mass index (BMI), estimated blood loss (EBL), port set up time (PST), robot operating time (ROT), total case time (TCT), length of stay (LOS), complications, conversions, and resident involvement. Statistical analysis was con-ducted. Results: 124 foregut operations: 45 males, 79 females, mean age of 54.8 ± 16.7 (18 - 85) years, mean TCT 174.4 ± 45.0 (102 - 321) min. Nissen fundoplication: mean BMI of 30.8 ± 3.9 (22.4 - 46.8) kg/m2, EBL 30.2 ± 21.8 (5 - 100) ml, PST 32.3 ± 9 (14 - 63) min, ROT 111.4 ± 37.3 (51 - 229) min, TCT 175.0 ± 46.4 (102 - 321) min, median LOS 1 (0 - 9) day, complication rate 7.0% (5/71), conversion rate 5.6%, resident involvement 69.0% (49/71). Esophagomyotomy: mean BMI of 26.5 ± 6.1 (15.4 - 36.6) kg/m2, EBL 39.1 ± 41.7 (10 - 200) ml, PST 28.0 ± 8.6 (16 - 47) min, ROT 122.9 ± 45 (31 - 217) min, and TCT 178.0 ± 40.5 (105 - 262) min, median LOS 1 (0 - 6) day, complication rate 15.4% (4/26), conversion rate 0%, resident involvement 69.2% (18/26). Hiatal hernia repair: mean BMI of 28.4 ± 4.2 (21.9 - 36.8) kg/m2, EBL 38.4 ± 32.7 (10 - 150) ml, PST 28.8 ± 8.0 (17 - 52) min, ROT 109.0 ± 44.5 (49 - 250) min, and TCT 169.2 ± 46.5 (102 - 299) min, median LOS 1 (1 - 14) day, complication rate 11.1% (3/27), conversion rate 3.7%, resident involvement 66.7% (18/27). Conclusion: Robotic-assisted foregut surgery is safe and effective. This series compares favorably with other robotic studies in length of hospital stay, total case time, and complication and conver-sion rates. Foregut surgery is an excellent robotic training ground for residents.

关键词： Robot Foregut Nissen Fundoplication Hiatal Hernia Esophagomyotomy

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184例疑似输入性埃及血吸虫病病例回顾性调查

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中国血吸虫病防治杂志 2011年第4期23卷 441-442,470页

作者：易平袁里平王璋华何永康荆群山周杰王洪波李胜明 franziska Bieri 湖南省血吸虫病防治所岳阳414000 Queensland Institute for Medical Research

目的了解出国务工人员感染埃及血吸虫情况。方法采用回顾性调查和个别访谈法,对湖南省血吸虫病防治专科医院收治的疑似输入性埃及血吸虫病人感染和收治等情况进行调查。结果收治的184例疑似输入埃及血吸虫病人劳务输出务工地主要为安哥... 详细信息

目的了解出国务工人员感染埃及血吸虫情况。方法采用回顾性调查和个别访谈法,对湖南省血吸虫病防治专科医院收治的疑似输入性埃及血吸虫病人感染和收治等情况进行调查。结果收治的184例疑似输入埃及血吸虫病人劳务输出务工地主要为安哥拉(111例,占60.3%)、莫桑比克(57例,占31.0%)等非洲国家。其中13例作病原学检查,分别在尿液、直肠活组织和膀胱等检查中发现埃及血吸虫卵6例。病人均经IHA和ELISA检测日本血吸虫抗体,阳性率为96.7%。病人中有112例(60.9%)出现不同程度的泌尿道症状,乏力者52例(28.3%),但有72例(39.1%)无任何自觉症状。结论建议国家有关部门尽快制订和完善埃及血吸虫病和曼氏血吸虫病等输入性疾病的防控机制,保护劳务输出人员健康。

关键词：劳务输出输入性病例埃及血吸虫病回顾性调查

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Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques

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World Journal of Gastroenterology 2015年第16期21卷 4894-4902页

作者： Thomas Karlas Joachim Berger Nikita Garnov franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim IFB Adiposity Diseases Leipzig University Medical Center Department of Medicine Neurology and DermatologyDivision of Gastroenterology and RheumatologyUniversity Hospital Leipzig Department of Diagnostic and Interventional Radiology University Hospital Leipzig Internistische Hausarzt- und Diabetologische Schwerpunktpraxis Dr. Relke Department of Medicine Neurology and DermatologyDivision of Endocrinology and NephrologyUniversity Hospital Leipzig

AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver ***:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and *** parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP ***:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the *** ASQ parameters showed differences between healthy controls and diabetic patients(P0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver *** estimation with ASQ should be further evaluated in biopsy-controlled studies.

关键词： Transient elastography Non-alcoholic fatty liver disease Liver stiffness Fibrosis score Controlled attenuation parameter

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Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers

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Cancer Biology & Medicine 2019年第2期16卷 319-330页

作者： Andreas M. Luebke Ali Attarchi-Tehrani Jan Meiners Claudia Hube-Magg Dagmar S. Lang Martina Kluth Maria Christina Tsourlakis Sarah Minner Ronald Simon Guido Sauter franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland Markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer Institute of Pathology University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany General Visceral and Thoracic Surgery Department and Clinic University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany Department of Urology Charite-Universitatsmedizin Berlin Berlin 10117 Germany Martini-Clinic Prostate Cancer Center University Medical Center Hamburg-Eppendorf Hamburg 20246 Germany

Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is ***: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TMPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was ***: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P < 0.0001) and largely unrelated to the ERG status, but strongly correlated with high Gleason grade, advanced tumor stage, and nodal metastasis(P <0.0001 each). The fraction of PSP94-negative cancer specimens increased from 40% in pT2 to 52%in pT3 b-pT4(P < 0.0001) and from 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P <0.0001). Loss of PSP94 was linked to early prostate-specific antigen recurrence, but with little absolute effect(P < 0.0001).However, it provided additional prognostic impact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P < 0.0001). The combination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason ***: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer.

关键词： MSMB PSP94 PTEN prostate cancer tissue microarray

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学历与一生的收入德国最新的有关调查统计(下)

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应用型高等教育研究 2018年第1期3卷 57-64页

作者： Marc Piopiunik franziska Kugler Ludger Woβmann 陈颖(翻译) ifo研究所教育经济学中心德国慕尼黑81679 路德维希-马克西米利安-慕尼黑大学德国慕尼黑80539 奥斯纳布吕克应用科学大学

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,根据不同受教育程度计... 详细信息

教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,根据不同受教育程度计算人们终生收入的差异。我们的研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别、特别是不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。

关键词：教育教育收益职业教育高等教育

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