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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

5-Bromo-2'-deoxyuridine labeling:historical perspectives,factors infiuencing the detection,toxicity,and its implications in the neurogenesis

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neural Regeneration Research 2024年第2期19卷 302-308页

作者： Joaquín martí-Clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine 5-bromo-2′-deoxyuridine(BrdU)is an exogenous marker of DnA *** the introduction of monoclonal antibodies against BrdU,an increasing number of methodologies have been used for the immunodetection of this synthesized bromine-tagged base analogue into replicating *** labeling is widely used for identifying neuron precursors and following their fate during the embryonic,perinatal,and adult neurogenesis in a variety of vertebrate species including birds,reptiles,and *** to BrdU toxicity,its incorporation into replicating DnA presents adverse consequences on the generation,survival,and settled patterns of *** may lead to false results and misinterpretation in the identification of proliferative *** this review,I will indicate the detrimental effects of this nucleoside during the development of the central nervous system,as well as the reliability of BrdU labeling to detect proliferating ***,it will show factors influencing BrdU immunodetection and the contribution of this nucleoside to the study of prenatal,perinatal,and adult *** adult neurogenesis will also be *** is my hope that this review serves as a reference for those researchers who focused on detecting cells that are in the synthetic phase of the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult neurogenesis human adult neurogenesis labeling pitfalls prenatal neurogenesis proliferation S-phase suturing S-phase toxicity

Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： Jose Enrique martÍn-ALFOnSO María Jose martÍn-ALFOnSO Concepción VALEnCIA María Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remarkable lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

THE BAnACH-LIE GROUP OF LIE TRIPLE AUTOMORPHISMS OF An H^＊-ALGEBRA^＊

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Acta Mathematica Scientia 2010年第4期30卷 1219-1226页

作者： A.J.Calderón martín C.martín González Departamento de Matemáticas Universidad de Cádiz Departamento de Algebra Geometría y Topología Universidad de Málaga

We study the Banach-Lie group Ltaut（A） of Lie triple automorphisms of a complex associative H^＊-algebra A. Some consequences about its Lie algebra, the algebra of Lie triple derivations of A, Ltder（A）, are obtained. For a topologically simple A, in the infinite-dimensional case we have Ltaut（A）0 = Aut（A） implying Ltder（A） = Der（A）. In the finite-dimensional case Ltaut（A）0 is a direct product of Aut（A） and a certain subgroup of Lie derivations δ from A to its center, annihilating commutators.

关键词： Banach-Lie group Lie triple automorphism Lie triple derivation

On Integrable Roots in Split Lie Triple Systems

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Acta Mathematica Sinica,English Series 2009年第11期25卷 1759-1774页

作者： A.J.CALDERón martín Departamento de Matemáticas Universidad de Cádiz

We focus on the notion of an integrable root in the framework of split Lie triple systems T with a coherent 0-root space. As a main result, it is shown that if T has all its nonzero roots integrable, then its standard embedding is a split Lie algebra having all its nonzero roots integrable. As a consequence, a local finiteness theorem for split Lie triple systems, saying that whenever all nonzero roots of T are integrable then T is locally finite, is stated. Finally, a classification theorem for split simple Lie triple systems having all its nonzero roots integrable is given.

关键词： Lie triple system root split Lie algebra classification theory

Evaluation of glial cell proliferation with non-invasive molecular imaging methods after stroke

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neural Regeneration Research 2021年第11期16卷 2209-2210页

作者： Ana Joya Abraham martín Achucarro Basque Center for neuroscience LeioaSpain CIC biomaGUnE Basque Research and Technology Alliance(BRTA)PaseoSpain Ikerbasque Basque Foundation for Science BilbaoSpain

Glial proliferation:For the last decades,glial cells have been wrongly believed to have a mere passive supporting role for ***,this notion has clearly changed and it is now admitted that these cells are essential for the correct development and regulation of the nervous *** cell population are commonly subdivided in astrocytes,oligodendrocytes and *** the development,neural stem cells(nSCs)(called neuroepithelial progenitor cells or nPCs)transform into radial glia,the primary progenitor cells for neurons,astrocytes and oligodendrocytes(Zuchero and Barres,2015).Microglial cells,however,derive from a mesenchymal precursor infiltration,meaning that during brain development,precursors generated in the bone narrow invade the nervous parenchyma and differentiate into microglial cells(Zuchero and Barres,2015).This proliferative capacity is preserved in the adult mammalian brain,and neurogenic nSCs are stored in two restricted regions of the central nervous system(CnS),the forebrain subventricular zone(SVZ)and the hippocampal dentate gyrus(subgranular zone).These cells continue to produce neurons and glial cells during the adulthood,being activated after certain signals and leaving the quiescent state(Urbán et al.,2019).This process,in which glial progenitor cells differentiate into mature glia during development and in the adult brain to maintain and regulate brain function,is called gliogenesis(Ardaya et al.,2020).

关键词： admitted maintain supporting

nanomechanical hydrodynamic force sensing using suspended microfluidic channels

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Microsystems & nanoengineering 2023年第3期9卷 95-102页

作者： Alberto martín-Pérez Daniel Ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

A new player in the beneficial effects of exercise on the aged brain

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Signal Transduction and Targeted Therapy 2020年第1期5卷 901-902页

作者： M.Llorens-martín Department of Molecular neuropathology Centro de Biología Molecular“Severo Ochoa”CBMSOCSIC-UAMMadridSpain Center for networked Biomedical Research on neurodegenerative Diseases(CIBERnED) MadridSpain Department of Molecular Biology Faculty of SciencesUniversidad Autónoma de MadridMadridSpain

In a recent article in Science,Horowitz et *** glycosylphosphatidylinositol(GPI)-degrading enzyme Gpld1 as the most critical player in the blood that can transfer the effects of exercise on adult neurogenesis and cognition to sedentary aged *** also demonstrate the importance of this liver-to-brain axis in ameliorating age-related regenerative and cognitive impairments.

关键词： tar player critical