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Esophageal lichen planus:Current knowledge,challenges and future perspectives

World Journal of Gastroenterology 2022年第41期28卷 5893-5909页

作者： Annegrit Decker franziska schauer Adhara Lazaro Carmen Monasterio Arthur Robert Schmidt Annette Schmitt-Graeff Wolfgang Kreisel Department of Medicine II GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical Center-University of FreiburgFaculty of MedicineFreiburg 79106Germany Department of Dermatology Medical Center-University of FreiburgFaculty of MedicineFreiburg 79104Germany Department of Medicine Institute of Exercise and Occupational MedicineMedical Center–University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute for Dermatohistology Pathologyand Molecular Pathology Prof.Dr.LaafFreiburgGermany and:University of FreiburgFreiburg 79106Germany

Lichen planus(LP)is a frequent,chronic inflammatory disease involving the skin,mucous membranes and/or skin *** involvement in lichen planus(ELP)is a clinically important albeit underdiagnosed inflammatory *** narrative review aims to give an overview of the current knowledge on ELP,its prevalence,pathogenesis,clinical manifestation,diagnostic criteria,and therapeutic options in order to provide support in clinical *** on ELP were collected using PubMed/*** clinical and therapeutical characteristics from published patient cohorts including our own cohort were extracted and *** mainly affects middle-aged *** principal symptom is ***,asymptomatic cases despite progressed macroscopic esophageal lesions may *** pathogenesis is unknown,however an immune-mediated mechanism is ***,ELP is characterized by mucosal denudation and tearing,trachealization,and *** esophageal stenosis may occur in chronic *** findings include mucosal detachment,T-lymphocytic infiltrations,epithelial apoptosis(Civatte bodies),dyskeratosis,and *** immuno-fluorescence shows fibrinogen deposits along the basement membrane *** date,there is no established ***,treatment with topical steroids induces symptomatic and histologic improvement in two thirds of ELP patients in *** severe cases may require therapy with *** symptomatic esophageal stenosis,endoscopic dilation may be *** may be regarded as a precancerous condition as transition to squamous cell carcinoma has been documented in *** is an underdiagnosed yet clinically important differential diagnosis for patients with unclear dysphagia or *** diagnosis and therapy might prevent potential sequelae such as esophageal stenosis or development of invasive squamous cell *** studies are needed to gain

关键词： Lichen planus Esophagitis T-lymphocytes Budesonide Dysphagia Precancerosis

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